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Database: UniProt
Entry: H2YYU6_CIOSA
LinkDB: H2YYU6_CIOSA
Original site: H2YYU6_CIOSA 
ID   H2YYU6_CIOSA            Unreviewed;      2652 AA.
AC   H2YYU6;
DT   18-APR-2012, integrated into UniProtKB/TrEMBL.
DT   18-APR-2012, sequence version 1.
DT   05-DEC-2018, entry version 35.
DE   SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSCSAVP00000010507};
OS   Ciona savignyi (Pacific transparent sea squirt).
OC   Eukaryota; Metazoa; Chordata; Tunicata; Ascidiacea; Enterogona;
OC   Phlebobranchia; Cionidae; Ciona.
OX   NCBI_TaxID=51511 {ECO:0000313|Ensembl:ENSCSAVP00000010507, ECO:0000313|Proteomes:UP000007875};
RN   [1] {ECO:0000313|Ensembl:ENSCSAVP00000010507}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Birren B., Nusbaum C., Abebe A., Abouelleil A., Adekoya E.,
RA   Ait-zahra M., Allen N., Allen T., An P., Anderson M., Anderson S.,
RA   Arachchi H., Armbruster J., Bachantsang P., Baldwin J., Barry A.,
RA   Bayul T., Blitshsteyn B., Bloom T., Blye J., Boguslavskiy L.,
RA   Borowsky M., Boukhgalter B., Brunache A., Butler J., Calixte N.,
RA   Calvo S., Camarata J., Campo K., Chang J., Cheshatsang Y., Citroen M.,
RA   Collymore A., Considine T., Cook A., Cooke P., Corum B., Cuomo C.,
RA   David R., Dawoe T., Degray S., Dodge S., Dooley K., Dorje P.,
RA   Dorjee K., Dorris L., Duffey N., Dupes A., Elkins T., Engels R.,
RA   Erickson J., Farina A., Faro S., Ferreira P., Fischer H.,
RA   Fitzgerald M., Foley K., Gage D., Galagan J., Gearin G., Gnerre S.,
RA   Gnirke A., Goyette A., Graham J., Grandbois E., Gyaltsen K., Hafez N.,
RA   Hagopian D., Hagos B., Hall J., Hatcher B., Heller A., Higgins H.,
RA   Honan T., Horn A., Houde N., Hughes L., Hulme W., Husby E., Iliev I.,
RA   Jaffe D., Jones C., Kamal M., Kamat A., Kamvysselis M., Karlsson E.,
RA   Kells C., Kieu A., Kisner P., Kodira C., Kulbokas E., Labutti K.,
RA   Lama D., Landers T., Leger J., Levine S., Lewis D., Lewis T.,
RA   Lindblad-toh K., Liu X., Lokyitsang T., Lokyitsang Y., Lucien O.,
RA   Lui A., Ma L.J., Mabbitt R., Macdonald J., Maclean C., Major J.,
RA   Manning J., Marabella R., Maru K., Matthews C., Mauceli E.,
RA   Mccarthy M., Mcdonough S., Mcghee T., Meldrim J., Meneus L.,
RA   Mesirov J., Mihalev A., Mihova T., Mikkelsen T., Mlenga V., Moru K.,
RA   Mozes J., Mulrain L., Munson G., Naylor J., Newes C., Nguyen C.,
RA   Nguyen N., Nguyen T., Nicol R., Nielsen C., Nizzari M., Norbu C.,
RA   Norbu N., O'donnell P., Okoawo O., O'leary S., Omotosho B.,
RA   O'neill K., Osman S., Parker S., Perrin D., Phunkhang P., Piqani B.,
RA   Purcell S., Rachupka T., Ramasamy U., Rameau R., Ray V., Raymond C.,
RA   Retta R., Richardson S., Rise C., Rodriguez J., Rogers J., Rogov P.,
RA   Rutman M., Schupbach R., Seaman C., Settipalli S., Sharpe T.,
RA   Sheridan J., Sherpa N., Shi J., Smirnov S., Smith C., Sougnez C.,
RA   Spencer B., Stalker J., Stange-thomann N., Stavropoulos S.,
RA   Stetson K., Stone C., Stone S., Stubbs M., Talamas J., Tchuinga P.,
RA   Tenzing P., Tesfaye S., Theodore J., Thoulutsang Y., Topham K.,
RA   Towey S., Tsamla T., Tsomo N., Vallee D., Vassiliev H.,
RA   Venkataraman V., Vinson J., Vo A., Wade C., Wang S., Wangchuk T.,
RA   Wangdi T., Whittaker C., Wilkinson J., Wu Y., Wyman D., Yadav S.,
RA   Yang S., Yang X., Yeager S., Yee E., Young G., Zainoun J., Zembeck L.,
RA   Zimmer A., Zody M., Lander E.;
RL   Submitted (AUG-2003) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSCSAVP00000010507}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (FEB-2012) to UniProtKB.
