ID H2ZKQ6_CIOSA Unreviewed; 1667 AA.
AC H2ZKQ6;
DT 18-APR-2012, integrated into UniProtKB/TrEMBL.
DT 18-APR-2012, sequence version 1.
DT 27-MAR-2024, entry version 54.
DE RecName: Full=Clathrin heavy chain {ECO:0000256|PIRNR:PIRNR002290};
OS Ciona savignyi (Pacific transparent sea squirt).
OC Eukaryota; Metazoa; Chordata; Tunicata; Ascidiacea; Phlebobranchia;
OC Cionidae; Ciona.
OX NCBI_TaxID=51511 {ECO:0000313|Ensembl:ENSCSAVP00000018172.1, ECO:0000313|Proteomes:UP000007875};
RN [1] {ECO:0000313|Proteomes:UP000007875}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Birren B., Nusbaum C., Abebe A., Abouelleil A., Adekoya E., Ait-zahra M.,
RA Allen N., Allen T., An P., Anderson M., Anderson S., Arachchi H.,
RA Armbruster J., Bachantsang P., Baldwin J., Barry A., Bayul T.,
RA Blitshsteyn B., Bloom T., Blye J., Boguslavskiy L., Borowsky M.,
RA Boukhgalter B., Brunache A., Butler J., Calixte N., Calvo S., Camarata J.,
RA Campo K., Chang J., Cheshatsang Y., Citroen M., Collymore A., Considine T.,
RA Cook A., Cooke P., Corum B., Cuomo C., David R., Dawoe T., Degray S.,
RA Dodge S., Dooley K., Dorje P., Dorjee K., Dorris L., Duffey N., Dupes A.,
RA Elkins T., Engels R., Erickson J., Farina A., Faro S., Ferreira P.,
RA Fischer H., Fitzgerald M., Foley K., Gage D., Galagan J., Gearin G.,
RA Gnerre S., Gnirke A., Goyette A., Graham J., Grandbois E., Gyaltsen K.,
RA Hafez N., Hagopian D., Hagos B., Hall J., Hatcher B., Heller A.,
RA Higgins H., Honan T., Horn A., Houde N., Hughes L., Hulme W., Husby E.,
RA Iliev I., Jaffe D., Jones C., Kamal M., Kamat A., Kamvysselis M.,
RA Karlsson E., Kells C., Kieu A., Kisner P., Kodira C., Kulbokas E.,
RA Labutti K., Lama D., Landers T., Leger J., Levine S., Lewis D., Lewis T.,
RA Lindblad-toh K., Liu X., Lokyitsang T., Lokyitsang Y., Lucien O., Lui A.,
RA Ma L.J., Mabbitt R., Macdonald J., Maclean C., Major J., Manning J.,
RA Marabella R., Maru K., Matthews C., Mauceli E., Mccarthy M., Mcdonough S.,
RA Mcghee T., Meldrim J., Meneus L., Mesirov J., Mihalev A., Mihova T.,
RA Mikkelsen T., Mlenga V., Moru K., Mozes J., Mulrain L., Munson G.,
RA Naylor J., Newes C., Nguyen C., Nguyen N., Nguyen T., Nicol R., Nielsen C.,
RA Nizzari M., Norbu C., Norbu N., O'donnell P., Okoawo O., O'leary S.,
RA Omotosho B., O'neill K., Osman S., Parker S., Perrin D., Phunkhang P.,
RA Piqani B., Purcell S., Rachupka T., Ramasamy U., Rameau R., Ray V.,
RA Raymond C., Retta R., Richardson S., Rise C., Rodriguez J., Rogers J.,
RA Rogov P., Rutman M., Schupbach R., Seaman C., Settipalli S., Sharpe T.,
RA Sheridan J., Sherpa N., Shi J., Smirnov S., Smith C., Sougnez C.,
RA Spencer B., Stalker J., Stange-thomann N., Stavropoulos S., Stetson K.,
RA Stone C., Stone S., Stubbs M., Talamas J., Tchuinga P., Tenzing P.,
RA Tesfaye S., Theodore J., Thoulutsang Y., Topham K., Towey S., Tsamla T.,
RA Tsomo N., Vallee D., Vassiliev H., Venkataraman V., Vinson J., Vo A.,
RA Wade C., Wang S., Wangchuk T., Wangdi T., Whittaker C., Wilkinson J.,
RA Wu Y., Wyman D., Yadav S., Yang S., Yang X., Yeager S., Yee E., Young G.,
RA Zainoun J., Zembeck L., Zimmer A., Zody M., Lander E.;
RL Submitted (AUG-2003) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSCSAVP00000018172.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- FUNCTION: Clathrin is the major protein of the polyhedral coat of
CC coated pits and vesicles. {ECO:0000256|PIRNR:PIRNR002290}.
