ID H2Z075_CIOSA Unreviewed; 1982 AA.
AC H2Z075;
DT 18-APR-2012, integrated into UniProtKB/TrEMBL.
DT 18-APR-2012, sequence version 1.
DT 27-MAR-2024, entry version 40.
DE RecName: Full=C2 domain-containing protein {ECO:0000259|PROSITE:PS50004};
OS Ciona savignyi (Pacific transparent sea squirt).
OC Eukaryota; Metazoa; Chordata; Tunicata; Ascidiacea; Phlebobranchia;
OC Cionidae; Ciona.
OX NCBI_TaxID=51511 {ECO:0000313|Ensembl:ENSCSAVP00000010987.1, ECO:0000313|Proteomes:UP000007875};
RN [1] {ECO:0000313|Proteomes:UP000007875}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Birren B., Nusbaum C., Abebe A., Abouelleil A., Adekoya E., Ait-zahra M.,
RA Allen N., Allen T., An P., Anderson M., Anderson S., Arachchi H.,
RA Armbruster J., Bachantsang P., Baldwin J., Barry A., Bayul T.,
RA Blitshsteyn B., Bloom T., Blye J., Boguslavskiy L., Borowsky M.,
RA Boukhgalter B., Brunache A., Butler J., Calixte N., Calvo S., Camarata J.,
RA Campo K., Chang J., Cheshatsang Y., Citroen M., Collymore A., Considine T.,
RA Cook A., Cooke P., Corum B., Cuomo C., David R., Dawoe T., Degray S.,
RA Dodge S., Dooley K., Dorje P., Dorjee K., Dorris L., Duffey N., Dupes A.,
RA Elkins T., Engels R., Erickson J., Farina A., Faro S., Ferreira P.,
RA Fischer H., Fitzgerald M., Foley K., Gage D., Galagan J., Gearin G.,
RA Gnerre S., Gnirke A., Goyette A., Graham J., Grandbois E., Gyaltsen K.,
RA Hafez N., Hagopian D., Hagos B., Hall J., Hatcher B., Heller A.,
RA Higgins H., Honan T., Horn A., Houde N., Hughes L., Hulme W., Husby E.,
RA Iliev I., Jaffe D., Jones C., Kamal M., Kamat A., Kamvysselis M.,
RA Karlsson E., Kells C., Kieu A., Kisner P., Kodira C., Kulbokas E.,
RA Labutti K., Lama D., Landers T., Leger J., Levine S., Lewis D., Lewis T.,
RA Lindblad-toh K., Liu X., Lokyitsang T., Lokyitsang Y., Lucien O., Lui A.,
RA Ma L.J., Mabbitt R., Macdonald J., Maclean C., Major J., Manning J.,
RA Marabella R., Maru K., Matthews C., Mauceli E., Mccarthy M., Mcdonough S.,
RA Mcghee T., Meldrim J., Meneus L., Mesirov J., Mihalev A., Mihova T.,
RA Mikkelsen T., Mlenga V., Moru K., Mozes J., Mulrain L., Munson G.,
RA Naylor J., Newes C., Nguyen C., Nguyen N., Nguyen T., Nicol R., Nielsen C.,
RA Nizzari M., Norbu C., Norbu N., O'donnell P., Okoawo O., O'leary S.,
RA Omotosho B., O'neill K., Osman S., Parker S., Perrin D., Phunkhang P.,
RA Piqani B., Purcell S., Rachupka T., Ramasamy U., Rameau R., Ray V.,
RA Raymond C., Retta R., Richardson S., Rise C., Rodriguez J., Rogers J.,
RA Rogov P., Rutman M., Schupbach R., Seaman C., Settipalli S., Sharpe T.,
RA Sheridan J., Sherpa N., Shi J., Smirnov S., Smith C., Sougnez C.,
RA Spencer B., Stalker J., Stange-thomann N., Stavropoulos S., Stetson K.,
RA Stone C., Stone S., Stubbs M., Talamas J., Tchuinga P., Tenzing P.,
RA Tesfaye S., Theodore J., Thoulutsang Y., Topham K., Towey S., Tsamla T.,
RA Tsomo N., Vallee D., Vassiliev H., Venkataraman V., Vinson J., Vo A.,
RA Wade C., Wang S., Wangchuk T., Wangdi T., Whittaker C., Wilkinson J.,
RA Wu Y., Wyman D., Yadav S., Yang S., Yang X., Yeager S., Yee E., Young G.,
RA Zainoun J., Zembeck L., Zimmer A., Zody M., Lander E.;
RL Submitted (AUG-2003) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSCSAVP00000010987.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR Ensembl; ENSCSAVT00000011118.1; ENSCSAVP00000010987.1; ENSCSAVG00000006436.1.
