ID H2ZPE1_CIOSA Unreviewed; 2309 AA.
AC H2ZPE1;
DT 18-APR-2012, integrated into UniProtKB/TrEMBL.
DT 18-APR-2012, sequence version 1.
DT 27-MAR-2024, entry version 65.
DE RecName: Full=Spectrin beta chain {ECO:0000256|PIRNR:PIRNR002297};
OS Ciona savignyi (Pacific transparent sea squirt).
OC Eukaryota; Metazoa; Chordata; Tunicata; Ascidiacea; Phlebobranchia;
OC Cionidae; Ciona.
OX NCBI_TaxID=51511 {ECO:0000313|Ensembl:ENSCSAVP00000019457.1, ECO:0000313|Proteomes:UP000007875};
RN [1] {ECO:0000313|Proteomes:UP000007875}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Birren B., Nusbaum C., Abebe A., Abouelleil A., Adekoya E., Ait-zahra M.,
RA Allen N., Allen T., An P., Anderson M., Anderson S., Arachchi H.,
RA Armbruster J., Bachantsang P., Baldwin J., Barry A., Bayul T.,
RA Blitshsteyn B., Bloom T., Blye J., Boguslavskiy L., Borowsky M.,
RA Boukhgalter B., Brunache A., Butler J., Calixte N., Calvo S., Camarata J.,
RA Campo K., Chang J., Cheshatsang Y., Citroen M., Collymore A., Considine T.,
RA Cook A., Cooke P., Corum B., Cuomo C., David R., Dawoe T., Degray S.,
RA Dodge S., Dooley K., Dorje P., Dorjee K., Dorris L., Duffey N., Dupes A.,
RA Elkins T., Engels R., Erickson J., Farina A., Faro S., Ferreira P.,
RA Fischer H., Fitzgerald M., Foley K., Gage D., Galagan J., Gearin G.,
RA Gnerre S., Gnirke A., Goyette A., Graham J., Grandbois E., Gyaltsen K.,
RA Hafez N., Hagopian D., Hagos B., Hall J., Hatcher B., Heller A.,
RA Higgins H., Honan T., Horn A., Houde N., Hughes L., Hulme W., Husby E.,
RA Iliev I., Jaffe D., Jones C., Kamal M., Kamat A., Kamvysselis M.,
RA Karlsson E., Kells C., Kieu A., Kisner P., Kodira C., Kulbokas E.,
RA Labutti K., Lama D., Landers T., Leger J., Levine S., Lewis D., Lewis T.,
RA Lindblad-toh K., Liu X., Lokyitsang T., Lokyitsang Y., Lucien O., Lui A.,
RA Ma L.J., Mabbitt R., Macdonald J., Maclean C., Major J., Manning J.,
RA Marabella R., Maru K., Matthews C., Mauceli E., Mccarthy M., Mcdonough S.,
RA Mcghee T., Meldrim J., Meneus L., Mesirov J., Mihalev A., Mihova T.,
RA Mikkelsen T., Mlenga V., Moru K., Mozes J., Mulrain L., Munson G.,
RA Naylor J., Newes C., Nguyen C., Nguyen N., Nguyen T., Nicol R., Nielsen C.,
RA Nizzari M., Norbu C., Norbu N., O'donnell P., Okoawo O., O'leary S.,
RA Omotosho B., O'neill K., Osman S., Parker S., Perrin D., Phunkhang P.,
RA Piqani B., Purcell S., Rachupka T., Ramasamy U., Rameau R., Ray V.,
RA Raymond C., Retta R., Richardson S., Rise C., Rodriguez J., Rogers J.,
RA Rogov P., Rutman M., Schupbach R., Seaman C., Settipalli S., Sharpe T.,
RA Sheridan J., Sherpa N., Shi J., Smirnov S., Smith C., Sougnez C.,
RA Spencer B., Stalker J., Stange-thomann N., Stavropoulos S., Stetson K.,
RA Stone C., Stone S., Stubbs M., Talamas J., Tchuinga P., Tenzing P.,
RA Tesfaye S., Theodore J., Thoulutsang Y., Topham K., Towey S., Tsamla T.,
RA Tsomo N., Vallee D., Vassiliev H., Venkataraman V., Vinson J., Vo A.,
RA Wade C., Wang S., Wangchuk T., Wangdi T., Whittaker C., Wilkinson J.,
RA Wu Y., Wyman D., Yadav S., Yang S., Yang X., Yeager S., Yee E., Young G.,
RA Zainoun J., Zembeck L., Zimmer A., Zody M., Lander E.;
RL Submitted (AUG-2003) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSCSAVP00000019457.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the spectrin family.
CC {ECO:0000256|ARBA:ARBA00006826, ECO:0000256|PIRNR:PIRNR002297}.
