ID H2ZHS7_CIOSA Unreviewed; 1862 AA.
AC H2ZHS7;
DT 18-APR-2012, integrated into UniProtKB/TrEMBL.
DT 18-APR-2012, sequence version 1.
DT 27-MAR-2024, entry version 53.
DE RecName: Full=C2 domain-containing protein {ECO:0000259|PROSITE:PS50004};
OS Ciona savignyi (Pacific transparent sea squirt).
OC Eukaryota; Metazoa; Chordata; Tunicata; Ascidiacea; Phlebobranchia;
OC Cionidae; Ciona.
OX NCBI_TaxID=51511 {ECO:0000313|Ensembl:ENSCSAVP00000017143.1, ECO:0000313|Proteomes:UP000007875};
RN [1] {ECO:0000313|Proteomes:UP000007875}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Birren B., Nusbaum C., Abebe A., Abouelleil A., Adekoya E., Ait-zahra M.,
RA Allen N., Allen T., An P., Anderson M., Anderson S., Arachchi H.,
RA Armbruster J., Bachantsang P., Baldwin J., Barry A., Bayul T.,
RA Blitshsteyn B., Bloom T., Blye J., Boguslavskiy L., Borowsky M.,
RA Boukhgalter B., Brunache A., Butler J., Calixte N., Calvo S., Camarata J.,
RA Campo K., Chang J., Cheshatsang Y., Citroen M., Collymore A., Considine T.,
RA Cook A., Cooke P., Corum B., Cuomo C., David R., Dawoe T., Degray S.,
RA Dodge S., Dooley K., Dorje P., Dorjee K., Dorris L., Duffey N., Dupes A.,
RA Elkins T., Engels R., Erickson J., Farina A., Faro S., Ferreira P.,
RA Fischer H., Fitzgerald M., Foley K., Gage D., Galagan J., Gearin G.,
RA Gnerre S., Gnirke A., Goyette A., Graham J., Grandbois E., Gyaltsen K.,
RA Hafez N., Hagopian D., Hagos B., Hall J., Hatcher B., Heller A.,
RA Higgins H., Honan T., Horn A., Houde N., Hughes L., Hulme W., Husby E.,
RA Iliev I., Jaffe D., Jones C., Kamal M., Kamat A., Kamvysselis M.,
RA Karlsson E., Kells C., Kieu A., Kisner P., Kodira C., Kulbokas E.,
RA Labutti K., Lama D., Landers T., Leger J., Levine S., Lewis D., Lewis T.,
RA Lindblad-toh K., Liu X., Lokyitsang T., Lokyitsang Y., Lucien O., Lui A.,
RA Ma L.J., Mabbitt R., Macdonald J., Maclean C., Major J., Manning J.,
RA Marabella R., Maru K., Matthews C., Mauceli E., Mccarthy M., Mcdonough S.,
RA Mcghee T., Meldrim J., Meneus L., Mesirov J., Mihalev A., Mihova T.,
RA Mikkelsen T., Mlenga V., Moru K., Mozes J., Mulrain L., Munson G.,
RA Naylor J., Newes C., Nguyen C., Nguyen N., Nguyen T., Nicol R., Nielsen C.,
RA Nizzari M., Norbu C., Norbu N., O'donnell P., Okoawo O., O'leary S.,
RA Omotosho B., O'neill K., Osman S., Parker S., Perrin D., Phunkhang P.,
RA Piqani B., Purcell S., Rachupka T., Ramasamy U., Rameau R., Ray V.,
RA Raymond C., Retta R., Richardson S., Rise C., Rodriguez J., Rogers J.,
RA Rogov P., Rutman M., Schupbach R., Seaman C., Settipalli S., Sharpe T.,
RA Sheridan J., Sherpa N., Shi J., Smirnov S., Smith C., Sougnez C.,
RA Spencer B., Stalker J., Stange-thomann N., Stavropoulos S., Stetson K.,
RA Stone C., Stone S., Stubbs M., Talamas J., Tchuinga P., Tenzing P.,
RA Tesfaye S., Theodore J., Thoulutsang Y., Topham K., Towey S., Tsamla T.,
RA Tsomo N., Vallee D., Vassiliev H., Venkataraman V., Vinson J., Vo A.,
RA Wade C., Wang S., Wangchuk T., Wangdi T., Whittaker C., Wilkinson J.,
RA Wu Y., Wyman D., Yadav S., Yang S., Yang X., Yeager S., Yee E., Young G.,
RA Zainoun J., Zembeck L., Zimmer A., Zody M., Lander E.;
RL Submitted (AUG-2003) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSCSAVP00000017143.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cytoplasmic vesicle membrane
CC {ECO:0000256|ARBA:ARBA00004483}; Single-pass type II membrane protein
CC {ECO:0000256|ARBA:ARBA00004483}. Membrane
CC {ECO:0000256|ARBA:ARBA00004606}; Single-pass type II membrane protein
CC {ECO:0000256|ARBA:ARBA00004606}.
