ID H2YSE4_CIOSA Unreviewed; 3182 AA.
AC H2YSE4;
DT 18-APR-2012, integrated into UniProtKB/TrEMBL.
DT 18-APR-2012, sequence version 1.
DT 27-MAR-2024, entry version 57.
DE RecName: Full=AAA+ ATPase domain-containing protein {ECO:0000259|SMART:SM00382};
OS Ciona savignyi (Pacific transparent sea squirt).
OC Eukaryota; Metazoa; Chordata; Tunicata; Ascidiacea; Phlebobranchia;
OC Cionidae; Ciona.
OX NCBI_TaxID=51511 {ECO:0000313|Ensembl:ENSCSAVP00000008254.1, ECO:0000313|Proteomes:UP000007875};
RN [1] {ECO:0000313|Proteomes:UP000007875}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Birren B., Nusbaum C., Abebe A., Abouelleil A., Adekoya E., Ait-zahra M.,
RA Allen N., Allen T., An P., Anderson M., Anderson S., Arachchi H.,
RA Armbruster J., Bachantsang P., Baldwin J., Barry A., Bayul T.,
RA Blitshsteyn B., Bloom T., Blye J., Boguslavskiy L., Borowsky M.,
RA Boukhgalter B., Brunache A., Butler J., Calixte N., Calvo S., Camarata J.,
RA Campo K., Chang J., Cheshatsang Y., Citroen M., Collymore A., Considine T.,
RA Cook A., Cooke P., Corum B., Cuomo C., David R., Dawoe T., Degray S.,
RA Dodge S., Dooley K., Dorje P., Dorjee K., Dorris L., Duffey N., Dupes A.,
RA Elkins T., Engels R., Erickson J., Farina A., Faro S., Ferreira P.,
RA Fischer H., Fitzgerald M., Foley K., Gage D., Galagan J., Gearin G.,
RA Gnerre S., Gnirke A., Goyette A., Graham J., Grandbois E., Gyaltsen K.,
RA Hafez N., Hagopian D., Hagos B., Hall J., Hatcher B., Heller A.,
RA Higgins H., Honan T., Horn A., Houde N., Hughes L., Hulme W., Husby E.,
RA Iliev I., Jaffe D., Jones C., Kamal M., Kamat A., Kamvysselis M.,
RA Karlsson E., Kells C., Kieu A., Kisner P., Kodira C., Kulbokas E.,
RA Labutti K., Lama D., Landers T., Leger J., Levine S., Lewis D., Lewis T.,
RA Lindblad-toh K., Liu X., Lokyitsang T., Lokyitsang Y., Lucien O., Lui A.,
RA Ma L.J., Mabbitt R., Macdonald J., Maclean C., Major J., Manning J.,
RA Marabella R., Maru K., Matthews C., Mauceli E., Mccarthy M., Mcdonough S.,
RA Mcghee T., Meldrim J., Meneus L., Mesirov J., Mihalev A., Mihova T.,
RA Mikkelsen T., Mlenga V., Moru K., Mozes J., Mulrain L., Munson G.,
RA Naylor J., Newes C., Nguyen C., Nguyen N., Nguyen T., Nicol R., Nielsen C.,
RA Nizzari M., Norbu C., Norbu N., O'donnell P., Okoawo O., O'leary S.,
RA Omotosho B., O'neill K., Osman S., Parker S., Perrin D., Phunkhang P.,
RA Piqani B., Purcell S., Rachupka T., Ramasamy U., Rameau R., Ray V.,
RA Raymond C., Retta R., Richardson S., Rise C., Rodriguez J., Rogers J.,
RA Rogov P., Rutman M., Schupbach R., Seaman C., Settipalli S., Sharpe T.,
RA Sheridan J., Sherpa N., Shi J., Smirnov S., Smith C., Sougnez C.,
RA Spencer B., Stalker J., Stange-thomann N., Stavropoulos S., Stetson K.,
RA Stone C., Stone S., Stubbs M., Talamas J., Tchuinga P., Tenzing P.,
RA Tesfaye S., Theodore J., Thoulutsang Y., Topham K., Towey S., Tsamla T.,
RA Tsomo N., Vallee D., Vassiliev H., Venkataraman V., Vinson J., Vo A.,
RA Wade C., Wang S., Wangchuk T., Wangdi T., Whittaker C., Wilkinson J.,
RA Wu Y., Wyman D., Yadav S., Yang S., Yang X., Yeager S., Yee E., Young G.,
RA Zainoun J., Zembeck L., Zimmer A., Zody M., Lander E.;
RL Submitted (AUG-2003) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSCSAVP00000008254.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the dynein heavy chain family.
