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Database: UniProt
Entry: H2ZWB1_LATCH
LinkDB: H2ZWB1_LATCH
Original site: H2ZWB1_LATCH 
ID   H2ZWB1_LATCH            Unreviewed;      1303 AA.
AC   H2ZWB1;
DT   18-APR-2012, integrated into UniProtKB/TrEMBL.
DT   18-APR-2012, sequence version 1.
DT   16-OCT-2019, entry version 57.
DE   SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSLACP00000001682};
GN   Name=ARHGAP5 {ECO:0000313|Ensembl:ENSLACP00000001682};
OS   Latimeria chalumnae (Coelacanth).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Coelacanthiformes; Coelacanthidae; Latimeria.
OX   NCBI_TaxID=7897 {ECO:0000313|Ensembl:ENSLACP00000001682, ECO:0000313|Proteomes:UP000008672};
RN   [1] {ECO:0000313|Ensembl:ENSLACP00000001682}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Wild caught {ECO:0000313|Ensembl:ENSLACP00000001682};
RX   PubMed=9215903;
RA   Zardoya R., Meyer A.;
RT   "The complete DNA sequence of the mitochondrial genome of a 'living
RT   fossil,' the coelacanth (Latimeria chalumnae).";
RL   Genetics 146:995-1010(1997).
RN   [2] {ECO:0000313|Proteomes:UP000008672}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Wild caught {ECO:0000313|Proteomes:UP000008672};
RA   Di Palma F., Alfoldi J., Johnson J., Berlin A., Gnerre S., Jaffe D.,
RA   MacCallum I., Young S., Walker B.J., Lander E., Lindblad-Toh K.;
RT   "The draft genome of Latimeria chalumnae.";
RL   Submitted (AUG-2011) to the EMBL/GenBank/DDBJ databases.
RN   [3] {ECO:0000313|Ensembl:ENSLACP00000001682}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (FEB-2012) to UniProtKB.
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DR   EMBL; AFYH01171102; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AFYH01171103; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   RefSeq; XP_006006418.1; XM_006006356.2.
DR   RefSeq; XP_014350269.1; XM_014494783.1.
DR   STRING; 7897.ENSLACP00000001682; -.
DR   Ensembl; ENSLACT00000001695; ENSLACP00000001682; ENSLACG00000001505.
DR   GeneID; 102361826; -.
DR   KEGG; lcm:102361826; -.
DR   CTD; 394; -.
DR   eggNOG; KOG4271; Eukaryota.
DR   eggNOG; ENOG410XR4E; LUCA.
DR   GeneTree; ENSGT00940000154553; -.
DR   InParanoid; H2ZWB1; -.
DR   KO; K13709; -.
DR   OMA; HIDKVND; -.
DR   OrthoDB; 110157at2759; -.
DR   TreeFam; TF324451; -.
DR   Proteomes; UP000008672; Unassembled WGS sequence.
DR   GO; GO:0005525; F:GTP binding; IEA:InterPro.
DR   GO; GO:0003924; F:GTPase activity; IEA:InterPro.
DR   GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR   Gene3D; 1.10.10.440; -; 3.
DR   Gene3D; 1.10.555.10; -; 1.
DR   InterPro; IPR002713; FF_domain.
DR   InterPro; IPR036517; FF_domain_sf.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR039007; pG1.
DR   InterPro; IPR008936; Rho_GTPase_activation_prot.
DR   InterPro; IPR032835; RhoGAP-FF1.
DR   InterPro; IPR039006; RhoGAP_pG2.
DR   InterPro; IPR001806; Small_GTPase.
DR   Pfam; PF01846; FF; 1.
DR   Pfam; PF00071; Ras; 1.
DR   Pfam; PF16512; RhoGAP-FF1; 1.
DR   SMART; SM00441; FF; 4.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   SUPFAM; SSF81698; SSF81698; 2.
DR   PROSITE; PS51676; FF; 4.
DR   PROSITE; PS51852; PG1; 1.
DR   PROSITE; PS51853; PG2; 1.
PE   4: Predicted;
KW   Complete proteome {ECO:0000313|Proteomes:UP000008672};
KW   Reference proteome {ECO:0000313|Proteomes:UP000008672}.
FT   DOMAIN      275    334       FF. {ECO:0000259|PROSITE:PS51676}.
FT   DOMAIN      375    429       FF. {ECO:0000259|PROSITE:PS51676}.
FT   DOMAIN      436    490       FF. {ECO:0000259|PROSITE:PS51676}.
FT   DOMAIN      491    557       FF. {ECO:0000259|PROSITE:PS51676}.
FT   DOMAIN      599    772       PG1 pseudoGTPase. {ECO:0000259|PROSITE:
FT                                PS51852}.
