ID H2ZY24_LATCH Unreviewed; 2134 AA.
AC H2ZY24;
DT 18-APR-2012, integrated into UniProtKB/TrEMBL.
DT 18-APR-2012, sequence version 1.
DT 27-MAR-2024, entry version 73.
DE SubName: Full=Bromodomain adjacent to zinc finger domain 2B {ECO:0000313|Ensembl:ENSLACP00000002295.1};
GN Name=BAZ2B {ECO:0000313|Ensembl:ENSLACP00000002295.1};
OS Latimeria chalumnae (Coelacanth).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Coelacanthiformes; Coelacanthidae; Latimeria.
OX NCBI_TaxID=7897 {ECO:0000313|Ensembl:ENSLACP00000002295.1, ECO:0000313|Proteomes:UP000008672};
RN [1] {ECO:0000313|Proteomes:UP000008672}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Wild caught {ECO:0000313|Proteomes:UP000008672};
RA Di Palma F., Alfoldi J., Johnson J., Berlin A., Gnerre S., Jaffe D.,
RA MacCallum I., Young S., Walker B.J., Lander E., Lindblad-Toh K.;
RT "The draft genome of Latimeria chalumnae.";
RL Submitted (AUG-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSLACP00000002295.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the WAL family. {ECO:0000256|ARBA:ARBA00007444}.
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DR EMBL; AFYH01193208; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01193209; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01193210; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01193211; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01193212; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01193213; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01193214; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01193215; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01193216; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01193217; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR STRING; 7897.ENSLACP00000002295; -.
DR Ensembl; ENSLACT00000002313.1; ENSLACP00000002295.1; ENSLACG00000002050.2.
DR eggNOG; KOG1245; Eukaryota.
DR GeneTree; ENSGT00940000155359; -.
DR HOGENOM; CLU_000899_0_0_1; -.
DR InParanoid; H2ZY24; -.
DR OMA; XASGQTL; -.
DR TreeFam; TF329083; -.
DR Proteomes; UP000008672; Unassembled WGS sequence.
DR Bgee; ENSLACG00000002050; Expressed in pharyngeal gill and 6 other cell types or tissues.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-KW.
DR GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR CDD; cd05503; Bromo_BAZ2A_B_like; 1.
DR CDD; cd01397; HAT_MBD; 1.
DR CDD; cd15630; PHD_BAZ2B; 1.
DR Gene3D; 1.20.920.10; Bromodomain-like; 1.
DR Gene3D; 3.30.40.10; Zinc/RING finger domain, C3HC4 (zinc finger); 1.
DR InterPro; IPR037374; BAZ2A/B_Bromo.
DR InterPro; IPR001487; Bromodomain.
DR InterPro; IPR036427; Bromodomain-like_sf.
DR InterPro; IPR018359; Bromodomain_CS.
DR InterPro; IPR018501; DDT_dom.
DR InterPro; IPR016177; DNA-bd_dom_sf.
DR InterPro; IPR001739; Methyl_CpG_DNA-bd.
DR InterPro; IPR028941; WHIM2_dom.
DR InterPro; IPR011011; Znf_FYVE_PHD.
DR InterPro; IPR001965; Znf_PHD.
DR InterPro; IPR019787; Znf_PHD-finger.
DR InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR PANTHER; PTHR45915:SF1; BROMODOMAIN ADJACENT TO ZINC FINGER DOMAIN PROTEIN 2B; 1.
DR PANTHER; PTHR45915; TRANSCRIPTION INTERMEDIARY FACTOR; 1.
DR Pfam; PF00439; Bromodomain; 1.
DR Pfam; PF02791; DDT; 1.
DR Pfam; PF01429; MBD; 1.
DR Pfam; PF00628; PHD; 1.
DR Pfam; PF15613; WSD; 2.
DR PRINTS; PR00503; BROMODOMAIN.
DR SMART; SM00297; BROMO; 1.
DR SMART; SM00571; DDT; 1.
DR SMART; SM00391; MBD; 1.
DR SMART; SM00249; PHD; 1.
DR SUPFAM; SSF47370; Bromodomain; 1.
DR SUPFAM; SSF54171; DNA-binding domain; 1.
DR SUPFAM; SSF57903; FYVE/PHD zinc finger; 1.
DR PROSITE; PS00633; BROMODOMAIN_1; 1.
DR PROSITE; PS50014; BROMODOMAIN_2; 1.
DR PROSITE; PS50827; DDT; 1.
DR PROSITE; PS50982; MBD; 1.
DR PROSITE; PS50016; ZF_PHD_2; 1.
PE 3: Inferred from homology;
KW Bromodomain {ECO:0000256|ARBA:ARBA00023117, ECO:0000256|PROSITE-
KW ProRule:PRU00035}; Coiled coil {ECO:0000256|SAM:Coils};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000008672};
KW Transcription {ECO:0000256|ARBA:ARBA00023163};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW ProRule:PRU00146}.
