ID H2YX21_CIOSA Unreviewed; 2225 AA.
AC H2YX21;
DT 18-APR-2012, integrated into UniProtKB/TrEMBL.
DT 18-APR-2012, sequence version 1.
DT 27-MAR-2024, entry version 54.
DE RecName: Full=ABC transporter domain-containing protein {ECO:0000259|PROSITE:PS50893};
OS Ciona savignyi (Pacific transparent sea squirt).
OC Eukaryota; Metazoa; Chordata; Tunicata; Ascidiacea; Phlebobranchia;
OC Cionidae; Ciona.
OX NCBI_TaxID=51511 {ECO:0000313|Ensembl:ENSCSAVP00000009882.1, ECO:0000313|Proteomes:UP000007875};
RN [1] {ECO:0000313|Proteomes:UP000007875}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Birren B., Nusbaum C., Abebe A., Abouelleil A., Adekoya E., Ait-zahra M.,
RA Allen N., Allen T., An P., Anderson M., Anderson S., Arachchi H.,
RA Armbruster J., Bachantsang P., Baldwin J., Barry A., Bayul T.,
RA Blitshsteyn B., Bloom T., Blye J., Boguslavskiy L., Borowsky M.,
RA Boukhgalter B., Brunache A., Butler J., Calixte N., Calvo S., Camarata J.,
RA Campo K., Chang J., Cheshatsang Y., Citroen M., Collymore A., Considine T.,
RA Cook A., Cooke P., Corum B., Cuomo C., David R., Dawoe T., Degray S.,
RA Dodge S., Dooley K., Dorje P., Dorjee K., Dorris L., Duffey N., Dupes A.,
RA Elkins T., Engels R., Erickson J., Farina A., Faro S., Ferreira P.,
RA Fischer H., Fitzgerald M., Foley K., Gage D., Galagan J., Gearin G.,
RA Gnerre S., Gnirke A., Goyette A., Graham J., Grandbois E., Gyaltsen K.,
RA Hafez N., Hagopian D., Hagos B., Hall J., Hatcher B., Heller A.,
RA Higgins H., Honan T., Horn A., Houde N., Hughes L., Hulme W., Husby E.,
RA Iliev I., Jaffe D., Jones C., Kamal M., Kamat A., Kamvysselis M.,
RA Karlsson E., Kells C., Kieu A., Kisner P., Kodira C., Kulbokas E.,
RA Labutti K., Lama D., Landers T., Leger J., Levine S., Lewis D., Lewis T.,
RA Lindblad-toh K., Liu X., Lokyitsang T., Lokyitsang Y., Lucien O., Lui A.,
RA Ma L.J., Mabbitt R., Macdonald J., Maclean C., Major J., Manning J.,
RA Marabella R., Maru K., Matthews C., Mauceli E., Mccarthy M., Mcdonough S.,
RA Mcghee T., Meldrim J., Meneus L., Mesirov J., Mihalev A., Mihova T.,
RA Mikkelsen T., Mlenga V., Moru K., Mozes J., Mulrain L., Munson G.,
RA Naylor J., Newes C., Nguyen C., Nguyen N., Nguyen T., Nicol R., Nielsen C.,
RA Nizzari M., Norbu C., Norbu N., O'donnell P., Okoawo O., O'leary S.,
RA Omotosho B., O'neill K., Osman S., Parker S., Perrin D., Phunkhang P.,
RA Piqani B., Purcell S., Rachupka T., Ramasamy U., Rameau R., Ray V.,
RA Raymond C., Retta R., Richardson S., Rise C., Rodriguez J., Rogers J.,
RA Rogov P., Rutman M., Schupbach R., Seaman C., Settipalli S., Sharpe T.,
RA Sheridan J., Sherpa N., Shi J., Smirnov S., Smith C., Sougnez C.,
RA Spencer B., Stalker J., Stange-thomann N., Stavropoulos S., Stetson K.,
RA Stone C., Stone S., Stubbs M., Talamas J., Tchuinga P., Tenzing P.,
RA Tesfaye S., Theodore J., Thoulutsang Y., Topham K., Towey S., Tsamla T.,
RA Tsomo N., Vallee D., Vassiliev H., Venkataraman V., Vinson J., Vo A.,
RA Wade C., Wang S., Wangchuk T., Wangdi T., Whittaker C., Wilkinson J.,
RA Wu Y., Wyman D., Yadav S., Yang S., Yang X., Yeager S., Yee E., Young G.,
RA Zainoun J., Zembeck L., Zimmer A., Zody M., Lander E.;
RL Submitted (AUG-2003) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSCSAVP00000009882.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
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DR Ensembl; ENSCSAVT00000010002.1; ENSCSAVP00000009882.1; ENSCSAVG00000005809.1.