CC -!- SUBCELLULAR LOCATION: Cytoplasmic vesicle membrane
CC {ECO:0000256|PIRNR:PIRNR002290}; Peripheral membrane protein
CC {ECO:0000256|PIRNR:PIRNR002290}; Cytoplasmic side
CC {ECO:0000256|PIRNR:PIRNR002290}. Membrane, coated pit
CC {ECO:0000256|PIRNR:PIRNR002290}; Peripheral membrane protein
CC {ECO:0000256|PIRNR:PIRNR002290}; Cytoplasmic side
CC {ECO:0000256|PIRNR:PIRNR002290}. Membrane
CC {ECO:0000256|ARBA:ARBA00004287}; Peripheral membrane protein
CC {ECO:0000256|ARBA:ARBA00004287}; Cytoplasmic side
CC {ECO:0000256|ARBA:ARBA00004287}.
CC -!- SIMILARITY: Belongs to the clathrin heavy chain family.
CC {ECO:0000256|ARBA:ARBA00009535, ECO:0000256|PIRNR:PIRNR002290}.
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DR Ensembl; ENSCSAVT00000018370.1; ENSCSAVP00000018172.1; ENSCSAVG00000010696.1.
DR GeneTree; ENSGT00950000183166; -.
DR Proteomes; UP000007875; Unassembled WGS sequence.
DR GO; GO:0030132; C:clathrin coat of coated pit; IEA:InterPro.
DR GO; GO:0030130; C:clathrin coat of trans-Golgi network vesicle; IEA:InterPro.
DR GO; GO:0071439; C:clathrin complex; IEA:InterPro.
DR GO; GO:0032051; F:clathrin light chain binding; IEA:InterPro.
DR GO; GO:0005198; F:structural molecule activity; IEA:InterPro.
DR GO; GO:0006886; P:intracellular protein transport; IEA:UniProtKB-UniRule.
DR GO; GO:0016192; P:vesicle-mediated transport; IEA:InterPro.
DR Gene3D; 1.25.40.730; -; 1.
DR Gene3D; 2.130.10.110; Clathrin heavy-chain terminal domain; 1.
DR Gene3D; 1.25.40.10; Tetratricopeptide repeat domain; 3.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR000547; Clathrin_H-chain/VPS_repeat.
DR InterPro; IPR015348; Clathrin_H-chain_linker_core.
DR InterPro; IPR016025; Clathrin_H-chain_N.
DR InterPro; IPR022365; Clathrin_H-chain_propeller_rpt.
DR InterPro; IPR016341; Clathrin_heavy_chain.
DR InterPro; IPR011990; TPR-like_helical_dom_sf.
DR PANTHER; PTHR10292:SF1; CLATHRIN HEAVY CHAIN; 1.
DR PANTHER; PTHR10292; CLATHRIN HEAVY CHAIN RELATED; 1.
DR Pfam; PF00637; Clathrin; 6.
DR Pfam; PF09268; Clathrin-link; 1.
DR Pfam; PF13838; Clathrin_H_link; 1.
DR Pfam; PF01394; Clathrin_propel; 5.
DR PIRSF; PIRSF002290; Clathrin_H_chain; 2.
DR SMART; SM00299; CLH; 6.
DR SUPFAM; SSF48371; ARM repeat; 5.
DR SUPFAM; SSF50989; Clathrin heavy-chain terminal domain; 1.
DR PROSITE; PS50236; CHCR; 6.
