ID H2ZYC1_LATCH Unreviewed; 520 AA.
AC H2ZYC1;
DT 18-APR-2012, integrated into UniProtKB/TrEMBL.
DT 18-APR-2012, sequence version 1.
DT 27-MAR-2024, entry version 70.
DE RecName: Full=Sorting nexin-2 {ECO:0000256|ARBA:ARBA00020435};
GN Name=SNX2 {ECO:0000313|Ensembl:ENSLACP00000002392.1};
OS Latimeria chalumnae (Coelacanth).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Coelacanthiformes; Coelacanthidae; Latimeria.
OX NCBI_TaxID=7897 {ECO:0000313|Ensembl:ENSLACP00000002392.1, ECO:0000313|Proteomes:UP000008672};
RN [1] {ECO:0000313|Proteomes:UP000008672}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Wild caught {ECO:0000313|Proteomes:UP000008672};
RA Di Palma F., Alfoldi J., Johnson J., Berlin A., Gnerre S., Jaffe D.,
RA MacCallum I., Young S., Walker B.J., Lander E., Lindblad-Toh K.;
RT "The draft genome of Latimeria chalumnae.";
RL Submitted (AUG-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSLACP00000002392.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cell projection, lamellipodium
CC {ECO:0000256|ARBA:ARBA00004510}. Early endosome membrane
CC {ECO:0000256|ARBA:ARBA00004469}; Peripheral membrane protein
CC {ECO:0000256|ARBA:ARBA00004469}; Cytoplasmic side
CC {ECO:0000256|ARBA:ARBA00004469}. Endosome membrane
CC {ECO:0000256|ARBA:ARBA00004125}; Peripheral membrane protein
CC {ECO:0000256|ARBA:ARBA00004125}; Cytoplasmic side
CC {ECO:0000256|ARBA:ARBA00004125}. Membrane
CC {ECO:0000256|ARBA:ARBA00004287}; Peripheral membrane protein
CC {ECO:0000256|ARBA:ARBA00004287}; Cytoplasmic side
CC {ECO:0000256|ARBA:ARBA00004287}.
CC -!- SIMILARITY: Belongs to the sorting nexin family.
CC {ECO:0000256|ARBA:ARBA00010883}.
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DR EMBL; AFYH01227569; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01227570; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01227571; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01227572; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01227573; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; H2ZYC1; -.
DR STRING; 7897.ENSLACP00000002392; -.
DR Ensembl; ENSLACT00000002412.1; ENSLACP00000002392.1; ENSLACG00000002138.1.
DR eggNOG; KOG2273; Eukaryota.
DR GeneTree; ENSGT00940000155798; -.
DR InParanoid; H2ZYC1; -.
DR OMA; YWESFLP; -.
DR TreeFam; TF313698; -.
DR Proteomes; UP000008672; Unassembled WGS sequence.
DR Bgee; ENSLACG00000002138; Expressed in pelvic fin and 6 other cell types or tissues.
DR GO; GO:0031901; C:early endosome membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0030027; C:lamellipodium; IEA:UniProtKB-SubCell.
DR GO; GO:0030904; C:retromer complex; IEA:InterPro.
DR GO; GO:0035091; F:phosphatidylinositol binding; IEA:InterPro.
DR GO; GO:0006886; P:intracellular protein transport; IEA:InterPro.
DR CDD; cd07282; PX_SNX2; 1.
DR Gene3D; 1.20.1270.60; Arfaptin homology (AH) domain/BAR domain; 1.
DR Gene3D; 3.30.1520.10; Phox-like domain; 1.
DR InterPro; IPR027267; AH/BAR_dom_sf.
DR InterPro; IPR001683; PX_dom.
DR InterPro; IPR036871; PX_dom_sf.
DR InterPro; IPR037918; SNX2_PX.
DR InterPro; IPR005329; Sorting_nexin_N.
DR InterPro; IPR015404; Vps5_C.
DR PANTHER; PTHR10555; SORTING NEXIN; 1.
DR PANTHER; PTHR10555:SF31; SORTING NEXIN-2; 1.
DR Pfam; PF00787; PX; 1.
DR Pfam; PF03700; Sorting_nexin; 1.
DR Pfam; PF09325; Vps5; 1.
DR SMART; SM00312; PX; 1.
DR SUPFAM; SSF103657; BAR/IMD domain-like; 1.
DR SUPFAM; SSF64268; PX domain; 1.
DR PROSITE; PS50195; PX; 1.
PE 3: Inferred from homology;
KW Acetylation {ECO:0000256|ARBA:ARBA00022990};
KW Cell projection {ECO:0000256|ARBA:ARBA00023273};
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Endosome {ECO:0000256|ARBA:ARBA00022753};
KW Lipid-binding {ECO:0000256|ARBA:ARBA00023121};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Protein transport {ECO:0000256|ARBA:ARBA00022927};
KW Reference proteome {ECO:0000313|Proteomes:UP000008672};
KW Transport {ECO:0000256|ARBA:ARBA00022927}.
FT DOMAIN 140..269
FT /note="PX"
FT /evidence="ECO:0000259|PROSITE:PS50195"
FT REGION 1..63
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 79..103
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 436..470
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 10..26
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 27..44
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 520 AA; 58969 MW; 82BF4D5EC5035321 CRC64;
MAAEREPPPL GEGEQTDFRE LEDGDDLFTS TVSTLESSPS SPEPASLPAE DISTKSNGPK
AAELLLDDDR EDLFAEATEE VSLDSPEREP ILSPEPTPAI TPVTPTALVM PRVDSHTMSI
PSMFDRNQEE IEEEENGDMF DIQISVSDPE KVGDGMNAYM AYKVTTKTSL SMFSKNEFSV
KRRFSDFLGL HSKLATKYMH IGYIVPPVPE KSIVGMTKVK VGKEDPSSAE FVEKRRSALE
RFLERTVKHP TLLQDPDLRQ FLENSELPRA VSTQALSGAG ILRMVNKAAD AVNKMTIKMN
ESDAWFEEKQ QQFENLDQQL RKLHTSVEAL VCHRKELSAN TAAFAKSAAM LGNSEDHTAL
SRALSQLAEV EEKIDQLHQE QAYADFYLFS ELLSDYIRLI SAVKGVFDQR IKCWQKWQDA
QATLQKKREA EAKLQYANKP DKLQQAKEEI REWEAKVQQG ERDFEQISKT IRKEVGRFER
ERVKDFKSVI VKYLESLVQT QQQDETPWWL AQIPSAEIEL
//