ID H3A0V8_LATCH Unreviewed; 6179 AA.
AC H3A0V8;
DT 18-APR-2012, integrated into UniProtKB/TrEMBL.
DT 18-APR-2012, sequence version 1.
DT 27-MAR-2024, entry version 72.
DE SubName: Full=Dystonin {ECO:0000313|Ensembl:ENSLACP00000003279.1};
GN Name=DST {ECO:0000313|Ensembl:ENSLACP00000003279.1};
OS Latimeria chalumnae (Coelacanth).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Coelacanthiformes; Coelacanthidae; Latimeria.
OX NCBI_TaxID=7897 {ECO:0000313|Ensembl:ENSLACP00000003279.1, ECO:0000313|Proteomes:UP000008672};
RN [1] {ECO:0000313|Proteomes:UP000008672}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Wild caught {ECO:0000313|Proteomes:UP000008672};
RA Di Palma F., Alfoldi J., Johnson J., Berlin A., Gnerre S., Jaffe D.,
RA MacCallum I., Young S., Walker B.J., Lander E., Lindblad-Toh K.;
RT "The draft genome of Latimeria chalumnae.";
RL Submitted (AUG-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSLACP00000003279.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR EMBL; AFYH01110609; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01110610; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01110611; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01110612; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01110613; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01110614; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01110615; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01110616; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01110617; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01110618; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR STRING; 7897.ENSLACP00000003279; -.
DR Ensembl; ENSLACT00000003309.1; ENSLACP00000003279.1; ENSLACG00000002933.1.
DR eggNOG; KOG0516; Eukaryota.
DR eggNOG; KOG0517; Eukaryota.
DR GeneTree; ENSGT00940000155008; -.
DR HOGENOM; CLU_000015_0_0_1; -.
DR InParanoid; H3A0V8; -.
DR OMA; QVHKESM; -.
DR TreeFam; TF335163; -.
DR Proteomes; UP000008672; Unassembled WGS sequence.
DR Bgee; ENSLACG00000002933; Expressed in muscle tissue and 6 other cell types or tissues.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR GO; GO:0005874; C:microtubule; IEA:UniProtKB-KW.
DR GO; GO:0003779; F:actin binding; IEA:UniProtKB-KW.
DR GO; GO:0045104; P:intermediate filament cytoskeleton organization; IEA:InterPro.
DR CDD; cd21239; CH_DYST_rpt2; 1.
DR CDD; cd00176; SPEC; 12.
DR Gene3D; 1.20.58.1060; -; 1.
DR Gene3D; 1.20.58.60; -; 26.
DR Gene3D; 1.10.418.10; Calponin-like domain; 2.
DR Gene3D; 3.90.1290.10; Plakin repeat; 2.
DR Gene3D; 2.30.30.40; SH3 Domains; 1.
DR InterPro; IPR001589; Actinin_actin-bd_CS.
DR InterPro; IPR001715; CH_dom.
DR InterPro; IPR036872; CH_dom_sf.
DR InterPro; IPR041615; Desmoplakin_SH3.
DR InterPro; IPR041573; Desmoplakin_Spectrin-like.
DR InterPro; IPR049538; PCN-like_spectrin-like_rpt.
DR InterPro; IPR043197; Plakin.
DR InterPro; IPR035915; Plakin_repeat_sf.
DR InterPro; IPR001101; Plectin_repeat.
DR InterPro; IPR001452; SH3_domain.
DR InterPro; IPR018159; Spectrin/alpha-actinin.
DR InterPro; IPR002017; Spectrin_repeat.
DR PANTHER; PTHR23169; ENVOPLAKIN; 1.
DR PANTHER; PTHR23169:SF23; SHORT STOP, ISOFORM H; 1.
DR Pfam; PF00307; CH; 2.
DR Pfam; PF00681; Plectin; 4.
DR Pfam; PF17902; SH3_10; 1.
DR Pfam; PF00435; Spectrin; 15.
DR Pfam; PF18373; Spectrin_2; 1.
DR Pfam; PF21019; Spectrin_3; 1.
DR Pfam; PF21020; Spectrin_4; 1.
DR Pfam; PF21097; SR_plectin_7; 1.
