ID H2ZYY1_LATCH Unreviewed; 430 AA.
AC H2ZYY1;
DT 18-APR-2012, integrated into UniProtKB/TrEMBL.
DT 18-APR-2012, sequence version 1.
DT 27-MAR-2024, entry version 54.
DE RecName: Full=Serpin domain-containing protein {ECO:0000259|SMART:SM00093};
OS Latimeria chalumnae (Coelacanth).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Coelacanthiformes; Coelacanthidae; Latimeria.
OX NCBI_TaxID=7897 {ECO:0000313|Ensembl:ENSLACP00000002602.1, ECO:0000313|Proteomes:UP000008672};
RN [1] {ECO:0000313|Proteomes:UP000008672}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Wild caught {ECO:0000313|Proteomes:UP000008672};
RA Di Palma F., Alfoldi J., Johnson J., Berlin A., Gnerre S., Jaffe D.,
RA MacCallum I., Young S., Walker B.J., Lander E., Lindblad-Toh K.;
RT "The draft genome of Latimeria chalumnae.";
RL Submitted (AUG-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSLACP00000002602.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the serpin family.
CC {ECO:0000256|ARBA:ARBA00009500, ECO:0000256|RuleBase:RU000411}.
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DR EMBL; AFYH01145463; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01145464; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01145465; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; H2ZYY1; -.
DR STRING; 7897.ENSLACP00000002602; -.
DR Ensembl; ENSLACT00000002623.1; ENSLACP00000002602.1; ENSLACG00000002328.1.
DR eggNOG; KOG2392; Eukaryota.
DR GeneTree; ENSGT00940000160877; -.
DR HOGENOM; CLU_023330_2_1_1; -.
DR InParanoid; H2ZYY1; -.
DR OMA; MVLINHI; -.
DR TreeFam; TF343201; -.
DR Proteomes; UP000008672; Unassembled WGS sequence.
DR Bgee; ENSLACG00000002328; Expressed in pharyngeal gill and 2 other cell types or tissues.
DR GO; GO:0005615; C:extracellular space; IEA:InterPro.
DR GO; GO:0004867; F:serine-type endopeptidase inhibitor activity; IEA:InterPro.
DR CDD; cd19957; serpinA; 1.
DR Gene3D; 2.30.39.10; Alpha-1-antitrypsin, domain 1; 1.
DR Gene3D; 3.30.497.10; Antithrombin, subunit I, domain 2; 1.
DR Gene3D; 2.10.310.10; Serpins superfamily; 1.
DR InterPro; IPR023795; Serpin_CS.
DR InterPro; IPR023796; Serpin_dom.
DR InterPro; IPR000215; Serpin_fam.
DR InterPro; IPR036186; Serpin_sf.
DR InterPro; IPR042178; Serpin_sf_1.
DR InterPro; IPR042185; Serpin_sf_2.
DR PANTHER; PTHR11461:SF165; ALPHA-1-ANTITRYPSIN; 1.
DR PANTHER; PTHR11461; SERINE PROTEASE INHIBITOR, SERPIN; 1.
DR Pfam; PF00079; Serpin; 1.
DR SMART; SM00093; SERPIN; 1.
DR SUPFAM; SSF56574; Serpins; 1.
DR PROSITE; PS00284; SERPIN; 1.
PE 3: Inferred from homology;
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Protease inhibitor {ECO:0000256|ARBA:ARBA00022690};
KW Reference proteome {ECO:0000313|Proteomes:UP000008672};
KW Serine protease inhibitor {ECO:0000256|ARBA:ARBA00022900};
KW Signal {ECO:0000256|ARBA:ARBA00022729}.
FT DOMAIN 70..428
FT /note="Serpin"
FT /evidence="ECO:0000259|SMART:SM00093"
FT REGION 1..48
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..45
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 430 AA; 49105 MW; 64868209EED1568C CRC64;
GPHHGHHHSP HHGHHHSPHH GHRHGPHHGH HHSPHHGHHH DHHRHHHDLY NEDEDMLCHK
LTPANSDFAI RFYNKVLSCP TRATKNIFFS PISISTALSM LSLGAKSSTL HQLHEGLGFN
TTELSEDEIH KAFEHLILML NKDHNELQIN TGNVIYLNEG FEPIQKFIDD AKLYYDAEVS
NVDFQKSEET MQKINAHVKN QTHGKIEDLI KDLDNDTIML LLNYIFFRGE WEKPFSPNAT
EEGDFFVNND ITVKVPMMTR TSFFEAQYEK NISATILKLP YKGNATMMLI LPDEGKMEKV
EKTLSHKVLM KWVFNKEHNF ITLNLPKFSI SASHELKEIL MEMGITDVFG DNSDPSGITE
SPNLKVSKAV HKAILEVGEK GTEAGGTTHV GIIPLSLPGE VHFNRPFLMF IWHRLTRSIL
FMGKIVNPTE
//