PE 3: Inferred from homology;
KW Coated pit {ECO:0000256|ARBA:ARBA00023176, ECO:0000256|PIRNR:PIRNR002290};
KW Cytoplasmic vesicle {ECO:0000256|ARBA:ARBA00023329,
KW ECO:0000256|PIRNR:PIRNR002290};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|PIRNR:PIRNR002290};
KW Reference proteome {ECO:0000313|Proteomes:UP000007875};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT DOMAIN 330..353
FT /note="Clathrin heavy chain linker core motif"
FT /evidence="ECO:0000259|Pfam:PF09268"
SQ SEQUENCE 1667 AA; 190039 MW; 4B364E2BB525BCEC CRC64;
QNLPIKFQEH LQLQNVGINA ANIGFSTLTM ESDKFICVRE KVGDQAQVVI IDLADSANPI
RRPISAESAI MNPASKVIAL KAGRTLQIFN MEMKSKLKAH TMNEDVVFWK WISTNMIGLV
TETSVYHWSM EGDSQQPVKM FDKHPSLANC QIINYRTDAK QKWLLLIGIS AQSNRVVGAM
QLYSVERRVS QPIEGHAASF AQLKLEGNKE ESTLFCFAVR GAQGGKLHII EVGTPAAGNQ
PFSKKAVDVF FPPEAANDFP VAMQVSPNQN VVFVVTKYGY IHMYDLETAV CIFMNRISAD
TIFVTAPHEA TGGLIGVNRK GQVLSVSVDE ENVVPYITST LQNPDLALRF AIRNNLAGGE
ELFSRKFNTL FAQGNYTEAA KVAANAPKGI LRTSQTIQKF LSVPAQPGQS SPPLLQYFGI
LLDQGKLNKF ESLELCRPVL QQGRKQLMEK WLKEEKLECS EELGDLVKPM DSTLALSIYL
RANIPNKVIM CFAETGQFQK IVLYAKKVGY TPDYVFLLRN VMRVNPETGK QFAMMLVQDD
EPLADVAQIV DVFMEQNLIQ QCTAFLLDAL KNNRPAEGAL QTRLLEMNLM HAPQVADAIL
GNQMFTHYDR AHVAQLCEKA GLLQRALEHF VDLYDIKRAI IHTHLLNPEW LVNYFGSLSV
EDSLECLKVW ILNLADLSLA MLTANIRQNL QISVQVATKY HEQLTTEKLI EVFESFKSFE
GLFYFLGSIV NFSQDADVHF KYIQAACKTG QIKEVERICR ESNCYDADKV VKNFLKEAKL
TDQLPLIIVC DRFDFVHDLV LYLYRNNIPK YIEIYVQKVG SRFCTIWVKA VKIYCDNCIH
AIPMGLVQIQ VKSKSYWSEK KINYFSLPCS FYLKLICFSN SLKKIVLVKN DFFSVNKNIF
SAFKIPHLPS TTVFSPNFCS FRINLCNENS LFKSEARYLV RRKDVELWGK VLEDTNQYRR
QLIDQVVQTA LGEAQDPDEI SVAVKAFMAA DLPNELIELL EKIVLDNSMF SDHRNLQNLL
ILTAIKADSS RVMDYITQLD NYDAPDIANI SIENELFEEA FAIFNKFDVN TSAISVSTIK
NNLDRAYEFA ERCNEPTVWS QLARAQLNAG MIKEAIDSYI KADDPSSYME VVEASNKSEN
WEDLVRYLLM ARKKARESYV ETELVFAFAK TNRLADLEEF ISGPNNANIQ QVGDRCYDQK
MYEAAKVLFN NISNFARLAS TVVHLGEYQT AVDSARKANS TRTWKEICFA CEFILAHICG
LHICCTRHLE ELINYNQDRG YFEELITMLE AALGLERAHM GMFTELAILY SKYKPGKMRE
HLELFWSRVN IPKVLRAAEQ AHLWAELVFL YDKYEEYDNA VVTMMAHPTD AWKEGQYKDI
ITKVANIELY YKSLQHYLDY KPMLINDLLN VLSPRMDHTR AVAFFRKAQR LALVKPYLRT
VQTHNNKAIN EALNDLLIEE EDYSGLRNSI DAYDNFDTIA LAQRLEKHEL IEFRRIAAYL
YKGNNRWKQS VELCKKDLLY KDAMTYAGES RDTELAEELL EWFLDRQRYE CFSAGLYSCY
DLLRPDVVLE QAWRHGITDY AMPYLIQVMR EYSTRIDKLE TSENVRKQEE EQTENKPIVY
DNPTLMITAG AAYPQPGFVN PQMPGMPGGM PPGAMPPGPM PGAPGMM
//
