ID H2ZUC0_LATCH Unreviewed; 800 AA.
AC H2ZUC0;
DT 18-APR-2012, integrated into UniProtKB/TrEMBL.
DT 18-APR-2012, sequence version 1.
DT 27-MAR-2024, entry version 71.
DE RecName: Full=G-protein coupled receptors family 3 profile domain-containing protein {ECO:0000259|PROSITE:PS50259};
GN Name=LOC102356107 {ECO:0000313|Ensembl:ENSLACP00000000991.1};
OS Latimeria chalumnae (Coelacanth).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Coelacanthiformes; Coelacanthidae; Latimeria.
OX NCBI_TaxID=7897 {ECO:0000313|Ensembl:ENSLACP00000000991.1, ECO:0000313|Proteomes:UP000008672};
RN [1] {ECO:0000313|Proteomes:UP000008672}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Wild caught {ECO:0000313|Proteomes:UP000008672};
RA Di Palma F., Alfoldi J., Johnson J., Berlin A., Gnerre S., Jaffe D.,
RA MacCallum I., Young S., Walker B.J., Lander E., Lindblad-Toh K.;
RT "The draft genome of Latimeria chalumnae.";
RL Submitted (AUG-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSLACP00000000991.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004651};
CC Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
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DR EMBL; AFYH01264129; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; H2ZUC0; -.
DR Ensembl; ENSLACT00000001000.1; ENSLACP00000000991.1; ENSLACG00000000886.1.
DR eggNOG; KOG1056; Eukaryota.
DR GeneTree; ENSGT00950000182788; -.
DR HOGENOM; CLU_005389_5_1_1; -.
DR InParanoid; H2ZUC0; -.
DR TreeFam; TF331269; -.
DR Proteomes; UP000008672; Unassembled WGS sequence.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0004930; F:G protein-coupled receptor activity; IEA:UniProtKB-KW.
DR CDD; cd15283; 7tmC_V2R_pheromone; 1.
DR Gene3D; 3.40.50.2300; -; 2.
DR Gene3D; 2.10.50.30; GPCR, family 3, nine cysteines domain; 1.
DR InterPro; IPR001828; ANF_lig-bd_rcpt.
DR InterPro; IPR000337; GPCR_3.
DR InterPro; IPR011500; GPCR_3_9-Cys_dom.
DR InterPro; IPR038550; GPCR_3_9-Cys_sf.
DR InterPro; IPR017978; GPCR_3_C.
DR InterPro; IPR000068; GPCR_3_Ca_sens_rcpt-rel.
DR InterPro; IPR028082; Peripla_BP_I.
DR PANTHER; PTHR24061; CALCIUM-SENSING RECEPTOR-RELATED; 1.
DR PANTHER; PTHR24061:SF0; VOMERONASAL 2, RECEPTOR 23-RELATED; 1.
DR Pfam; PF00003; 7tm_3; 1.
DR Pfam; PF01094; ANF_receptor; 1.
DR Pfam; PF07562; NCD3G; 1.
DR PRINTS; PR00592; CASENSINGR.
DR PRINTS; PR00248; GPCRMGR.
DR SUPFAM; SSF53822; Periplasmic binding protein-like I; 1.
DR PROSITE; PS50259; G_PROTEIN_RECEP_F3_4; 1.
PE 4: Predicted;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW G-protein coupled receptor {ECO:0000256|ARBA:ARBA00023040};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Receptor {ECO:0000256|ARBA:ARBA00023170};
KW Reference proteome {ECO:0000313|Proteomes:UP000008672};
KW Transducer {ECO:0000256|ARBA:ARBA00023224};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 531..555
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 570..590
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 602..625
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 645..670
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 691..714
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 726..746
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 758..781
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 532..790
FT /note="G-protein coupled receptors family 3 profile"
FT /evidence="ECO:0000259|PROSITE:PS50259"
SQ SEQUENCE 800 AA; 90135 MW; 947CBE1BB120CB6A CRC64;
RFQLRQYRWL QSMVFAIEEI NRSEILLPNI TLGFGIYDSC FTESRAIKGT MWLMSGQEKT
IPNYQCQSHS PLAVVIGDTP SGSVISMARL LSIYHYPQIS YAAGSNSLSD KHKFPTFFRT
TSSNAFQSVS LAQLVMHFGC IWVGLLAVDG NNNNRVEGMR IVKEEILKAG GCIAFSEIVP
KYYSKEVYQH ITEVIKKSKA NAIVFFATEQ TLSPLMEEIV RQNITGKVWL TNAAWSLSPL
FSKRKFMNTL SGTIGIIPKS GNIPGFHDYQ YNIHPSTSPK DTWFKLFWEA AFECNWPESH
SSQTVNNVLS HENKMCSGKE KLSELDNIFF DVTDFRYTYN VYTAVYAAAH ALHNLHACKP
EEGPFSNGTC ANIREFEPWQ LLHYIKKVHF KMNDGRDIFF DRNGNLPPVY DILNWQITPS
NTLKNIKVGS IDFTAPKGQE LILNESAIFW NGGYTKVPRS VCSENCAPGY RKSVQLGQPV
CCFDCILCSD GEIANQSDSI MCQKCRDDEW SNERHDECIP KLIDYLSYEE LMGITFAVIS
LSSTLFPALI LYTFIKYRDT PLVKPNNREI SYLLLVGLML SFLCSLIFIG RPTRVTCMMR
QTVFGIIFAL CVSCVLAKTI MVVIAFNATK PNSMLKKWVG PKLSISIVVF CTVIQISICI
AWLSSAPPFP EKDMKSQIGM IIIGCNEGST TAFWCVLGYM GLLAIISFIV AFLARNLPDS
FNEASFITFS MLIFVSVWLA FIPAYVSTRG KYMVAVEIFA ILASSTGLLT CIFFSKCYII
LLMSDRNTKE YLLGKGTKSK
//
