ID   H2ZWX4_LATCH            Unreviewed;       784 AA.
AC   H2ZWX4;
DT   18-APR-2012, integrated into UniProtKB/TrEMBL.
DT   18-APR-2012, sequence version 1.
DT   27-MAR-2024, entry version 63.
DE   SubName: Full=Thrombospondin type 1 domain containing 7A {ECO:0000313|Ensembl:ENSLACP00000001895.1};
GN   Name=THSD7A {ECO:0000313|Ensembl:ENSLACP00000001895.1};
OS   Latimeria chalumnae (Coelacanth).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Coelacanthiformes; Coelacanthidae; Latimeria.
OX   NCBI_TaxID=7897 {ECO:0000313|Ensembl:ENSLACP00000001895.1, ECO:0000313|Proteomes:UP000008672};
RN   [1] {ECO:0000313|Proteomes:UP000008672}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Wild caught {ECO:0000313|Proteomes:UP000008672};
RA   Di Palma F., Alfoldi J., Johnson J., Berlin A., Gnerre S., Jaffe D.,
RA   MacCallum I., Young S., Walker B.J., Lander E., Lindblad-Toh K.;
RT   "The draft genome of Latimeria chalumnae.";
RL   Submitted (AUG-2011) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSLACP00000001895.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (NOV-2023) to UniProtKB.
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DR   EMBL; AFYH01165751; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AFYH01165752; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AFYH01165753; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AFYH01165754; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AFYH01165755; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   AlphaFoldDB; H2ZWX4; -.
DR   STRING; 7897.ENSLACP00000001895; -.
DR   Ensembl; ENSLACT00000001908.1; ENSLACP00000001895.1; ENSLACG00000001693.1.
DR   eggNOG; KOG3538; Eukaryota.
DR   GeneTree; ENSGT00940000155427; -.
DR   HOGENOM; CLU_357755_0_0_1; -.
DR   InParanoid; H2ZWX4; -.
DR   OMA; CEKGYME; -.
DR   TreeFam; TF329791; -.
DR   Proteomes; UP000008672; Unassembled WGS sequence.
DR   Bgee; ENSLACG00000001693; Expressed in post-anal tail muscle.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR   Gene3D; 2.20.100.10; Thrombospondin type-1 (TSP1) repeat; 5.
DR   InterPro; IPR000884; TSP1_rpt.
DR   InterPro; IPR036383; TSP1_rpt_sf.
DR   InterPro; IPR044004; TSP1_spondin_dom.
DR   PANTHER; PTHR11311; SPONDIN; 1.
DR   PANTHER; PTHR11311:SF32; TSP1_SPONDIN DOMAIN-CONTAINING PROTEIN; 1.
DR   Pfam; PF19030; TSP1_ADAMTS; 1.
DR   Pfam; PF19028; TSP1_spondin; 3.
DR   Pfam; PF00090; TSP_1; 3.
DR   SMART; SM00209; TSP1; 8.
DR   SUPFAM; SSF82895; TSP-1 type 1 repeat; 7.
DR   PROSITE; PS50092; TSP1; 6.
PE   4: Predicted;
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000008672};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        734..757
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          166..208
FT                   /note="Spondin-like TSP1"
FT                   /evidence="ECO:0000259|Pfam:PF19028"
FT   DOMAIN          414..467
FT                   /note="Spondin-like TSP1"
FT                   /evidence="ECO:0000259|Pfam:PF19028"
FT   DOMAIN          542..601
FT                   /note="Spondin-like TSP1"
FT                   /evidence="ECO:0000259|Pfam:PF19028"
FT   REGION          691..717
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        702..717
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   784 AA;  87531 MW;  EE4D9F36D375F32C CRC64;
     ISCRRQDAGQ ADISECLKYA SSMPPITQTC QLPCQDDCQL TSWSKFSSCS GDCGTVRTRR
     RSLVGKSKKK DKCKNNQLFP LIETQFCPCD KYNAQPVGNW SDCILPEGKV EVLLGMKVQG
     DIKECGQGYR YQAMACYSEN RLVETARCNS HGYIEEACII PCPSDCKLSE WSNWSRCSKS
     CGSGVKVRSK WLREKPYNGG RPCPKLDHVN QVYEVVPCHS HCSQYVWVPE PWTACKVSNV
     DLKENCGEGV QTRKVRCMQN TIDGPSDVAE DYLCDPEEMP LGARKCKLPC PEDCVMSEWG
     EWTSCPLPCD GSVFRQRSAI PVRQPGEGKH CPNATEAEPC VLNRNCYHYE YNVTDWSTCQ
     LSEKAVCGSG IKTRMLDCVR SDGKSVNLEY CEELGLEKAW QMNMSCMVEC PVNCQLSDWS
     RWSECSQTCG LTGRMWRRRM VIQPSQGDGR PCPSLMTQSK PCPVKPCYKW QYRQWSECMV
     EDAQCGEGFR VRNLSCMVFD GSSDDPGKVV DEEFCGDLEL VVEGERRIVL KEACTVPCPG
     DCYLTGWSVW SPCQLTCVGG EEFGLGGLQV RSRSVIIQLL ENQDLCPEQT WESQPCTDGQ
     CYEYTWMTGA WKDSSRSVWC QRSDGVNVTG GCSLVKPDSD RSCKPPCSKP HSFCTEAGVC
     GCEEGYTEVM TSDGTLDQCT LIPVLEIPTS GDKKGDVKTS RAVNPTPPSN NQSGRGAKTW
     FLQPFGPDGK LKTWVYGVAA GAFVLLIFIV SMIYLACKKP KKPQRRQNNR LKPLTLAYDG
     DADM
//