ID H2Z641_CIOSA Unreviewed; 545 AA.
AC H2Z641;
DT 18-APR-2012, integrated into UniProtKB/TrEMBL.
DT 18-APR-2012, sequence version 1.
DT 18-JUN-2025, entry version 50.
DE RecName: Full=Centromere protein Cenp-F leucine-rich repeat-containing domain-containing protein {ECO:0000259|Pfam:PF10473};
OS Ciona savignyi (Pacific transparent sea squirt).
OC Eukaryota; Metazoa; Chordata; Tunicata; Ascidiacea; Phlebobranchia;
OC Cionidae; Ciona.
OX NCBI_TaxID=51511 {ECO:0000313|Ensembl:ENSCSAVP00000013053.1, ECO:0000313|Proteomes:UP000007875};
RN [1] {ECO:0000313|Proteomes:UP000007875}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Birren B., Nusbaum C., Abebe A., Abouelleil A., Adekoya E., Ait-zahra M.,
RA Allen N., Allen T., An P., Anderson M., Anderson S., Arachchi H.,
RA Armbruster J., Bachantsang P., Baldwin J., Barry A., Bayul T.,
RA Blitshsteyn B., Bloom T., Blye J., Boguslavskiy L., Borowsky M.,
RA Boukhgalter B., Brunache A., Butler J., Calixte N., Calvo S., Camarata J.,
RA Campo K., Chang J., Cheshatsang Y., Citroen M., Collymore A., Considine T.,
RA Cook A., Cooke P., Corum B., Cuomo C., David R., Dawoe T., Degray S.,
RA Dodge S., Dooley K., Dorje P., Dorjee K., Dorris L., Duffey N., Dupes A.,
RA Elkins T., Engels R., Erickson J., Farina A., Faro S., Ferreira P.,
RA Fischer H., Fitzgerald M., Foley K., Gage D., Galagan J., Gearin G.,
RA Gnerre S., Gnirke A., Goyette A., Graham J., Grandbois E., Gyaltsen K.,
RA Hafez N., Hagopian D., Hagos B., Hall J., Hatcher B., Heller A.,
RA Higgins H., Honan T., Horn A., Houde N., Hughes L., Hulme W., Husby E.,
RA Iliev I., Jaffe D., Jones C., Kamal M., Kamat A., Kamvysselis M.,
RA Karlsson E., Kells C., Kieu A., Kisner P., Kodira C., Kulbokas E.,
RA Labutti K., Lama D., Landers T., Leger J., Levine S., Lewis D., Lewis T.,
RA Lindblad-toh K., Liu X., Lokyitsang T., Lokyitsang Y., Lucien O., Lui A.,
RA Ma L.J., Mabbitt R., Macdonald J., Maclean C., Major J., Manning J.,
RA Marabella R., Maru K., Matthews C., Mauceli E., Mccarthy M., Mcdonough S.,
RA Mcghee T., Meldrim J., Meneus L., Mesirov J., Mihalev A., Mihova T.,
RA Mikkelsen T., Mlenga V., Moru K., Mozes J., Mulrain L., Munson G.,
RA Naylor J., Newes C., Nguyen C., Nguyen N., Nguyen T., Nicol R., Nielsen C.,
RA Nizzari M., Norbu C., Norbu N., O'donnell P., Okoawo O., O'leary S.,
RA Omotosho B., O'neill K., Osman S., Parker S., Perrin D., Phunkhang P.,
RA Piqani B., Purcell S., Rachupka T., Ramasamy U., Rameau R., Ray V.,
RA Raymond C., Retta R., Richardson S., Rise C., Rodriguez J., Rogers J.,
RA Rogov P., Rutman M., Schupbach R., Seaman C., Settipalli S., Sharpe T.,
RA Sheridan J., Sherpa N., Shi J., Smirnov S., Smith C., Sougnez C.,
RA Spencer B., Stalker J., Stange-thomann N., Stavropoulos S., Stetson K.,
RA Stone C., Stone S., Stubbs M., Talamas J., Tchuinga P., Tenzing P.,
RA Tesfaye S., Theodore J., Thoulutsang Y., Topham K., Towey S., Tsamla T.,
RA Tsomo N., Vallee D., Vassiliev H., Venkataraman V., Vinson J., Vo A.,
RA Wade C., Wang S., Wangchuk T., Wangdi T., Whittaker C., Wilkinson J.,
RA Wu Y., Wyman D., Yadav S., Yang S., Yang X., Yeager S., Yee E., Young G.,
RA Zainoun J., Zembeck L., Zimmer A., Zody M., Lander E.;
RL Submitted (AUG-2003) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSCSAVP00000013053.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (MAR-2025) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, microtubule organizing
CC center, centrosome, centriole {ECO:0000256|ARBA:ARBA00004114}.