DR GeneTree; ENSGT00940000154658; -.
DR Proteomes; UP000007875; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0140359; F:ABC-type transporter activity; IEA:InterPro.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR CDD; cd03263; ABC_subfamily_A; 2.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR InterPro; IPR003593; AAA+_ATPase.
DR InterPro; IPR013525; ABC2_TM.
DR InterPro; IPR003439; ABC_transporter-like_ATP-bd.
DR InterPro; IPR017871; ABC_transporter-like_CS.
DR InterPro; IPR026082; ABCA.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR19229:SF185; ABC TRANSPORTER DOMAIN-CONTAINING PROTEIN; 1.
DR PANTHER; PTHR19229; ATP-BINDING CASSETTE TRANSPORTER SUBFAMILY A ABCA; 1.
DR Pfam; PF12698; ABC2_membrane_3; 2.
DR Pfam; PF00005; ABC_tran; 2.
DR SMART; SM00382; AAA; 2.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 2.
DR PROSITE; PS00211; ABC_TRANSPORTER_1; 1.
DR PROSITE; PS50893; ABC_TRANSPORTER_2; 2.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000007875};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 21..41
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 636..662
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 683..705
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 717..737
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 744..762
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 774..795
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 822..843
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1342..1363
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1648..1669
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1689..1715
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1727..1746
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1758..1784
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1845..1868
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 902..1134
FT /note="ABC transporter"
FT /evidence="ECO:0000259|PROSITE:PS50893"
FT DOMAIN 1907..2143
FT /note="ABC transporter"
FT /evidence="ECO:0000259|PROSITE:PS50893"
SQ SEQUENCE 2225 AA; 249124 MW; 89F2823621C6987F CRC64;
MFWQQLRLLL WKNFILRKRH PIRTIIEVLW PIFLFAILVA IRKTQPIDTK GECHYPGRAM
PSAGIYPWFK SMFCDLENPC FSKEVPSEVP GQINSPGNAN SAWMGNAVSS ILMLLQQNTS
ITQNQNQIIK DLQAVQNFTA QLPFNSTRVG FSTVIQNSTA YTEFVTNNLS IPYDVVKALL
