ID H2Z1P8_CIOSA Unreviewed; 1893 AA.
AC H2Z1P8;
DT 18-APR-2012, integrated into UniProtKB/TrEMBL.
DT 18-APR-2012, sequence version 1.
DT 27-MAR-2024, entry version 62.
DE RecName: Full=Myosin motor domain-containing protein {ECO:0008006|Google:ProtNLM};
OS Ciona savignyi (Pacific transparent sea squirt).
OC Eukaryota; Metazoa; Chordata; Tunicata; Ascidiacea; Phlebobranchia;
OC Cionidae; Ciona.
OX NCBI_TaxID=51511 {ECO:0000313|Ensembl:ENSCSAVP00000011510.1, ECO:0000313|Proteomes:UP000007875};
RN [1] {ECO:0000313|Proteomes:UP000007875}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Birren B., Nusbaum C., Abebe A., Abouelleil A., Adekoya E., Ait-zahra M.,
RA Allen N., Allen T., An P., Anderson M., Anderson S., Arachchi H.,
RA Armbruster J., Bachantsang P., Baldwin J., Barry A., Bayul T.,
RA Blitshsteyn B., Bloom T., Blye J., Boguslavskiy L., Borowsky M.,
RA Boukhgalter B., Brunache A., Butler J., Calixte N., Calvo S., Camarata J.,
RA Campo K., Chang J., Cheshatsang Y., Citroen M., Collymore A., Considine T.,
RA Cook A., Cooke P., Corum B., Cuomo C., David R., Dawoe T., Degray S.,
RA Dodge S., Dooley K., Dorje P., Dorjee K., Dorris L., Duffey N., Dupes A.,
RA Elkins T., Engels R., Erickson J., Farina A., Faro S., Ferreira P.,
RA Fischer H., Fitzgerald M., Foley K., Gage D., Galagan J., Gearin G.,
RA Gnerre S., Gnirke A., Goyette A., Graham J., Grandbois E., Gyaltsen K.,
RA Hafez N., Hagopian D., Hagos B., Hall J., Hatcher B., Heller A.,
RA Higgins H., Honan T., Horn A., Houde N., Hughes L., Hulme W., Husby E.,
RA Iliev I., Jaffe D., Jones C., Kamal M., Kamat A., Kamvysselis M.,
RA Karlsson E., Kells C., Kieu A., Kisner P., Kodira C., Kulbokas E.,
RA Labutti K., Lama D., Landers T., Leger J., Levine S., Lewis D., Lewis T.,
RA Lindblad-toh K., Liu X., Lokyitsang T., Lokyitsang Y., Lucien O., Lui A.,
RA Ma L.J., Mabbitt R., Macdonald J., Maclean C., Major J., Manning J.,
RA Marabella R., Maru K., Matthews C., Mauceli E., Mccarthy M., Mcdonough S.,
RA Mcghee T., Meldrim J., Meneus L., Mesirov J., Mihalev A., Mihova T.,
RA Mikkelsen T., Mlenga V., Moru K., Mozes J., Mulrain L., Munson G.,
RA Naylor J., Newes C., Nguyen C., Nguyen N., Nguyen T., Nicol R., Nielsen C.,
RA Nizzari M., Norbu C., Norbu N., O'donnell P., Okoawo O., O'leary S.,
RA Omotosho B., O'neill K., Osman S., Parker S., Perrin D., Phunkhang P.,
RA Piqani B., Purcell S., Rachupka T., Ramasamy U., Rameau R., Ray V.,
RA Raymond C., Retta R., Richardson S., Rise C., Rodriguez J., Rogers J.,
RA Rogov P., Rutman M., Schupbach R., Seaman C., Settipalli S., Sharpe T.,
RA Sheridan J., Sherpa N., Shi J., Smirnov S., Smith C., Sougnez C.,
RA Spencer B., Stalker J., Stange-thomann N., Stavropoulos S., Stetson K.,
RA Stone C., Stone S., Stubbs M., Talamas J., Tchuinga P., Tenzing P.,
RA Tesfaye S., Theodore J., Thoulutsang Y., Topham K., Towey S., Tsamla T.,
RA Tsomo N., Vallee D., Vassiliev H., Venkataraman V., Vinson J., Vo A.,
RA Wade C., Wang S., Wangchuk T., Wangdi T., Whittaker C., Wilkinson J.,
RA Wu Y., Wyman D., Yadav S., Yang S., Yang X., Yeager S., Yee E., Young G.,
RA Zainoun J., Zembeck L., Zimmer A., Zody M., Lander E.;
RL Submitted (AUG-2003) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSCSAVP00000011510.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the TRAFAC class myosin-kinesin ATPase
CC superfamily. Myosin family. {ECO:0000256|ARBA:ARBA00008314,
CC ECO:0000256|PROSITE-ProRule:PRU00782}.
