ID H2YRX4_CIOSA Unreviewed; 1944 AA.
AC H2YRX4;
DT 18-APR-2012, integrated into UniProtKB/TrEMBL.
DT 18-APR-2012, sequence version 1.
DT 27-MAR-2024, entry version 71.
DE RecName: Full=Myosin VIIAb {ECO:0008006|Google:ProtNLM};
OS Ciona savignyi (Pacific transparent sea squirt).
OC Eukaryota; Metazoa; Chordata; Tunicata; Ascidiacea; Phlebobranchia;
OC Cionidae; Ciona.
OX NCBI_TaxID=51511 {ECO:0000313|Ensembl:ENSCSAVP00000008084.1, ECO:0000313|Proteomes:UP000007875};
RN [1] {ECO:0000313|Proteomes:UP000007875}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Birren B., Nusbaum C., Abebe A., Abouelleil A., Adekoya E., Ait-zahra M.,
RA Allen N., Allen T., An P., Anderson M., Anderson S., Arachchi H.,
RA Armbruster J., Bachantsang P., Baldwin J., Barry A., Bayul T.,
RA Blitshsteyn B., Bloom T., Blye J., Boguslavskiy L., Borowsky M.,
RA Boukhgalter B., Brunache A., Butler J., Calixte N., Calvo S., Camarata J.,
RA Campo K., Chang J., Cheshatsang Y., Citroen M., Collymore A., Considine T.,
RA Cook A., Cooke P., Corum B., Cuomo C., David R., Dawoe T., Degray S.,
RA Dodge S., Dooley K., Dorje P., Dorjee K., Dorris L., Duffey N., Dupes A.,
RA Elkins T., Engels R., Erickson J., Farina A., Faro S., Ferreira P.,
RA Fischer H., Fitzgerald M., Foley K., Gage D., Galagan J., Gearin G.,
RA Gnerre S., Gnirke A., Goyette A., Graham J., Grandbois E., Gyaltsen K.,
RA Hafez N., Hagopian D., Hagos B., Hall J., Hatcher B., Heller A.,
RA Higgins H., Honan T., Horn A., Houde N., Hughes L., Hulme W., Husby E.,
RA Iliev I., Jaffe D., Jones C., Kamal M., Kamat A., Kamvysselis M.,
RA Karlsson E., Kells C., Kieu A., Kisner P., Kodira C., Kulbokas E.,
RA Labutti K., Lama D., Landers T., Leger J., Levine S., Lewis D., Lewis T.,
RA Lindblad-toh K., Liu X., Lokyitsang T., Lokyitsang Y., Lucien O., Lui A.,
RA Ma L.J., Mabbitt R., Macdonald J., Maclean C., Major J., Manning J.,
RA Marabella R., Maru K., Matthews C., Mauceli E., Mccarthy M., Mcdonough S.,
RA Mcghee T., Meldrim J., Meneus L., Mesirov J., Mihalev A., Mihova T.,
RA Mikkelsen T., Mlenga V., Moru K., Mozes J., Mulrain L., Munson G.,
RA Naylor J., Newes C., Nguyen C., Nguyen N., Nguyen T., Nicol R., Nielsen C.,
RA Nizzari M., Norbu C., Norbu N., O'donnell P., Okoawo O., O'leary S.,
RA Omotosho B., O'neill K., Osman S., Parker S., Perrin D., Phunkhang P.,
RA Piqani B., Purcell S., Rachupka T., Ramasamy U., Rameau R., Ray V.,
RA Raymond C., Retta R., Richardson S., Rise C., Rodriguez J., Rogers J.,
RA Rogov P., Rutman M., Schupbach R., Seaman C., Settipalli S., Sharpe T.,
RA Sheridan J., Sherpa N., Shi J., Smirnov S., Smith C., Sougnez C.,
RA Spencer B., Stalker J., Stange-thomann N., Stavropoulos S., Stetson K.,
RA Stone C., Stone S., Stubbs M., Talamas J., Tchuinga P., Tenzing P.,
RA Tesfaye S., Theodore J., Thoulutsang Y., Topham K., Towey S., Tsamla T.,
RA Tsomo N., Vallee D., Vassiliev H., Venkataraman V., Vinson J., Vo A.,
RA Wade C., Wang S., Wangchuk T., Wangdi T., Whittaker C., Wilkinson J.,
RA Wu Y., Wyman D., Yadav S., Yang S., Yang X., Yeager S., Yee E., Young G.,
RA Zainoun J., Zembeck L., Zimmer A., Zody M., Lander E.;
RL Submitted (AUG-2003) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSCSAVP00000008084.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the TRAFAC class myosin-kinesin ATPase
CC superfamily. Myosin family. {ECO:0000256|ARBA:ARBA00008314,
CC ECO:0000256|PROSITE-ProRule:PRU00782}.
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DR Ensembl; ENSCSAVT00000008192.1; ENSCSAVP00000008084.1; ENSCSAVG00000004814.1.
