ID   H2ZWK8_LATCH            Unreviewed;       535 AA.
AC   H2ZWK8;
DT   18-APR-2012, integrated into UniProtKB/TrEMBL.
DT   18-APR-2012, sequence version 1.
DT   27-MAR-2024, entry version 59.
DE   SubName: Full=Polypyrimidine tract binding protein 2 {ECO:0000313|Ensembl:ENSLACP00000001779.1};
GN   Name=PTBP2 {ECO:0000313|Ensembl:ENSLACP00000001779.1};
OS   Latimeria chalumnae (Coelacanth).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Coelacanthiformes; Coelacanthidae; Latimeria.
OX   NCBI_TaxID=7897 {ECO:0000313|Ensembl:ENSLACP00000001779.1, ECO:0000313|Proteomes:UP000008672};
RN   [1] {ECO:0000313|Proteomes:UP000008672}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Wild caught {ECO:0000313|Proteomes:UP000008672};
RA   Di Palma F., Alfoldi J., Johnson J., Berlin A., Gnerre S., Jaffe D.,
RA   MacCallum I., Young S., Walker B.J., Lander E., Lindblad-Toh K.;
RT   "The draft genome of Latimeria chalumnae.";
RL   Submitted (AUG-2011) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSLACP00000001779.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (NOV-2023) to UniProtKB.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; AFYH01164077; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AFYH01164078; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AFYH01164079; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AFYH01164080; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AFYH01164081; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AFYH01164082; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AFYH01164083; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   AlphaFoldDB; H2ZWK8; -.
DR   STRING; 7897.ENSLACP00000001779; -.
DR   Ensembl; ENSLACT00000001792.1; ENSLACP00000001779.1; ENSLACG00000001589.1.
DR   eggNOG; KOG1190; Eukaryota.
DR   GeneTree; ENSGT01050000244924; -.
DR   HOGENOM; CLU_015171_7_1_1; -.
DR   InParanoid; H2ZWK8; -.
DR   OMA; IHHVLYP; -.
DR   TreeFam; TF319824; -.
DR   Proteomes; UP000008672; Unassembled WGS sequence.
DR   Bgee; ENSLACG00000001589; Expressed in pelvic fin and 6 other cell types or tissues.
DR   GO; GO:0005634; C:nucleus; IEA:InterPro.
DR   GO; GO:0003723; F:RNA binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0006397; P:mRNA processing; IEA:InterPro.
DR   CDD; cd12778; RRM1_PTBP2; 1.
DR   CDD; cd12783; RRM2_PTBP2; 1.
DR   Gene3D; 3.30.70.330; -; 4.
DR   InterPro; IPR006536; HnRNP-L/PTB.
DR   InterPro; IPR012677; Nucleotide-bd_a/b_plait_sf.
DR   InterPro; IPR021790; PTBP1-like_RRM2.
DR   InterPro; IPR035002; PTBP2_RRM1.
DR   InterPro; IPR035979; RBD_domain_sf.
DR   InterPro; IPR000504; RRM_dom.
DR   NCBIfam; TIGR01649; hnRNP-L_PTB; 1.
DR   PANTHER; PTHR15592; MATRIN 3/NUCLEAR PROTEIN 220-RELATED; 1.
DR   PANTHER; PTHR15592:SF16; POLYPYRIMIDINE TRACT-BINDING PROTEIN 2; 1.
DR   Pfam; PF00076; RRM_1; 1.
DR   Pfam; PF13893; RRM_5; 1.
DR   Pfam; PF11835; RRM_8; 1.
DR   SMART; SM00360; RRM; 3.
DR   SUPFAM; SSF54928; RNA-binding domain, RBD; 4.
DR   PROSITE; PS50102; RRM; 3.
PE   4: Predicted;
KW   Reference proteome {ECO:0000313|Proteomes:UP000008672};
KW   Repeat {ECO:0000256|ARBA:ARBA00022737};
KW   RNA-binding {ECO:0000256|ARBA:ARBA00022884, ECO:0000256|PROSITE-
KW   ProRule:PRU00176}.
FT   DOMAIN          58..142
FT                   /note="RRM"
FT                   /evidence="ECO:0000259|PROSITE:PS50102"
FT   DOMAIN          180..256
FT                   /note="RRM"
FT                   /evidence="ECO:0000259|PROSITE:PS50102"
FT   DOMAIN          458..533
FT                   /note="RRM"
FT                   /evidence="ECO:0000259|PROSITE:PS50102"
SQ   SEQUENCE   535 AA;  58497 MW;  312C4899A1E6AB10 CRC64;
     MLSITTRPYI GKRGSDELLS ASVLNGPNSN MSSIVVTANG NDNKKFKGDD RMDGTTSRVL
     HIRKLPSEVN ETEVISLGLP FGKVTNILML KGKNQAFLEL ATEEAAITMV NYYTAVTPHL
     RNQPIYIQYS NHKELKTDIT LNQRAQAVLQ AVTAVQAVNT PLSGSTVSES ALTPAQSPVL
     RIIIDNMYYP VTLDVLHQIF SKFGAVLKII TFTKNNQFQA LLQYADPMNA QQARLALDGQ
     NIYNACCTLR IDFSKLVNLN VKYNNDKSRD YTRPELPAGD GQPALDPTLA TAFTKETSLL
     AVPGALSPLA IPSAAAAAAA AAAAGRVALP GISAGGNTVL LVSNLNEEMV TPQSLFTLFG
     MLSKKKKKKS LHRRKICLLM HGSKGEKSGL IFLAMSHLNG QKMYGKIIRV TLSKHQTVQL
     PREGLDDQGL TKDFSNSPLH RFKKPGSKNF QNIFPPSATL HLSNIPPSVT EDDLRTLFAN
     TGGTVKAFKF FQRDHKMALL QMGTVEEAIQ ALIDLHNYNL GENHHLRVSF SKSTI
//