ID H2Z716_CIOSA Unreviewed; 1617 AA.
AC H2Z716;
DT 18-APR-2012, integrated into UniProtKB/TrEMBL.
DT 18-APR-2012, sequence version 1.
DT 27-MAR-2024, entry version 51.
DE RecName: Full=Ras GTPase-activating-like protein IQGAP1 {ECO:0008006|Google:ProtNLM};
OS Ciona savignyi (Pacific transparent sea squirt).
OC Eukaryota; Metazoa; Chordata; Tunicata; Ascidiacea; Phlebobranchia;
OC Cionidae; Ciona.
OX NCBI_TaxID=51511 {ECO:0000313|Ensembl:ENSCSAVP00000013378.1, ECO:0000313|Proteomes:UP000007875};
RN [1] {ECO:0000313|Proteomes:UP000007875}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Birren B., Nusbaum C., Abebe A., Abouelleil A., Adekoya E., Ait-zahra M.,
RA Allen N., Allen T., An P., Anderson M., Anderson S., Arachchi H.,
RA Armbruster J., Bachantsang P., Baldwin J., Barry A., Bayul T.,
RA Blitshsteyn B., Bloom T., Blye J., Boguslavskiy L., Borowsky M.,
RA Boukhgalter B., Brunache A., Butler J., Calixte N., Calvo S., Camarata J.,
RA Campo K., Chang J., Cheshatsang Y., Citroen M., Collymore A., Considine T.,
RA Cook A., Cooke P., Corum B., Cuomo C., David R., Dawoe T., Degray S.,
RA Dodge S., Dooley K., Dorje P., Dorjee K., Dorris L., Duffey N., Dupes A.,
RA Elkins T., Engels R., Erickson J., Farina A., Faro S., Ferreira P.,
RA Fischer H., Fitzgerald M., Foley K., Gage D., Galagan J., Gearin G.,
RA Gnerre S., Gnirke A., Goyette A., Graham J., Grandbois E., Gyaltsen K.,
RA Hafez N., Hagopian D., Hagos B., Hall J., Hatcher B., Heller A.,
RA Higgins H., Honan T., Horn A., Houde N., Hughes L., Hulme W., Husby E.,
RA Iliev I., Jaffe D., Jones C., Kamal M., Kamat A., Kamvysselis M.,
RA Karlsson E., Kells C., Kieu A., Kisner P., Kodira C., Kulbokas E.,
RA Labutti K., Lama D., Landers T., Leger J., Levine S., Lewis D., Lewis T.,
RA Lindblad-toh K., Liu X., Lokyitsang T., Lokyitsang Y., Lucien O., Lui A.,
RA Ma L.J., Mabbitt R., Macdonald J., Maclean C., Major J., Manning J.,
RA Marabella R., Maru K., Matthews C., Mauceli E., Mccarthy M., Mcdonough S.,
RA Mcghee T., Meldrim J., Meneus L., Mesirov J., Mihalev A., Mihova T.,
RA Mikkelsen T., Mlenga V., Moru K., Mozes J., Mulrain L., Munson G.,
RA Naylor J., Newes C., Nguyen C., Nguyen N., Nguyen T., Nicol R., Nielsen C.,
RA Nizzari M., Norbu C., Norbu N., O'donnell P., Okoawo O., O'leary S.,
RA Omotosho B., O'neill K., Osman S., Parker S., Perrin D., Phunkhang P.,
RA Piqani B., Purcell S., Rachupka T., Ramasamy U., Rameau R., Ray V.,
RA Raymond C., Retta R., Richardson S., Rise C., Rodriguez J., Rogers J.,
RA Rogov P., Rutman M., Schupbach R., Seaman C., Settipalli S., Sharpe T.,
RA Sheridan J., Sherpa N., Shi J., Smirnov S., Smith C., Sougnez C.,
RA Spencer B., Stalker J., Stange-thomann N., Stavropoulos S., Stetson K.,
RA Stone C., Stone S., Stubbs M., Talamas J., Tchuinga P., Tenzing P.,
RA Tesfaye S., Theodore J., Thoulutsang Y., Topham K., Towey S., Tsamla T.,
RA Tsomo N., Vallee D., Vassiliev H., Venkataraman V., Vinson J., Vo A.,
RA Wade C., Wang S., Wangchuk T., Wangdi T., Whittaker C., Wilkinson J.,
RA Wu Y., Wyman D., Yadav S., Yang S., Yang X., Yeager S., Yee E., Young G.,
RA Zainoun J., Zembeck L., Zimmer A., Zody M., Lander E.;
RL Submitted (AUG-2003) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSCSAVP00000013378.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR Ensembl; ENSCSAVT00000013530.1; ENSCSAVP00000013378.1; ENSCSAVG00000007847.1.