DR SMART; SM00033; CH; 2.
DR SMART; SM00250; PLEC; 10.
DR SMART; SM00150; SPEC; 25.
DR SUPFAM; SSF47576; Calponin-homology domain, CH-domain; 1.
DR SUPFAM; SSF75399; Plakin repeat; 2.
DR SUPFAM; SSF46966; Spectrin repeat; 24.
DR PROSITE; PS00020; ACTININ_2; 1.
DR PROSITE; PS50021; CH; 2.
DR PROSITE; PS50002; SH3; 1.
PE 4: Predicted;
KW Actin-binding {ECO:0000256|ARBA:ARBA00023203};
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Microtubule {ECO:0000256|ARBA:ARBA00022701};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000008672};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW SH3 domain {ECO:0000256|ARBA:ARBA00022443, ECO:0000256|PROSITE-
KW ProRule:PRU00192}.
FT DOMAIN 1..93
FT /note="Calponin-homology (CH)"
FT /evidence="ECO:0000259|PROSITE:PS50021"
FT DOMAIN 106..210
FT /note="Calponin-homology (CH)"
FT /evidence="ECO:0000259|PROSITE:PS50021"
FT DOMAIN 841..898
FT /note="SH3"
FT /evidence="ECO:0000259|PROSITE:PS50002"
FT REGION 1413..1447
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2214..2250
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2503..2554
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 695..722
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 1162..1196
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 1256..1288
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 1372..1400
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 1466..1493
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 3756..3787
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 4118..4152
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 4177..4251
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 4365..4399
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 4600..4675
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 4898..4960
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 5083..5161
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 6062..6089
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 1416..1431
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2216..2250
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2503..2517
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2524..2554
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 6179 AA; 702726 MW; D62F483F4D0A5D7A CRC64;
