ID H2Z3A3_CIOSA Unreviewed; 483 AA.
AC H2Z3A3;
DT 18-APR-2012, integrated into UniProtKB/TrEMBL.
DT 18-APR-2012, sequence version 1.
DT 27-MAR-2024, entry version 42.
DE RecName: Full=Integrator complex subunit 14 {ECO:0000256|ARBA:ARBA00016816};
DE AltName: Full=von Willebrand factor A domain-containing protein 9 {ECO:0000256|ARBA:ARBA00029992};
OS Ciona savignyi (Pacific transparent sea squirt).
OC Eukaryota; Metazoa; Chordata; Tunicata; Ascidiacea; Phlebobranchia;
OC Cionidae; Ciona.
OX NCBI_TaxID=51511 {ECO:0000313|Ensembl:ENSCSAVP00000012065.1, ECO:0000313|Proteomes:UP000007875};
RN [1] {ECO:0000313|Proteomes:UP000007875}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Birren B., Nusbaum C., Abebe A., Abouelleil A., Adekoya E., Ait-zahra M.,
RA Allen N., Allen T., An P., Anderson M., Anderson S., Arachchi H.,
RA Armbruster J., Bachantsang P., Baldwin J., Barry A., Bayul T.,
RA Blitshsteyn B., Bloom T., Blye J., Boguslavskiy L., Borowsky M.,
RA Boukhgalter B., Brunache A., Butler J., Calixte N., Calvo S., Camarata J.,
RA Campo K., Chang J., Cheshatsang Y., Citroen M., Collymore A., Considine T.,
RA Cook A., Cooke P., Corum B., Cuomo C., David R., Dawoe T., Degray S.,
RA Dodge S., Dooley K., Dorje P., Dorjee K., Dorris L., Duffey N., Dupes A.,
RA Elkins T., Engels R., Erickson J., Farina A., Faro S., Ferreira P.,
RA Fischer H., Fitzgerald M., Foley K., Gage D., Galagan J., Gearin G.,
RA Gnerre S., Gnirke A., Goyette A., Graham J., Grandbois E., Gyaltsen K.,
RA Hafez N., Hagopian D., Hagos B., Hall J., Hatcher B., Heller A.,
RA Higgins H., Honan T., Horn A., Houde N., Hughes L., Hulme W., Husby E.,
RA Iliev I., Jaffe D., Jones C., Kamal M., Kamat A., Kamvysselis M.,
RA Karlsson E., Kells C., Kieu A., Kisner P., Kodira C., Kulbokas E.,
RA Labutti K., Lama D., Landers T., Leger J., Levine S., Lewis D., Lewis T.,
RA Lindblad-toh K., Liu X., Lokyitsang T., Lokyitsang Y., Lucien O., Lui A.,
RA Ma L.J., Mabbitt R., Macdonald J., Maclean C., Major J., Manning J.,
RA Marabella R., Maru K., Matthews C., Mauceli E., Mccarthy M., Mcdonough S.,
RA Mcghee T., Meldrim J., Meneus L., Mesirov J., Mihalev A., Mihova T.,
RA Mikkelsen T., Mlenga V., Moru K., Mozes J., Mulrain L., Munson G.,
RA Naylor J., Newes C., Nguyen C., Nguyen N., Nguyen T., Nicol R., Nielsen C.,
RA Nizzari M., Norbu C., Norbu N., O'donnell P., Okoawo O., O'leary S.,
RA Omotosho B., O'neill K., Osman S., Parker S., Perrin D., Phunkhang P.,
RA Piqani B., Purcell S., Rachupka T., Ramasamy U., Rameau R., Ray V.,
RA Raymond C., Retta R., Richardson S., Rise C., Rodriguez J., Rogers J.,
RA Rogov P., Rutman M., Schupbach R., Seaman C., Settipalli S., Sharpe T.,
RA Sheridan J., Sherpa N., Shi J., Smirnov S., Smith C., Sougnez C.,
RA Spencer B., Stalker J., Stange-thomann N., Stavropoulos S., Stetson K.,
RA Stone C., Stone S., Stubbs M., Talamas J., Tchuinga P., Tenzing P.,
RA Tesfaye S., Theodore J., Thoulutsang Y., Topham K., Towey S., Tsamla T.,
RA Tsomo N., Vallee D., Vassiliev H., Venkataraman V., Vinson J., Vo A.,
RA Wade C., Wang S., Wangchuk T., Wangdi T., Whittaker C., Wilkinson J.,
RA Wu Y., Wyman D., Yadav S., Yang S., Yang X., Yeager S., Yee E., Young G.,
RA Zainoun J., Zembeck L., Zimmer A., Zody M., Lander E.;
RL Submitted (AUG-2003) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSCSAVP00000012065.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- FUNCTION: Probable component of the Integrator (INT) complex, a complex
CC involved in the small nuclear RNAs (snRNA) U1 and U2 transcription and
CC in their 3'-box-dependent processing. {ECO:0000256|ARBA:ARBA00003473}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC -!- SIMILARITY: Belongs to the INTS14 family.
