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Database: UniProt
Entry: H2YYU9_CIOSA
LinkDB: H2YYU9_CIOSA
Original site: H2YYU9_CIOSA 
ID   H2YYU9_CIOSA            Unreviewed;      2705 AA.
AC   H2YYU9;
DT   18-APR-2012, integrated into UniProtKB/TrEMBL.
DT   18-APR-2012, sequence version 1.
DT   05-DEC-2018, entry version 32.
DE   SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSCSAVP00000010510};
OS   Ciona savignyi (Pacific transparent sea squirt).
OC   Eukaryota; Metazoa; Chordata; Tunicata; Ascidiacea; Enterogona;
OC   Phlebobranchia; Cionidae; Ciona.
OX   NCBI_TaxID=51511 {ECO:0000313|Ensembl:ENSCSAVP00000010510, ECO:0000313|Proteomes:UP000007875};
RN   [1] {ECO:0000313|Ensembl:ENSCSAVP00000010510}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Birren B., Nusbaum C., Abebe A., Abouelleil A., Adekoya E.,
RA   Ait-zahra M., Allen N., Allen T., An P., Anderson M., Anderson S.,
RA   Arachchi H., Armbruster J., Bachantsang P., Baldwin J., Barry A.,
RA   Bayul T., Blitshsteyn B., Bloom T., Blye J., Boguslavskiy L.,
RA   Borowsky M., Boukhgalter B., Brunache A., Butler J., Calixte N.,
RA   Calvo S., Camarata J., Campo K., Chang J., Cheshatsang Y., Citroen M.,
RA   Collymore A., Considine T., Cook A., Cooke P., Corum B., Cuomo C.,
RA   David R., Dawoe T., Degray S., Dodge S., Dooley K., Dorje P.,
RA   Dorjee K., Dorris L., Duffey N., Dupes A., Elkins T., Engels R.,
RA   Erickson J., Farina A., Faro S., Ferreira P., Fischer H.,
RA   Fitzgerald M., Foley K., Gage D., Galagan J., Gearin G., Gnerre S.,
RA   Gnirke A., Goyette A., Graham J., Grandbois E., Gyaltsen K., Hafez N.,
RA   Hagopian D., Hagos B., Hall J., Hatcher B., Heller A., Higgins H.,
RA   Honan T., Horn A., Houde N., Hughes L., Hulme W., Husby E., Iliev I.,
RA   Jaffe D., Jones C., Kamal M., Kamat A., Kamvysselis M., Karlsson E.,
RA   Kells C., Kieu A., Kisner P., Kodira C., Kulbokas E., Labutti K.,
RA   Lama D., Landers T., Leger J., Levine S., Lewis D., Lewis T.,
RA   Lindblad-toh K., Liu X., Lokyitsang T., Lokyitsang Y., Lucien O.,
RA   Lui A., Ma L.J., Mabbitt R., Macdonald J., Maclean C., Major J.,
RA   Manning J., Marabella R., Maru K., Matthews C., Mauceli E.,
RA   Mccarthy M., Mcdonough S., Mcghee T., Meldrim J., Meneus L.,
RA   Mesirov J., Mihalev A., Mihova T., Mikkelsen T., Mlenga V., Moru K.,
RA   Mozes J., Mulrain L., Munson G., Naylor J., Newes C., Nguyen C.,
RA   Nguyen N., Nguyen T., Nicol R., Nielsen C., Nizzari M., Norbu C.,
RA   Norbu N., O'donnell P., Okoawo O., O'leary S., Omotosho B.,
RA   O'neill K., Osman S., Parker S., Perrin D., Phunkhang P., Piqani B.,
RA   Purcell S., Rachupka T., Ramasamy U., Rameau R., Ray V., Raymond C.,
RA   Retta R., Richardson S., Rise C., Rodriguez J., Rogers J., Rogov P.,
RA   Rutman M., Schupbach R., Seaman C., Settipalli S., Sharpe T.,
RA   Sheridan J., Sherpa N., Shi J., Smirnov S., Smith C., Sougnez C.,
RA   Spencer B., Stalker J., Stange-thomann N., Stavropoulos S.,
RA   Stetson K., Stone C., Stone S., Stubbs M., Talamas J., Tchuinga P.,
RA   Tenzing P., Tesfaye S., Theodore J., Thoulutsang Y., Topham K.,
RA   Towey S., Tsamla T., Tsomo N., Vallee D., Vassiliev H.,
RA   Venkataraman V., Vinson J., Vo A., Wade C., Wang S., Wangchuk T.,
RA   Wangdi T., Whittaker C., Wilkinson J., Wu Y., Wyman D., Yadav S.,
RA   Yang S., Yang X., Yeager S., Yee E., Young G., Zainoun J., Zembeck L.,
RA   Zimmer A., Zody M., Lander E.;
RL   Submitted (AUG-2003) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSCSAVP00000010510}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (FEB-2012) to UniProtKB.