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DR Ensembl; ENSCSAVT00000011643.1; ENSCSAVP00000011510.1; ENSCSAVG00000006742.1.
DR GeneTree; ENSGT00940000160705; -.
DR Proteomes; UP000007875; Unassembled WGS sequence.
DR GO; GO:0016459; C:myosin complex; IEA:UniProtKB-KW.
DR GO; GO:0051015; F:actin filament binding; IEA:InterPro.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0003774; F:cytoskeletal motor activity; IEA:UniProtKB-UniRule.
DR CDD; cd01377; MYSc_class_II; 1.
DR Gene3D; 1.10.10.820; -; 1.
DR Gene3D; 1.20.5.340; -; 3.
DR Gene3D; 1.20.5.370; -; 3.
DR Gene3D; 1.20.5.4820; -; 1.
DR Gene3D; 1.20.58.530; -; 1.
DR Gene3D; 3.40.850.10; Kinesin motor domain; 1.
DR Gene3D; 2.30.30.360; Myosin S1 fragment, N-terminal; 1.
DR Gene3D; 1.20.120.720; Myosin VI head, motor domain, U50 subdomain; 1.
DR InterPro; IPR000048; IQ_motif_EF-hand-BS.
DR InterPro; IPR036961; Kinesin_motor_dom_sf.
DR InterPro; IPR001609; Myosin_head_motor_dom.
DR InterPro; IPR004009; Myosin_N.
DR InterPro; IPR008989; Myosin_S1_N.
DR InterPro; IPR002928; Myosin_tail.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR014751; XRCC4-like_C.
DR PANTHER; PTHR45615:SF40; MYOSIN HEAVY CHAIN, MUSCLE-RELATED; 1.
DR PANTHER; PTHR45615; MYOSIN HEAVY CHAIN, NON-MUSCLE; 1.
DR Pfam; PF00063; Myosin_head; 1.
DR Pfam; PF02736; Myosin_N; 1.
DR Pfam; PF01576; Myosin_tail_1; 2.
DR PRINTS; PR00193; MYOSINHEAVY.
DR SMART; SM00242; MYSc; 1.
DR SUPFAM; SSF90257; Myosin rod fragments; 6.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS50096; IQ; 1.
DR PROSITE; PS51456; MYOSIN_MOTOR; 1.
DR PROSITE; PS51844; SH3_LIKE; 1.
PE 3: Inferred from homology;
KW Actin-binding {ECO:0000256|ARBA:ARBA00023203, ECO:0000256|PROSITE-
KW ProRule:PRU00782};
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|PROSITE-
KW ProRule:PRU00782};
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils};
KW Motor protein {ECO:0000256|ARBA:ARBA00023175, ECO:0000256|PROSITE-
KW ProRule:PRU00782};
KW Myosin {ECO:0000256|ARBA:ARBA00023123, ECO:0000256|PROSITE-
KW ProRule:PRU00782};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|PROSITE-
KW ProRule:PRU00782}; Reference proteome {ECO:0000313|Proteomes:UP000007875}.
