ID H2YU29_CIOSA Unreviewed; 1955 AA.
AC H2YU29;
DT 18-APR-2012, integrated into UniProtKB/TrEMBL.
DT 18-APR-2012, sequence version 1.
DT 27-MAR-2024, entry version 59.
DE RecName: Full=HELP domain-containing protein {ECO:0000259|Pfam:PF03451};
OS Ciona savignyi (Pacific transparent sea squirt).
OC Eukaryota; Metazoa; Chordata; Tunicata; Ascidiacea; Phlebobranchia;
OC Cionidae; Ciona.
OX NCBI_TaxID=51511 {ECO:0000313|Ensembl:ENSCSAVP00000008839.1, ECO:0000313|Proteomes:UP000007875};
RN [1] {ECO:0000313|Proteomes:UP000007875}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Birren B., Nusbaum C., Abebe A., Abouelleil A., Adekoya E., Ait-zahra M.,
RA Allen N., Allen T., An P., Anderson M., Anderson S., Arachchi H.,
RA Armbruster J., Bachantsang P., Baldwin J., Barry A., Bayul T.,
RA Blitshsteyn B., Bloom T., Blye J., Boguslavskiy L., Borowsky M.,
RA Boukhgalter B., Brunache A., Butler J., Calixte N., Calvo S., Camarata J.,
RA Campo K., Chang J., Cheshatsang Y., Citroen M., Collymore A., Considine T.,
RA Cook A., Cooke P., Corum B., Cuomo C., David R., Dawoe T., Degray S.,
RA Dodge S., Dooley K., Dorje P., Dorjee K., Dorris L., Duffey N., Dupes A.,
RA Elkins T., Engels R., Erickson J., Farina A., Faro S., Ferreira P.,
RA Fischer H., Fitzgerald M., Foley K., Gage D., Galagan J., Gearin G.,
RA Gnerre S., Gnirke A., Goyette A., Graham J., Grandbois E., Gyaltsen K.,
RA Hafez N., Hagopian D., Hagos B., Hall J., Hatcher B., Heller A.,
RA Higgins H., Honan T., Horn A., Houde N., Hughes L., Hulme W., Husby E.,
RA Iliev I., Jaffe D., Jones C., Kamal M., Kamat A., Kamvysselis M.,
RA Karlsson E., Kells C., Kieu A., Kisner P., Kodira C., Kulbokas E.,
RA Labutti K., Lama D., Landers T., Leger J., Levine S., Lewis D., Lewis T.,
RA Lindblad-toh K., Liu X., Lokyitsang T., Lokyitsang Y., Lucien O., Lui A.,
RA Ma L.J., Mabbitt R., Macdonald J., Maclean C., Major J., Manning J.,
RA Marabella R., Maru K., Matthews C., Mauceli E., Mccarthy M., Mcdonough S.,
RA Mcghee T., Meldrim J., Meneus L., Mesirov J., Mihalev A., Mihova T.,
RA Mikkelsen T., Mlenga V., Moru K., Mozes J., Mulrain L., Munson G.,
RA Naylor J., Newes C., Nguyen C., Nguyen N., Nguyen T., Nicol R., Nielsen C.,
RA Nizzari M., Norbu C., Norbu N., O'donnell P., Okoawo O., O'leary S.,
RA Omotosho B., O'neill K., Osman S., Parker S., Perrin D., Phunkhang P.,
RA Piqani B., Purcell S., Rachupka T., Ramasamy U., Rameau R., Ray V.,
RA Raymond C., Retta R., Richardson S., Rise C., Rodriguez J., Rogers J.,
RA Rogov P., Rutman M., Schupbach R., Seaman C., Settipalli S., Sharpe T.,
RA Sheridan J., Sherpa N., Shi J., Smirnov S., Smith C., Sougnez C.,
RA Spencer B., Stalker J., Stange-thomann N., Stavropoulos S., Stetson K.,
RA Stone C., Stone S., Stubbs M., Talamas J., Tchuinga P., Tenzing P.,
RA Tesfaye S., Theodore J., Thoulutsang Y., Topham K., Towey S., Tsamla T.,
RA Tsomo N., Vallee D., Vassiliev H., Venkataraman V., Vinson J., Vo A.,
RA Wade C., Wang S., Wangchuk T., Wangdi T., Whittaker C., Wilkinson J.,
RA Wu Y., Wyman D., Yadav S., Yang S., Yang X., Yeager S., Yee E., Young G.,
RA Zainoun J., Zembeck L., Zimmer A., Zody M., Lander E.;
RL Submitted (AUG-2003) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSCSAVP00000008839.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the WD repeat EMAP family.