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DR   Ensembl; ENSCSAVT00000010634; ENSCSAVP00000010507; ENSCSAVG00000006185.
DR   GeneTree; ENSGT00940000167397; -.
DR   Proteomes; UP000007875; Unassembled WGS sequence.
DR   GO; GO:0005783; C:endoplasmic reticulum; IEA:InterPro.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0070679; F:inositol 1,4,5 trisphosphate binding; IEA:InterPro.
DR   GO; GO:0005220; F:inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity; IEA:InterPro.
DR   InterPro; IPR016024; ARM-type_fold.
DR   InterPro; IPR014821; Ins145_P3_rcpt.
DR   InterPro; IPR000493; InsP3_rcpt.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR036300; MIR_dom_sf.
DR   InterPro; IPR016093; MIR_motif.
DR   InterPro; IPR013662; RIH_assoc-dom.
DR   InterPro; IPR000699; RIH_dom.
DR   InterPro; IPR015925; Ryanodine_recept-rel.
DR   InterPro; IPR035910; RyR/IP3R_RIH_dom_sf.
DR   PANTHER; PTHR13715; PTHR13715; 2.
DR   Pfam; PF08709; Ins145_P3_rec; 1.
DR   Pfam; PF00520; Ion_trans; 1.
DR   Pfam; PF02815; MIR; 1.
DR   Pfam; PF08454; RIH_assoc; 1.
DR   Pfam; PF01365; RYDR_ITPR; 2.
DR   PRINTS; PR00779; INSP3RECEPTR.
DR   SMART; SM00472; MIR; 4.
DR   SUPFAM; SSF100909; SSF100909; 2.
DR   SUPFAM; SSF48371; SSF48371; 1.
DR   SUPFAM; SSF82109; SSF82109; 2.
DR   PROSITE; PS50919; MIR; 5.
PE   4: Predicted;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000007875};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000007875};
KW   Repeat {ECO:0000256|SAAS:SAAS00903904};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   2165   2187       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   2223   2250       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   2256   2276       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   2288   2310       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   2343   2365       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   2475   2498       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN      115    169       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      176    226       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      234    290       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      297    368       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      374    430       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   COILED       92    112       {ECO:0000256|SAM:Coils}.
FT   COILED     2610   2644       {ECO:0000256|SAM:Coils}.
SQ   SEQUENCE   2652 AA;  302205 MW;  EE957BAB45DFEDD0 CRC64;
     AVMASSFLHI GDVISLFAEG SGPNSVCGFI STLGLVDDRC VVQPDAGNLQ NPPKKFRDCL
     FKICPMNRYN AQKQFWKTLK SGATRIADAV IMKRLQESAG VEKDQNEREN QKLLGQVVKY
     GSVVQLLHLK SNKYLTVNKR LPALLEKNAM RVSLDPDGNE GSWFYIQLFY KLRSTGDNVV
     IGDKVVIMPV NAGQPLHASK CELADNPGCK EVNSVSCNTS WKIVLFMTWE DDRKDVLKGG
     DVVRMFHAEQ EKFLTCDEYR RSLHVFLRTT GRMSATSATS SKALWEIEVV QKDPCQGGAG
