ID H2Z642_CIOSA Unreviewed; 1800 AA.
AC H2Z642;
DT 18-APR-2012, integrated into UniProtKB/TrEMBL.
DT 18-APR-2012, sequence version 1.
DT 27-MAR-2024, entry version 60.
DE RecName: Full=Activating signal cointegrator 1 complex subunit 3 {ECO:0000256|ARBA:ARBA00014590};
OS Ciona savignyi (Pacific transparent sea squirt).
OC Eukaryota; Metazoa; Chordata; Tunicata; Ascidiacea; Phlebobranchia;
OC Cionidae; Ciona.
OX NCBI_TaxID=51511 {ECO:0000313|Ensembl:ENSCSAVP00000013054.1, ECO:0000313|Proteomes:UP000007875};
RN [1] {ECO:0000313|Proteomes:UP000007875}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Birren B., Nusbaum C., Abebe A., Abouelleil A., Adekoya E., Ait-zahra M.,
RA Allen N., Allen T., An P., Anderson M., Anderson S., Arachchi H.,
RA Armbruster J., Bachantsang P., Baldwin J., Barry A., Bayul T.,
RA Blitshsteyn B., Bloom T., Blye J., Boguslavskiy L., Borowsky M.,
RA Boukhgalter B., Brunache A., Butler J., Calixte N., Calvo S., Camarata J.,
RA Campo K., Chang J., Cheshatsang Y., Citroen M., Collymore A., Considine T.,
RA Cook A., Cooke P., Corum B., Cuomo C., David R., Dawoe T., Degray S.,
RA Dodge S., Dooley K., Dorje P., Dorjee K., Dorris L., Duffey N., Dupes A.,
RA Elkins T., Engels R., Erickson J., Farina A., Faro S., Ferreira P.,
RA Fischer H., Fitzgerald M., Foley K., Gage D., Galagan J., Gearin G.,
RA Gnerre S., Gnirke A., Goyette A., Graham J., Grandbois E., Gyaltsen K.,
RA Hafez N., Hagopian D., Hagos B., Hall J., Hatcher B., Heller A.,
RA Higgins H., Honan T., Horn A., Houde N., Hughes L., Hulme W., Husby E.,
RA Iliev I., Jaffe D., Jones C., Kamal M., Kamat A., Kamvysselis M.,
RA Karlsson E., Kells C., Kieu A., Kisner P., Kodira C., Kulbokas E.,
RA Labutti K., Lama D., Landers T., Leger J., Levine S., Lewis D., Lewis T.,
RA Lindblad-toh K., Liu X., Lokyitsang T., Lokyitsang Y., Lucien O., Lui A.,
RA Ma L.J., Mabbitt R., Macdonald J., Maclean C., Major J., Manning J.,
RA Marabella R., Maru K., Matthews C., Mauceli E., Mccarthy M., Mcdonough S.,
RA Mcghee T., Meldrim J., Meneus L., Mesirov J., Mihalev A., Mihova T.,
RA Mikkelsen T., Mlenga V., Moru K., Mozes J., Mulrain L., Munson G.,
RA Naylor J., Newes C., Nguyen C., Nguyen N., Nguyen T., Nicol R., Nielsen C.,
RA Nizzari M., Norbu C., Norbu N., O'donnell P., Okoawo O., O'leary S.,
RA Omotosho B., O'neill K., Osman S., Parker S., Perrin D., Phunkhang P.,
RA Piqani B., Purcell S., Rachupka T., Ramasamy U., Rameau R., Ray V.,
RA Raymond C., Retta R., Richardson S., Rise C., Rodriguez J., Rogers J.,
RA Rogov P., Rutman M., Schupbach R., Seaman C., Settipalli S., Sharpe T.,
RA Sheridan J., Sherpa N., Shi J., Smirnov S., Smith C., Sougnez C.,
RA Spencer B., Stalker J., Stange-thomann N., Stavropoulos S., Stetson K.,
RA Stone C., Stone S., Stubbs M., Talamas J., Tchuinga P., Tenzing P.,
RA Tesfaye S., Theodore J., Thoulutsang Y., Topham K., Towey S., Tsamla T.,
RA Tsomo N., Vallee D., Vassiliev H., Venkataraman V., Vinson J., Vo A.,
RA Wade C., Wang S., Wangchuk T., Wangdi T., Whittaker C., Wilkinson J.,
RA Wu Y., Wyman D., Yadav S., Yang S., Yang X., Yeager S., Yee E., Young G.,
RA Zainoun J., Zembeck L., Zimmer A., Zody M., Lander E.;
RL Submitted (AUG-2003) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSCSAVP00000013054.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the helicase family.