NRHFSKVRKH VNDLYEDLRD GHNLISLLEV LSGETLPREK GRMRFHRLQN VQIALDYLKR
RQVKLVNIRN DDITDGNPKL TLGLIWTIIL HFQISDIRVT GESEDMSAKE KLLLWSQQIT
EGYTGVRCEN FTTCWRDGRL FNAIIHKYRP DLIDMNKVAV QGNRANLEQA FYVAEKLGVT
RLLDPEDVDV QSPDEKSVIT YVSSLYDAFP KIPEDGDGIN ANDVDVKWIE YQNMVNYLIQ
WIRHHVTIML DRTFPNNPVE LKALYNQYLQ FKETELPPKE TDKTKIKHLY KLLEAWIEFG
RIKLPQGYHP NDVEKEWGKL IIAMLEREKT LRPEVERLEM LQQIANRVQR DSLGCEDKLI
LAQNALQSDA KRLESGLQFQ NETEIAGYLL ECENLLRQQL IDVQILLDGK YYQAEQLLQR
VAKLRDDLMV LRTECSSVYS KGHSLTTEQT KLVISGISQS LNSGFTQNLN PSLSSSLASS
LSPGFNSSLT SGLTSSLTTS LTPSLTPSLT PAFTPGMTPN YVTEIDSSAL QTLKLVQIRK
PLMKSSIADQ NLTEEEINMN FVQDLINWVE EMQVQLDRAE WGSDLPSVES HLENHKNFHK
AIVEFESSLK EAKLSEIQLT APFKHSYSEK LNKLESQYSK LLNTSRNRER HLNSLHNFVS
RATRELIWLN EKEEEEVAYD WSDRNANMSR KKDYHTDLMR ELDQKEEVIR SVQEMAEQLL
LENHPARLTI EAYKAAMQTQ WSWILQLCYC VEQHLKENAA YFEFFNDAKE AMDYLKNLKD
TIQRKYSCDK SSSLHKLEDL VHESMEEKEQ LLQYKSTVAG LVGRAKGIVQ LKPRSPDSPP
KTSIAIKAIC DYRQIEITIY KDDECVLASN SHRAKWKVIS PTGNEAMVPS VCFSVPPPNK
EAIDSASRIE QLYQNVLALW HEAHINMKSI VSWHYLLNEI EAIRTGNVAS IKTMLPGEHQ
HVLSNLQARF EDFLVDSQES KIFSVADTVQ LERDVEICKQ YYEELLKSAE REEHEESVYN
LYVSEVRNIR LHLENCEERL IRKIRTPLDR DDLQESVLRI SDQEKLKKEL DHLKEDLEKV
SEKCETFFSQ ATSSPSVPTL RSELNVVIQN MNQLYSMSSI YLEKLKTVNL VLKNTQGAEA
LVKLYETKLC EEDAVTADAK AIEKLMGTLK QWRSEVDEKR EVFHALEDEL QKAKAISDQM
LKSHKERDVD LEWHKEKADQ LAERWQNVRY QIESRLRDLE SIGKFLKYYK DTYRTMDEWI
KEAEDAQLKM QETQIEDSKA LAEKLNQQKM LVSEIETKQS KIEECQKYSE QYSAAIKDYE
LQLMTYRAMV DSQQKSPVKR RRMQSSSDFI IQEFMDLRTR YTALVTLMTQ YIKFASEALK
RTEEEEKSVE EEKKEHIENV SELLKWVSNT NKVHSKEQAG QKEDEKSAGK EQVSKQQVSS
EEISTKKEQI SEALQSAQTF LVKHSDKLTE KERQEMEKQV KSLQEAYDKL CQQTTAQPPQ
LQKLIDGQAE QKVNKVIAGV TDVETGEVFS VFQSVVKGLI DYDTGIALLE AQVITSGLIS
PETKECFDME EAIKNGLIDE QIATQLQEIS NASSLTSAAL CTTLPVVTAF EKGIISESLA
VKIIEIQLAS GGLGYTITGE KLSLQNAFQR KLMPAILFSK LLERQTNSQN LIDPNTAERV
SLQELIQRST LHEGTGLRLL PLKRMADGEI ALKSGRKINV LRAAHEGFID RETMFRLIDA
QLYSGGIVDP KSGQRLTVEQ AVQQNIFDLD TACGMLNHQV QTGGIISPST GKRLTLDEAV
QCNLISSSSA LLVIERQKGF MGLIWPHSGE IFPVSTSLQQ GMITNEIAQK MLNNRQKIIA
LYIPEISEVI STHKAAQLGI IDNNAAEVLS TVILPDIMPN IESLEFPCKD TSRWVSSCDF
QYSAVQKSMY DQEMSDSDES PAPSLGQAHK LFVSYLMINS YLDAGAGQRL LLYDEDLDEA
VSMLKEAAEN AFQEGELESE LNSIQNDYNY SNFQQYKNVV IQLTNRVQSE NNFQRDLPED