DR GeneTree; ENSGT00940000169673; -.
DR Proteomes; UP000007875; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR CDD; cd08373; C2A_Ferlin; 1.
DR CDD; cd04011; C2B_Ferlin; 1.
DR CDD; cd04018; C2C_Ferlin; 1.
DR CDD; cd04017; C2D_Ferlin; 1.
DR CDD; cd04037; C2E_Ferlin; 1.
DR CDD; cd08374; C2F_Ferlin; 1.
DR Gene3D; 2.60.40.150; C2 domain; 6.
DR InterPro; IPR000008; C2_dom.
DR InterPro; IPR035892; C2_domain_sf.
DR InterPro; IPR037726; C2A_Ferlin.
DR InterPro; IPR037720; C2B_Ferlin.
DR InterPro; IPR037722; C2C_Ferlin.
DR InterPro; IPR037723; C2D_Ferlin.
DR InterPro; IPR037724; C2E_Ferlin.
DR InterPro; IPR037725; C2F_Ferlin.
DR InterPro; IPR012968; FerIin_dom.
DR InterPro; IPR037721; Ferlin.
DR InterPro; IPR012561; Ferlin_B-domain.
DR InterPro; IPR032362; Ferlin_C.
DR PANTHER; PTHR12546; FER-1-LIKE; 1.
DR PANTHER; PTHR12546:SF60; MISFIRE, ISOFORM F; 1.
DR Pfam; PF00168; C2; 6.
DR Pfam; PF08150; FerB; 1.
DR Pfam; PF08151; FerI; 1.
DR Pfam; PF16165; Ferlin_C; 1.
DR PRINTS; PR00360; C2DOMAIN.
DR SMART; SM00239; C2; 6.
DR SMART; SM01201; FerB; 1.
DR SMART; SM01202; FerI; 1.
DR SUPFAM; SSF49562; C2 domain (Calcium/lipid-binding domain, CaLB); 7.
DR PROSITE; PS50004; C2; 7.
PE 4: Predicted;
KW Calcium {ECO:0000256|ARBA:ARBA00022837};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Reference proteome {ECO:0000313|Proteomes:UP000007875};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 1949..1969
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 1..98
FT /note="C2"
FT /evidence="ECO:0000259|PROSITE:PS50004"
FT DOMAIN 230..351
FT /note="C2"
FT /evidence="ECO:0000259|PROSITE:PS50004"
FT DOMAIN 389..524
FT /note="C2"
FT /evidence="ECO:0000259|PROSITE:PS50004"
FT DOMAIN 935..1060
FT /note="C2"
FT /evidence="ECO:0000259|PROSITE:PS50004"
FT DOMAIN 1107..1232
FT /note="C2"
FT /evidence="ECO:0000259|PROSITE:PS50004"
FT DOMAIN 1452..1573
FT /note="C2"
FT /evidence="ECO:0000259|PROSITE:PS50004"
FT DOMAIN 1695..1842
FT /note="C2"
FT /evidence="ECO:0000259|PROSITE:PS50004"
FT REGION 181..202
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 641..684
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1982 AA; 225219 MW; 4A40A86728E7DF9B CRC64;