CC {ECO:0000256|ARBA:ARBA00008708}.
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DR STRING; 51511.ENSCSAVP00000013054; -.
DR Ensembl; ENSCSAVT00000013203.1; ENSCSAVP00000013054.1; ENSCSAVG00000007670.1.
DR eggNOG; KOG0952; Eukaryota.
DR GeneTree; ENSGT00940000155377; -.
DR InParanoid; H2Z642; -.
DR OMA; MCSATEF; -.
DR TreeFam; TF105778; -.
DR Proteomes; UP000007875; Unassembled WGS sequence.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR GO; GO:0004386; F:helicase activity; IEA:UniProtKB-KW.
DR GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR GO; GO:0010467; P:gene expression; IEA:UniProt.
DR GO; GO:0090304; P:nucleic acid metabolic process; IEA:UniProt.
DR CDD; cd18020; DEXHc_ASCC3_1; 1.
DR CDD; cd18022; DEXHc_ASCC3_2; 1.
DR CDD; cd18795; SF2_C_Ski2; 2.
DR Gene3D; 1.10.150.20; 5' to 3' exonuclease, C-terminal subdomain; 1.
DR Gene3D; 2.60.40.150; C2 domain; 2.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 4.
DR Gene3D; 1.10.3380.10; Sec63 N-terminal domain-like domain; 2.
DR Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 2.
DR InterPro; IPR003593; AAA+_ATPase.
DR InterPro; IPR035892; C2_domain_sf.
DR InterPro; IPR011545; DEAD/DEAH_box_helicase_dom.
DR InterPro; IPR014001; Helicase_ATP-bd.
DR InterPro; IPR001650; Helicase_C.
DR InterPro; IPR014756; Ig_E-set.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR004179; Sec63-dom.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR PANTHER; PTHR47961; DNA POLYMERASE THETA, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G05260)-RELATED; 1.
DR PANTHER; PTHR47961:SF13; SEC63 DOMAIN-CONTAINING PROTEIN; 1.
DR Pfam; PF00270; DEAD; 2.
DR Pfam; PF00271; Helicase_C; 2.
DR Pfam; PF02889; Sec63; 2.
DR PIRSF; PIRSF039073; BRR2; 1.
DR SMART; SM00382; AAA; 2.
DR SMART; SM00487; DEXDc; 2.
DR SMART; SM00490; HELICc; 2.
DR SMART; SM00973; Sec63; 2.
DR SUPFAM; SSF81296; E set domains; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 4.
DR SUPFAM; SSF158702; Sec63 N-terminal domain-like; 2.
DR SUPFAM; SSF46785; Winged helix' DNA-binding domain; 2.
DR PROSITE; PS51192; HELICASE_ATP_BIND_1; 2.
DR PROSITE; PS51194; HELICASE_CTER; 2.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Helicase {ECO:0000256|ARBA:ARBA00022806};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000007875}.
