ID H2ZUH0_LATCH Unreviewed; 1420 AA.
AC H2ZUH0;
DT 18-APR-2012, integrated into UniProtKB/TrEMBL.
DT 18-APR-2012, sequence version 1.
DT 27-MAR-2024, entry version 75.
DE RecName: Full=Cytoplasmic dynein 2 heavy chain 1 {ECO:0008006|Google:ProtNLM};
OS Latimeria chalumnae (Coelacanth).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Coelacanthiformes; Coelacanthidae; Latimeria.
OX NCBI_TaxID=7897 {ECO:0000313|Ensembl:ENSLACP00000001041.1, ECO:0000313|Proteomes:UP000008672};
RN [1] {ECO:0000313|Proteomes:UP000008672}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Wild caught {ECO:0000313|Proteomes:UP000008672};
RA Di Palma F., Alfoldi J., Johnson J., Berlin A., Gnerre S., Jaffe D.,
RA MacCallum I., Young S., Walker B.J., Lander E., Lindblad-Toh K.;
RT "The draft genome of Latimeria chalumnae.";
RL Submitted (AUG-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSLACP00000001041.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the dynein heavy chain family.
CC {ECO:0000256|ARBA:ARBA00008887}.
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DR EMBL; AFYH01094485; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01094486; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01094487; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01094488; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01094489; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01094490; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01094491; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01094492; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01094493; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01094494; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR STRING; 7897.ENSLACP00000001041; -.
DR Ensembl; ENSLACT00000001051.1; ENSLACP00000001041.1; ENSLACG00000000931.1.
DR eggNOG; KOG3595; Eukaryota.
DR GeneTree; ENSGT00940000154620; -.
DR HOGENOM; CLU_000038_1_1_1; -.
DR InParanoid; H2ZUH0; -.
DR OMA; SVVSHMH; -.
DR TreeFam; TF335573; -.
DR Proteomes; UP000008672; Unassembled WGS sequence.
DR GO; GO:0030286; C:dynein complex; IEA:InterPro.
DR GO; GO:0045505; F:dynein intermediate chain binding; IEA:InterPro.
DR GO; GO:0051959; F:dynein light intermediate chain binding; IEA:InterPro.
DR GO; GO:0008569; F:minus-end-directed microtubule motor activity; IEA:InterPro.
DR GO; GO:0007018; P:microtubule-based movement; IEA:InterPro.
DR Gene3D; 1.10.8.1220; -; 1.
DR Gene3D; 1.20.920.20; -; 1.
DR Gene3D; 1.20.920.30; -; 1.
DR Gene3D; 6.10.140.1060; -; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 3.
DR Gene3D; 1.10.8.720; Region D6 of dynein motor; 1.
DR InterPro; IPR035706; AAA_9.
DR InterPro; IPR041658; AAA_lid_11.
DR InterPro; IPR042219; AAA_lid_11_sf.
DR InterPro; IPR026983; DHC_fam.
DR InterPro; IPR024743; Dynein_HC_stalk.
DR InterPro; IPR024317; Dynein_heavy_chain_D4_dom.
DR InterPro; IPR004273; Dynein_heavy_D6_P-loop.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR45703:SF22; CYTOPLASMIC DYNEIN 2 HEAVY CHAIN 1; 1.
DR PANTHER; PTHR45703; DYNEIN HEAVY CHAIN; 1.
DR Pfam; PF12780; AAA_8; 1.
DR Pfam; PF12781; AAA_9; 1.
DR Pfam; PF18198; AAA_lid_11; 1.
DR Pfam; PF03028; Dynein_heavy; 1.
DR Pfam; PF12777; MT; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Reference proteome {ECO:0000313|Proteomes:UP000008672}.