     HWNNLFRFKH LASGNYLAAK MAESENGGSS EKESSRSRNR APPVGMSFCL VATAESSSVS
     SIFELDPTSF TKSDALVPSN SYVRLKHLCT DTWVHSTMIP IDKEEDRPVM LKIGTCKYKE
     DKEAFAIVNV NVEEVRDLDF ANDSSKVLAD CAKDMETKQI TVNERRFVIK LLEDLIFFVA
     RQPRGAMDAL DVMVVDPDRE RQKLLREQNI LKQVFKILQA PFKDSGDGAL LHLDELRDKK
     NVHYQHMLKL CYRLLRHSTQ DYRKNQEYIA KSFGLMQQQI GHDILAEDTI TALLHNNRKL
     LEQHITGTEI ETFVALVRKN REPRFLDYLA DLCVTNKQAI PKTQELICRN ILALKNKDIL
     IETKLGIDES GEEVALLSYG DGKAVEKSIR HLAQSNILDD KTVLTYYRHQ LDLFSKMCLD
     RQYLAINPIS EELTIPIILK CMADTQLPYD LRASFVQLML HMHVDKEPQE QVIPVQYARL
     WSGIPNQINI NDYDNDVGRH GFEKFVPTMQ FVEEYLNSFV NNAWIFKNKK ENKLTFEVVN
     LARHLIYFGF YSFADLLSLN RTLLQILDCV NGVPTNFGVD AVSRGVGNIG LLVSTMTLGG
     TLPPQSGGNE TTPQNPSSPS IHMNSHDEYV LETKLKIIEI LHFILDVRLD YRISLLSIFK
     REFDENNGRQ RELPSSADSS TQSEGSCAPP PINLGVISAK SEGIFDGSLE SSDLDLDEDG
     GRMFLRVLLN LVMHDYPPLV SGALQLLFRH FSQRQEVLGA FKNVQLLVTK DEHENYTEIK
     RNLDQLRLLV EKSELWVWKG KSQNTTSNPR EIRDESVDYA PVLDANRPSI KSSSLKNYNT
     IKEILRKLAG LCTDASSEKP CKEQQRLLRN MGAHGVVLDL LQISYERGTD EEMQRVMTQA
     HRFLQLFCKG NPQNQALLHK NLNLFMTPGL LEAETMQAIF QDNVALCKEV THGVIQHFVH
     CIESHGRRTE YLRFLQAIIK SEGKVHIRRC QDMVMAELVN TQAGEEVLLF YNDRASFTTF
     IKLMEDYARD CALQSQLQQT PDLDAEQSPL LYHIELCSTA RFHTATEGKN VYTEIKCHSL
     LPLDDIVQVV THESCIPEVK NAYVNFLNHC YVDTEVEMKE IYSSNHIWRL FDDFMEDMER
     VRSKEADDHI RKLQHYLATT VMDIITMFFS SPFSDATTVI QTRQTTYNQL LRSIAMLNQS
     SHLLPQFKPK LEDTMKKMGE VAKDRKIAIP GALDTEVNGA LNRPTVLEVI KKFRSLRTSG
     SWREGEPTLG QSYRDIIECL QDSVAVLDAQ LRPLVQAELS VLVDILHRPE LLFPVDTDAR
     KQCEGGGFIS KLIKHTEKLL EDREDKLCVK VLQTLREMMT VHISFNKGEA LRQILLSRYY
     GSNYHHLRDL AQRDNSSTRG SSTRYDWRLY KLTLEEVQCH LKKEGATDLV INLIIGNYSE
     KIFHESVLLG IALLEGGNND NQTSFYNQLL QDQGSEKFFE VFHEKIEAAQ LELKNSSTVN
     ASEIGRCCRA DQESDRERST PPCGKQVVIG TSFNWYCESD RHDEEKTLSP VISIMKPILR
     FLQLLCENHN AHLQNYLRTQ NNKNSYNLVC DTLKFLDCIC GSTTGGLGLL GLYINEHNVE
     LINQTLESLT EYCQGPCHDN QNAIASHESN GIDIIIALIL NDIIPLGKQR MDLVMQLKNN
     ASKLLLAIME SRHDSENAER ILRNINHTQL VSVIEQAYTK EEELEGVVGD SQLDMTGDGS
     PRAVGHNIYI LAHQLARHNT SLAQSLKPDN SLTGTEALHY YKKHTAQIEI VRSDRTMEQI
     VFPVPHVCSY LTKETMDRVW NTTDRDEQGS KVGSFFKQTE DMYREMVWQK KLREYTSLYW
     FSRHISLWST ISTNFIIIIN ILVALFYPFK TLDYKGKLLP HIVTPPSPAW NDKAQLILWP
     SMLVSLAAIT NPLAVRCFTL CIMVKTIFWI GVQNALLILG VLNLLNRFIY LLSFLGNKGM
     KDQGVMKVLM ETQFIIHVGH IFFCFIGLFW DELFYSILFF DLIYGEETLL NVIRSVTRNV
     RSLLLTAMLA LILVYLFSIV GYLFLKQDFK VSVSPRCSST SPERLQSLRD KLDKELRNTQ
     VCRQDDGSCN STGIALPDVL EGYLCDGGDS VEENHCESLL MCIITTLNEG LRNGGGIGDI
     LRKPSQSGIL FMGRVVYDLL FFFILIIIVL NLIFGVIIDT FADLRSEKQQ KDDVLRNTCF
     ICGLERKSFD NKTVSFETHV KEEHNMWHYL YFVVLVKVKD PTEFTGPESY VYNQVKERLL
     EWFPRMQAMS LAADDDAVEN NDVRGLLVQL EANSNLVKSL SAQLQDLQDQ VTEQRRKQQR
     LNIINPHNNM QF
//
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