FT   DOMAIN      788    953       PG2 pseudoGTPase. {ECO:0000259|PROSITE:
FT                                PS51853}.
FT   REGION      962   1013       Disordered. {ECO:0000256|SAM:MobiDB-
FT                                lite}.
FT   REGION     1033   1059       Disordered. {ECO:0000256|SAM:MobiDB-
FT                                lite}.
FT   REGION     1081   1101       Disordered. {ECO:0000256|SAM:MobiDB-
FT                                lite}.
FT   REGION     1135   1157       Disordered. {ECO:0000256|SAM:MobiDB-
FT                                lite}.
FT   REGION     1177   1265       Disordered. {ECO:0000256|SAM:MobiDB-
FT                                lite}.
FT   COMPBIAS    962    984       Polar. {ECO:0000256|SAM:MobiDB-lite}.
FT   COMPBIAS   1035   1049       Polyampholyte. {ECO:0000256|SAM:MobiDB-
FT                                lite}.
FT   COMPBIAS   1142   1157       Polyampholyte. {ECO:0000256|SAM:MobiDB-
FT                                lite}.
FT   COMPBIAS   1177   1205       Polyampholyte. {ECO:0000256|SAM:MobiDB-
FT                                lite}.
SQ   SEQUENCE   1303 AA;  149337 MW;  F59A05BDB20ADA85 CRC64;
     MLKNERRIMM AKNKEPRPPA YSISVVGLSG TEKDKGNCGV GKSCLCNRYV RPKADEYYPE
     HTSVLSTIDF GGRVVNNDHF LYWGEVAYSG EDGVECKIQV IEQTEFIDDQ TFLPHRSTNL
     QPYVKRAAAT KLQSAEKLMY ICTDQLGLEQ DFEQKQMLDG KLNIDAFLLC IDVSQGCNRK
     FDDQVKFVSN LYTQLAKSKK PIVIAATKCD ECVDHYLREV QLFASSKKNL IVVETSARFN
     VNVESCFTAL VQMLDKTRGK PKIILYLDAY KTQRQLVATA ADKFEKLIGQ TVRDFHATWK
     TVSNKLKNHP DYEEYINLEG TKKAKNIFSK HIEQLKQEHI RKRRDEYIAA LPKAFNSLLS
     DLEEIVTLSW SEAQKLLEKR ADFPFWFVVL EKTPWDETEH IDKVNDRRIP FDLLLTSEAE
     KVYQNHVQHL ISEKRRGEMK EKFKKTLEKV QFISPGQPWE EVMCFVMEDE AYKYITETDR
     RDVYSRHQGE IVEKAKEEFQ EMLFEHSELF YDLDLNATPS IDKMSEIHRV LGEEPRYRAL
     QRLAPDRESL LFKHIGFVYH PTKETCLSGQ CCMDIKVEHV LANSLLHLDL GRLNLYHDSA
     NFDRVNLFIL GREGLAQELA NEIRAQSTDD EYALDGKIYE LDLRPMDANS PFLLSHFWTS
     SFKPHGCFCV FNSIESLNFV GECIEKIRAE AAQVRRDRYI AHLPFTLILA NQRDSVGKNL
     PILRHQGQQL ANQLQCPFVD VPSGTYPRKF NETQIKQALR GILETMKHSL DVVSSVPAIK
     DLSEADLRIV MCAMCGDPFS VDLILSPFLD SHSCSAAQPG QNNSLMLDKI IGEKRRRIQI
     TILSYHSSIG VRKDELVHGY ILVYSAKRKA SMAMLRAFLA EVQDVIPVQL VAVTDSQADF
     FENEAIKELM TEGEHIATEI TAKFTALYSL SQYHRQTEVF TLFFSEVLEK KNVIENSYLC
     DSTRDSTNAS EDVFTQSPRE SSPAYNYYEG SDDDTEAPPP YSPIGDDVQL LPTPSDRAKY
     RLDLEGNEYP MHSTPANTHD HERNHKVPPP VKPKPAIPKA NVKKLDPNLL KTIEAGIGKN
     PRKRVPLAHP EDIDSSDNYA DPVDALKSRR FSDDNYAVPD DSQHRIIKIR NSFISNPQGD
     EENGLSDRKL LGERRPSKYK YKSQTLFSKA KSYYRRTHSD ASDDESVPAC KTKKKGRHRG
     SEEDPLLSPV DTWKGGIDNP AITSDQELDD KKTKKKKPPK VKENKKQKPK TKPFNPPTRR
     NWESNYFGMP LQDLVTPEKP IPQFIKKCVE FIEDTGRVQV WSF
//
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