FT DOMAIN 694..765
FT /note="MBD"
FT /evidence="ECO:0000259|PROSITE:PS50982"
FT DOMAIN 1042..1107
FT /note="DDT"
FT /evidence="ECO:0000259|PROSITE:PS50827"
FT DOMAIN 1896..1946
FT /note="PHD-type"
FT /evidence="ECO:0000259|PROSITE:PS50016"
FT DOMAIN 2043..2113
FT /note="Bromo"
FT /evidence="ECO:0000259|PROSITE:PS50014"
FT REGION 94..130
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 145..289
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 548..643
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 796..836
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 976..998
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1217..1289
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1439..1490
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1543..1572
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1634..1674
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1948..2003
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 1358..1385
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 96..130
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 176..197
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 198..217
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 218..243
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 244..280
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 565..614
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 628..643
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 796..825
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1253..1275
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1447..1490
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1634..1660
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1952..1966
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 2134 AA; 237614 MW; 3EF21BF9E1AFB0FA CRC64;
FLGHLLRAAG DPPFNLSAVS SAFPMVSHPV FGIHTTSSGR SEFGGLGTLG ASAALATHAQ
LSPFPGVEWW RTTDVHARAG APFFPPLLGI PQLFAPSPQN HDSSSFHSRT TNENGQSTQK
GLKGMNGAVN GSSIISTSDV SASQATTTTS SSGQAKVIKS GGHGRICSQE QTKSQLLDTE
AEKFKNKKPR KKTVDSSSNS ESDSGSSSDS SSEGMSSSDS EDLEEDDEDE DQSVEESEDD
DSDSESEAQH KNKTKVLMHS VKEVKNDEKK ALEQKSQDKR THQQIPLAAD LQTRASFQPQ
QKQPQVLSQQ LNFVFQSSQA KEESANKHPS VIQSTGLAPS VKPLSLVNQA KKETSPKLIV
PSPEIVKAGN KNTSDEKGSP INDLRMKREQ FKQTFPVQLK KQQEQYKNQK KVTGAVSSLK
STYVSPIHQK LLRVDGNHSN PFLANALLGH HQPNGVIQSV IQEAPLALTT KSRSQAKTNE
KLIPNSTSTT FCSPVNLSTT VKNHSSNPMT VVKPSTSPAL IQASGKDNLA SNNLLIGVKT
HLYTAPKSLD QCRGTDSDIP SSKDSDDSNE DDDEEDDEED DDEEEDTDDS QSESDSNSET
DSDGSEEDKG QDETETDTEG EKTPLKLYKT TPSKSNSSTG QLAHSAPLNL QLIKDSNSVP
AALARSPASP VFLGTSAALS SPSTPSGSVK RRRITDEREL RIPLEYGWQR EIRIKNIGGR
LQGEVAYYAP CGKKLRQYPE VIKYLNRNGI TDITRDNFSF SAKIRVGDFY EARDGPQGMQ
WCLLKEEEII PRIRSMEGRR GRPPNPDRQR VREELRMRRR KGRPPNVGTS EFPDSNNTKL
LRKLQAQEIA RQAAQIKLLR KLQKQEQARA AKEARKQQAI IAAEEKRKQK EQLKILKQQE
KIKRIQQVRM EKELRAQQIL EAKRKKKEEA ANAKIVEAEK RIKEKEMRRQ QAVLLKHQER
ERRRQHMMLM KAMEARKKAE EKERLKQEKR DEKRLNKERK LEQRRLELEM AKELKKPNED
MCLADQKPLP ELSRIPGLVL SGNTFSDCLM VVQFLRNFGK VLGFDVNIDV PSMSVLQEGL
LNVGDSMGEV QDLLVRLLSA AVCDPGVPSG HKVKTALGDN LMNVGINRDN VSEILQIYME
AHCGQTELTE SLTTKAFQAH TPAQKASVLA FLVNELACSK SIVSEIDKNI DYMSNLRRDK
WMVEGKLRKL RIIHAKKTGK KDSTMGADGS EEQHSLGTPT PGRKRKRKGG DSDDDDDEDD
DSDDQADEDD EDEEEKEEKK GKKETCEDEK TENNYVTNIF ALDRPSINIA KQQSQYRRKL
FEASHSLRSM MFGQDRYKRR YWVLPQCGGV FVEGMESGEG LEEMVKEKEK LKNAANAEIK
AEILEVSEHK TVSIKPASNY NQQCQEDFKE KANTNLFLQK PGSFSKLSKL LEVAKMPPES
DIVSKKQNGD PENITSVVSS SSQNNSQNSY CGSQPATSQS SSEKDSNVSP FSPLLSGSGK
YYNSPLLPND QLLKVLTEKS GQWFSLLPRT PCDDSSLLRK YEPATSSSLT PQTQSSSPSA
SPSPLLGSGS LQSPMGLNPF ALSTLQMKSG LPMMGLPFCG WPTGILSTNL PFSSPLPTLG
SGFGLAEGSN NPFLTPSIPT IKSESPGPQN DKTSSAPSPA VEGTKPMDYP SPRPIPEEMQ
CGWWRITDPE KLKALLKVLH LRGIREKTLQ KQIQKHIDYI SQACIKNKDV TIIDVNETEE
KLLTRKAVEN WSVEQKAMEI DLAILQQVED LERRVASASL QVKGWTYPEL DSERDDLVYC
EHKLLNKVCT AAEGEHGVED DARDSSIERQ SNNPLDLAVT RLAELERNIE RRAEENIAPG
LKVWRKALLD ARSAAQVALC IQQLQKSIAW EKSIMKVYCQ ICRKGDNEEL LLLCDGCDKG
CHTYCHRPKI TTIPEGDWFC PACIAKASGQ SPKSKKHNKG KKCNDQKRGR KTSLSGEAEE
EDAASTSSTP KKGGKEPKKR KLDEIISVNL SKQEIILPTK KPKATRDDSK DLAMCSMILS
EMETHEDAWP FLLPVNLKLV PGYKKVIKKP MDFFTIREKL SNGQYTDLET FALDVRLVFD
NCETFNEDDS DIGRAGHNMR SFFERRWIEL FKGS
//