CC -!- SIMILARITY: Belongs to the CEP135/TSGA10 family.
CC {ECO:0000256|ARBA:ARBA00038123}.
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DR AlphaFoldDB; H2Z641; -.
DR Ensembl; ENSCSAVT00000013202.1; ENSCSAVP00000013053.1; ENSCSAVG00000007669.1.
DR GeneTree; ENSGT00940000165649; -.
DR Proteomes; UP000007875; Unassembled WGS sequence.
DR GO; GO:0005814; C:centriole; IEA:UniProtKB-SubCell.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR GO; GO:0070840; F:dynein complex binding; IEA:InterPro.
DR GO; GO:0042803; F:protein homodimerization activity; IEA:InterPro.
DR Gene3D; 1.10.287.1490; -; 1.
DR Gene3D; 1.20.5.340; -; 1.
DR InterPro; IPR051877; Centriole_BasalBody_StrucProt.
DR InterPro; IPR019513; Centromere_CenpF_leu-rich_rpt.
DR PANTHER; PTHR20544; CENTROSOMAL PROTEIN CEP135; 1.
DR PANTHER; PTHR20544:SF0; NUCLEOPROTEIN TPR_MLP1 DOMAIN-CONTAINING PROTEIN; 1.
DR Pfam; PF10473; CENP-F_leu_zip; 1.
DR SUPFAM; SSF46966; Spectrin repeat; 1.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Cytoskeleton {ECO:0000256|ARBA:ARBA00023212};
KW Reference proteome {ECO:0000313|Proteomes:UP000007875}.
FT DOMAIN 295..395
FT /note="Centromere protein Cenp-F leucine-rich repeat-
FT containing"
FT /evidence="ECO:0000259|Pfam:PF10473"
FT COILED 3..226
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 262..359
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 395..436
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 510..537
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 545 AA; 63110 MW; FCDC9D1CC9F21996 CRC64;
RERDELQSML SKFERHMAEI QSNVKVVTQE RDKTNLLYEQ SNEELQRLRH EFVRSPKSPK
ASLTAQAILR RVENDRDTAV ADLRRMTTER DSLRERLKIQ QEQSISERSR LEQRAEDLEA
KARALGQERI DLQSRIDSLK DVNLSQEDDI KALRLKMQQT EEDYTVVRAE LDDVKALKSQ
ISSSLDVAQR NLSRKSSDLA LSEDRVRTLE NRISELLDAA AKQSEEAATL RATTTSLDRE
KDALQAALDE RTERAAALDE HLSRRERDMS DLRVAISDLE AKLDRAGDDL ASSEREVRSL
RRQLDATQTD LAEASRAKET ALRENRRMQD DLSTLTRENQ DINMELDDVM RDRDDLKNKV
QDHVGRISSL ESSVSSKDRE LHDVLDQYRK VTSERDSAES RYRVTNDESQ SLRNELLSAD
SERKRLCEKI SSLEREISDH MHLHSSYEDL SREVEILHKH LESERLGNKN LEELVGNARE
KEFQAQLDSQ EQKSEGQLLR DKLALNESKL QSMGREVASL RDRASQLDAE LEVAKRHLTN
ERYER
//
