ID H2Z1P2_CIOSA Unreviewed; 1901 AA.
AC H2Z1P2;
DT 18-APR-2012, integrated into UniProtKB/TrEMBL.
DT 18-APR-2012, sequence version 1.
DT 27-MAR-2024, entry version 63.
DE RecName: Full=Myosin motor domain-containing protein {ECO:0008006|Google:ProtNLM};
OS Ciona savignyi (Pacific transparent sea squirt).
OC Eukaryota; Metazoa; Chordata; Tunicata; Ascidiacea; Phlebobranchia;
OC Cionidae; Ciona.
OX NCBI_TaxID=51511 {ECO:0000313|Ensembl:ENSCSAVP00000011504.1, ECO:0000313|Proteomes:UP000007875};
RN [1] {ECO:0000313|Proteomes:UP000007875}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Birren B., Nusbaum C., Abebe A., Abouelleil A., Adekoya E., Ait-zahra M.,
RA Allen N., Allen T., An P., Anderson M., Anderson S., Arachchi H.,
RA Armbruster J., Bachantsang P., Baldwin J., Barry A., Bayul T.,
RA Blitshsteyn B., Bloom T., Blye J., Boguslavskiy L., Borowsky M.,
RA Boukhgalter B., Brunache A., Butler J., Calixte N., Calvo S., Camarata J.,
RA Campo K., Chang J., Cheshatsang Y., Citroen M., Collymore A., Considine T.,
RA Cook A., Cooke P., Corum B., Cuomo C., David R., Dawoe T., Degray S.,
RA Dodge S., Dooley K., Dorje P., Dorjee K., Dorris L., Duffey N., Dupes A.,
RA Elkins T., Engels R., Erickson J., Farina A., Faro S., Ferreira P.,
RA Fischer H., Fitzgerald M., Foley K., Gage D., Galagan J., Gearin G.,
RA Gnerre S., Gnirke A., Goyette A., Graham J., Grandbois E., Gyaltsen K.,
RA Hafez N., Hagopian D., Hagos B., Hall J., Hatcher B., Heller A.,
RA Higgins H., Honan T., Horn A., Houde N., Hughes L., Hulme W., Husby E.,
RA Iliev I., Jaffe D., Jones C., Kamal M., Kamat A., Kamvysselis M.,
RA Karlsson E., Kells C., Kieu A., Kisner P., Kodira C., Kulbokas E.,
RA Labutti K., Lama D., Landers T., Leger J., Levine S., Lewis D., Lewis T.,
RA Lindblad-toh K., Liu X., Lokyitsang T., Lokyitsang Y., Lucien O., Lui A.,
RA Ma L.J., Mabbitt R., Macdonald J., Maclean C., Major J., Manning J.,
RA Marabella R., Maru K., Matthews C., Mauceli E., Mccarthy M., Mcdonough S.,
RA Mcghee T., Meldrim J., Meneus L., Mesirov J., Mihalev A., Mihova T.,
RA Mikkelsen T., Mlenga V., Moru K., Mozes J., Mulrain L., Munson G.,
RA Naylor J., Newes C., Nguyen C., Nguyen N., Nguyen T., Nicol R., Nielsen C.,
RA Nizzari M., Norbu C., Norbu N., O'donnell P., Okoawo O., O'leary S.,
RA Omotosho B., O'neill K., Osman S., Parker S., Perrin D., Phunkhang P.,
RA Piqani B., Purcell S., Rachupka T., Ramasamy U., Rameau R., Ray V.,
RA Raymond C., Retta R., Richardson S., Rise C., Rodriguez J., Rogers J.,
RA Rogov P., Rutman M., Schupbach R., Seaman C., Settipalli S., Sharpe T.,
RA Sheridan J., Sherpa N., Shi J., Smirnov S., Smith C., Sougnez C.,
RA Spencer B., Stalker J., Stange-thomann N., Stavropoulos S., Stetson K.,
RA Stone C., Stone S., Stubbs M., Talamas J., Tchuinga P., Tenzing P.,
RA Tesfaye S., Theodore J., Thoulutsang Y., Topham K., Towey S., Tsamla T.,
RA Tsomo N., Vallee D., Vassiliev H., Venkataraman V., Vinson J., Vo A.,
RA Wade C., Wang S., Wangchuk T., Wangdi T., Whittaker C., Wilkinson J.,
RA Wu Y., Wyman D., Yadav S., Yang S., Yang X., Yeager S., Yee E., Young G.,
RA Zainoun J., Zembeck L., Zimmer A., Zody M., Lander E.;
RL Submitted (AUG-2003) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSCSAVP00000011504.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the TRAFAC class myosin-kinesin ATPase
CC superfamily. Myosin family. {ECO:0000256|ARBA:ARBA00008314,
CC ECO:0000256|PROSITE-ProRule:PRU00782}.
