ID H2YY76_CIOSA Unreviewed; 973 AA.
AC H2YY76;
DT 18-APR-2012, integrated into UniProtKB/TrEMBL.
DT 18-APR-2012, sequence version 1.
DT 27-MAR-2024, entry version 48.
DE RecName: Full=Chordin {ECO:0000256|ARBA:ARBA00016968};
OS Ciona savignyi (Pacific transparent sea squirt).
OC Eukaryota; Metazoa; Chordata; Tunicata; Ascidiacea; Phlebobranchia;
OC Cionidae; Ciona.
OX NCBI_TaxID=51511 {ECO:0000313|Ensembl:ENSCSAVP00000010287.1, ECO:0000313|Proteomes:UP000007875};
RN [1] {ECO:0000313|Proteomes:UP000007875}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Birren B., Nusbaum C., Abebe A., Abouelleil A., Adekoya E., Ait-zahra M.,
RA Allen N., Allen T., An P., Anderson M., Anderson S., Arachchi H.,
RA Armbruster J., Bachantsang P., Baldwin J., Barry A., Bayul T.,
RA Blitshsteyn B., Bloom T., Blye J., Boguslavskiy L., Borowsky M.,
RA Boukhgalter B., Brunache A., Butler J., Calixte N., Calvo S., Camarata J.,
RA Campo K., Chang J., Cheshatsang Y., Citroen M., Collymore A., Considine T.,
RA Cook A., Cooke P., Corum B., Cuomo C., David R., Dawoe T., Degray S.,
RA Dodge S., Dooley K., Dorje P., Dorjee K., Dorris L., Duffey N., Dupes A.,
RA Elkins T., Engels R., Erickson J., Farina A., Faro S., Ferreira P.,
RA Fischer H., Fitzgerald M., Foley K., Gage D., Galagan J., Gearin G.,
RA Gnerre S., Gnirke A., Goyette A., Graham J., Grandbois E., Gyaltsen K.,
RA Hafez N., Hagopian D., Hagos B., Hall J., Hatcher B., Heller A.,
RA Higgins H., Honan T., Horn A., Houde N., Hughes L., Hulme W., Husby E.,
RA Iliev I., Jaffe D., Jones C., Kamal M., Kamat A., Kamvysselis M.,
RA Karlsson E., Kells C., Kieu A., Kisner P., Kodira C., Kulbokas E.,
RA Labutti K., Lama D., Landers T., Leger J., Levine S., Lewis D., Lewis T.,
RA Lindblad-toh K., Liu X., Lokyitsang T., Lokyitsang Y., Lucien O., Lui A.,
RA Ma L.J., Mabbitt R., Macdonald J., Maclean C., Major J., Manning J.,
RA Marabella R., Maru K., Matthews C., Mauceli E., Mccarthy M., Mcdonough S.,
RA Mcghee T., Meldrim J., Meneus L., Mesirov J., Mihalev A., Mihova T.,
RA Mikkelsen T., Mlenga V., Moru K., Mozes J., Mulrain L., Munson G.,
RA Naylor J., Newes C., Nguyen C., Nguyen N., Nguyen T., Nicol R., Nielsen C.,
RA Nizzari M., Norbu C., Norbu N., O'donnell P., Okoawo O., O'leary S.,
RA Omotosho B., O'neill K., Osman S., Parker S., Perrin D., Phunkhang P.,
RA Piqani B., Purcell S., Rachupka T., Ramasamy U., Rameau R., Ray V.,
RA Raymond C., Retta R., Richardson S., Rise C., Rodriguez J., Rogers J.,
RA Rogov P., Rutman M., Schupbach R., Seaman C., Settipalli S., Sharpe T.,
RA Sheridan J., Sherpa N., Shi J., Smirnov S., Smith C., Sougnez C.,
RA Spencer B., Stalker J., Stange-thomann N., Stavropoulos S., Stetson K.,
RA Stone C., Stone S., Stubbs M., Talamas J., Tchuinga P., Tenzing P.,
RA Tesfaye S., Theodore J., Thoulutsang Y., Topham K., Towey S., Tsamla T.,
RA Tsomo N., Vallee D., Vassiliev H., Venkataraman V., Vinson J., Vo A.,
RA Wade C., Wang S., Wangchuk T., Wangdi T., Whittaker C., Wilkinson J.,
RA Wu Y., Wyman D., Yadav S., Yang S., Yang X., Yeager S., Yee E., Young G.,
RA Zainoun J., Zembeck L., Zimmer A., Zody M., Lander E.;
RL Submitted (AUG-2003) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSCSAVP00000010287.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|ARBA:ARBA00004613}.
CC -!- SIMILARITY: Belongs to the chordin family.
CC {ECO:0000256|ARBA:ARBA00007156, ECO:0000256|PIRNR:PIRNR002496}.
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DR AlphaFoldDB; H2YY76; -.
DR STRING; 51511.ENSCSAVP00000010287; -.
DR Ensembl; ENSCSAVT00000010412.1; ENSCSAVP00000010287.1; ENSCSAVG00000006066.1.
