ID H2Z3C0_CIOSA Unreviewed; 1263 AA.
AC H2Z3C0;
DT 18-APR-2012, integrated into UniProtKB/TrEMBL.
DT 18-APR-2012, sequence version 1.
DT 24-JAN-2024, entry version 55.
DE RecName: Full=Calcium-dependent secretion activator 1 {ECO:0008006|Google:ProtNLM};
OS Ciona savignyi (Pacific transparent sea squirt).
OC Eukaryota; Metazoa; Chordata; Tunicata; Ascidiacea; Phlebobranchia;
OC Cionidae; Ciona.
OX NCBI_TaxID=51511 {ECO:0000313|Ensembl:ENSCSAVP00000012082.1, ECO:0000313|Proteomes:UP000007875};
RN [1] {ECO:0000313|Proteomes:UP000007875}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Birren B., Nusbaum C., Abebe A., Abouelleil A., Adekoya E., Ait-zahra M.,
RA Allen N., Allen T., An P., Anderson M., Anderson S., Arachchi H.,
RA Armbruster J., Bachantsang P., Baldwin J., Barry A., Bayul T.,
RA Blitshsteyn B., Bloom T., Blye J., Boguslavskiy L., Borowsky M.,
RA Boukhgalter B., Brunache A., Butler J., Calixte N., Calvo S., Camarata J.,
RA Campo K., Chang J., Cheshatsang Y., Citroen M., Collymore A., Considine T.,
RA Cook A., Cooke P., Corum B., Cuomo C., David R., Dawoe T., Degray S.,
RA Dodge S., Dooley K., Dorje P., Dorjee K., Dorris L., Duffey N., Dupes A.,
RA Elkins T., Engels R., Erickson J., Farina A., Faro S., Ferreira P.,
RA Fischer H., Fitzgerald M., Foley K., Gage D., Galagan J., Gearin G.,
RA Gnerre S., Gnirke A., Goyette A., Graham J., Grandbois E., Gyaltsen K.,
RA Hafez N., Hagopian D., Hagos B., Hall J., Hatcher B., Heller A.,
RA Higgins H., Honan T., Horn A., Houde N., Hughes L., Hulme W., Husby E.,
RA Iliev I., Jaffe D., Jones C., Kamal M., Kamat A., Kamvysselis M.,
RA Karlsson E., Kells C., Kieu A., Kisner P., Kodira C., Kulbokas E.,
RA Labutti K., Lama D., Landers T., Leger J., Levine S., Lewis D., Lewis T.,
RA Lindblad-toh K., Liu X., Lokyitsang T., Lokyitsang Y., Lucien O., Lui A.,
RA Ma L.J., Mabbitt R., Macdonald J., Maclean C., Major J., Manning J.,
RA Marabella R., Maru K., Matthews C., Mauceli E., Mccarthy M., Mcdonough S.,
RA Mcghee T., Meldrim J., Meneus L., Mesirov J., Mihalev A., Mihova T.,
RA Mikkelsen T., Mlenga V., Moru K., Mozes J., Mulrain L., Munson G.,
RA Naylor J., Newes C., Nguyen C., Nguyen N., Nguyen T., Nicol R., Nielsen C.,
RA Nizzari M., Norbu C., Norbu N., O'donnell P., Okoawo O., O'leary S.,
RA Omotosho B., O'neill K., Osman S., Parker S., Perrin D., Phunkhang P.,
RA Piqani B., Purcell S., Rachupka T., Ramasamy U., Rameau R., Ray V.,
RA Raymond C., Retta R., Richardson S., Rise C., Rodriguez J., Rogers J.,
RA Rogov P., Rutman M., Schupbach R., Seaman C., Settipalli S., Sharpe T.,
RA Sheridan J., Sherpa N., Shi J., Smirnov S., Smith C., Sougnez C.,
RA Spencer B., Stalker J., Stange-thomann N., Stavropoulos S., Stetson K.,
RA Stone C., Stone S., Stubbs M., Talamas J., Tchuinga P., Tenzing P.,
RA Tesfaye S., Theodore J., Thoulutsang Y., Topham K., Towey S., Tsamla T.,
RA Tsomo N., Vallee D., Vassiliev H., Venkataraman V., Vinson J., Vo A.,
RA Wade C., Wang S., Wangchuk T., Wangdi T., Whittaker C., Wilkinson J.,
RA Wu Y., Wyman D., Yadav S., Yang S., Yang X., Yeager S., Yee E., Young G.,
RA Zainoun J., Zembeck L., Zimmer A., Zody M., Lander E.;
RL Submitted (AUG-2003) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSCSAVP00000012082.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (JUL-2023) to UniProtKB.
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DR AlphaFoldDB; H2Z3C0; -.
DR Ensembl; ENSCSAVT00000012222.1; ENSCSAVP00000012082.1; ENSCSAVG00000007108.1.
DR GeneTree; ENSGT00590000083094; -.
DR Proteomes; UP000007875; Unassembled WGS sequence.
DR GO; GO:0031410; C:cytoplasmic vesicle; IEA:UniProtKB-KW.
DR GO; GO:0098793; C:presynapse; IEA:GOC.
DR GO; GO:1990504; P:dense core granule exocytosis; IEA:InterPro.