DR GeneTree; ENSGT00940000157247; -.
DR HOGENOM; CLU_000192_14_1_1; -.
DR Proteomes; UP000007875; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0016459; C:myosin complex; IEA:UniProtKB-KW.
DR GO; GO:0003779; F:actin binding; IEA:UniProtKB-KW.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0003774; F:cytoskeletal motor activity; IEA:UniProtKB-UniRule.
DR CDD; cd17092; FERM1_F1_Myosin-VII; 1.
DR CDD; cd17093; FERM2_F1_Myosin-VII; 1.
DR CDD; cd14473; FERM_B-lobe; 2.
DR CDD; cd13198; FERM_C1_MyoVII; 1.
DR CDD; cd13199; FERM_C2_MyoVII; 1.
DR CDD; cd01381; MYSc_Myo7; 1.
DR Gene3D; 1.20.5.190; -; 1.
DR Gene3D; 1.20.58.530; -; 1.
DR Gene3D; 1.20.80.10; -; 2.
DR Gene3D; 6.20.240.20; -; 1.
DR Gene3D; 3.40.850.10; Kinesin motor domain; 2.
DR Gene3D; 1.20.120.720; Myosin VI head, motor domain, U50 subdomain; 1.
DR Gene3D; 1.25.40.530; MyTH4 domain; 3.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 2.
DR Gene3D; 2.30.30.40; SH3 Domains; 1.
DR InterPro; IPR019749; Band_41_domain.
DR InterPro; IPR014352; FERM/acyl-CoA-bd_prot_sf.
DR InterPro; IPR035963; FERM_2.
DR InterPro; IPR019748; FERM_central.
DR InterPro; IPR000299; FERM_domain.
DR InterPro; IPR000048; IQ_motif_EF-hand-BS.
DR InterPro; IPR036961; Kinesin_motor_dom_sf.
DR InterPro; IPR001609; Myosin_head_motor_dom.
DR InterPro; IPR041793; MyoVII_FERM_C1.
DR InterPro; IPR041794; MyoVII_FERM_C2.
DR InterPro; IPR036106; MYSc_Myo7.
DR InterPro; IPR000857; MyTH4_dom.
DR InterPro; IPR038185; MyTH4_dom_sf.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR001452; SH3_domain.
DR InterPro; IPR029071; Ubiquitin-like_domsf.
DR PANTHER; PTHR22692; MYOSIN VII, XV; 1.
DR PANTHER; PTHR22692:SF26; MYTH4 DOMAIN-CONTAINING PROTEIN; 1.
DR Pfam; PF00373; FERM_M; 1.
DR Pfam; PF00063; Myosin_head; 1.
DR Pfam; PF00784; MyTH4; 1.
DR PRINTS; PR00193; MYOSINHEAVY.
DR SMART; SM00295; B41; 2.
DR SMART; SM00242; MYSc; 1.
DR SMART; SM00139; MyTH4; 2.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR SUPFAM; SSF47031; Second domain of FERM; 2.
DR SUPFAM; SSF54236; Ubiquitin-like; 2.
DR PROSITE; PS50057; FERM_3; 2.
DR PROSITE; PS50096; IQ; 2.
DR PROSITE; PS51456; MYOSIN_MOTOR; 1.
DR PROSITE; PS51016; MYTH4; 2.
DR PROSITE; PS50002; SH3; 1.
PE 3: Inferred from homology;
KW Actin-binding {ECO:0000256|ARBA:ARBA00023203, ECO:0000256|PROSITE-
KW ProRule:PRU00782};
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|PROSITE-
KW ProRule:PRU00782};
KW Motor protein {ECO:0000256|ARBA:ARBA00023175, ECO:0000256|PROSITE-
KW ProRule:PRU00782};
KW Myosin {ECO:0000256|ARBA:ARBA00023123, ECO:0000256|PROSITE-
KW ProRule:PRU00782};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|PROSITE-
KW ProRule:PRU00782}; Reference proteome {ECO:0000313|Proteomes:UP000007875};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW SH3 domain {ECO:0000256|ARBA:ARBA00022443, ECO:0000256|PROSITE-
KW ProRule:PRU00192}.