CC {ECO:0000256|ARBA:ARBA00006489}.
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DR STRING; 51511.ENSCSAVP00000008839; -.
DR Ensembl; ENSCSAVT00000008953.1; ENSCSAVP00000008839.1; ENSCSAVG00000005245.1.
DR eggNOG; KOG2106; Eukaryota.
DR GeneTree; ENSGT00940000169727; -.
DR HOGENOM; CLU_001930_1_0_1; -.
DR InParanoid; H2YU29; -.
DR OMA; WIFGYSA; -.
DR TreeFam; TF317832; -.
DR Proteomes; UP000007875; Unassembled WGS sequence.
DR Gene3D; 2.130.10.10; YVTN repeat-like/Quinoprotein amine dehydrogenase; 6.
DR InterPro; IPR005108; HELP.
DR InterPro; IPR011047; Quinoprotein_ADH-like_supfam.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR InterPro; IPR036322; WD40_repeat_dom_sf.
DR InterPro; IPR001680; WD40_rpt.
DR PANTHER; PTHR13720:SF33; HELP DOMAIN-CONTAINING PROTEIN; 1.
DR PANTHER; PTHR13720; WD-40 REPEAT PROTEIN; 1.
DR Pfam; PF03451; HELP; 3.
DR Pfam; PF00400; WD40; 10.
DR SMART; SM00320; WD40; 31.
DR SUPFAM; SSF50998; Quinoprotein alcohol dehydrogenase-like; 2.
DR SUPFAM; SSF50978; WD40 repeat-like; 3.
DR PROSITE; PS50082; WD_REPEATS_2; 4.
DR PROSITE; PS50294; WD_REPEATS_REGION; 1.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP000007875};
KW WD repeat {ECO:0000256|PROSITE-ProRule:PRU00221}.
FT DOMAIN 3..48
FT /note="HELP"
FT /evidence="ECO:0000259|Pfam:PF03451"
FT REPEAT 233..263
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REPEAT 559..601
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT DOMAIN 676..719
FT /note="HELP"
FT /evidence="ECO:0000259|Pfam:PF03451"
FT REPEAT 1238..1271
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT DOMAIN 1361..1402
FT /note="HELP"
FT /evidence="ECO:0000259|Pfam:PF03451"
FT REPEAT 1920..1955
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REGION 606..625
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 658..678
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1281..1347
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 609..623
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1310..1325
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1326..1347
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1955 AA; 216303 MW; C2BB43F64E8C8FF4 CRC64;