DR GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
DR GO; GO:0016079; P:synaptic vesicle exocytosis; IEA:InterPro.
DR CDD; cd01234; PH_CADPS; 1.
DR Gene3D; 2.60.40.150; C2 domain; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR InterPro; IPR000008; C2_dom.
DR InterPro; IPR035892; C2_domain_sf.
DR InterPro; IPR033227; CAPS.
DR InterPro; IPR010439; MUN_dom.
DR InterPro; IPR014770; Munc13_1.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR001849; PH_domain.
DR PANTHER; PTHR12166; CALCIUM-DEPENDENT SECRETION ACTIVATOR; 1.
DR PANTHER; PTHR12166:SF8; CALCIUM-DEPENDENT SECRETION ACTIVATOR; 1.
DR Pfam; PF06292; MUN; 2.
DR Pfam; PF00169; PH; 1.
DR SMART; SM00239; C2; 1.
DR SMART; SM01145; DUF1041; 1.
DR SMART; SM00233; PH; 1.
DR SUPFAM; SSF49562; C2 domain (Calcium/lipid-binding domain, CaLB); 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR PROSITE; PS50004; C2; 1.
DR PROSITE; PS51258; MHD1; 1.
DR PROSITE; PS50003; PH_DOMAIN; 1.
PE 4: Predicted;
KW Cytoplasmic vesicle {ECO:0000256|ARBA:ARBA00023329};
KW Exocytosis {ECO:0000256|ARBA:ARBA00022483};
KW Protein transport {ECO:0000256|ARBA:ARBA00022927};
KW Reference proteome {ECO:0000313|Proteomes:UP000007875};
KW Transport {ECO:0000256|ARBA:ARBA00022927}.
FT DOMAIN 355..469
FT /note="C2"
FT /evidence="ECO:0000259|PROSITE:PS50004"
FT DOMAIN 495..598
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT DOMAIN 888..1020
FT /note="MHD1"
FT /evidence="ECO:0000259|PROSITE:PS51258"
FT REGION 1..77
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 20..68
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1263 AA; 144398 MW; A82157316DD89BAD CRC64;
MIYPSSSDEE SDIEQVEEEV STLAINSHKN PTRSPSKTDS YSVASNQDSS QSSIRGASPS
PSTTSEDVDA RTRQQEEEER RMRLQLYIFV LRCISYPFNA KQPTDMARRQ TKVNKQQLQT
IKDRFSSFLA GETQIVADEA FCNAVSSYFE VFLKSDRVMR MVQSGGCSAN DFREVFKNNI
EKRVKGLPEI DGLSKETVLS SWMAKFDAIY RGEEDPRRPG NRLPSSAASE LILSKEQLYE
MFQNILSIKK FEHQLLYNAC QLDSSDEQAA AIRRELDGRM HAADKIEGQR RFPKFFRKSS
ESEGQLQGQY IDELRSQVNL LMANLESLPV SRGSNDKSYP LRGLRRMQAP ISMDQPNEDD
VALSKADVIL QFTLEVVVVE VQGLKSLAPN KIVYCTMEAD GGEKLQTDQA EASKPVWDTQ
GDFTTTHPLP LVKVKLFTES TGMLSIDDKE LGKVVLHPTP NSPKSPEWYH MQVAKNSPDQ
QIRIKLAVRM DRPLNMKHCG YLWAQGRSVW KKWKRRYFIL VQVSQYNFAM CSYQERKSEP
NEMMQLDGFT VDYTVPELDH EGGRAFFNAV KEGDSVMFAS DDEQDRILWV QAMYRATGQS
HKPVPPTQVQ KLSAGKHGQL DAPISQFYAD RARKHGMDDY ISADPCRYDH SSLFELLQRL
TLDHRLNESY SCLGWFSPGQ VFVLDEYCAR YGVRGCHRHL CYLADLLDRA RNGIMIDPTL
LHYSFAFCAS HIYGNRPDGI GTITLDEKQR FDEIQEQLKS HLMNQITHFR YCFPFGRPQG
ALKATLSLLE RVMMRDIVTP VPAEDVRAII KHCLEEAALV NYSRVSEYAK VDESLNDSQS
KRLQVTIHLA ELCIDVLQQN EEHHFEAFAW FSDLMTEHSE IFWSLFAVDM DAVIENQPPD
TWNSFPLFQL LNDYLINDHT LRDGRFHCHL RDTFAPLVIR YTDLMESSIA QSIHHGFGKD
GWTASNSGQN TIANDVLWKL DALQSFVREL HWPDAIFACH IEHRLKLMAS DMIQILIYRT
VQRFNAILAS CKISVDFEVS QQICSLINVA LECRKQSVKI CASGHDASGT QHLYHVEVDE
VLESAFSQME SQIVDKFTKV LESVLAKLSR YDEGSFTASL FTLTFCSENV LALEVIKPGM
ELANNFIYFI RANQDILRDT ISDELFVEAL FLNWYEKGVN VLSAWLTERA ELQLHLHQLK
TLIKIFKKFY HDFEMQGVTG VRTNKNFESV HKRLTVEEAT ASVTTGPLGN HVTMKESDDE
VED
//