CC {ECO:0000256|ARBA:ARBA00008887}.
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DR Ensembl; ENSCSAVT00000008362.1; ENSCSAVP00000008254.1; ENSCSAVG00000004914.1.
DR GeneTree; ENSGT00940000154959; -.
DR HOGENOM; CLU_000038_3_1_1; -.
DR OMA; CEWLLPP; -.
DR Proteomes; UP000007875; Unassembled WGS sequence.
DR GO; GO:0005930; C:axoneme; IEA:UniProt.
DR GO; GO:0030286; C:dynein complex; IEA:UniProtKB-KW.
DR GO; GO:0005874; C:microtubule; IEA:UniProtKB-KW.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR GO; GO:0045505; F:dynein intermediate chain binding; IEA:InterPro.
DR GO; GO:0051959; F:dynein light intermediate chain binding; IEA:InterPro.
DR GO; GO:0008569; F:minus-end-directed microtubule motor activity; IEA:InterPro.
DR GO; GO:0007018; P:microtubule-based movement; IEA:InterPro.
DR Gene3D; 1.10.8.1220; -; 1.
DR Gene3D; 1.10.8.710; -; 1.
DR Gene3D; 1.20.58.1120; -; 1.
DR Gene3D; 1.20.920.20; -; 1.
DR Gene3D; 1.20.920.30; -; 1.
DR Gene3D; 6.10.140.1060; -; 1.
DR Gene3D; 1.20.140.100; Dynein heavy chain, N-terminal domain 2; 1.
DR Gene3D; 3.20.180.20; Dynein heavy chain, N-terminal domain 2; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 6.
DR Gene3D; 1.10.8.720; Region D6 of dynein motor; 1.
DR InterPro; IPR003593; AAA+_ATPase.
DR InterPro; IPR035699; AAA_6.
DR InterPro; IPR035706; AAA_9.
DR InterPro; IPR041658; AAA_lid_11.
DR InterPro; IPR042219; AAA_lid_11_sf.
DR InterPro; IPR026983; DHC_fam.
DR InterPro; IPR041589; DNAH3_AAA_lid_1.
DR InterPro; IPR042222; Dynein_2_N.
DR InterPro; IPR043157; Dynein_AAA1S.
DR InterPro; IPR041466; Dynein_AAA5_ext.
DR InterPro; IPR041228; Dynein_C.
DR InterPro; IPR024743; Dynein_HC_stalk.
DR InterPro; IPR024317; Dynein_heavy_chain_D4_dom.
DR InterPro; IPR004273; Dynein_heavy_D6_P-loop.
DR InterPro; IPR013602; Dynein_heavy_linker.
DR InterPro; IPR042228; Dynein_linker_3.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR45703; DYNEIN HEAVY CHAIN; 1.
DR PANTHER; PTHR45703:SF1; DYNEIN HEAVY CHAIN; 1.
DR Pfam; PF12774; AAA_6; 1.
DR Pfam; PF12775; AAA_7; 1.
DR Pfam; PF12780; AAA_8; 2.
DR Pfam; PF12781; AAA_9; 1.
DR Pfam; PF17857; AAA_lid_1; 1.
DR Pfam; PF18198; AAA_lid_11; 1.
DR Pfam; PF08393; DHC_N2; 1.
DR Pfam; PF17852; Dynein_AAA_lid; 1.
DR Pfam; PF18199; Dynein_C; 1.
DR Pfam; PF03028; Dynein_heavy; 1.
DR Pfam; PF12777; MT; 1.
DR SMART; SM00382; AAA; 2.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 4.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Cell projection {ECO:0000256|ARBA:ARBA00023273};
KW Cilium {ECO:0000256|ARBA:ARBA00023069};
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Cytoskeleton {ECO:0000256|ARBA:ARBA00023212};
KW Dynein {ECO:0000256|ARBA:ARBA00023017};
KW Microtubule {ECO:0000256|ARBA:ARBA00022701};
KW Motor protein {ECO:0000256|ARBA:ARBA00023175};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000007875}.