FT DOMAIN 11..720
FT /note="Myosin motor"
FT /evidence="ECO:0000259|PROSITE:PS51456"
FT DOMAIN 831..1022
FT /note="MyTH4"
FT /evidence="ECO:0000259|PROSITE:PS51016"
FT DOMAIN 1027..1370
FT /note="FERM"
FT /evidence="ECO:0000259|PROSITE:PS50057"
FT DOMAIN 1365..1434
FT /note="SH3"
FT /evidence="ECO:0000259|PROSITE:PS50002"
FT DOMAIN 1484..1654
FT /note="MyTH4"
FT /evidence="ECO:0000259|PROSITE:PS51016"
FT DOMAIN 1660..1944
FT /note="FERM"
FT /evidence="ECO:0000259|PROSITE:PS50057"
FT REGION 600..622
FT /note="Actin-binding"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00782"
FT BINDING 119..126
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00782"
SQ SEQUENCE 1944 AA; 224520 MW; EC77DCE9CFB493A9 CRC64;
NIKVMHPTSV EGVEDMIRLG DLNEAGILRN LLIRYNEDHI YTFTGSILVA VNPYQELPLY
DIDAIRKYTG NWGSYPPHIF AIADNAYNNM LRSKQDQCVI PHAYTFMLSY NSHSHHCSGE
SGAGKTESTK LVLQYLAAIS GQHSWIEQQI LEANPILEAF GNAKTIRNDN SSRFGKFIDI
RFNQDGIIQS AKIDQYLLEK SRLVHQTTDE RNYHVFYCML AGMAANKKQE LGLGKPSEYV
NLTQGSCLQC AGRNDKEEYG DIVRGMKLLL ECEAEIYEIF RLLAGILHTG NFQFRETMTD
NLDSVELIHN SGVKRTAQLL GVSNLMIKYR IIIIFLMNRE TIQGVVSITV NEQSLMRALT
QRTIITREDT VTSPMNLEQS NDVKDAFIKG IYGRMFVWIV DKINSAIFKD SKTKKKHWNT
IGLLDIFGFE NFGNNSFEQL CINFANENLQ QFFVRHVFKL EQEEYNKEAI EWKHITFKDN
QDVLDMIAVK PMNILALISE EAMFPRVRNL IRQHGKNILF KNPKNQFDET FGIEHFAGAV
RYSCAGFLER NRDTFHRDLM NLIQGSKNKF LKLLFYQDSG SKSNSHRRNH TLCEQFKKSL
DSLMRTLSAC QPFFVRCIKP NETKSAHNFD RELVARQLRY SGMMETIRIR RAGYPIRYSF
SEFIDRYWLV FNCTNSTSVL KSGCKRIISE ALGENSDCQV GKTKVFLKDA HDARLEIARD
AAISRCVCIV IFYFKGTHPF TILIPTNSCP RWVIVIQRAV RGWYCRHRYL TQRKSAIRIQ
SAWRKIIRFQ VQCRGFLARK NVRHKLWAII KIQSCIRGGG CMCVITHHRE YMQTSHTLII
AKQEKRRKMS LAIDHTEMVD KIFGYLDLED GNGEAADTSI PHMEEKEDIS EYKFSKFAAT
YFQANATNAH TKRQLKTPLL HHENEGDKMA SLAVWITILR FMGDLPEPSR RRKSSSKQNR
LISMTLKKKS KLTGEDFVKY LQNFIRGGPL NYAPYCEQRL LRTFANGPRS QPPSWLELQA
TKSRKMIMLP ITFMDGATNT FLADSATTAK ELCDVLAKKI GLTDQFGFSL YIALFDKVKF
KFWFVLLLLK IALIKSPWSS LNFPSLGVSS LGSSGDHVMD AISQCEQYAK EQGAQEKHAQ
WRLFYRKEIF TPWHDPCIDK VSTTLIYQQI VRGVKFNEYR CNTDLELAQL ASKQYYVEHG
ASIQTTSLAP LISSYLPDRI VTSQKPLSHW SSMIMKQHKE AIYTRERWEP LRVREDVVKQ
ARFSWPMMFS RFYEAYRLSG LPLPTNEVLI AVNWTGVFFL DDQEQVLLEL PFAEMTGITA
NKGSEKMKAA TITVTTVRGD ALTMTSSSSD DVCELVNLFI DGLKERSRYV VTLNTNPNKV
MDESSILKFK KGDLLVLNQP AGADFNSSAW RPGRNERTGV SGDFPTDCVY VIPTLVKPLD
DLNMFTMSPG ELAQHGRRVS KVGDNDFDLD EKPYTLEEYA DEFFSREPIK QPLLKKLEHN
HDMTQEAVST FLDILLLPSY LNLDRIVWDL HDLSSFLYMG DYPSKKQRHG NEQTDQIFEA
PLKHEQLRDE VFCQIMKQLT NNKQRLVEER GWELMWLATG VFAPSNQLMP HLHKFLGTRR
ENPMANDCYH RYKRPTTHGH RKYPPHLVEV EAIQHKTTQI FHKVYFPDDT DEARIKFFFH
TRAKDFCQNI ANRLRLKSAD GFSLFVKIAD KVISVPENDF FFDFVRHLTD WLKKARPTKD
GSTPTLTYQV FFMKKLWATT KPGKDPNADN IFHYFQEKPK YLRGYHKCSK EDAYELAALI
YRVQFGDDKS QFPNIPRMLK ELAPLFLLRQ ASPDDWKRNI VQHYNKSTIR TKDEAKLAFL
NIIFKWKTFG SAFFEVRQTT EPSFPENLII AINKHGVSLI DPKTKTVLVT YHFAKISNWS
SGNSYFHMTI GNLVKGNKLL CETS
//
