ID H2ZXL8_LATCH Unreviewed; 358 AA.
AC H2ZXL8;
DT 18-APR-2012, integrated into UniProtKB/TrEMBL.
DT 18-APR-2012, sequence version 1.
DT 27-MAR-2024, entry version 50.
DE RecName: Full=NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, mitochondrial {ECO:0000256|ARBA:ARBA00017279, ECO:0000256|PIRNR:PIRNR000543};
GN Name=NDUFA10 {ECO:0000313|Ensembl:ENSLACP00000002139.1};
OS Latimeria chalumnae (Coelacanth).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Coelacanthiformes; Coelacanthidae; Latimeria.
OX NCBI_TaxID=7897 {ECO:0000313|Ensembl:ENSLACP00000002139.1, ECO:0000313|Proteomes:UP000008672};
RN [1] {ECO:0000313|Proteomes:UP000008672}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Wild caught {ECO:0000313|Proteomes:UP000008672};
RA Di Palma F., Alfoldi J., Johnson J., Berlin A., Gnerre S., Jaffe D.,
RA MacCallum I., Young S., Walker B.J., Lander E., Lindblad-Toh K.;
RT "The draft genome of Latimeria chalumnae.";
RL Submitted (AUG-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSLACP00000002139.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- FUNCTION: Accessory subunit of the mitochondrial membrane respiratory
CC chain NADH dehydrogenase (Complex I), that is believed not to be
CC involved in catalysis. Complex I functions in the transfer of electrons
CC from NADH to the respiratory chain. The immediate electron acceptor for
CC the enzyme is believed to be ubiquinone.
CC {ECO:0000256|ARBA:ARBA00003195, ECO:0000256|PIRNR:PIRNR000543}.
CC -!- COFACTOR:
CC Name=FAD; Xref=ChEBI:CHEBI:57692;
CC Evidence={ECO:0000256|ARBA:ARBA00001974,
CC ECO:0000256|PIRNR:PIRNR000543};
CC -!- SUBUNIT: Complex I is composed of 45 different subunits. This a
CC component of the hydrophobic protein fraction.
CC {ECO:0000256|ARBA:ARBA00011514}.
CC -!- SUBCELLULAR LOCATION: Mitochondrion matrix
CC {ECO:0000256|ARBA:ARBA00004305, ECO:0000256|PIRNR:PIRNR000543}.
CC -!- SIMILARITY: Belongs to the complex I NDUFA10 subunit family.
CC {ECO:0000256|ARBA:ARBA00008606, ECO:0000256|PIRNR:PIRNR000543}.
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DR EMBL; AFYH01069805; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01069806; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01069807; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01069808; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01069809; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; H2ZXL8; -.
DR STRING; 7897.ENSLACP00000002139; -.
DR Ensembl; ENSLACT00000002155.1; ENSLACP00000002139.1; ENSLACG00000001912.1.
DR eggNOG; KOG3877; Eukaryota.
DR GeneTree; ENSGT00390000016151; -.
DR InParanoid; H2ZXL8; -.
DR OMA; MFRQGYI; -.
DR TreeFam; TF314616; -.
DR Proteomes; UP000008672; Unassembled WGS sequence.
DR Bgee; ENSLACG00000001912; Expressed in chordate pharynx and 6 other cell types or tissues.
DR GO; GO:0005759; C:mitochondrial matrix; IEA:UniProtKB-SubCell.
DR GO; GO:0005747; C:mitochondrial respiratory chain complex I; IEA:InterPro.
DR GO; GO:0006120; P:mitochondrial electron transport, NADH to ubiquinone; IEA:InterPro.
DR CDD; cd02030; NDUO42; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR InterPro; IPR031314; DNK_dom.
DR InterPro; IPR015828; NDUFA10.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR10513; DEOXYNUCLEOSIDE KINASE; 1.
DR PANTHER; PTHR10513:SF15; NADH DEHYDROGENASE [UBIQUINONE] 1 ALPHA SUBCOMPLEX SUBUNIT 10, MITOCHONDRIAL; 1.
DR Pfam; PF01712; dNK; 1.
DR PIRSF; PIRSF000543; NADH_UQ_42KD; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
PE 3: Inferred from homology;
KW Electron transport {ECO:0000256|ARBA:ARBA00022982,
KW ECO:0000256|PIRNR:PIRNR000543};
KW FAD {ECO:0000256|ARBA:ARBA00022827, ECO:0000256|PIRNR:PIRNR000543};
KW Flavoprotein {ECO:0000256|ARBA:ARBA00022630,
KW ECO:0000256|PIRNR:PIRNR000543};
KW Mitochondrion {ECO:0000256|PIRNR:PIRNR000543};
KW Reference proteome {ECO:0000313|Proteomes:UP000008672};
KW Respiratory chain {ECO:0000256|ARBA:ARBA00022660,
KW ECO:0000256|PIRNR:PIRNR000543};
KW Transport {ECO:0000256|ARBA:ARBA00022448, ECO:0000256|PIRNR:PIRNR000543}.
FT DOMAIN 63..274
FT /note="Deoxynucleoside kinase"
FT /evidence="ECO:0000259|Pfam:PF01712"
SQ SEQUENCE 358 AA; 41461 MW; A2D7F0AAD32D3EDC CRC64;
MAAALGFGAR GLWKVVSARA LWAAGQKLAR LHVSATRKLQ YGWLAYVLGE RTTSRFNEKS
KIITVDGNLA SGKENVARNL ADKLGMLYMP EADVHYLDRI TGDGQLLDPR FSGNCSLEKF
YLDPKCPDGN SYRLQFWMYT VRLLQYSDAL EHLICTGQGV VLERSPYSDF VFLEAMYKQG
FIRKECVEHY NEVKGISICE FLPPHIVIYV DQPVSEVEKR LKSRRQRFKY NLPIDYLKSI
EDAYKKTFLP QISETSEVLE YNIEQVQNIE RVVEDIEYLK FDKGPWLEQD DVTFHRLRLL
VQDKDKVSDL VIIPRFLPEV TIGAHEYDKA YHDYKSLPGR KYDAGFNADV GDKWIWLK
//