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DR   Ensembl; ENSCSAVT00000010637; ENSCSAVP00000010510; ENSCSAVG00000006185.
DR   GeneTree; ENSGT00940000167397; -.
DR   Proteomes; UP000007875; Unassembled WGS sequence.
DR   GO; GO:0005783; C:endoplasmic reticulum; IEA:InterPro.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0070679; F:inositol 1,4,5 trisphosphate binding; IEA:InterPro.
DR   GO; GO:0005220; F:inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity; IEA:InterPro.
DR   InterPro; IPR014821; Ins145_P3_rcpt.
DR   InterPro; IPR000493; InsP3_rcpt.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR036300; MIR_dom_sf.
DR   InterPro; IPR016093; MIR_motif.
DR   InterPro; IPR013662; RIH_assoc-dom.
DR   InterPro; IPR000699; RIH_dom.
DR   InterPro; IPR015925; Ryanodine_recept-rel.
DR   InterPro; IPR035910; RyR/IP3R_RIH_dom_sf.
DR   PANTHER; PTHR13715; PTHR13715; 4.
DR   Pfam; PF08709; Ins145_P3_rec; 1.
DR   Pfam; PF00520; Ion_trans; 1.
DR   Pfam; PF02815; MIR; 1.
DR   Pfam; PF08454; RIH_assoc; 1.
DR   Pfam; PF01365; RYDR_ITPR; 2.
DR   PRINTS; PR00779; INSP3RECEPTR.
DR   SMART; SM00472; MIR; 4.
DR   SUPFAM; SSF100909; SSF100909; 2.
DR   SUPFAM; SSF82109; SSF82109; 2.
DR   PROSITE; PS50919; MIR; 5.
PE   4: Predicted;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000007875};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000007875};
KW   Repeat {ECO:0000256|SAAS:SAAS00903904};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   2035   2056       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   2239   2263       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   2290   2309       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   2321   2348       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   2368   2396       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   2417   2439       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   2538   2561       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN      116    170       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      177    227       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      235    291       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      298    375       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      381    437       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   COILED       93    113       {ECO:0000256|SAM:Coils}.
FT   COILED     2669   2703       {ECO:0000256|SAM:Coils}.
SQ   SEQUENCE   2705 AA;  308802 MW;  600CC137041E9342 CRC64;
     QAVMASSFLH IGDVISLFAE GSGPNSVCGF ISTLGLVDDR CVVQPDAGNL QNPPKKFRDC
     LFKICPMNRY NAQKQFWKTL KSGATRIADA VIMKRLQESA GVEKDQNERE NQKLLGQVVK
     YGSVVQLLHL KSNKYLTVNK RLPALLEKNA MRVSLDPDGN EGSWFYIQLF YKLRSTGDNV
     VIGDKVVIMP VNAGQPLHAS KCELADNPGC KEVNSVSCNT SWKIVLFMTW EDDRKDVLKG
     GDVVRMFHAE QEKFLTCDEY RRSLHVFLRT TGRMSATSAT SSKALWEIEV VQKDPCQGGA
