ID H2ZR06_CIOSA Unreviewed; 1057 AA.
AC H2ZR06;
DT 18-APR-2012, integrated into UniProtKB/TrEMBL.
DT 18-APR-2012, sequence version 1.
DT 27-MAR-2024, entry version 45.
DE RecName: Full=Importin N-terminal domain-containing protein {ECO:0000259|PROSITE:PS50166};
OS Ciona savignyi (Pacific transparent sea squirt).
OC Eukaryota; Metazoa; Chordata; Tunicata; Ascidiacea; Phlebobranchia;
OC Cionidae; Ciona.
OX NCBI_TaxID=51511 {ECO:0000313|Ensembl:ENSCSAVP00000020022.1, ECO:0000313|Proteomes:UP000007875};
RN [1] {ECO:0000313|Proteomes:UP000007875}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Birren B., Nusbaum C., Abebe A., Abouelleil A., Adekoya E., Ait-zahra M.,
RA Allen N., Allen T., An P., Anderson M., Anderson S., Arachchi H.,
RA Armbruster J., Bachantsang P., Baldwin J., Barry A., Bayul T.,
RA Blitshsteyn B., Bloom T., Blye J., Boguslavskiy L., Borowsky M.,
RA Boukhgalter B., Brunache A., Butler J., Calixte N., Calvo S., Camarata J.,
RA Campo K., Chang J., Cheshatsang Y., Citroen M., Collymore A., Considine T.,
RA Cook A., Cooke P., Corum B., Cuomo C., David R., Dawoe T., Degray S.,
RA Dodge S., Dooley K., Dorje P., Dorjee K., Dorris L., Duffey N., Dupes A.,
RA Elkins T., Engels R., Erickson J., Farina A., Faro S., Ferreira P.,
RA Fischer H., Fitzgerald M., Foley K., Gage D., Galagan J., Gearin G.,
RA Gnerre S., Gnirke A., Goyette A., Graham J., Grandbois E., Gyaltsen K.,
RA Hafez N., Hagopian D., Hagos B., Hall J., Hatcher B., Heller A.,
RA Higgins H., Honan T., Horn A., Houde N., Hughes L., Hulme W., Husby E.,
RA Iliev I., Jaffe D., Jones C., Kamal M., Kamat A., Kamvysselis M.,
RA Karlsson E., Kells C., Kieu A., Kisner P., Kodira C., Kulbokas E.,
RA Labutti K., Lama D., Landers T., Leger J., Levine S., Lewis D., Lewis T.,
RA Lindblad-toh K., Liu X., Lokyitsang T., Lokyitsang Y., Lucien O., Lui A.,
RA Ma L.J., Mabbitt R., Macdonald J., Maclean C., Major J., Manning J.,
RA Marabella R., Maru K., Matthews C., Mauceli E., Mccarthy M., Mcdonough S.,
RA Mcghee T., Meldrim J., Meneus L., Mesirov J., Mihalev A., Mihova T.,
RA Mikkelsen T., Mlenga V., Moru K., Mozes J., Mulrain L., Munson G.,
RA Naylor J., Newes C., Nguyen C., Nguyen N., Nguyen T., Nicol R., Nielsen C.,
RA Nizzari M., Norbu C., Norbu N., O'donnell P., Okoawo O., O'leary S.,
RA Omotosho B., O'neill K., Osman S., Parker S., Perrin D., Phunkhang P.,
RA Piqani B., Purcell S., Rachupka T., Ramasamy U., Rameau R., Ray V.,
RA Raymond C., Retta R., Richardson S., Rise C., Rodriguez J., Rogers J.,
RA Rogov P., Rutman M., Schupbach R., Seaman C., Settipalli S., Sharpe T.,
RA Sheridan J., Sherpa N., Shi J., Smirnov S., Smith C., Sougnez C.,
RA Spencer B., Stalker J., Stange-thomann N., Stavropoulos S., Stetson K.,
RA Stone C., Stone S., Stubbs M., Talamas J., Tchuinga P., Tenzing P.,
RA Tesfaye S., Theodore J., Thoulutsang Y., Topham K., Towey S., Tsamla T.,
RA Tsomo N., Vallee D., Vassiliev H., Venkataraman V., Vinson J., Vo A.,
RA Wade C., Wang S., Wangchuk T., Wangdi T., Whittaker C., Wilkinson J.,
RA Wu Y., Wyman D., Yadav S., Yang S., Yang X., Yeager S., Yee E., Young G.,
RA Zainoun J., Zembeck L., Zimmer A., Zody M., Lander E.;
RL Submitted (AUG-2003) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSCSAVP00000020022.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
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DR AlphaFoldDB; H2ZR06; -.