DR GeneTree; ENSGT00950000183076; -.
DR HOGENOM; CLU_000972_2_1_1; -.
DR Proteomes; UP000007875; Unassembled WGS sequence.
DR GO; GO:0120025; C:plasma membrane bounded cell projection; IEA:UniProt.
DR GO; GO:0016043; P:cellular component organization; IEA:UniProt.
DR CDD; cd00201; WW; 1.
DR Gene3D; 2.20.70.10; -; 1.
DR Gene3D; 1.10.418.10; Calponin-like domain; 1.
DR Gene3D; 4.10.270.10; Myosin, subunit A; 1.
DR InterPro; IPR001715; CH_dom.
DR InterPro; IPR036872; CH_dom_sf.
DR InterPro; IPR000048; IQ_motif_EF-hand-BS.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR000593; RasGAP_C.
DR InterPro; IPR023152; RasGAP_CS.
DR InterPro; IPR001936; RasGAP_dom.
DR InterPro; IPR008936; Rho_GTPase_activation_prot.
DR InterPro; IPR001202; WW_dom.
DR PANTHER; PTHR14149:SF14; PATTERNED EXPRESSION SITE; 1.
DR PANTHER; PTHR14149; RAS GTPASE-ACTIVATING PROTEIN WITH IQ MOTIF; 1.
DR Pfam; PF00307; CH; 1.
DR Pfam; PF00612; IQ; 3.
DR Pfam; PF00616; RasGAP; 1.
DR Pfam; PF03836; RasGAP_C; 1.
DR SMART; SM00033; CH; 1.
DR SMART; SM00015; IQ; 3.
DR SMART; SM00323; RasGAP; 1.
DR SUPFAM; SSF47576; Calponin-homology domain, CH-domain; 1.
DR SUPFAM; SSF48350; GTPase activation domain, GAP; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF143885; RGC domain-like; 1.
DR PROSITE; PS50021; CH; 1.
DR PROSITE; PS50096; IQ; 3.
DR PROSITE; PS00509; RAS_GTPASE_ACTIV_1; 1.
DR PROSITE; PS50018; RAS_GTPASE_ACTIV_2; 1.
DR PROSITE; PS01159; WW_DOMAIN_1; 1.
DR PROSITE; PS50020; WW_DOMAIN_2; 1.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Reference proteome {ECO:0000313|Proteomes:UP000007875}.
