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Database: UniProt
Entry: H2ZX84_LATCH
LinkDB: H2ZX84_LATCH
Original site: H2ZX84_LATCH 
ID   H2ZX84_LATCH            Unreviewed;       203 AA.
AC   H2ZX84;
DT   18-APR-2012, integrated into UniProtKB/TrEMBL.
DT   18-APR-2012, sequence version 1.
DT   31-JUL-2019, entry version 45.
DE   RecName: Full=RING-type domain-containing protein {ECO:0000259|PROSITE:PS50089};
GN   Name=RNF152 {ECO:0000313|Ensembl:ENSLACP00000002005};
OS   Latimeria chalumnae (Coelacanth).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Coelacanthiformes; Coelacanthidae; Latimeria.
OX   NCBI_TaxID=7897 {ECO:0000313|Ensembl:ENSLACP00000002005, ECO:0000313|Proteomes:UP000008672};
RN   [1] {ECO:0000313|Ensembl:ENSLACP00000002005}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Wild caught {ECO:0000313|Ensembl:ENSLACP00000002005};
RX   PubMed=9215903;
RA   Zardoya R., Meyer A.;
RT   "The complete DNA sequence of the mitochondrial genome of a 'living
RT   fossil,' the coelacanth (Latimeria chalumnae).";
RL   Genetics 146:995-1010(1997).
RN   [2] {ECO:0000313|Proteomes:UP000008672}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Wild caught {ECO:0000313|Proteomes:UP000008672};
RA   Di Palma F., Alfoldi J., Johnson J., Berlin A., Gnerre S., Jaffe D.,
RA   MacCallum I., Young S., Walker B.J., Lander E., Lindblad-Toh K.;
RT   "The draft genome of Latimeria chalumnae.";
RL   Submitted (AUG-2011) to the EMBL/GenBank/DDBJ databases.
RN   [3] {ECO:0000313|Ensembl:ENSLACP00000002005}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (FEB-2012) to UniProtKB.
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DR   EMBL; AFYH01193924; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   RefSeq; XP_006008379.1; XM_006008317.2.
DR   STRING; 7897.ENSLACP00000002005; -.
DR   Ensembl; ENSLACT00000002019; ENSLACP00000002005; ENSLACG00000001793.
DR   GeneID; 102367085; -.
DR   KEGG; lcm:102367085; -.
DR   CTD; 220441; -.
DR   eggNOG; ENOG410ITF4; Eukaryota.
DR   eggNOG; ENOG4111BNB; LUCA.
DR   GeneTree; ENSGT00730000111317; -.
DR   InParanoid; H2ZX84; -.
DR   KO; K15705; -.
DR   OMA; SQKDLRC; -.
DR   OrthoDB; 489543at2759; -.
DR   TreeFam; TF331690; -.
DR   Proteomes; UP000008672; Unassembled WGS sequence.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005764; C:lysosome; IEA:InterPro.
DR   GO; GO:0061630; F:ubiquitin protein ligase activity; IEA:InterPro.
DR   GO; GO:0006915; P:apoptotic process; IEA:InterPro.
DR   GO; GO:1904262; P:negative regulation of TORC1 signaling; IEA:InterPro.
DR   GO; GO:0010508; P:positive regulation of autophagy; IEA:InterPro.
DR   GO; GO:0000209; P:protein polyubiquitination; IEA:InterPro.
DR   Gene3D; 3.30.40.10; -; 1.
DR   InterPro; IPR033609; RNF152.
DR   InterPro; IPR001841; Znf_RING.
DR   InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR   PANTHER; PTHR25464:SF1; PTHR25464:SF1; 1.
DR   Pfam; PF14634; zf-RING_5; 1.
DR   SMART; SM00184; RING; 1.
DR   PROSITE; PS50089; ZF_RING_2; 1.
PE   4: Predicted;
KW   Complete proteome {ECO:0000313|Proteomes:UP000008672};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Metal-binding {ECO:0000256|PROSITE-ProRule:PRU00175};
KW   Reference proteome {ECO:0000313|Proteomes:UP000008672};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius};
KW   Zinc {ECO:0000256|PROSITE-ProRule:PRU00175};
KW   Zinc-finger {ECO:0000256|PROSITE-ProRule:PRU00175}.
FT   TRANSMEM    166    187       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN       12     55       RING-type. {ECO:0000259|PROSITE:PS50089}.
SQ   SEQUENCE   203 AA;  22682 MW;  84B22BC007ED1E1D CRC64;
     METLSQDSLF ECQICFNYYS PRRRPKLLDC KHTCCSVCLQ QMRTSQKDLR CPWCRGVTKL
     PPGFSVSQLP DDPEIIAIIA IPHVSEHTPV FIRLPSNGCY MLPLPMSKER ELLPGDLGCR
     LLPSNQQKSV TVVALPVEQQ PFQNGPGPEV EEEESEQRGI VKSSTWSGVC TVILVACVLL
     FLLGIVLHNM SCISKRFTMI SCG
//
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