DR Ensembl; ENSCSAVT00000020236.1; ENSCSAVP00000020022.1; ENSCSAVG00000011751.1.
DR GeneTree; ENSGT00940000154666; -.
DR HOGENOM; CLU_004196_1_1_1; -.
DR Proteomes; UP000007875; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0031267; F:small GTPase binding; IEA:InterPro.
DR GO; GO:0006886; P:intracellular protein transport; IEA:InterPro.
DR Gene3D; 1.25.10.10; Leucine-rich Repeat Variant; 1.
DR InterPro; IPR011989; ARM-like.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR001494; Importin-beta_N.
DR InterPro; IPR013713; XPO2_central.
DR PANTHER; PTHR10997:SF18; D-IMPORTIN 7_RANBP7; 1.
DR PANTHER; PTHR10997; IMPORTIN-7, 8, 11; 1.
DR Pfam; PF08506; Cse1; 1.
DR Pfam; PF03810; IBN_N; 1.
DR SMART; SM00913; IBN_N; 1.
DR SUPFAM; SSF48371; ARM repeat; 1.
DR PROSITE; PS50166; IMPORTIN_B_NT; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000007875}.
FT DOMAIN 22..103
FT /note="Importin N-terminal"
FT /evidence="ECO:0000259|PROSITE:PS50166"
FT REGION 885..961
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 890..916
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 940..961
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1057 AA; 120909 MW; 19516447E036654B CRC64;
MDPNKVLNAL EATMNPNLRK EAEAQLDQMH KIAGFSPLLI QLIMSDEVQM AIRQSGAIYL
KNMCVQSWHE RSDKDGTPVT DVFSIHENDR SVIRTNIVKA IIHAPDIIRS QLTVIIHNII
KHDFPERWPN VVDDINIHLQ DESPRSWMGA LMALYQLVKT YEFKKPEART PVISAMKHLL
PVMLGMFRNL MEDNSASSAL LQKQLLKILY ALVQYSLPME LFNEKILDEW VHIMRVIIET
PPPPETSEVD ELERCELPWW KSKKWAVHFL ARVFERYGSP GSVSKEYNEF SEFFLKRYTV
SILQVLLKIF DAYRNKEYVS PRVLQQALHF LDQAVSHAHT WKVMKGAYHD LLKDIIFPLM
CFTDEDKETW EDDPHEYIRM KFDIFEDFLS PSSAAQHLLH SAASKRKQVL QKTMGFCYSV
LTDTTTSPES SRKKDGALHI IGSLADTLLK KKMYKDQLEL MLRTHVIPEL SSEVGFMRAR
ASWVIQHFSE AKFKKKENII NVVEALKHLL LNDGELPVRV EAAMAIQAFL SEQELAEKHC
VQYVRPIMQA LLQLVHETEN DDLTTIVQKV ICLYCEQVIP YAVEITQNLV MVGSCTKEGS
ATGDAGDNDD KAVTAMGILS TIETVLDMME EEREITLQLE SIVAPLVAHV LKTTNMDYYE
EIFSLMYSLT CQAISPHMWE ALPLIAEVFE DDAFDYFTDM MPVLHNFCTI DTPTLLSNSK
YLEIIFAMCK QILEKETGED PECHAAKLLE VIILQCRGQI DQCIPLFVEA TLARLTREVK
TSELRTMCLQ VVIAALYYNP SLLIQTLESM RFPNTSETIS EQFFRQWIND VDCFLGIHDR
RMCVLGLCTL MDLPHRPPCI EELSNRFIPS LIVLFQGLVR AYKASDSSDS SSEDEEEDFE
TAELASDEDE IDEESTEYLE MLQKKLVTQE KGSDTSSVYS DEETDLENDE DDDASDDEFG
DEGETMLEAF PTSMEAESSS VDEFVAFKQV HSSLLARDPQ WYNVLMTGLS DEQRKSLEEI
YVLADQRHAA AESKKIEKTG GYRFENASVP SSFSFAT
//