FT DOMAIN 30..79
FT /note="Myosin N-terminal SH3-like"
FT /evidence="ECO:0000259|PROSITE:PS51844"
FT DOMAIN 83..766
FT /note="Myosin motor"
FT /evidence="ECO:0000259|PROSITE:PS51456"
FT REGION 645..667
FT /note="Actin-binding"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00782"
FT REGION 1872..1893
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 830..1144
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 1188..1285
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 1378..1478
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 1526..1729
FT /evidence="ECO:0000256|SAM:Coils"
FT BINDING 176..183
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00782"
SQ SEQUENCE 1893 AA; 218741 MW; 60DB649B38438E9C CRC64;
TGECGPGDDP MPFLEPTEKE KLAFAGMAYD GKKSVWVPHK KEGFVRGELL NSTADKCTIK
TVKNETITIK KDDVQQMNPP KFEQTADMAN MTFLNEASVL NNLRSRYASL RIYTYSGLFC
VCVNPYKWLP VYGVKVVQMY RGKKRSEMPP HLFSVADNAY HDMLMDRENQ SILITGESGA
GKTENTKKVI QYFANIAASG VSKPGEEKKA NLEDQIVQTN PVLEAWGNAK TIRNNNSSRF
GKFIRIHFGT SGKLSGGDIE SYLLEKSRVI FQLPAERGYH IFYQIMASGK PDMLESLCIS
NNPRDYFWVS QGVIKVDNMD DTEEFNFTNV PFEVLGFTEE ERFNCYRLTA GCMVFGSMLY
KQKPRDEQAE VDSIEVADKV AHLFGISSPE LCKAITRPRV KVGTEYVQKG QNVDQCTNST
GALAKATYDK LFKWIVYRLN ITLDTKLPRN YFVGVLDIAG FEIFDFNTFE QLCINFTNEK
LQQFFNHHMF VLEQEEYKKE GIEWVFIDFG MDLQACIELL EKPMGVFSIL EEESIVPKAT
DETFKNKLYE KHDKKSEAFV KPKVGKKGNA HFCVKHYAGI VEYNVDGWLN KNKDPLNSSV
ISLFTKSTNK LMASVYPEVK EEAAGKKKKK GGSFQTVSAL YREQLNKLMT NLRNTKPHFV
RCLIPNEMKQ CGIMEASLVL GQLKCNGVLE GIRICRKGFP NRLQYPEFKQ RYQILAAAKV
ANLVDSKKAT ETILLHIELD TALYKVGHTK IFFKAGVLAD LEDQRDTILS IIMTKMQAKA
RGKLMRIEFK KMLERQRAAK AIQRNIRKFL QFRDWQWWKL YTKVKPLLNV VRVEDELKAK
DEEIAELKEK FGHEEKLRKD YEEKCVSLLS EKNDLTLQLQ AEQENLADAE ERNEQMVKVK
GDLEAQVADM SERLEEEEAN NLQVSAAKKK LEKQCEDLGH DIEEAESNIN HLEKDKQGLE
LKLRGLSSDL EQREDSIQRL NKEKKQLDQV NQQTLEDLQS MEDKANHLGK IKIKLEQQIE
DVEDSLEQER KHKNDLEKAK RKLETDLRTA QDTIMDLEKD KSSLEDGIRK REFEINQLTS
RTEDDQNVIA QLNRKLKELQ ARVEDTESEL DMERQARSKV ERNRSELVRE LDQLTEQLEE
AGGATQAQIE LIKRRESDYL KLRRDYEEAV MQNDAAVSQM KKKHVDTVNE LVEQVENLSR
VKNKIEKDRA QLHMELDDVT TQLEEISKVK ARAEANVRVM EEQVTDYKFR VEEHVRMVNE
LTIIKNKLTS ETTESAHQLE EAENKVRCGG VGNNSLQNPV YTKSDCGVLV LNFKETSGHF
KIHQEYDPVC NLFCNTTPQD TLYDKSTICS TSGNQPVRLN YSDKQSEKIY FTQPLSQVNA
LSRTKSNMTS MVEDLKRQLE EESKANATIS ALDKKQRNFD KEISMWTLKV EELQAELDAS
QRDCRNYQTE IYKIKVSYEE SIEHLEIVKR ENKNLTGELH GDDVVGRLAW NFQNDGPKDY
RIETCRFVIL LRNTNKINEL FHQSRVLRLQ LELTQVKADI DRKLQEKEEE FDSTRKNHQR
AIESMQASLD VEIKSRTDAV RAKKKLESQL NDAEMQLDHA NRNLAEQIKL VRKLQVTIKE
IQDQMDEDQR IHEELREQYS IQERRLTIMV SELEETKSAL ESNERARKHA EAELLDISDR
INALSAQNSA LSSAKRKLET DNEQLRGELE EALLEAKGAD ERAKKATMDA SRMSEELRSE
QQHVLSIERV KKTMEIQIHE MTVKLDEAEA YALKGGRKAL AQLQSRLKDV ESELEAEQRR
HAETLKNYRK MDRRLKELSF QADEDQKNQI RMQELVEKLQ LKLKQYKKMA EEAEEQANQN
LAKYRKVTHE LEEAEERAEI SESALNKVRT KSR
//