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DR Ensembl; ENSCSAVT00000019667.1; ENSCSAVP00000019457.1; ENSCSAVG00000011411.1.
DR GeneTree; ENSGT00940000154864; -.
DR Proteomes; UP000007875; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProt.
DR GO; GO:0008091; C:spectrin; IEA:InterPro.
DR GO; GO:0003779; F:actin binding; IEA:UniProtKB-KW.
DR GO; GO:0005543; F:phospholipid binding; IEA:InterPro.
DR GO; GO:0005200; F:structural constituent of cytoskeleton; IEA:UniProtKB-UniRule.
DR GO; GO:0051693; P:actin filament capping; IEA:UniProtKB-UniRule.
DR CDD; cd21246; CH_SPTB-like_rpt1; 1.
DR CDD; cd21248; CH_SPTB_like_rpt2; 1.
DR CDD; cd10571; PH_beta_spectrin; 1.
DR CDD; cd00176; SPEC; 9.
DR Gene3D; 1.20.58.60; -; 14.
DR Gene3D; 1.10.418.10; Calponin-like domain; 2.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR InterPro; IPR001589; Actinin_actin-bd_CS.
DR InterPro; IPR001715; CH_dom.
DR InterPro; IPR036872; CH_dom_sf.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR041681; PH_9.
DR InterPro; IPR001605; PH_dom-spectrin-type.
DR InterPro; IPR001849; PH_domain.
DR InterPro; IPR018159; Spectrin/alpha-actinin.
DR InterPro; IPR016343; Spectrin_bsu.
DR InterPro; IPR002017; Spectrin_repeat.
DR PANTHER; PTHR11915:SF447; SPECTRIN BETA CHAIN; 1.
DR PANTHER; PTHR11915; SPECTRIN/FILAMIN RELATED CYTOSKELETAL PROTEIN; 1.
DR Pfam; PF00307; CH; 2.
DR Pfam; PF15410; PH_9; 1.
DR Pfam; PF00435; Spectrin; 16.
DR PIRSF; PIRSF002297; Spectrin_beta_subunit; 1.
DR PRINTS; PR00683; SPECTRINPH.
DR SMART; SM00033; CH; 2.
DR SMART; SM00233; PH; 1.
DR SMART; SM00150; SPEC; 17.
DR SUPFAM; SSF47576; Calponin-homology domain, CH-domain; 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR SUPFAM; SSF46966; Spectrin repeat; 14.
DR PROSITE; PS00019; ACTININ_1; 1.
DR PROSITE; PS00020; ACTININ_2; 1.
DR PROSITE; PS50021; CH; 2.
DR PROSITE; PS50003; PH_DOMAIN; 1.
PE 3: Inferred from homology;
KW Actin capping {ECO:0000256|ARBA:ARBA00022467,
KW ECO:0000256|PIRNR:PIRNR002297};
KW Actin-binding {ECO:0000256|ARBA:ARBA00023203,
KW ECO:0000256|PIRNR:PIRNR002297}; Coiled coil {ECO:0000256|SAM:Coils};
KW Cytoplasm {ECO:0000256|PIRNR:PIRNR002297};
KW Cytoskeleton {ECO:0000256|ARBA:ARBA00023212,
KW ECO:0000256|PIRNR:PIRNR002297};
KW Reference proteome {ECO:0000313|Proteomes:UP000007875};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT DOMAIN 8..112
FT /note="Calponin-homology (CH)"
FT /evidence="ECO:0000259|PROSITE:PS50021"
FT DOMAIN 127..232
FT /note="Calponin-homology (CH)"
FT /evidence="ECO:0000259|PROSITE:PS50021"
FT DOMAIN 2192..2302
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT REGION 2043..2077
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2121..2174
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 411..445
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 947..988
