ID H3A008_LATCH Unreviewed; 802 AA.
AC H3A008;
DT 18-APR-2012, integrated into UniProtKB/TrEMBL.
DT 18-APR-2012, sequence version 1.
DT 27-MAR-2024, entry version 49.
DE RecName: Full=ribonuclease H {ECO:0000256|ARBA:ARBA00012180};
DE EC=3.1.26.4 {ECO:0000256|ARBA:ARBA00012180};
OS Latimeria chalumnae (Coelacanth).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Coelacanthiformes; Coelacanthidae; Latimeria.
OX NCBI_TaxID=7897 {ECO:0000313|Ensembl:ENSLACP00000002979.1, ECO:0000313|Proteomes:UP000008672};
RN [1] {ECO:0000313|Proteomes:UP000008672}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Wild caught {ECO:0000313|Proteomes:UP000008672};
RA Di Palma F., Alfoldi J., Johnson J., Berlin A., Gnerre S., Jaffe D.,
RA MacCallum I., Young S., Walker B.J., Lander E., Lindblad-Toh K.;
RT "The draft genome of Latimeria chalumnae.";
RL Submitted (AUG-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSLACP00000002979.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the beta type-B retroviral polymerase family.
CC HERV class-II K(HML-2) pol subfamily. {ECO:0000256|ARBA:ARBA00010879}.
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DR EMBL; AFYH01197857; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; H3A008; -.
DR STRING; 7897.ENSLACP00000002979; -.
DR Ensembl; ENSLACT00000003005.1; ENSLACP00000002979.1; ENSLACG00000002665.1.
DR eggNOG; KOG0017; Eukaryota.
DR GeneTree; ENSGT01100000263560; -.
DR HOGENOM; CLU_000384_10_2_1; -.
DR InParanoid; H3A008; -.
DR OMA; CANCLEC; -.
DR Proteomes; UP000008672; Unassembled WGS sequence.
DR Bgee; ENSLACG00000002665; Expressed in chordate pharynx and 1 other cell type or tissue.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR GO; GO:0003964; F:RNA-directed DNA polymerase activity; IEA:UniProtKB-KW.
DR GO; GO:0004523; F:RNA-DNA hybrid ribonuclease activity; IEA:InterPro.
DR GO; GO:0015074; P:DNA integration; IEA:InterPro.
DR Gene3D; 3.10.20.370; -; 1.
DR Gene3D; 3.30.70.270; -; 2.
DR Gene3D; 3.10.10.10; HIV Type 1 Reverse Transcriptase, subunit A, domain 1; 1.
DR Gene3D; 3.30.420.10; Ribonuclease H-like superfamily/Ribonuclease H; 2.
DR InterPro; IPR043502; DNA/RNA_pol_sf.
DR InterPro; IPR001584; Integrase_cat-core.
DR InterPro; IPR043128; Rev_trsase/Diguanyl_cyclase.
DR InterPro; IPR012337; RNaseH-like_sf.
DR InterPro; IPR002156; RNaseH_domain.
DR InterPro; IPR036397; RNaseH_sf.
DR InterPro; IPR000477; RT_dom.
DR InterPro; IPR041577; RT_RNaseH_2.
DR PANTHER; PTHR33064; POL PROTEIN; 1.
DR PANTHER; PTHR33064:SF37; RIBONUCLEASE H; 1.
DR Pfam; PF00075; RNase_H; 1.
DR Pfam; PF17919; RT_RNaseH_2; 1.
DR Pfam; PF00665; rve; 1.
DR Pfam; PF00078; RVT_1; 1.
DR SUPFAM; SSF56672; DNA/RNA polymerases; 1.
DR SUPFAM; SSF53098; Ribonuclease H-like; 2.
DR PROSITE; PS50994; INTEGRASE; 1.
DR PROSITE; PS50879; RNASE_H_1; 1.
DR PROSITE; PS50878; RT_POL; 1.
PE 3: Inferred from homology;
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Reference proteome {ECO:0000313|Proteomes:UP000008672}.
FT DOMAIN 1..149
FT /note="Reverse transcriptase"
FT /evidence="ECO:0000259|PROSITE:PS50878"
FT DOMAIN 387..528
FT /note="RNase H type-1"
FT /evidence="ECO:0000259|PROSITE:PS50879"
FT DOMAIN 646..802
FT /note="Integrase catalytic"
FT /evidence="ECO:0000259|PROSITE:PS50994"
SQ SEQUENCE 802 AA; 89050 MW; BE02610F3ACBA481 CRC64;
RRLNAVTPPM APIVADLSLL TTTLHPTYSI FTVLDIANGF WSLPHHPDCQ YKFAFAFQGT
QYTWTCLPQG FHNSPALFHA AMRDALIPFP YRDNLVQYVD DLLLASSSKE EHLLHLEALL
ETISKAGLKV NPDKAQIAKD CVSFLGIAIT PSGRALDRHK LKVLLALPLP TDLTSLCSFL
GMCNFMRSFM WNFSALCKPL YQLLKLQQPF LWTESHTAAV MSLKTALTSA PTLSSPDYTL
PFHLFFTSTI TSLAAVMAQH TDAWHPLAFA SRLTSSVEQK YTPCELTLLA VHWALQHFLY
LTGTHEVIIH TTHSTSPSTI SSPRLSCMLL SLQHRCIQVS PLLPLLSFLP AALLAFPFPP
HTCPLPPPVP PPLALPFPSP PPPSGLHPSF CTLYIDGSCF HKEGTVYTGF AIYDPVSNHS
ELFKCEMHSA QYAELAALIQ ALHSFSSESL LICSDSLWTV LSATRHKNGF LSTDGKPLKH
QYLLKVLFVV VYIRRGKSLS TLMLKVKAHD RSNTYNCTVD GLAKQAAVSG LLWKPPQMDL
SIIDTPAVPV ATVQLPDDLN TLQDMDTTIP NLVTMDPHVI VEHRLFLRKD PETGINAFIP
PSDMRGLLIA NPKMREQIEQ YCANCLECAM INPAPRRVVG PLPIGAIKGP WHSIFMDYID
GLPRAPGGHT HLLVVVCAFT KWVEAFPMTT TTAKATAKVL LRLFSTWGIP DTVDSDRGPH
FANEVMEQTL AALGVKHHLH IPYRPQASRQ VERVNRTLKA GLKKMCLEQG AHWADALPWL
LMALRSRVDK RTGYSPFQIM MG
//