FT DOMAIN 355..494
FT /note="AAA+ ATPase"
FT /evidence="ECO:0000259|SMART:SM00382"
FT DOMAIN 1177..1324
FT /note="AAA+ ATPase"
FT /evidence="ECO:0000259|SMART:SM00382"
FT COILED 2135..2187
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 3182 AA; 365560 MW; FD7E02B119357F18 CRC64;
LLINSQQQAR SIIESWLAVQ SAWLYLEPIF GSEDIRNQIP VQGKMFTQVD THYKDIMARA
AQNTKAMVVL SERGMLKNLL SSQALLENIQ NGLNEYLEKK RIFFPRFFFL SNDELLEILS
ETKDPLRVQP HLKKCFEGIA RLVFTDDKRI VAMQSAEEEN VELIQVITPS DAGGLVEKWL
FEVEQDMKIS IRESMSRSVD AYPEMPFKQW CLQWPGQVVL ATSIIYWTAE VTQAIKEKGG
LTKYLGICSS HIDDIIQLVR GKLSKMDRVT LGALVTIDVH ARDVVAKLGE DSVSDVRDFQ
WISQMRYYWE NSAVMVRMIS TTVPYDYEYL GNSGRLVITP LTERCYRTLM GALQLNLGGA
PEGPAGTGKT ETCKDLAKAV AKQCVVFNCS DGLDYKAMGK FFKGLAQSGA WACFDEFNRI
DLEVLSVVAQ QIQTIQRAVA DQVTVFVFEG TEISLDPSCT IFITMNPGYA GRAELPDNLK
VLFRTVAMMI PDYALIAEIS LYSMGFVAAR TLAAKIVATY RLCSEQLSSQ HHYDYGMRAV
KSVLTTAGTS KDFKDCSYVD QREDELMLRA INDVNLPKFL SHDIPLFDGI ISDLFPGVRL
PKPDHGLLEK AIRTNITTMN LQPNPWFIEK VFQLHEMMKV RHGFMVVGRA LSGKTSAYRV
LIAALGEVSV LDEVHVKIIN PKAVTMAQLY GSFDPVSHEW SDGILANTFR GHANSTDDNR
KWLVFDGPVD AVWVENLNTV LDDNKKLCLM SGEIIAMNAK QNMMFEVENL EQASPATVSR
CGMIYMDPDE LGSTSLVTSW LTTSLPDFLT KQQKDNVRML FNWLVPPCVH FVLKSCHHIL
RLSSMHMTAN LLKLYSCLLT ELRDRNLCLI PVNGKLQKIY HIQFSEAHSK MMIRKVYQQL
LPMMHRKDGF NDFFRDLLDT DGGKVGFPRP RELRIPRNLL IPKRGSIFDY VYIKQNYGSW
HRWDNLTQNP ELTDSTQVRF FIFSAFIHSV KTFKGKNFSL FSTCFSFKYA KLHMLVITQF
CCQFDICNGY SWHLKFEHLI LNKRSFKLGA FKQIKVTEVC YALPRHFFLA LLIFVLLGKK
NRAPYNMSNH QITSGPESVG SPRKMACMDS EPKTLICMCL VIFLNNFVHV LKQISVGFKS
STIFIQKQLN TSMLSNVIIQ TVDTYRQTYF LKKFISRNEQ LLFVGPTGTG KSAITNSHLR
SLSKKQYTVN NVNFSAQTSA SQTQDMIFSK LDRRRKNTYG PSPGKKMLVF VDDVNMPAKE
RYGAQPPIEL LRQWIDHGHW FDKKDTSQLY LVDMSLVCAM APPGGGRNEI TERFLRHFNV
ISIHAFDEDT MKTIFQPLLD WHFSFDNALR RFGRIIIWAT TDVYMQAISR FLPTPSKSHY
IFNLRDYARV IQVVLLFRSE RCIEGVPGAL KLARLWVHEV YRVFYDRLVD DEDRDTFFGI
VKVIFTYLLL QCLENDADIA AVFFFYISTS HDCVIATTMH FKEKMNNIFQ HLVLHKSGRK