CC -!- SIMILARITY: Belongs to the ferlin family.
CC {ECO:0000256|ARBA:ARBA00007561}.
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DR Ensembl; ENSCSAVT00000017328.1; ENSCSAVP00000017143.1; ENSCSAVG00000010089.1.
DR GeneTree; ENSGT00940000167153; -.
DR Proteomes; UP000007875; Unassembled WGS sequence.
DR GO; GO:0030659; C:cytoplasmic vesicle membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProt.
DR CDD; cd04011; C2B_Ferlin; 1.
DR CDD; cd04018; C2C_Ferlin; 1.
DR CDD; cd04017; C2D_Ferlin; 1.
DR CDD; cd04037; C2E_Ferlin; 1.
DR CDD; cd08374; C2F_Ferlin; 1.
DR Gene3D; 2.60.40.150; C2 domain; 5.
DR InterPro; IPR000008; C2_dom.
DR InterPro; IPR035892; C2_domain_sf.
DR InterPro; IPR037720; C2B_Ferlin.
DR InterPro; IPR037722; C2C_Ferlin.
DR InterPro; IPR037723; C2D_Ferlin.
DR InterPro; IPR037724; C2E_Ferlin.
DR InterPro; IPR037725; C2F_Ferlin.
DR InterPro; IPR037721; Ferlin.
DR InterPro; IPR012560; Ferlin_A-domain.
DR InterPro; IPR012561; Ferlin_B-domain.
DR InterPro; IPR032362; Ferlin_C.
DR InterPro; IPR006614; Peroxin/Ferlin.
DR PANTHER; PTHR12546; FER-1-LIKE; 1.
DR PANTHER; PTHR12546:SF33; SPERM VESICLE FUSION PROTEIN FER-1; 1.
DR Pfam; PF00168; C2; 5.
DR Pfam; PF08150; FerB; 1.
DR Pfam; PF16165; Ferlin_C; 1.
DR SMART; SM00239; C2; 6.
DR SMART; SM00694; DysFC; 2.
DR SMART; SM01200; FerA; 1.
DR SMART; SM01201; FerB; 1.
DR SUPFAM; SSF49562; C2 domain (Calcium/lipid-binding domain, CaLB); 6.
DR PROSITE; PS50004; C2; 6.
PE 3: Inferred from homology;
KW Cytoplasmic vesicle {ECO:0000256|ARBA:ARBA00023329};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000007875};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Signal-anchor {ECO:0000256|ARBA:ARBA00022968};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 1839..1861
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 1..110
FT /note="C2"
FT /evidence="ECO:0000259|PROSITE:PS50004"
FT DOMAIN 163..300
FT /note="C2"
FT /evidence="ECO:0000259|PROSITE:PS50004"
FT DOMAIN 940..1067
FT /note="C2"
FT /evidence="ECO:0000259|PROSITE:PS50004"
FT DOMAIN 1098..1226
FT /note="C2"
FT /evidence="ECO:0000259|PROSITE:PS50004"
FT DOMAIN 1347..1465
FT /note="C2"
FT /evidence="ECO:0000259|PROSITE:PS50004"
FT DOMAIN 1584..1734
FT /note="C2"
FT /evidence="ECO:0000259|PROSITE:PS50004"
