ID H3A0R2_LATCH Unreviewed; 414 AA.
AC H3A0R2;
DT 18-APR-2012, integrated into UniProtKB/TrEMBL.
DT 18-APR-2012, sequence version 1.
DT 27-MAR-2024, entry version 58.
DE RecName: Full=Arrestin domain-containing protein 3 {ECO:0000256|ARBA:ARBA00041132};
GN Name=ARRDC3 {ECO:0000313|Ensembl:ENSLACP00000003233.1};
OS Latimeria chalumnae (Coelacanth).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Coelacanthiformes; Coelacanthidae; Latimeria.
OX NCBI_TaxID=7897 {ECO:0000313|Ensembl:ENSLACP00000003233.1, ECO:0000313|Proteomes:UP000008672};
RN [1] {ECO:0000313|Proteomes:UP000008672}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Wild caught {ECO:0000313|Proteomes:UP000008672};
RA Di Palma F., Alfoldi J., Johnson J., Berlin A., Gnerre S., Jaffe D.,
RA MacCallum I., Young S., Walker B.J., Lander E., Lindblad-Toh K.;
RT "The draft genome of Latimeria chalumnae.";
RL Submitted (AUG-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSLACP00000003233.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004413};
CC Peripheral membrane protein {ECO:0000256|ARBA:ARBA00004413};
CC Cytoplasmic side {ECO:0000256|ARBA:ARBA00004413}. Cytoplasm
CC {ECO:0000256|ARBA:ARBA00004496}. Early endosome
CC {ECO:0000256|ARBA:ARBA00004412}. Endosome
CC {ECO:0000256|ARBA:ARBA00004177}. Lysosome
CC {ECO:0000256|ARBA:ARBA00004371}. Membrane
CC {ECO:0000256|ARBA:ARBA00004287}; Peripheral membrane protein
CC {ECO:0000256|ARBA:ARBA00004287}; Cytoplasmic side
CC {ECO:0000256|ARBA:ARBA00004287}.
CC -!- SIMILARITY: Belongs to the arrestin family.
CC {ECO:0000256|ARBA:ARBA00005298}.
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DR EMBL; AFYH01215288; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01215289; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_006010252.1; XM_006010190.1.
DR AlphaFoldDB; H3A0R2; -.
DR STRING; 7897.ENSLACP00000003233; -.
DR Ensembl; ENSLACT00000003263.1; ENSLACP00000003233.1; ENSLACG00000002890.1.
DR GeneID; 102360612; -.
DR KEGG; lcm:102360612; -.
DR CTD; 566685; -.
DR eggNOG; KOG3780; Eukaryota.
DR GeneTree; ENSGT00940000155411; -.
DR HOGENOM; CLU_039221_1_1_1; -.
DR InParanoid; H3A0R2; -.
DR OMA; IHAGRHE; -.
DR OrthoDB; 22053at2759; -.
DR TreeFam; TF313650; -.
DR Proteomes; UP000008672; Unassembled WGS sequence.
DR Bgee; ENSLACG00000002890; Expressed in post-anal tail muscle and 6 other cell types or tissues.
DR GO; GO:0005769; C:early endosome; IEA:UniProtKB-SubCell.
DR GO; GO:0005764; C:lysosome; IEA:UniProtKB-SubCell.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR Gene3D; 2.60.40.640; -; 2.
DR InterPro; IPR014752; Arrestin-like_C.
DR InterPro; IPR011021; Arrestin-like_N.
DR InterPro; IPR011022; Arrestin_C-like.
DR InterPro; IPR014756; Ig_E-set.
DR PANTHER; PTHR11188; ARRESTIN DOMAIN CONTAINING PROTEIN; 1.
DR PANTHER; PTHR11188:SF49; ARRESTIN DOMAIN-CONTAINING PROTEIN 3; 1.
DR Pfam; PF02752; Arrestin_C; 1.
DR Pfam; PF00339; Arrestin_N; 1.
DR SMART; SM01017; Arrestin_C; 1.
DR SUPFAM; SSF81296; E set domains; 2.
PE 3: Inferred from homology;
KW Endosome {ECO:0000256|ARBA:ARBA00022753};
KW Lysosome {ECO:0000256|ARBA:ARBA00023228};
KW Reference proteome {ECO:0000313|Proteomes:UP000008672};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT DOMAIN 187..314
FT /note="Arrestin C-terminal-like"
FT /evidence="ECO:0000259|SMART:SM01017"
FT REGION 392..414
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 400..414
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 414 AA; 46353 MW; ED82390417600C21 CRC64;
MVLGKVKSFT VSFDCLNDSN VPVYSSGDTV SGRVIIEVTG EIRVKSLKIH ARGHAKVRWT
ESRNAGSNTA YTQNYTEEVE YFNHKDILIG HERDDDNSEE DLTTIHSGRH EYAFSFELPQ
TPLATSFEGK HGFVRYWVKA ELHRPWLLPL KMKKEFTVFE HIDINTPLLL SPQAGTKEKT
LCCWLCTSGP ISLSAKIERK GYTPGESVQI FAEVENCSSR MVVPKAAIYQ TQTFYAKGKM
KEVKQLVANL RGESLSSGKT ETWNGKLLKI PPVSPSILDC SIIHVEYSLM VYVDIPGAMN
LFLNLPLVIG TIPLHPFGSR TSSVSSQCSM NMNWLSLALP ERPEAPPSYA DIVTEEQRQG
GLAPAAARDD FERALEGPMF AYIQEFRFQP PPLYSEIDPN PDVSTEQRPS CPSR
//