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DR Ensembl; ENSCSAVT00000011637.1; ENSCSAVP00000011504.1; ENSCSAVG00000006742.1.
DR Ensembl; ENSCSAVT00000011638.1; ENSCSAVP00000011505.1; ENSCSAVG00000006742.1.
DR GeneTree; ENSGT00940000160705; -.
DR HOGENOM; CLU_000192_8_0_1; -.
DR Proteomes; UP000007875; Unassembled WGS sequence.
DR GO; GO:0016459; C:myosin complex; IEA:UniProtKB-KW.
DR GO; GO:0051015; F:actin filament binding; IEA:InterPro.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0003774; F:cytoskeletal motor activity; IEA:UniProtKB-UniRule.
DR CDD; cd01377; MYSc_class_II; 1.
DR Gene3D; 1.10.10.820; -; 1.
DR Gene3D; 1.20.5.340; -; 3.
DR Gene3D; 1.20.5.370; -; 3.
DR Gene3D; 1.20.5.4820; -; 1.
DR Gene3D; 1.20.58.530; -; 1.
DR Gene3D; 3.40.850.10; Kinesin motor domain; 1.
DR Gene3D; 2.30.30.360; Myosin S1 fragment, N-terminal; 1.
DR Gene3D; 1.20.120.720; Myosin VI head, motor domain, U50 subdomain; 1.
DR InterPro; IPR000048; IQ_motif_EF-hand-BS.
DR InterPro; IPR036961; Kinesin_motor_dom_sf.
DR InterPro; IPR001609; Myosin_head_motor_dom.
DR InterPro; IPR004009; Myosin_N.
DR InterPro; IPR008989; Myosin_S1_N.
DR InterPro; IPR002928; Myosin_tail.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR014751; XRCC4-like_C.
DR PANTHER; PTHR45615:SF40; MYOSIN HEAVY CHAIN, MUSCLE-RELATED; 1.
DR PANTHER; PTHR45615; MYOSIN HEAVY CHAIN, NON-MUSCLE; 1.
DR Pfam; PF00063; Myosin_head; 1.
DR Pfam; PF02736; Myosin_N; 1.
DR Pfam; PF01576; Myosin_tail_1; 2.
DR PRINTS; PR00193; MYOSINHEAVY.
DR SMART; SM00242; MYSc; 1.
DR SUPFAM; SSF90257; Myosin rod fragments; 6.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS50096; IQ; 1.
DR PROSITE; PS51456; MYOSIN_MOTOR; 1.
DR PROSITE; PS51844; SH3_LIKE; 1.
PE 3: Inferred from homology;
KW Actin-binding {ECO:0000256|ARBA:ARBA00023203, ECO:0000256|PROSITE-
KW ProRule:PRU00782};
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|PROSITE-
KW ProRule:PRU00782};
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils};
KW Motor protein {ECO:0000256|ARBA:ARBA00023175, ECO:0000256|PROSITE-
KW ProRule:PRU00782};
KW Myosin {ECO:0000256|ARBA:ARBA00023123, ECO:0000256|PROSITE-
KW ProRule:PRU00782};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|PROSITE-
KW ProRule:PRU00782}; Reference proteome {ECO:0000313|Proteomes:UP000007875}.