FT REGION 1790..1812
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1790..1809
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1862 AA; 215516 MW; EDCB9A192BD332B2 CRC64;
RLKLSEKVED FQIRLKVICG RQLTGSNIKP VVQVKMGKVK MKITKIRKGS SPVWNELLMY
NFHESLKELY DYVVEFTVNN SRKLRSDSLI GSFKLDVGSI YDQPGKTLQK KHNFANLIIL
LRPQKLNIML HCLTYQLSLF ITVHLADSLI IVIQDESAAK DENEDDVEGN LLTPAGATLH
SANFALSLFS AEDLPQSITA FKSMKQKIGL GGDEDVSQTS VDAYLTFKFA GKKRVTEVIK
ETNQPVWNER LNLPLKFPSM CDSIKLTLKD WDRVGCDDPI GSVTIPLSHI SSTGEAGIGG
RRDLFLYSTN GPFVLFLGFL PTFGPSFVNF YGSPREFTQL GNSLDELNTG KASCAYRGRA
MMELLMRMDE EGAEPKPPSQ PVNEEKIALV QKYMRRRQYR LVVGFESANL IRKPLERIEF
EVSMGNYGNK FDCDVKSSAS TTEPHNAVFD GVHYHYLAWT SKKPIMMVTS QWEDISFRLY
ALNLILRIIE ELQEQISQVN LMVKQKEDDI EIASKIVTIL DEVILKTSKK LPNPRGRTVS
NQLDRRIHRQ RVHMFEMICQ EAKELRQNCT DAQEAIAALH DFIQRLELVS HEPQNSFPDV
IIWMLSDNKR VAYTRIPAYD LLYSPERQDY CGRFCSKPCT LTLKYPTANT KSKKHYKVPA
QLRIIAWLGR AKDQSNFEFH SKGDISVIQD TYETEIKLPF KGWTADGYTD ITGEIPLPKS
VFRCPTGWLW DGDWKINSDL ASLYDTSLGH MHVVEDAFEF EMRDVGTAWQ VRKVTNGKME
TICDMGAIKV PSGWEWENEW TVDTQRACDE DGWEYATSDD QTVGELVWST VEKVYHNSRK
RRLVRSRVCV DHKAFKKAEK TAELLEEGWE YATTMGSEFH IDPKMLDLVR RRKWSRRMVT
SDDRGSAAIF QLDKSIFYVH LFCVLESDKK ANKKDRHYHK MPLPKIYVVY ESVWQLHLRA
YIYQGRDLIA MDGDSLSDPL VLVSFLNHTA RTEVQKHTLN PSWDETMMLD IKFYGDIDHL
KKYCPEVSVE VFDSDDLNSL QFMGRTSVKP IVKLDPENNQ TPKLEWHNIT KANYTTGNVL
TAFEMILKND KIEMPLPPPL KPGVNLPMVP FGIRPVLQRT AIEFLIWGVR TMKPFKLLSV
NSPSVLIQIG AVELRTKIIK NLKKQPNFTE PLYYIEANLP VDDLYFPPIM IRVKDNRKFG
SRPTVGQHII TKSIQYRIKP SVDQPQQDEG FEESKDSTDL EIEVDPPAKS GLKLQIREEE
LDWWSKFYAS LGDGGNCRSY MESGLDLIKV YKDELEKQEE FNHFSDFIQT FQLFRGKVEN
KDEEPDFAGQ FKGTFRIYTL PEDSREPSPP RYFQHLPPSD VVEVKVRIYV IRAFGLAPQD
ANGLSDPYIK IKAGKKRIVG RENYIPMTLE PTFGKMFELD LVLPMEKDLY VEVFDWDLIG
TDDKIGETVI DLENRYLSKF KAWCSLPETY CVTGPCPWRD QMKPKEWLDD KCCKEGWDEP
VWNGNTCVMV DGKTYKLDDY EKDKVRMILH NHHWGPADER LALYILRKFP HVSEHVETRP
LLHDALPNIE QGRLQLWVDM FPKSYGDPGL PYNIEPRKPS KYFLRMIVWN CSEIPMMDVS
VLGDKMSDIY FKGWISGLEH KQQKTDVHYR SLDGTGNFNW RFVFPFDYLP QERMVHVAKK
DHLWSLDKTV TKFPPVLNIQ VWDNDLFGPN EYISEIVLPI TNIPKCCKFQ RFCTLKNVPD
MQGNCKMEMV NLFDKKMPLK GWWPLYRMVD CGREQAGKLE MSIEILTEQE EEEKRAGQGR
DEPNMHPKLD KPNRPATSFA WFSSPFKSLR YIIWRKYKWI ILGLLAFALF LTFFVMFIYS
FP
//