DIVDTHIRSV FFGDYMSPKV DEGASERFYD EVTDMNVYKS ILVDIPIRLD THIFILTYMC
YKHIECLKTT IERYLDDYNT MSKAPMDLVM FQFAIEHISR ISRILKQPNG HALLVGIGGS
GRQSSARIAA FMADYELFQV NVTKSYSVSD WRNDLKRVLR RTGEDLAPTV FLFGDYQIKD
ESFLEDINLL LNTGDIPNIF ENEERLEIID KMQGLAQADG DERVEITPLN MYTKFIERVN
SKKIIENFYV AKLQIFEFLP SSYSSKDIYH SNLKINNFIQ LKLIVFRCLH VVLAFSPVGD
DFRTRLRNFP SLINCCTIDW FQAWPDDALE MVANHFLDEV EMSQSMRQAA VKMCKYFHQD
VRLLSDKYFD SLRRRTFITP TSYLELIKTF KRLLQKKRLE LLTLKNRYVT GLEKLEFAES
QINVMQQELT ALQPRLEESS LEVEALVADI SAESAEVELV KKLVEADEAV AANAADDAQQ
IKQECEEKLA VAMPAMNAAI AALDTLRQQD IALVKTMQNP PAGVKITTEA ICILKVSHVF
VFGRAIDDYW PAAKKMLGDM KFLDSLRDYD KENIPNAIMR KIRERFIGDP NFRPELIRNV
SSACEGLCSW VLAIEVYDRV AKVIAPKRKS LLLAEDDLER LMSLLQVKRK ELEEITNKLQ
LLNDNLKEKL DEKKVRLEDN IELTKVKLIR AEKLISGLGG EKERWTEMTH SLHNTYHNIV
GDVLLSSAVV AYLPPFTPLY RQDTIKNWWV ECKNRDIPVS EDFSLSNTLG DPVQIMEWQL
AGLPKDNSSV DNAIIVNNAN RWPLMVDPQG QACKWIKNME RKNNLHVCKL TDADYLRTLE
NCLQFGNPIL IENISEHIDP ILDPILLHQT FKQSGMEYVK LGENTVQYSH DFKLYITTRM
RNPHYLPEVS VKVTLINFMI TPIALEDQLL RLVAAKERPE LEEKKSELIL EGANNRRLLK
NIEDKILEVL SREGNILEDE TAIRILSESR QLSEEISTKQ EITSKTEVEL DSTRNGYKPV
AIHSSILFFV ISELANIDPM YQYSLWWFIN LYVQSIEQSE KSLDLDQRIL NLKQHFTQLI
FRNVCRSLFE KDKLLFSFLL CIGIMKGRLE FNFMLLFMLN AKRVRCFNQE INQNILGNNV
FTRTSMLKNN LGEVDDTHWR FLLTGGVALD NPFPNPAYDW LPDKSWAEIV RCNELPTFTG
LMRHFRINVS SNKKIIEMGR LKAYYGNLHI KIEYGYTFKL LIFNISSIQS TAWKAIYDSS
VPHTETLPEP WDGRLGPLEK LVVVRCIRPD KVVPAVQDFI VSKMGAMYIE PPTFDLHSSY
QDSDSSTPLI FILSPGADPM ASLIKFAEEN GMSSGMQTIS LGQGQGPIAE RMIEYARTNG
TWVVLQNCHL AVSWLPELRR ICEEVHEFRL WLTSYPSPDF PVPVLQNSVK MTNEPPKGLR
ANLLRSYISD PISDPIFFSG MEEMQKNMRI LFSLCFFHAL VQERRKFGPL GWNIPYGFNE
SDLRISVRQT QMFLKDYEEV PLVALKYLIG ECNYGGRVTD ERDRRLLQSL LSTFMCSEVF
NDSDYKFSSI DLYFAPSYQE YDKFLHFIRS LPINTHPEVF GFHENADISK DQQETQQMFD
GILSTLPRQS ASFDGRLSQT IVQDLASDIL SKLPDMFNVE EIQNKYPIDY SESMNTVLNQ
EL
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