FDLAVQGEDI CIVHSGESIT PDNLRSVETL DDFMEDNEGG CFNDKNETTL VIHDSDGNEA
DTTPYVQKSY SKNDLFDQSL EVIEEEEEEN SQDHNYNYKM NSKESTSFAC LIGQPLTDQL
TPQDDTLEYM DQAVHASNKE KIVNGRINQT STNESISDVT STFQKAQLSL FESEMVEESK
TTHGDDASFD DKSEKVHKEN KDLERKDEQS RVISEVTGES KMFQLNAMRN SDNESEVTVQ
SNFHRNDNFT TCIENYSLHK DTLLKKFSPD SRSEGTVQSD FNNSETLMPP IGEYSLHKDT
LVNILSLEHH EQKTGEYEDL NKNKEQGTLQ NQTFPIATEE TDFNEEFFDC PNKETIEAAD
SLQKGFIDEN VIDSVLCSDS LNDPERMNLH SRDAVKPGFS DDNLVQGQAD THAVLERTVS
SPQAHRLEVE TKMVSEDFVE TEEITADQPE NNRATFQQIC LQSEDSDSEN SETKQSVLLP
EAVKKGEEGI RSVTDLIEPD GETSQEKSDL STSVKKDAKL GLLEKQSEAE KSSPWDDQLE
VFDNCLQAEI VESVKIAHSQ EMSTPHEYKE ADDNDIFCEN AVQNNFKVEL SEIPHLRTDQ
IETFARVIDN AENKQNKNDQ AETFDRTIQF QSPEGSKMES SEETTVCREQ SEAHNNENIG
EVVDMNFQIE TPFHRNDQSE KSDKLCQTEA AYDETVGWSK VIEVTEESST EEQHSVADLY
QCEKTSPDLD LMMQTLDNSE PGNGCLDVKT NKKMFDAKNC SDEQKVETLF KVTPIHIENL
GEIFDATANH GSCETFKSDA FSHRVVTGDK EEPNKSGVEQ LNLAAYLKES AKDIKLETET
PETCDSTSLF LIEESHLENK VQLGKQLQKP IVDDIQAVAT NGKVNISSGN EMLTGSILQG
SEIDLDMVLN EVIEESSDQE KTMAPEKYDV IFTENTEFTI HDNRTVFESR SSEVSEDSFG
IEEPLIASSS EDICHPPKLQ NQLMLHLHDL LKNKLEDHHY FMQKTESQGA SETKSIIQNI
LKTISSTYLE KDTVQHEFSK VASSNLPNSD KNVQHDVLSY WTKNKSPDRF FDQLKEQANS
TNTDFKEDGA EVTEGKDTDK FPKLIPLQLE QIFQAPSADQ GPYRVKELIN DLRHEVLNTQ
TSDCHRLNEV KEQINDALSE DVQFLTTSTA DSEKVLKLEI QNGRNSGIDA SSEDNYEQEH
SASVSEIINS VEQCLQYTEK MQEYLTVVQD MRCQLNNQQP VSDNLETLKQ QLVQLESFET
GLLSFSGVLT RDLMTAEQFL TVAPNDVPEH LLRELEISCR CLQKSFSEVS EMSTKRARHI
VLAVDSEMSK LATLHHELLL RLQKLSEWVK GNSDPITSIK LSRVRESEAV KLNIQQHKDL
EQELSTRKLQ LDVAAFDVQF FISEHAQHLS PNQSKQLLRL LTTTQKSFQE LEKKTSQAET
SHSHFHTAED LDDQKLLEEK KQGYKEKLQD MCSLLVKTEN RLLSHQQTGV HGETLSNLQQ
YQTEHQALQR DVDAAGTDLA EIVKSTEKFL NENRDTLPPE DRVVIEQKLE EAKTKFQALV
LIAKDSKEQL DKAVTTAIKQ ETEKVAAVEQ LEESKSKIEG LLEWLSVVQK EEQSKEKEQV
QIEQLNGNYL PGSDVKSVTG EEDELNGNLL QPDNQTTVDG QVKAIKEGDL TQQYEKVKKQ
AQHKKILSQH QDFIISTQSA QALLEKQSHN FPPEERAKLQ KNLQELKVQY ENALAESEHK
MKSLQSVQEE LQKFTADYSE FENWLQQSEQ ELGNLGIGAA DLNSLNAKLQ RQKSFSEDVI
SHKGDLRYIT ISGQRVLDAA KACSKLDNGK GSSPDVDTSA TCTMVQGKLD STTDWYKGLH
SKCNLLGSQI KDVVDKYQQY HGALSVLQPW LQATETTAKR HLTEPIAADP KNLQKQLEEA
KDLQGQISTH QISVEKLRKA VEALVATEGG LLSNKQGIQK TLGDIVERYD SLSTSVSDRN
EKLQITLTRS LSVQDGLDEM LDWMENVEKS LKEQDQVPLN SVAIQDVISK NTMLEQDISS
RQSSIIAMKE KVNKFIETAD PSTGSSLKAK MDGLSSRFSE ANNKHKEKLL KLEELKAQIE