NSTVSPAQVN ILPLSLQQRL VVCSPPVLQT IFQLPSTSQL NITAVSNELC NLTDYQLTLL
GNYTTSSLET SSQLQSISGP ITNLLSTQQF STGFLGGNFS FNVRIVFERP SVNKCIVIAN
PATEKALLPF FLVEPFNMLT FFCIPRSSVV TLTQKQKFPN YLQMGIKILP VKLHYLLYHS
PVFCQNLTAI LESNNQFKLL WDVLKPLLLG KIPYSPDTPL VRSIIKRANA TFETIAIVKE
FGQMWQSTNG PALHNFLENG STVHILDTIP LSTLSTLLNI SVSNLEQVRT FLSNDYNATD
GVITWKDLYY QLNSGILFIT NVLGCFELNK FEGYQSEQRL VDASLSRTKN KTLWGAIVFM
NPTENSEVLP KIVKYKIRQD AGSVTKTTSI QSFSWEPDAE ADYTSNKMAY YNGGFLFLQD
MVEQAIIEGV VPEPFVGRYM QEFPYPCYTY DEFLEYLSAL LSLLMTLAWI YSVCIIIKNI
VYEKEQRLKE VMKMMGLSNG VHWVAWFINS FSLMFLSILL LILVLKVGDV TPYSNMFIVL
IWLCCFAIAT ISQCFLISCF FSRANLAAAC GGIIYFLMYI PYNMTYAWQD EMTISTKLVA
CLLSTVAFGY GAGYISQYEM SGDGIQFSNW NTSPDPSDHM NFLLSMLMML VDAAIYLILT
WYIEAVFPGQ YGVPRPWNFF LQRSYWCGST DDLRSNESYS AYNQDDPSIK LETEPSHLKL
GVSMHNLSKV YGNGKVAVDG LSLNFYENQI TAFLGHNGAG KTTTMSMLTG LFPPSGGTAS
IYKKDIQTDM DSIRHELGFC PQHNVLFGDL TVLEHLQLYA GLKGSSSGKT QSESETNNML
QDVGLPHKKH EMTRHLSGGM KRKLSVAIAF VGGSKCVVLD EPTAGVDPYA RRGIWDLLLH
YKQNRTIVLS THHMDEADLL GDRIAIISHG KLKCCGSSLF LKSCFGVGYY LTLVTDDKEI
SPGESPLTEK AVLPVSSQIN MISYKKSSIL AQMVTDTISG VKLYEDNGRE ITFVLPYSAQ
TDGSYAKLFE KLNNANANYG LTDTSLEEIF LNVAEHSKDD GKEENTKCWL LFNNNFISGL
FVLHSMHAFC SGNSGFSSAP LGKLHYFTSE MIDHSISDDV SMDDTSQGIG SYKVEGNKLI
RQQFLSLFVK RFHHARRNTK GIVAQVIVPA AFVALALTFA LIIPQTKEYP SLELQPWMYG
DTNTFFSNDN SSSNITSSAS NALINDPSIG MRCVKDYSVY NYDKKFLTCN AVANQDWKID
STKRALSQNV TSNETIECSC TDKQTRVLLA ECPVGTGGAP TPRIITRTSN PMYNMTQRNL
SDWLVKTVGE TLTYFINIIH RFKQSRFGGL SFGAQYYNTI GSMLTPLLQF SQSNSNFTLN
INPNSSNNIQ SVVQRLVRTD NSKVWFDNSG WHSMPTWLNI MNNAALRSSL PPSADPTEYG
IAAFNHPLNF TETEVDLAAF TQSATDTIIS ISVIFALAFV PASFVLFLIE EKVSKAKHLQ
FVSGVNQFIY WIANFTWDML NYSIPAIIVI IIFLCFQTDA YVSAANLPCL VCLLFLYGFA
ITPMMYPASF YFEVPSTAYV VLTCINLFIG INTSIATFIL EVILLDDPNL TEVNNALKII
FLAFPQYCLG RALIDMAINQ AYADAYASFG KLNNPFDYDL VGRNLLAMAI EGVVFFILTV
LIQYRFFIKH NKIEDLSKIP RRTGMEDDDV TAEKKRLLEE GDITDILQIK NLTKVYKKLG
SKKRLLAVDR MSIGVPRGEC FGLLGVNGAG KTTTFKMLTG DIAPTAGDAT ICHQSILDNI
REVQQNTGYC PQFEALNQLL TGREHLEFYA KLRGVPPEDI DRVAQWGIMK FGLKMYADKS
AGTYSGGNKR KLSAAIAFIG CPPVVFLDEP TAGMDPLSRR FLWSRISEVV SNGRCIVLTS
HSMEECEALC SRLAIMVNGS FKCIGSPQHL KNRYGEGYTI TVKVSDGTEN LENVQAFIQE
AFPNCVVKES HSSMIMYQVP LEDMNLSFLF DEMERNKSRL SIEDYSVNQT TLDEVFVSFA
KLQTD
//