CC {ECO:0000256|ARBA:ARBA00007451}.
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DR AlphaFoldDB; H2Z3A3; -.
DR STRING; 51511.ENSCSAVP00000012065; -.
DR Ensembl; ENSCSAVT00000012205.1; ENSCSAVP00000012065.1; ENSCSAVG00000007097.1.
DR eggNOG; ENOG502QQ37; Eukaryota.
DR GeneTree; ENSGT00390000009486; -.
DR HOGENOM; CLU_041485_0_0_1; -.
DR InParanoid; H2Z3A3; -.
DR OMA; QSSVVWI; -.
DR TreeFam; TF323245; -.
DR Proteomes; UP000007875; Unassembled WGS sequence.
DR GO; GO:0032039; C:integrator complex; IEA:InterPro.
DR Gene3D; 3.40.50.410; von Willebrand factor, type A domain; 1.
DR InterPro; IPR039841; INTS14.
DR InterPro; IPR045814; IntS14_b-barrel.
DR InterPro; IPR046471; IntS14_C.
DR InterPro; IPR002035; VWF_A.
DR InterPro; IPR036465; vWFA_dom_sf.
DR PANTHER; PTHR13532:SF3; INTEGRATOR COMPLEX SUBUNIT 14; 1.
DR PANTHER; PTHR13532; UNCHARACTERIZED; 1.
DR Pfam; PF19435; IntS14_b-barrel; 1.
DR Pfam; PF20504; IntS14_C; 1.
DR Pfam; PF13519; VWA_2; 1.
DR SUPFAM; SSF53300; vWA-like; 1.
PE 3: Inferred from homology;
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000007875}.
FT DOMAIN 3..117
FT /note="VWFA"
FT /evidence="ECO:0000259|Pfam:PF13519"
FT DOMAIN 204..330
FT /note="Integrator complex subunit 14 beta-barrel"
FT /evidence="ECO:0000259|Pfam:PF19435"
FT DOMAIN 381..483
FT /note="Integrator complex subunit 14 C-terminal"
FT /evidence="ECO:0000259|Pfam:PF20504"
SQ SEQUENCE 483 AA; 53523 MW; CA1B75F6ADC2B2FC CRC64;
MPVVVVVDSS LSMCRYALEA GEVKVTRLQL AEDCAVKILD HVTSKFKLEH IAALSISSEV
NLLCDFTRDY VALKTGLRNI NVGDKADFCA LTEYLNQFVV KTWGRMQPCP VLIITDGGIM
SNKKLKLQEG NTLFEFPCKL HFLCVKSFQC LKNCGSYDLF QEAIKKNNES GSIIPLYELT
QIDTSISAVV SASVVKFLNK EMKNFEATLS CGNLSSRVSI FPTPEEHKSP SSALKTKLYS
IDDELKIVGF LNISDVRNPP VLSRHLLLPV NPVETEQASL VPSFSVVLHG SLKMENKVAL
VKLSSEWYGI VYSWADSKTK SNLVLSILPV GLNSIPWLGN FNHLAPASFL PANPSGKKSA
VPSFPVQSKR FTKRSYSQPT VAWTRATGLQ TDVQKILRSA KKLPEKSHVF YKDLNRLRRA
ALSFGFHGLL DGISSLLERE CTLLPGTAHP EATLQLSHAA RELKSTINKG HEHTIEPLKT
DFK
//