FT DOMAIN 33..82
FT /note="Myosin N-terminal SH3-like"
FT /evidence="ECO:0000259|PROSITE:PS51844"
FT DOMAIN 86..769
FT /note="Myosin motor"
FT /evidence="ECO:0000259|PROSITE:PS51456"
FT REGION 648..670
FT /note="Actin-binding"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00782"
FT REGION 1880..1901
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 833..1147
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 1191..1288
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 1381..1481
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 1534..1737
FT /evidence="ECO:0000256|SAM:Coils"
FT BINDING 179..186
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00782"
SQ SEQUENCE 1901 AA; 219337 MW; C0E4581788C0F0EC CRC64;
LTSTGECGPG DDPMPFLEPT EKEKLAFAGM AYDGKKSVWV PHKKEGFVRG ELLNSTADKC
TIKTVKNETI TIKKDDVQQM NPPKFEQTAD MANMTFLNEA SVLNNLRSRY ASLRIYTYSG
LFCVCVNPYK WLPVYGVKVV QMYRGKKRSE MPPHLFSVAD NAYHDMLMDR ENQSILITGE
SGAGKTENTK KVIQYFANIA ASGVSKPGEE KKANLEDQIV QTNPVLEAWG NAKTIRNNNS
SRFGKFIRIH FGTSGKLSGG DIESYLLEKS RVIFQLPAER GYHIFYQIMA SGKPDMLESL
CISNNPRDYF WVSQGVIKVD NMDDTEEFNF TNEAFEVLGF TEEERFNCYR LTAGCMVFGS
MLYKQKPRDE QAEVDSIEVA DKVAHLFGIS SPELCKAITR PRVKVGTEYV QKGQNVDQCT
NSTGALAKAT YDKLFKWIVY RLNITLDTKL PRNYFVGVLD IAGFEIFDFN TFEQLCINFT
NEKLQQFFNH HMFVLEQEEY KKEGIEWVFI DFGMDLQACI ELLEKPMGVF SILEEESIVP
KATDETFKNK LYEKHDKKSE AFVKPKVGKK GNAHFCVKHY AGIVEYNVDG WLNKNKDPLN
SSVISLFTKS TNKLMASVYP EVKEEAAGKK KKKGGSFQTV SALYREQLNK LMTNLRNTKP
HFVRCLIPNE MKQCGIMEAS LVLGQLKCNG VLEGIRICRK GFPNRLQYPE FKQRYQILAA
AKVANLVDSK KATETILLHI ELDTALYKVG HTKIFFKAGV LADLEDQRDT ILSIIMTKMQ
AKARGKLMRI EFKKMLERQR AAKAIQRNIR KFLQFRDWQW WKLYTKVKPL LNVVRVEDEL
KAKDEEIAEL KEKFGHEEKL RKDYEEKCVS LLSEKNDLTL QLQAEQENLA DAEERNEQMV
KVKGDLEAQV ADMSERLEEE EANNLQVSAA KKKLEKQCED LGHDIEEAES NINHLEKDKQ
GLELKLRGLS SDLEQREDSI QRLNKEKKQL DQVNQQTLED LQSMEDKANH LGKIKIKLEQ
QIEDVEDSLE QERKHKNDLE KAKRKLETDL RTAQDTIMDL EKDKSSLEDG IRKREFEINQ
LTSRTEDDQN VIAQLNRKLK ELQARVEDTE SELDMERQAR SKVERNRSEL VRELDQLTEQ
LEEAGGATQA QIELIKRRES DYLKLRRDYE EAVMQNDAAV SQMKKKHVDT VNELVEQVEN
LSRVKNKIEK DRAQLHMELD DVTTQLEEIS KVKARAEANV RVMEEQVTDY KFRVEEHVRM
VNELTIIKNK LTSETTESAH QLEEAENKVR CGGVGNNSLQ NPVYTKSDCG VLVLNFKETS
GHFKIHQEYD PVCNLFCNTT PQDTLYDKST ICSTSGNQPV RLNYSDKQSE KIYFTQPLSQ
VNALSRTKSN MTSMVEDLKR QLEEESKANA TISALDKKQR NFDKEISMWT LKVEELQAEL
DASQRDCRNY QTEIYKIKVS YEESIEHLEI VKRENKNLTG ELHGDDVVGR LAWNFQNDGV
CKDALKRQLT GPAGYPILLR NTNKINELFH QSRVLRLQLE LTQVKADIDR KLQEKEEEFD
STRKNHQRAI ESMQASLDVE IKSRTDAVRA KKKLESQLND AEMQLDHANR NLAEQIKLVR
KLQVTIKEIQ DQMDEDQRIH EELREQYSIQ ERRLTIMVSE LEETKSALES NERARKHAEA
ELLDISDRIN ALSAQNSALS SAKRKLETDN EQLRGELEEA LLEAKGADER AKKATMDASR
MSEELRSEQQ HVLSIERVKK TMEIQIHEMT VKLDEAEAYA LKGGRKALAQ LQSRLKDVES
ELEAEQRRHA ETLKNYRKMD RRLKELSFQA DEDQKNQIRM QELVEKLQLK LKQYKKMAEE
AEEQANQNLA KYRKVTHELE EAEERAEISE SALNKVRTKS R
//