MSDKTAPRSQ LRLEWVYGYR GHQCRNNLFY ISNDEIVYFV AGVGIVCNRR KQTQNFFLGH
NDDIISLALH PHEQLVATGQ VGKEPYICVW NAKTMETVSI LKDQHTHGVA SLMFSHSGER
LASVGLDGNN TFVVWEWRKG RMIATAKGHT DRVFDISWDP TSEQRLVTCG VKHIKFWALC
GNSLTAKRGV FGKVADQQTV LCVSCADGHL TYSGTLNGDV YIWRDNNLER VVSSAHNGGV
FTLHKSTDGY ATGSRDGCVK LWDTSFNPLT TINFKDSSYG YKGVSIRSVC WSSDRILIGT
QNSEVFEILV RDRENPTPLT QGHSEGELWG LSVHPRKPIA ATASDDCSVR LWSLVDHALL
TCCNLEQQAR SCAFNMDGTQ LAVGCKNGSF YILRVRDMTE VCHIHDRKEV LHEMKYSTDG
SYLAVASNDN FVDIYSVTQR YKKVGTCSKS SSFITHIDWS NDSRHLQTND GAGERLVYSM
PAGRHVTCAE EIRAIRWQSW TCVLGSEVNG IWPKYTQIND VNAIDVSFPH EVAATGDDFG
LVKLFNFPSL KKGAKFRKYV GHSAHVTNVR FSSDHQWILS TGGADHSVFQ WRFITDQQEL
RGMADHLPTQ DSHTDSCSEG SDSDLSDVAE VDSEIEQEAQ ISYDREVYKE DLAKLKHATR
DGGEGAGRTK RRKGEHAPDS TSLKLNYVFG YRGYDCRDNV FYTQSAEVVY HVAALGIVCS
RERHEQRFYD KHDDDILCLN LHPVKDIVAT GQVGRDPAIH LWEADTMSTL SILKGCHERG
VSAVDFSGDG KKLVSIGLDN DHTMVLWDWK RGQKLATSKT HQDKVFGVRF DPNNHERVVT
VGVKHIKFWQ HVGGGCTSHR GIFGQVGKLD TMLCLAFGKS GNVYTGAANG QVYIWEGNNL
SRTQKAHDGA CFAIHALDKG FVTGGKDGVV CLWDDNFERC LKSYAITTSN LAEDCTGRLV
EENPTVRAIN LGHGKIVIGT KNSEILEIDK SGPITIIMQG HGEGEAWGLA FHPSKEECAS
VSNDRTLRTW CTTVGQQRMI ASRKLAIGGQ CCAYSPDGNA IAVGCNNGSF MVVNATTLEN
LVEFHHRKEA ISDIRFSPDM GKYLAVASHD NFVDIYNVLN SKRVGICKGA SSYITHIDWD
ARGKLLCVNS GAKELLYFEA PRGKRQTISS DDAIEWNSWT GVLGKQCEGI WPSYSDVTDV
NATSLSKSKK LLATGDDFGF VKLFTFPVKG KHGKFKKYVG HSAHVTNVRW SHDSSQLCSL
GGADTALFLW SYLTTPGNIR YHGDSEDSDT DSEEEGGYDS DVAREKNMDY GSKTYTNNLR
ETSGSKPNSK ELDEVEKQAV SRGVPKSDRV KRTNEVAVNK VNDLELHHVF GYRGFDCRDN
LHYIDDCAQI VYHAAGGGIV HNLASGQQSF YLEHTDDIIC LSVNQHPKFP NVIATGQIGS
NPTIHIWDAG SKQSVSILKG FHVNGVCSVN FSASGKLLLS VGLDEQHSVA VWRWQEGIKA
CSHTCSKYRV FSAQFRPDSD STFVTVGVKH VMFWQVCGSA LLGKRGVLGA TEGIQAQTML
CIAFGADNLT YTGAMNGDVY VWKGHILSRT VAKAHVGPVF SMFTTLRDGL IVTGGKEKMT
KEGGAVKLWD QDMRRCRAFQ VSTNVVKSVC RGKGKILVGT KDSEVMEIGE KNGACTTLVY
GHTEGELWGL ACHPTNMMCC TTSDDKTARI WDINEKIMLH KISLTSGSRG CTFSHDGNRI
AVGQNNGEFL VLDVVSLKVL CKKRDRSGAI HDIRFSPDDR LLAVGSAEQT LDFYELSANC
QLNRVGYCKQ IPSFVFQMDF SADGKYIQVG TGAYKQLVFK VPSGDPVTES NVISKITWNS
YTSVLGDDVI GIWPKNCDRG DVNCADVSRG GNAVATGDDF GFVKLFDFPC REKFAKHRKF
VGHSAHVTNA RFLRDDSKLI TTGGDDCCVF VWKCS
//