FT DOMAIN 25..140
FT /note="Calponin-homology (CH)"
FT /evidence="ECO:0000259|PROSITE:PS50021"
FT DOMAIN 656..683
FT /note="WW"
FT /evidence="ECO:0000259|PROSITE:PS50020"
FT DOMAIN 967..1201
FT /note="Ras-GAP"
FT /evidence="ECO:0000259|PROSITE:PS50018"
FT COILED 149..176
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 236..278
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 1459..1486
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 1617 AA; 185462 MW; 8C74CF0DE424EB47 CRC64;
ITKDDRLSAE EMDSLRDQAT AYEYLCHLEE AKQWMEYCLH EDLPPSVELE EGLRNGVFLG
KLAHFFAPDT IPLRKIYDKD MKKYEQKGLH FKHTDNINHF FRAMEKVGLP SIFYPETTDI
YDRKNMPKTV YCVHALSLYL FKLGLAPQMK DLYGIAEFTE EELNNMQKEL DKYGINMPQF
SKIGGILANE LSVDEAALHA AVIAINEALD AGDAEATMKA MHNPNACLTS IEDGYVEEYQ
ERLLASKKAK AEAAKNKSET TEEERDMYEE LLTHAELQGN ITKINCKCIQ HLVLYLVDGE
NLISDLKNLG ISNIDPNNRT WYLDQLQKDL NAKREVKSVP TLDKDEIQAA IIAANLLATK
QRQQDETVSN INSLLNDSGS PEDLERELKK MEGNFPAIVD GMAHLYHSEL TKQRELKGED
LTHEEICEAL RHLNALAALN RELEVGDVES VWAAMQNPDL GLERLEQGNR TRCCESLKQQ
KKDVQYLNLK SIQETVDLIN TQVSEEHSTI KAVHDVNEAL SKDDRDAILA ALLNPSLHLE
HVDPSNITQY LRLLKKRKHE KSVETGDADP ALWIDEIQAC IDDANAQTRQ ALKQASAVTA
VNIALEDDEW EQTYELLKHN DIALASLTSE CASTYHDQLR EMREEKLEEG LKDTTWVAYR
TKEGYTYYFN TENLNGSWDE PEGFNADTAQ LNKDEIQECI SMVSSAYDRA QLWRDNEPLI
IKLQSFCRMY LARKAYQERK DFIANHLPAI ICIQAHWRGF AQWKKYTDRM LYLQSHLATI
IMVNKFLQRL QYQKRLKYFR DHVHIIIKLQ AWFRSNKARH DYKTLTGVEN PPLTVVQKFV
HLLDQRANDF AEEIELQELK QNVVQCIKSN NELEEALNTM DIKIGLLVKN RITLQDVINH
SKNLKKKGGK DAGESSPAAG LKSLNKSNRA RLEAYQHLFY LLQTNPTYFG KLIFKMAAGR
TTNFMQSVIL SVYNYASNHR EEYLLLKLFK TALQEEIESK VDKVKEIATG NPLVIKMVVT
FNRGAKGQSS LRQILAPQVQ EVMKNKALNI NMSPVEIYKS WISQKETETG EASDLPYEVT
TTEAMKHDEV KKRVEDSISQ LRTVTDAFLA AILASIEEIP YGLRYIAKCL KNLLKKKFPD
TPEEEVLKMV GNLIYYRYMN PAIVAPDGFD VIDVSAGAAG LNNDQRKNLG SIAKVLQFAS
TGKTFAGDME HLRSINQYLM EAYVRFKKFF EAVCDVPEPE EKYNIDEYSD AVLLVKPVIF
ISLKEVLDTH KLLLEHEDEV ASDASDPIHE MLEELGEVPD IASLIGETGG TELTDEQKTA
LLNTEISLTL ASKVEIKEDD ESDIKNLILR TKRMVIDIIR IQVGENLTEV LNTPATDDQN
VEKLEMEKKK REDVKEDKDS MLRTRSLLNE NKLPLEDMKR RVLRNLKKLQ EHGIVTSDDH
YQAIVNMIAR DIRNQRRYRQ RRKQELTKLK QNLERLDQKS KFFEEQSDYY NQYIKSCLAS
LANKSKKAQK KKKRKVAAIK YTASELHRKK VLLEIEGLET GQFRNVMFEI GQTEDDVGRF
EVSAKLLGVN MEKVTLVFQD LLQLQYEGVS VMKMFDGRAK INVNLLIFLL NKKFFGK
//