     GHWNNLFRFK HLASGNYLAA KVTIFILDNT SENGGSSEKE SSRSRNRAPP VGMSFCLVAT
     AESSSVSSIF ELDPTSFTKS DALVPSNSYV RLKHLCTDTW VHSTMIPIDK EEDRPVMLKI
     GTCKYKEDKE AFAIVNVNVE EVRDLDFAND SSKVLADCAK DMETKQITVN ERRFVIKLLE
     DLIFFVARQP RGAMDALDVM VVDPDRERQK LLREQNILKQ VFKILQAPFK DSGDGALLHL
     DELRDKKNVH YQHMLKLCYR LLRHSTQDYR KNQCSVVAYM SLFHLSCEYI AKSFGLMQQQ
     IGHDILAEDT ITALLHNNRK LLEQHITGTE IETFVALVRK NREPRFLDYL ADLCVTNKQA
     IPKTQELICR NILALKNKDI LIETKLGIDE SGEEVALLSY GDGKAVEKSI RHLAQSNILD
     DKTVLTYYRH QLDLFSKMCL DRQYLAINPI SEELTIPIIL KCMADTQLPY DLRASFVQLM
     LHMHVDKEPQ EQVIPVQYAR LWSGIPNQIN INDYDNDVGR HGFEKFVPTM QFVEEYLNSF
     VNNAWIFKNK KENKLTFEVV NLARHLIYFG FYSFADLLSL NRTLLQILDC VNGVPTNLFN
     GRIADTGSGV DAVSRGVGNI GLLVSTMTLG GTLPPQSGGN ETTPQNPSSP SIHMNSHDEY
     VLETKLKIIE ILHFILDVRL DYRISLLSIF KREFDENNGR QRELPSSADS STQSEGSCAP
     PPINLGVISA KSEGIFDGSL ESSDLDLDED GGRMFLRVLL NLVMHDYPPL VSGALQLLFR
     HFSQRQEVLG AFKNVQLLVT KDEHENYTEI KRNLDQLRLL VEKSELWVWK GKSQNTTSNP
     REIRDESVDY APVLDANRPS IKSSSLKNYN TIKEILRKLA GLCTDASSEK PCKEQQRLLR
     NMGAHGVVLD LLQISYERGT DEEMQRVMTQ AHRFLQLFCK GNPQNQALLH KNLNLFMTPG
     LLEAETMQAI FQDNVALCKE VTHGVIQHFV HCIESHGRRT EYLRFLQAII KSEGKVHIRR
     CQDMVMAELV NTQAGEEVLL FYNDRASFTT FIKLMEDYAR DCALQHERWL VIFAHTATEG
     KNVYTEIKCH SLLPLDDIVQ VVTHESCIPE VKNAYVNFLN HCYVDTEVEM KEIYSSNHIW
     RLFDDFMEDM ERQCRVTVRS KEADDHIRKL QHYLATTVMD IITMFFSSPF SDATTVIQTR
     QTTYNQLLRS IAMLNQSSHL LPQFKPKLED TMKKMGEVAK DRKIAIPGAL DTEVNGALNR
     PTVLEVIKKF RSLRTSGSWR EGEPTLGQSY RDIIECLQDS VAVLDAQLRP LVQAELSVLV
     DILHRPELLF PVDTDARKQC EGGGFISKLI KHTEKLLEDR EDKLCVKVLQ TLREMMTVHI
     SFNKSNSVYN DHIWEEVNCI FLLCCSLDSP TQWCHPNIHS ATVMQYLLAR SCTYMFYYFS
     PVLMYRQNLK MKRAIIKHPI IRSIFRKTEL TLEEVQCHLK KEGATDLVIN LIIGNYSEKI
     FHESVLLGIA LLEGGNNDNQ TSFYNQLLQD QGSEKFFEVF HEKIEAAQLE LKNSSTVNAS
     DDRHDEEKTL SPVISIMKPI LRFLQLLCEN HNAHLQNYLR TQNNKNSYNL VCDTLKFLDC
     ICGSTTGGLG LLGLYINEHN VELINQTLES LTEYCQGPCH DNQNAIASHE SNGIDIIIAL
     ILNDIIPLGK QRMDLVMQLK NNASKLLLAI MESRHDSENA ERILRNINHT QLVSVYMGLH
     LWVLLWCIWS LTCMWLSQGQ RMAEEEELEG VVGDSQLDMT GDGSPRAVGH NIYILAHQLA
     RHNTSLAQSL KPDNSLTGTE ALHYYKKHTA QIEIVRSDRT MEQIVFPVPH VCSYLTKETM
     DRVWNTTDRD EQGSKVGSFF KQTEDMYREM VWQKKLRGQF VVEQEGYGFD SYPVVLHQFS
     GYNTYIAEYT SLYWFSRHIS LWSTISTNFI IIINILVALF YPFKTLDYKG KLLPHIVTPP
     SPAWNDKAQL ILWPSMLVSL AAITNPLAVR CFTLCIMVKT IFWIGVQNAL LILGVLNLLN
     RFIYLLSFLG NKGMKDQGVM KVLMETQFII HVGHIFFCFI GLFWDELFYS ILFFDLIYGE
     ETLLNVIRSV TRNVRSLLLT AMLALILVYL FSIVGYLFLK QDFKVSVSPR CSSTSPERLQ
     SLRDKLDKEL RNTQVCRQDD GYLCDGGDSV EENHCESLLM CIITTLNEGL RNGGGIGDIL
     RKPSQSGILF MGRVVYDLLF FFILIIIVLN LIFGVIIDTF ADLRSEKQQK DDVLRNTCFI
     CGLERKSFDN KTVSFETHVK EEHNMWHYLY FVVLVKVKDP TEFTGPESYV YNQVKERLLE
     WFPRMQAMSL AADDDAVENN DVRGLLVQLE ANSNLVKSLS AQLQDLQDQV TEQRRKQQRL
     NIINP
//
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