ID H2ZXV8_LATCH Unreviewed; 329 AA.
AC H2ZXV8;
DT 18-APR-2012, integrated into UniProtKB/TrEMBL.
DT 18-APR-2012, sequence version 1.
DT 27-MAR-2024, entry version 58.
DE RecName: Full=Interleukin-12 subunit beta {ECO:0000256|RuleBase:RU281113};
DE Short=IL-12B {ECO:0000256|RuleBase:RU281113};
DE AltName: Full=Cytotoxic lymphocyte maturation factor 40 kDa subunit {ECO:0000256|RuleBase:RU281113};
DE AltName: Full=IL-12 subunit p40 {ECO:0000256|RuleBase:RU281113};
GN Name=IL12B {ECO:0000256|RuleBase:RU281113,
GN ECO:0000313|Ensembl:ENSLACP00000002229.1};
OS Latimeria chalumnae (Coelacanth).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Coelacanthiformes; Coelacanthidae; Latimeria.
OX NCBI_TaxID=7897 {ECO:0000313|Ensembl:ENSLACP00000002229.1, ECO:0000313|Proteomes:UP000008672};
RN [1] {ECO:0000313|Proteomes:UP000008672}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Wild caught {ECO:0000313|Proteomes:UP000008672};
RA Di Palma F., Alfoldi J., Johnson J., Berlin A., Gnerre S., Jaffe D.,
RA MacCallum I., Young S., Walker B.J., Lander E., Lindblad-Toh K.;
RT "The draft genome of Latimeria chalumnae.";
RL Submitted (AUG-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSLACP00000002229.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBUNIT: Heterodimer with IL12A; disulfide-linked. The heterodimer is
CC known as interleukin IL-12. {ECO:0000256|RuleBase:RU281113}.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|RuleBase:RU281113}.
CC -!- SIMILARITY: Belongs to the IL-12B family.
CC {ECO:0000256|RuleBase:RU281113}.
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DR EMBL; AFYH01230441; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01230442; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; H2ZXV8; -.
DR Ensembl; ENSLACT00000002247.1; ENSLACP00000002229.1; ENSLACG00000001990.1.
DR eggNOG; ENOG502RZMA; Eukaryota.
DR GeneTree; ENSGT00390000012630; -.
DR HOGENOM; CLU_071206_1_0_1; -.
DR InParanoid; H2ZXV8; -.
DR OMA; VAIWELK; -.
DR TreeFam; TF334829; -.
DR Proteomes; UP000008672; Unassembled WGS sequence.
DR Bgee; ENSLACG00000001990; Expressed in mesonephros.
DR GO; GO:0005615; C:extracellular space; IEA:UniProtKB-KW.
DR GO; GO:0005125; F:cytokine activity; IEA:UniProtKB-KW.
DR GO; GO:0004896; F:cytokine receptor activity; IEA:UniProtKB-UniRule.
DR CDD; cd00063; FN3; 1.
DR Gene3D; 2.60.40.10; Immunoglobulins; 3.
DR InterPro; IPR003961; FN3_dom.
DR InterPro; IPR036116; FN3_sf.
DR InterPro; IPR007110; Ig-like_dom.
DR InterPro; IPR036179; Ig-like_dom_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR015528; IL-12_beta.
DR InterPro; IPR019482; IL-12_beta_cen-dom.
DR InterPro; IPR015373; Interferon/interleukin_rcp_dom.
DR PANTHER; PTHR48397:SF1; INTERLEUKIN-12 SUBUNIT BETA; 1.
DR PANTHER; PTHR48397; INTERLEUKIN-12 SUBUNIT BETA-RELATED; 1.
DR Pfam; PF10420; IL12p40_C; 1.
DR Pfam; PF09294; Interfer-bind; 1.
DR PIRSF; PIRSF038007; IL_12_beta; 1.
DR PRINTS; PR01928; INTRLEUKN12B.
DR SUPFAM; SSF49265; Fibronectin type III; 2.
DR SUPFAM; SSF48726; Immunoglobulin; 1.
DR PROSITE; PS50853; FN3; 1.
DR PROSITE; PS50835; IG_LIKE; 1.
PE 3: Inferred from homology;
KW Cytokine {ECO:0000256|RuleBase:RU281113};
KW Glycoprotein {ECO:0000256|RuleBase:RU281113};
KW Immunoglobulin domain {ECO:0000256|ARBA:ARBA00023319,
KW ECO:0000256|RuleBase:RU281113};
KW Reference proteome {ECO:0000313|Proteomes:UP000008672};
KW Secreted {ECO:0000256|RuleBase:RU281113};
KW Signal {ECO:0000256|RuleBase:RU281113}.
FT SIGNAL 1..20
FT /evidence="ECO:0000256|RuleBase:RU281113"
FT CHAIN 21..329
FT /note="Interleukin-12 subunit beta"
FT /evidence="ECO:0000256|RuleBase:RU281113"
FT /id="PRO_5009367213"
FT DOMAIN 26..104
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 238..329
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
SQ SEQUENCE 329 AA; 38228 MW; 5FBB2FB61DAF941F CRC64;
MHFLWIIFSL LCWSVNPLEG KWLFKPNIYI VDSEMTPDTP AEPITLHCDA PEDQNPSGIV
WKRNFGEGPY KIPEKGNTIT INVKDYPDAG NYTCHLASKD EIINYTVIAI HVVNKGKKEE
NSKKILKKID GPKQTRFVDC EARSYCGAFN CSWTLDKKTG KENVMFSIKF LEGFKSNRSV
ICDEPTTTDD LTYTAECRDQ NFCPYAEEDT PIDISLQVIQ GIQYENYTET FFIRDIVKPD
PPQHLTMKKE NNNLTISWQY PEFWSKPHSY FPLTFEVKVT EEQKAEKVNS YFTDEEEKVI
TVNPGKNYCV CVRAKDRYFN SRWSSWNCE
//