DR eggNOG; ENOG502QR4J; Eukaryota.
DR GeneTree; ENSGT00940000164682; -.
DR InParanoid; H2YY76; -.
DR OMA; CCKSCPG; -.
DR TreeFam; TF106451; -.
DR Proteomes; UP000007875; Unassembled WGS sequence.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0009790; P:embryo development; IEA:UniProt.
DR GO; GO:0007389; P:pattern specification process; IEA:UniProt.
DR GO; GO:0048731; P:system development; IEA:UniProt.
DR Gene3D; 6.20.200.20; -; 2.
DR InterPro; IPR016353; Chordin.
DR InterPro; IPR010895; CHRD.
DR InterPro; IPR001007; VWF_dom.
DR PANTHER; PTHR46526; CHORDIN; 1.
DR PANTHER; PTHR46526:SF1; CHORDIN; 1.
DR Pfam; PF07452; CHRD; 2.
DR Pfam; PF00093; VWC; 2.
DR PIRSF; PIRSF002496; Chordin; 1.
DR SMART; SM00754; CHRD; 2.
DR SMART; SM00214; VWC; 4.
DR SUPFAM; SSF57603; FnI-like domain; 2.
DR PROSITE; PS50933; CHRD; 4.
DR PROSITE; PS51257; PROKAR_LIPOPROTEIN; 1.
DR PROSITE; PS01208; VWFC_1; 2.
DR PROSITE; PS50184; VWFC_2; 2.
PE 3: Inferred from homology;
KW Developmental protein {ECO:0000256|ARBA:ARBA00022473,
KW ECO:0000256|PIRNR:PIRNR002496};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Reference proteome {ECO:0000313|Proteomes:UP000007875};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Secreted {ECO:0000256|ARBA:ARBA00022525}; Signal {ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..18
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 19..973
FT /note="Chordin"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5003578930"
FT DOMAIN 170..284
FT /note="CHRD"
FT /evidence="ECO:0000259|PROSITE:PS50933"
FT DOMAIN 286..405
FT /note="CHRD"
FT /evidence="ECO:0000259|PROSITE:PS50933"
FT DOMAIN 407..527
FT /note="CHRD"
FT /evidence="ECO:0000259|PROSITE:PS50933"
FT DOMAIN 533..657
FT /note="CHRD"
FT /evidence="ECO:0000259|PROSITE:PS50933"
FT DOMAIN 714..774
FT /note="VWFC"
FT /evidence="ECO:0000259|PROSITE:PS50184"
FT DOMAIN 815..883
FT /note="VWFC"
FT /evidence="ECO:0000259|PROSITE:PS50184"
FT REGION 106..143
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 659..686
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 118..141
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 973 AA; 107017 MW; 1BC406028D62F570 CRC64;
MTRYYVTLLI IALTSCLGSG FLRSFPNSVR MPAKSPRGCV FGRQYHVIGS SWHPNLGRPF
GIMYCVTCHC IKETTGLKPN GEPQDQTRVT CHDVRKDCPH VTCKGAKVPR GGCCKKSTRS
PPPTSSSSSH SSHTFDNNFS SKNEDLSERR KIFTEISMNS DDSKANLEEK TKHYVALLTS
ENQGPLLRAT FNLHRDNLHF TIQYLGDQRP SAIEMLTDDD VIIYTHVTEA SPKPGLPIVC
GVWRNLPKHV ISALDKKSLQ LKAVFAEADA LNVTSQGKIS RHRALSRETF SSILYPPRDG
ASGVIAMMSL GRHRFNRLHF AVILRNPLMM SEAKTVTVRL INHENRTLRS TEMTLPAQID
ELAEVWPINS EIHRSLGEGK LRIELVARTT EARDKVRYIG GIAPKASCDL LQTVLSGSDC
NQPASTGAAG SAIFNVNLDN TVTYQVALVG MSSRVTSISL VGEYRKKRTR VIADITPQFE
DGAAQGTLES LNGKELHLLL SDRVRVTVQT KQSNSGELGG HVTSLLFGGH LARYKGLPIP
LAGALVRPPV ATGAAGHAWL ELNNDCHLYY EIVVSGLNKE RDTTMAAHLH GLAEIAGIEA
EHKQLLKGFY GKEAQGILRE LTAEIYDHLN RGTAFVQIAT KSNPNGEIRG RVHIPNTCAG
NFRSETTRKH DSSNTDGRSR PIVGSDVTTS RLSDLDPVVH DGVITDRRLE LDPTSCYVTG
GWKRHGSEWA PDYDLKCTVC VCESGSVLCD PVFCPELECA RPVAIEGRCC PVCNDGFGGI
PTKDDDGASI GSLFGSPISP NLSDLKTTEK EKKEEGCYYG GDGKTYATGS WWHPYFKRFG
HIACVNCTCQ PDGEIVCSKI TCPAVTCSNP VKRNSGDCCK TCPDEVGRSR HEPRDHSMQE
DSGTRMCHFG GQLRAPGEKW KLQIPGRRLE CIECECATHG LKHKCRRKCP AVHHACSRVE
RSVNSCCPWR CLD
//