FT DOMAIN 110..293
FT /note="Helicase ATP-binding"
FT /evidence="ECO:0000259|PROSITE:PS51192"
FT DOMAIN 323..539
FT /note="Helicase C-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51194"
FT DOMAIN 960..1135
FT /note="Helicase ATP-binding"
FT /evidence="ECO:0000259|PROSITE:PS51192"
FT DOMAIN 1171..1362
FT /note="Helicase C-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51194"
SQ SEQUENCE 1800 AA; 204916 MW; 8AD72044D79F3419 CRC64;
RNKPLLISSE PTFSLRGQAR LPTIENFPFV YDSQRATQQT AAFVGGVRMA LPEGFEVKNT
KKYEEISIPA TSHYAGQPWP LVKIKELDEI GQMAFAGIKQ LNTIQSRVYK TAYHTNENLL
ICAPTGAGKT NVAMLTIVKE IVQNVENGVI QLDKFKIVYV APMKALAAEM AENFSRRLSP
LGINVRELTG DMQLTKKEIQ STQLLISTPE KWDVVTRKST SDVALARLVR LLIIDEVHLL
HDERGPVLET LVARTLRQVE TQQTMIRIVG LSATLPNYTD VARFLRVNPH KGLFFFDGRF
RPVPLQQTFV GVKAKSFTQQ RLDMDEACYE VVVENLRKDN QVLVFVHARN ATVRTAQAMA
EMARENNEVN LFSCQQMDGF GQAEKQVQRS RNREVRELFN SGLGVHHAGM LRADRTMLER
LFSKGLIRVL CCTATLAWGV NLPAHAVVIK GTQVYNAKQG AFVDLGILDV MQIFGRAGRP
QFDTTGEGTI ITAHNKLSHY LALLTRQNPI ESQFVECLVD NLNAEISLGT VNTVDDGVRW
LSYTYLYTRM RRNPLVYGIS ANQLENDPML TKWQRDLIIM AGRKLEKARM IRFLERTGYF
HSTDLGRTSS HFYIKYLSIE TFNEFINSSM DITAILSMIS KSHEFQQIKV RDDELTELDD
LKDDFCHLPI KSGPEDTEGK TNILFQTFIS SGEVRSFSLS SDLMYIAQNA GRIVRGVFEI
VLKQGKTRLA GRMLKLCKCV ERRLWPDSTP LRQFGPRLSK DVYRKIEEKE LKLEEILDSS
PSDIGNLLRH PRIGEKVLKC AQEIPKVQLQ VTIQPITRTI LRIKVVMTPD FTWNNNSHGN
TTEAFWIWVE DPDTDNMYHS EYVLMPKKTV VRKESINLTF TIPLIEPHPT QYLVHVESDR
WFGTGTVCPI SFKHLILPDR HPPHTELTDL EPLPITALDE KFQAVYNFTH FNPIQTQIFH
CLYHNDTNAL LGAPTGSGKT VAAELALFRM LRTQPGAKAV YVAPMKALVR ERMKDWEKRL
KTKLGLKLVE LTGDIAPDMG AVARADVIIT TPEKWDGVSR SWNTRGYVRK VSLLIIDEIH
LLGQDRGPVL EVIVSRTNFI SSHTEKAVRV VGLSTALANA RDLADWLGIK QMGLFNFRPS
VRPVPMEVHI QGFAGKHYCP RMASMNKTCF QAIQTHSPTK PVLIFVSSRR QTRITALDLI
AHLGGEDPKT WMHMEEWEME ELTHVVRDPN LRLTLAFGIG MHHAGLVERD RSLVEKLFSE
QKIQTLVATS TLAWGVNLPA HLVIVKGTEY FDGKQGRYED FPITDVLQMM GRAGRPQYDD
KAVAVILVHD VKKAFYKKFL YEPFPVESSL LQVLDDHLNA EIVAGTIISK QEAMDYLTWT
YFFRRLIMNP TYYDLQDTEN DSVNYYLSKL LERSIVELRT SGCVGMTDDE FDVTLVATNA
GRIASFYYLS HLTLRLLNEE MRPECSIDDI LRLLSNAQEY HELPVRHNED GINSDLAKEL
PIKVDGNSFD SPHTKTLLLL VSHFQRFTLP STDYVTDLKS VLDQAIRVLQ AYVDYSADLG
WLSTSLRCMH IIQMVSQASW FHDNTLTTLP HVEKNKVHIF KNLMFNKSPV ECLPQLLALY
HRSPSSVSNL LSQFFSNSEA SKICSHLSVL PQIDINIAVR GWWADHPEAE DQRAVSNAHN
TSLREKNTWL PLHADQEYFL IINLRKKTLS GKNKDEKAAT PRFPKPKLEG WFLVLGDRER
RELVALKRLN TLRRNTSETL SFFTPQRVGR MSLTLWLVSD SYLGLDQLRD VRLDIIPSDI
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