MSLEVRIFNV AGLKGKGSRN ARITFRGHSY STRTIEDCEN EALFNEVFDW PVASPIEDRE
MISIDVFNYN KVFSNRLIGR FQMVLQQVVK DGEISLEESL LDSNNTALKT TISIQIKYLA
PDGTVGNWAI EDFQPQRNMS DVMSINNMDD SNPARPLTGQ GLVRFRMLAI KATAARQIAR
QASIAGSQEG SEHPSTPTRE PRILLNQSNP ALDNISVVSL TVMDQPVTNR RSKPETKFES
AALKLHDFQV SVTVIEARQL SGTNMDPVVM VQLGDDKKYT TQKESTNCPY YNEVFVFDYH
LPRQVVFDKI VTFSVIHSRN LLRSGTLVGK FKMDLGTVYA NPDHNFSRKW AVLTDPDDLN
TGPKGYLKVD ISVVGKGDSI KIPKINEEEE DDIENNLLLP EGVQAERQRA RFIFKIYQAD
GLPKMNTSIT EKLKTVLQGE AKDLVDPYVE ITFCDQKGRT SVRKNSYEPC WNEQIIFTEL
FPPLCKRIKV QIRDKDNINN TVIGTTYISL DKISNSGDRG FLPTFGPTYV NMYGSPRNYT
MVNEHSDLNE GLGEGVAFRC RLLLALSVEL VNINASDGQG SSDVEVEYIP ALSELGAGKM
DEFFLFGSFL EANMIDRTMA DKPVTFEVTI GNFGNDIDGA NLSRKKRMSD GSEDSLEDTD
DESQSLLKGS VTDDPTIRPL TPPTRPLTSD KYYYHMPFFE NKPCVYLTSY WHDHKRRLYN
SNIMHRVADK LDEGLQDVQE MLKTSHERPD RRLRGVAEEL TNGCASYIRL VKGTGGMGAG
RTRLDRERNK LCLRDVEYIG KEAKKVKAMV KPSVLKENLS KMKSLHSKLK GLCDDPQHSI
PDVFIWMLSG PKRVAYARIA ARQILHSVRE EECGEHCGKI QTLFLRLPGK KSLGLSGWSI
QAKVDIYFWF GLAKNKRDFL KGLPQGYKAI RAGNSLKAPP KTLNYPDRLQ FELRAHMYQA
RGLLAADDTG LSDPFAKVIF STHTDTTQVI EETLSPTWDQ TLIMPNITLF GRAEELRDDP
PIIIIEVFDQ DTVGKNEYIG RTIAKPVVKM SHERYEEPRF PSQLDWYQMY RGMTKAGEIL
AAFELLQIKG KDQIESTKVT EAIQTSQGHK FTVPKGIRPL LAKHRIEVLF WGLRDLKRVQ
LISVDRPRVD IEIAGRCVSS CLINNYKKNP NFAEPVKFIE DVDLPEVEYW CPPISITCID
CRAFGRSVLV GTHIISNISK FVFRPPDKSK IYTANVINVL TGNLIPGVPR IKKNGEVSTE
TNDVVVNIND TPTLPPSGMV EIKLEVDEEK KTKEDEEDPL DEATLDWWSK YFASLETLNE
EKSKMDEANI QDVYNDDEDQ ESILSIFLPP EDQHKYTASS QIKKIKQAKK SLGAPVRKWK
HKKLPIDELK IYDTELENSN EFSGFNDLLN SFDLYRGKRE DLADDITDQK RIVGNFKGAF
KIYRHPLPHY VEQPDPQYGM FKGLPSNEPI HVLVRVYIIR ATDLHPTDPN GKSDPYIVIS
LGENKVNDKE NYISKQLNPT FGKAFDFEAT FPMESILNVQ IYDWDLLSAD DLIGETKIDL
ENRFYSKHRS LCGVAEKYAI FGYNQWRDPM KPSEILKKLC KELKLDGPHF MPGKVRVGNK
TFQGAIELED ENGHKKPTEE HVALVALRNW EEIPKVGCKL VPEHVETRSL YNSEKPGIEQ
GRVELWVDMF PMDMPLPGPP VDVSPRKPKG FQLRVIIWNT DEVLLQDDDF FTGEKASDIY
LKGWLLGDDK QETDIHYRSL TGEGNFNWRF IYPFDYLVAE EKCVVTKKES MFSWDETEFK
IPPRLNLQVW DADHFSADDF LGSLTLDLTR LPRGAKSANK CSLNMAAEDD DSSNVPMISI
FKQRRIKGLG WPFTAKNDQD ELGNHSTFGG KVEAEISLLT AEEAEKNPAG YGRDEPDPLE
KPNRPDTSFV WFMNPLKSLR YLICARFKWL IIKVFIALLL IALLVLFIYS SPSWIMKKIV
GA
//