LFESTSEKIE QFLLKKSKSL SEADEPGKDV TELSQLMKET NAELLNQKHD LESLQQLVEK
LAPHGSPTDK AQVLEKVSTL SKHFKELEET VKEKEEEVSS CQSQMDEFKS LADSLQKWLD
ETRTKIPVIQ PALSTEDLKK HLHNVQASLE EWSSKASNIQ ELNNKGLSII SLISAVTSPA
KSKSTKKGGM HFFKKKGCCI NTGKFLKMKE LTAIQQDMSK VNCSYEELGD QLKEKVSTLE
ELLARVQQVQ EEADSVRQWL NVVDKTAASW DVVSTDAEAV KAQVEQHKMF EADLKQNASK
LQGLKQKLTE LVEKNPDSPE AAKWKQMLEQ IDSKWKELNQ LAADREKSLE ESSNYLTQFQ
TAEAQLKQWL LEKELMMGVL GPLSVDPNML NTQKQQVQIL LKEFDTRKSQ YEQLNTAAQG
ILNKAGEVPP SATVVKDQLA SVASKWENLT GQLSDRCDRI DQAILKSNQY QNDLRKLSDK
VKALDHKLGG SPALSTHPDA VKQQLETARE IQSQLEQERK NVEEAKDLCK ELSALVGEEY
LKAELSRQLE SVLKPFKDLE ERAGNRIEQL QSAFASSQQF QQMSKDFQNW LDGKRQDLAQ
TPPISAKLDT LQSMINDQTQ FQSSLAQQIE SYEKIVAEGE GLLQNTQGTE KVELQSQLSD
LKVNWEELNK QAADRQDKIK DCLQKALRYK EHVENLQPWI TECENKESNI KICLDPGQIE
NSVTEVKTLQ KEVDKRRGML ELLNNAADSL VEASQADKEV IREEKALINQ KVDKITEQLH
HKKDSLEDIA QRLKEFQELS KETKKQFKSA QEQLKAHEAL GAQACSNKHL TIMQSQQKAL
QNLKPQVECL KKLACGLVVD APDADGVSDL LLQADSLEKD HDTLSQQIEE KCSFLETKLQ
GIGHFQNNTR EMFSQFADLD DELDGMPPVG RDLDTLQSQK DDIKNFICKL QELITNAENA
NKNCKKMMES ESSPDLMGLK RDLEALSKQC NKLLDRAKNR EEQVEMNLTR TEELYSKLKE
LASLIAVAED HEESQGSVGM ETEIINQQLD AFKVFQKEEI EPLQVKLQEV NWLGQGLIQS
AAKNVSTQSL EHDLEDVNTR WNTLNKKVAE RAAQLQEALL HCGRFQDALE SLLSWLTDTE
DLVANQKLPS AEFKVVKAQI QEQKLLQRLL DDRKPTVETI KREGEKIAES AEPTDKEKIL
KQLSSLGHRW DALLSKAETR DRQLEGILVV AQQFHETLEP LVEWLTATEK RLANSEPIGT
QASKLEQQIS QHKAVEEDIM THSKALNQAL SIGQSLKTMS SWEDKDMVQE KLESFQSRYL
ELQEKCSRKA ALLHQALSNA QVFGEDEVEL MNWLNVVHDR LNNVSIQDYN TDILRKQHTA
QLALHEDILL RKQNVDQAIQ NGLELLKQTT GDDVVIIQEK LDGIKNRYTD ITKMSSEVSK
TLEQALQLAT KLQTTHEGLS RWLDKVESEL VSYEAQALAG EQLTQTQERQ KELKKESGDT
KALLDTLNEV SSALLELVPW RAREGLDKLV TEDNERYRLV SDTITQKVEE IDAAILRSQQ
FEQAADAELA WITETENKLM SLGDIRLEQD QTSAQLQVQK TFTMDILRHK DSIDELVGTR
DEIMSSFTED EKQSLKEKLE ALLKKYEVVC HINSERYLQL ERAQSLVSQF WETHEELWPW
LLETKTVISE LPAPAIEYET LKQQQEELRQ LRELIAEHKP HIDKMNKTGP QLLELSPEEG
LSIQEKYTAA DVLYSQIKED VKQRALALDE AISQSTQFHD KIDVMLESLE RIAERLRQPP
PISAEIEKIK EQISENRNVS VELEKLQPAY ETLKQRGEEM IARSEGADKD ISAKAVQDKL
DQMVFIWEDI QALTEERDIK LLDVMDLVEK FWCEQSALIA TIKDLQDLIR ELDEPGVDPS
VVKQQQETAE SIKEEVDGLQ EDLDLVQNLG AELITACGEP DKPIVKKNTD EVSSAWDNLN
KAWKERVDKL DEAMQGAVQY QDGLQALFDW VDIAESKIVS MSPVGTDLET VKQQMKELK
//