FT DOMAIN 57..315
FT /note="Dynein heavy chain AAA module D4"
FT /evidence="ECO:0000259|Pfam:PF12780"
FT DOMAIN 331..662
FT /note="Dynein heavy chain coiled coil stalk"
FT /evidence="ECO:0000259|Pfam:PF12777"
FT DOMAIN 687..911
FT /note="Dynein heavy chain ATP-binding dynein motor region"
FT /evidence="ECO:0000259|Pfam:PF12781"
FT DOMAIN 1162..1270
FT /note="Dynein heavy chain region D6 P-loop"
FT /evidence="ECO:0000259|Pfam:PF03028"
FT DOMAIN 1303..1397
FT /note="Dynein heavy chain AAA lid"
FT /evidence="ECO:0000259|Pfam:PF18198"
FT COILED 331..411
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 547..630
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 1420 AA; 160866 MW; 5AD63E0429B70F14 CRC64;
ADCFYVTWGA LHEAGAVIAP GQPLPPHGKP LGRLTLPDLK EVVQKGITQY GRDNRELDIL
LFKEVLDYMS RVDRVLSCPG GSLLLAGRSG VGRRTATSVV SHMHGAVLFT PKISRGYGLK
QFKNDLKHVM QLAGIEGLQV VLLLEDHQFV HPAFLEMVNS LLSSGYCCEV PGLYTTEELE
PLLSPLKDQA SQDGFTGPIF NYFSYKIQQN LHIVLIMDCI NSNFTINCES NPALYKKCAV
QWMERWSDSS MKKIPEMLLS RTSGQEHNER IERGHKRKHS GDADLLKSFL MIHDSCREYG
ATPYQYMTFL HVYSSIYNTK KTELIKRQSH LQAGVSKLNE AKALVDELKR KAAEQSTLLK
TKQAEADAAL QEITVSMQNA SDQKTEMENI KHKIAEEVSK IEERKRKIEA ELKEVRPLVD
EAKLAVGNIK PEALSEIRSL RMPPDIIRDI LEGVLRLMGI FDTSWVSMKS FLAKRGVRED
IATFDARNIT KEIRQSVEEL LQRNRTSFEP KNAKRASAAA APLAAWVKAN VQYSHVLERI
QPLEKEQAGL LENLQKTEGK KHNLEELLNS VGQKVVELKD KFQTRTTEAA KLEAELNKAQ
ETIKAAEKLI SQLDGEHKRW NAQVAEITEE IETLPKRAQL AAAFITYLSA APEDQRKASL
EQWMQSSGLE KFDLRGFLCT ESEQLIWKSE GLPSDDLSME NAVVILQLSG MTSLSAACPF
LIDPSSQATE WLKTHLKESR LEVINQQDAN FITALELAVR FGKTLIIQEV DGVEPILYPL
LRRDLIAQGP RYVVQIGDKV IDHNEEFRLF LATRNPSPFI PPDAASVVTE INFTTTRAGL
RGQLLALTIQ HEKPDLEEQK TKLLHQEEEK KIQLAKLEES LLETLATSQG NILENKELIE
SLNQTKASSA LIEESLTESH RLQISLDQER DAYLPLAESA SKMYFIISDL SKINNMYCFS
LAAFLRLFQR ALQNKQECEK TEIRITSLIS SLTSMVYEYV CRSLFKVDQL MFALHFVRGM
HPELFQENEW DTFTGLIVGD MIRKPDSQKS IHDQIPAWID QDRAGAVITL KTTFPVLYQT
LLLEDTDLWL TFSRSSICEQ DFPPSIVKKI TLFQQVLVVQ AIRPDRLQSA MAFFASKALG
MKELSPPPLN LKRLYKETLE IEPILLIISP GADPSQELQE LATVEIGREC YHEVAMGQGQ
ADVAIQTLKE CAHNGEWLCL KNLHLVTAWL PVLEKDLNTL QPKSSFRLWL TAEVHPKFTP
ILLQSSLKIT YEAPPGLKKN LMRTYESWTS EQISKKGLLP RAHSLFSLAW FHAVCQERRN
YIPQGWTKFY EFSLSDLRAG YEIIDRLFDG TKDFQWEFVH GLLENAIYGG RIDNYFDLRV
LRSYLEQFFN VKSISGSQSR GKKLSGLPSS ISLPSSCNIL
//
