ID H2ZZ43_LATCH Unreviewed; 815 AA.
AC H2ZZ43;
DT 18-APR-2012, integrated into UniProtKB/TrEMBL.
DT 18-APR-2012, sequence version 1.
DT 27-MAR-2024, entry version 66.
DE RecName: Full=Latent transforming growth factor beta binding protein 3 {ECO:0008006|Google:ProtNLM};
OS Latimeria chalumnae (Coelacanth).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Coelacanthiformes; Coelacanthidae; Latimeria.
OX NCBI_TaxID=7897 {ECO:0000313|Ensembl:ENSLACP00000002664.1, ECO:0000313|Proteomes:UP000008672};
RN [1] {ECO:0000313|Proteomes:UP000008672}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Wild caught {ECO:0000313|Proteomes:UP000008672};
RA Di Palma F., Alfoldi J., Johnson J., Berlin A., Gnerre S., Jaffe D.,
RA MacCallum I., Young S., Walker B.J., Lander E., Lindblad-Toh K.;
RT "The draft genome of Latimeria chalumnae.";
RL Submitted (AUG-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSLACP00000002664.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Secreted, extracellular space, extracellular
CC matrix {ECO:0000256|ARBA:ARBA00004498}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00076}.
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DR EMBL; AFYH01178718; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01178719; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01178720; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01178721; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01178722; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01178723; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01178724; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01178725; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01178726; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01178727; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; H2ZZ43; -.
DR STRING; 7897.ENSLACP00000002664; -.
DR Ensembl; ENSLACT00000002686.1; ENSLACP00000002664.1; ENSLACG00000002385.1.
DR eggNOG; KOG1217; Eukaryota.
DR GeneTree; ENSGT00940000160285; -.
DR InParanoid; H2ZZ43; -.
DR OMA; FRWYSPP; -.
DR TreeFam; TF317514; -.
DR Proteomes; UP000008672; Unassembled WGS sequence.
DR Bgee; ENSLACG00000002385; Expressed in pharyngeal gill and 2 other cell types or tissues.
DR GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR GO; GO:0019838; F:growth factor binding; IEA:UniProtKB-KW.
DR CDD; cd00054; EGF_CA; 7.
DR Gene3D; 2.10.25.10; Laminin; 10.
DR Gene3D; 3.90.290.10; TGF-beta binding (TB) domain; 2.
DR InterPro; IPR001881; EGF-like_Ca-bd_dom.
DR InterPro; IPR013032; EGF-like_CS.
DR InterPro; IPR000742; EGF-like_dom.
DR InterPro; IPR000152; EGF-type_Asp/Asn_hydroxyl_site.
DR InterPro; IPR018097; EGF_Ca-bd_CS.
DR InterPro; IPR009030; Growth_fac_rcpt_cys_sf.
DR InterPro; IPR017878; TB_dom.
DR InterPro; IPR036773; TB_dom_sf.
DR PANTHER; PTHR24034; EGF-LIKE DOMAIN-CONTAINING PROTEIN; 1.
DR PANTHER; PTHR24034:SF43; LATENT-TRANSFORMING GROWTH FACTOR BETA-BINDING PROTEIN 4; 1.
DR Pfam; PF07645; EGF_CA; 9.
DR Pfam; PF12661; hEGF; 1.
DR Pfam; PF00683; TB; 2.
DR SMART; SM00181; EGF; 10.
DR SMART; SM00179; EGF_CA; 10.
DR SUPFAM; SSF57196; EGF/Laminin; 7.
DR SUPFAM; SSF57184; Growth factor receptor domain; 1.
DR SUPFAM; SSF57581; TB module/8-cys domain; 2.
DR PROSITE; PS00010; ASX_HYDROXYL; 6.
DR PROSITE; PS01186; EGF_2; 4.
DR PROSITE; PS50026; EGF_3; 7.
DR PROSITE; PS01187; EGF_CA; 5.
DR PROSITE; PS51364; TB; 2.
PE 4: Predicted;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW EGF-like domain {ECO:0000256|ARBA:ARBA00022536, ECO:0000256|PROSITE-
KW ProRule:PRU00076}; Extracellular matrix {ECO:0000256|ARBA:ARBA00022530};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Reference proteome {ECO:0000313|Proteomes:UP000008672};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Secreted {ECO:0000256|ARBA:ARBA00022530};
KW Signal {ECO:0000256|ARBA:ARBA00022729}.
FT DOMAIN 1..41
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 49..101
FT /note="TB"
FT /evidence="ECO:0000259|PROSITE:PS51364"
FT DOMAIN 211..252
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 293..335
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 411..445
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 446..491
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 492..534
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 541..595
FT /note="TB"
FT /evidence="ECO:0000259|PROSITE:PS51364"
FT DOMAIN 728..761
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
SQ SEQUENCE 815 AA; 91692 MW; 9D6F8F9D673B0168 CRC64;
DINECSMQGV CQNGECLNTF GSFLCACKPG FALGPSRTRC IADESKEKGP CYRMLAKNKT
CTHPLPGELP KTLCCCSVGK AWGASCEPCP VDGTDAFKEI CPSGKGYWTW YKTVTMTINP
EFVPQKLEAP PSDLPRMQES EESDGLYTTL LFFIFFGGGP SSFQASPIFR WYSPPSSIFR
WYSPPSPIFR WYCQVSPQRN AVIVVEKQIA ETDECKLNRN ICGHGDCIST ASGFSCHCNP
GFRPHPQRKF CVGKTPCQLE RLGGGSLYLT NIVASFSEGH SCGLSKTENR CSDVNECLKP
NICGEGGRCM NYPGYFTCEC YPGYRAKSSR HPFCEDINEC QEPNICPGGK CKNRPGTYEC
IPCPPGYTSR AGECYVHSFF NSQKKKSLSS NKEFTLLLRF KESFKSWECV YVDECEDRRL
CANGRCMNTK GSYHCHCNLG FYMSEDDNEC EDKNECENPL ACIGGDCVNT YGSYICNCSQ
GYQLMYRRNC QDIDECSLDP SLCAPHGDCE NTEGSFTCVC HEGYEKSDDG LSCEERLSDK
KECYVNLDDT VFCDSVLASN VTKEECCCSL GAGWGDHCEI YPCPVANSVE FVSLCPDGRG
YIPGENVLQY GLPAHRDIDE CALFGNEICK EGICTNTHPG YECYCKQGFY YDASLLECVY
VYILKHFSFF FIYHHYLLPK KCYGQCLPSN YVLVIECFAS LSRPPPQLQP LRCLFFFPPR
EEDSSEEDSD ECRCMNGHCV RLHHGGFSCE CLPGFQPDRA RRRCYDIDEC RELNQRGLLC
KNARCVNTSG SYYCVCRQGF VPAQRPNICI RQRRK
//