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 1053..1080
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 1383..1410
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 2150..2164
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 2309 AA; 266114 MW; 1A1A5764C9464B8F CRC64;
SILDEREAVQ KKTFTKWVNS HLVRVSCRIQ DLYMDLRDGR SLIKLLEILS GERLPKPTRG
KMRIHCLENT GKALQFLKSK KVHLENMGPH DIVDGNHRLI LGLIWTIILR FQIQDISVET
EDNRETRSAK DALLLWCQMK TAGYANVNVH NFNTSWRDGL AFNAIIHKHR PDLIDYDSLK
KSNAMHNLQN AFNVAEQQLG LTKLLDPEDI VVERPDEKSI ITYVVTYYHY FSKMKAIAVE
GKRIGKVLDS ALESNQMVEK YDSLASDLLD WIEQTIEILN DRTFANSLSG VSAQLAAFNN
YRTAEKPQKF QEKGNLEVLL FTLQSKMRAN NQKPYLPKEG KLVSDINKAW EKLEKAEHGR
ELAIRNELIR QERLELLASR FDRKAAMRET WLSENQKLVT QDNFGGDLPA VEAATKKHEA
IETDVKAYEE RVQAVVDVAS ELQREDYHDI TRVNQRKDNV LQLWEYLLEL LQGRRTRLEL
NVRLQQMFEE MMSLLDWMDD MKGQLANEDL GQHLMGVEDI LQKHMLLEQD ITVHGDRVKA
IESQSQEFLQ PTNDYSACEP SAVEDKVVGV RTTYDQLCKQ AADRRAKLDE SRRMHLFFAT
MAEEVAWVKE KEQLLNSDDL GRDLTSVHSL LTKQKALEDE MNGRKAMLAN AIAVGEDLIS
EDHFASQDIA KHISDINEQW KNLEELAEAR NELLRANKLY QFYADTDDVD TWLVDMFRIV
STDDCGRDEP SVLSLLKKHA QVQEELTKYE GVIKALHDEA DGLTEKDRES VEVQERLRSV
DSRYKELLDF AKLRKEKLID ARALYKFYGE ADTISAWIAE KEQVLENMLV PDNIEDMELV
QHRFEGYENE VNKLAPQVAV VNQMARGLVQ TQHPNSDDVS AKQNELNARW NALRALLEER
REILASAKGL HGFKLECDET EGWIKDKARV LAAGAEDQLS DRDLAGVVAL QRKLSSMELD
LAAIQAKLDN LRDEADRLSN EHPEEADEIR KKFEQMERVW QELRDMLRQR EDSLGEAGNL
QKFLRDLDRF QAWLSTTQTT IASEDMPQSL PEAEKLLQQH QAIKLEIDNY QADYEEIKST
GAQVTSGRED EPQYMFLGQR LQALDQGWIE LHKMWENRNH FLNEAKEYQA FIRDCKQAEQ
ILTNQEYALE SARRSSAAAS TPDSAEEVMK KHEAFVATMA SADERVEAVL RDAGKLADAD
HHAADKIKER AEKIAERRAK NKEEAGEVST MLRDNLALQK FVADCDELSE WVNEKMLTAK
DATYDDARNL HSKWQKHQAF SAELTANKDR LERLEEDGST LAKSKPEWKD QIDVRLDDLR
KHWEALESCT KTKEKTLFEA NKAELFSQTC EDLEKFASMM EEQLNSDDVG KDLASVNVLL
KDHLAQQDEI EVRKQEVQEL ESQAAVLRSE GDEDVDTMNE ERAKIKHRIE DLDEPLTKRK
DALENSKQLH QFYRDVQDEK LWIDEKHPQA TSNELGNSLQ EVQALQKKHQ ALRSELTAHE
PVVVAVCHRG VAMATEDNPN TDKINEKCHE LQENWNRLLE DVDERKRKLS EAENAQQYFF
DADEAVVLME EQELYMMSDE KAKDSQGATK MLKKHQAQEQ NIDDFADTIQ QLSKTCRDLC
EQEHPQSEQL STRQQQVDQT YAGLKDLAEE RRMKLRERCD LFRLSRDIDD LEQWIAQREV
VAASQEQGQD FDHVSMLQDQ FNDFQRDTIK TGEERVADAM RMSDELINAG HTDAQDIAGW
KDTIRDAWAD LLELIDTRVE MLAAAYALHK FHYDAAEILA RIQEKRQEVP EELGRDHDAV
ENFKREHDIF AQDIKAIGAQ VEAITSAGSE LEGRYAGDDL QEIQKKIEAV LSAWNNLLSL
VKKRAALLSD ALNKFRFFNM CRDLMDWMES TVRQIDLQEK PRDVSGVETA MSLHQGTKAE
IDARNGSFEE CTQLGQHLIT TGHYASDEIR VKLDELGAKR NHVVDRWQEK WELNLLMEVY
QFAHDANTCD AWVQQQLGLI RDMPVDTCRS ADDADQLLRR LDGFEKAAVP WEDRFAALEK
LTEVSQEEQE KKRKEEEEQE ERRRKAEEDE QKIKKEAELE AARPVSLALS PEDLWLPRNE
NSVMYSGLCL DSSEALKLLR KQGRTKPPLK PKRSNGDVGN LMRSQAHSLR MKMYENRRNR
RPSPIPTKDQ GNARRIQLFP QTKAPQDSES PDVPYQGFLK RKSTMFSPSK KAPNRSWNSV
FCVLQDKNLA FYKDPKAASQ RASFHGEQSI SLENATIEIA SDYKKRKNVL RLRLSAGMEY
LFQAKDEEEL NVWLNRLQSQ NLNASIGSG
//
