ID H2ZRM8_LATCH Unreviewed; 166 AA.
AC H2ZRM8;
DT 18-APR-2012, integrated into UniProtKB/TrEMBL.
DT 18-APR-2012, sequence version 1.
DT 27-MAR-2024, entry version 59.
DE RecName: Full=protein-tyrosine-phosphatase {ECO:0000256|ARBA:ARBA00013064};
DE EC=3.1.3.48 {ECO:0000256|ARBA:ARBA00013064};
OS Latimeria chalumnae (Coelacanth).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Coelacanthiformes; Coelacanthidae; Latimeria.
OX NCBI_TaxID=7897 {ECO:0000313|Ensembl:ENSLACP00000000049.1, ECO:0000313|Proteomes:UP000008672};
RN [1] {ECO:0000313|Proteomes:UP000008672}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Wild caught {ECO:0000313|Proteomes:UP000008672};
RA Di Palma F., Alfoldi J., Johnson J., Berlin A., Gnerre S., Jaffe D.,
RA MacCallum I., Young S., Walker B.J., Lander E., Lindblad-Toh K.;
RT "The draft genome of Latimeria chalumnae.";
RL Submitted (AUG-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSLACP00000000049.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=H2O + O-phospho-L-seryl-[protein] = L-seryl-[protein] +
CC phosphate; Xref=Rhea:RHEA:20629, Rhea:RHEA-COMP:9863, Rhea:RHEA-
CC COMP:11604, ChEBI:CHEBI:15377, ChEBI:CHEBI:29999, ChEBI:CHEBI:43474,
CC ChEBI:CHEBI:83421; EC=3.1.3.16;
CC Evidence={ECO:0000256|ARBA:ARBA00001512};
CC -!- CATALYTIC ACTIVITY:
CC Reaction=H2O + O-phospho-L-threonyl-[protein] = L-threonyl-[protein] +
CC phosphate; Xref=Rhea:RHEA:47004, Rhea:RHEA-COMP:11060, Rhea:RHEA-
CC COMP:11605, ChEBI:CHEBI:15377, ChEBI:CHEBI:30013, ChEBI:CHEBI:43474,
CC ChEBI:CHEBI:61977; EC=3.1.3.16;
CC Evidence={ECO:0000256|ARBA:ARBA00001482};
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DR EMBL; AFYH01217780; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01217781; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01217782; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01217783; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01217784; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01217785; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01217786; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01217787; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01217788; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01217789; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; H2ZRM8; -.
DR STRING; 7897.ENSLACP00000000049; -.
DR Ensembl; ENSLACT00000000050.1; ENSLACP00000000049.1; ENSLACG00000000043.1.
DR eggNOG; KOG1716; Eukaryota.
DR GeneTree; ENSGT00940000164598; -.
DR HOGENOM; CLU_027074_5_0_1; -.
DR InParanoid; H2ZRM8; -.
DR OMA; PFNDQQE; -.
DR TreeFam; TF105126; -.
DR Proteomes; UP000008672; Unassembled WGS sequence.
DR Bgee; ENSLACG00000000043; Expressed in muscle tissue and 5 other cell types or tissues.
DR GO; GO:0008138; F:protein tyrosine/serine/threonine phosphatase activity; IEA:InterPro.
DR GO; GO:0016311; P:dephosphorylation; IEA:InterPro.
DR Gene3D; 3.90.190.10; Protein tyrosine phosphatase superfamily; 1.
DR InterPro; IPR000340; Dual-sp_phosphatase_cat-dom.
DR InterPro; IPR029021; Prot-tyrosine_phosphatase-like.
DR InterPro; IPR016130; Tyr_Pase_AS.
DR InterPro; IPR000387; Tyr_Pase_dom.
DR InterPro; IPR020422; TYR_PHOSPHATASE_DUAL_dom.
DR PANTHER; PTHR45948:SF4; DUAL SPECIFICITY PROTEIN PHOSPHATASE 15; 1.
DR PANTHER; PTHR45948; DUAL SPECIFICITY PROTEIN PHOSPHATASE DDB_G0269404-RELATED; 1.
DR Pfam; PF00782; DSPc; 1.
DR SMART; SM00195; DSPc; 1.
DR SUPFAM; SSF52799; (Phosphotyrosine protein) phosphatases II; 1.
DR PROSITE; PS00383; TYR_PHOSPHATASE_1; 1.
DR PROSITE; PS50056; TYR_PHOSPHATASE_2; 1.
DR PROSITE; PS50054; TYR_PHOSPHATASE_DUAL; 1.
PE 4: Predicted;
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Protein phosphatase {ECO:0000256|ARBA:ARBA00022912};
KW Reference proteome {ECO:0000313|Proteomes:UP000008672}.
FT DOMAIN 1..97
FT /note="Tyrosine-protein phosphatase"
FT /evidence="ECO:0000259|PROSITE:PS50054"
FT DOMAIN 18..92
FT /note="Tyrosine specific protein phosphatases"
FT /evidence="ECO:0000259|PROSITE:PS50056"
FT REGION 126..146
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 166 AA; 19224 MW; 6F2C5738B0AD78B3 CRC64;
MTYLCIPAAD STSQNLIQHF KECIRFIHES RLHGGGCLVH CLAGVSRSTT ILVAYLMTVT
NFGWEECFSA VKTVRSYAGP NLGFQQQLQE YEMTLVNEYR RWLRKEYGVN PFKDQERLEG
LLSQYEEQQK EQQRRNGPSH WTNPSTSVYP LPYNAYGTSN SSWVKR
//