ID   H2ZXZ6_LATCH            Unreviewed;       662 AA.
AC   H2ZXZ6;
DT   18-APR-2012, integrated into UniProtKB/TrEMBL.
DT   18-APR-2012, sequence version 1.
DT   27-MAR-2024, entry version 51.
DE   RecName: Full=DUF4371 domain-containing protein {ECO:0000259|Pfam:PF14291};
OS   Latimeria chalumnae (Coelacanth).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Coelacanthiformes; Coelacanthidae; Latimeria.
OX   NCBI_TaxID=7897 {ECO:0000313|Ensembl:ENSLACP00000002267.1, ECO:0000313|Proteomes:UP000008672};
RN   [1] {ECO:0000313|Proteomes:UP000008672}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Wild caught {ECO:0000313|Proteomes:UP000008672};
RA   Di Palma F., Alfoldi J., Johnson J., Berlin A., Gnerre S., Jaffe D.,
RA   MacCallum I., Young S., Walker B.J., Lander E., Lindblad-Toh K.;
RT   "The draft genome of Latimeria chalumnae.";
RL   Submitted (AUG-2011) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSLACP00000002267.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (NOV-2023) to UniProtKB.
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DR   EMBL; AFYH01189989; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   AlphaFoldDB; H2ZXZ6; -.
DR   STRING; 7897.ENSLACP00000002267; -.
DR   Ensembl; ENSLACT00000002285.1; ENSLACP00000002267.1; ENSLACG00000002025.1.
DR   eggNOG; ENOG502QPQD; Eukaryota.
DR   GeneTree; ENSGT00940000154356; -.
DR   HOGENOM; CLU_006175_4_3_1; -.
DR   InParanoid; H2ZXZ6; -.
DR   OMA; CKVERRW; -.
DR   TreeFam; TF354338; -.
DR   Proteomes; UP000008672; Unassembled WGS sequence.
DR   InterPro; IPR025398; DUF4371.
DR   InterPro; IPR012337; RNaseH-like_sf.
DR   PANTHER; PTHR45749; -; 1.
DR   PANTHER; PTHR45749:SF29; DIMER_TNP_HAT DOMAIN-CONTAINING PROTEIN; 1.
DR   Pfam; PF14291; DUF4371; 1.
DR   SUPFAM; SSF53098; Ribonuclease H-like; 1.
PE   4: Predicted;
KW   Reference proteome {ECO:0000313|Proteomes:UP000008672}.
FT   DOMAIN          258..428
FT                   /note="DUF4371"
FT                   /evidence="ECO:0000259|Pfam:PF14291"
FT   REGION          26..108
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        51..65
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   662 AA;  74505 MW;  6726E2930F0861BC CRC64;
     PASKKRKLSG AEYLKRQKRI AAAQCQKLDT FFSPTTRSGN DDASMEDDGK ESGVSLSSST
     HEPVAPESHD NPVPQQDHAL PPAEADSADC DVDMDTSTGL DINDAEPHTG SSIDNALVRC
     LIEIGPCQPG LKDDFTFPYD ESHRRFSHDW YSKTVGNGSC KVERRWLIYL PRLHRLFCFA
     CWLAADRKNT WVGPKCGFSN LKKGVEKIEK HENLKIHCNA EKELLLTKHR FLQDKTVVTG
     LLKAEREQIQ KSRQILRLID AALFLAQQGL AFRGHREYSC GSQNEGNYLE LLKLLAKYDA
     LLAQHIKTPK RNETYLSHQI QNDFIHALAT EVLSAIKHEV QETKFFSVIV DSTIDIGHVD
     QFSLSLRYVK ATGQAVEHFI TFHDLPGSSA ENFFSILESS LETLNINMAH CQDQAYDRAS
     TMSGNISGLQ SRKEISPTAL FVHCCAHNLN LVLMDAASCC TNVQLFFGTI ESLYTFLTGS
     LPCLRILEDE QEQLDNAVQV LKKLSDTQWA CRKRAIDAAV QSLPTLYNAL DRIVSGGIPN
     CKPKVFSDVQ GLLSTTETFE FKFMLIFWRN VLNKIYTLST VLQSSTIDLT TTLKFLDTCL
     SDVEALRSDI ALQLAKECGT TVSFHEKRAK KKKKFPDENH EDGPIKDARQ KFKVETYFYL
     LD
//