ID H3A0Z3_LATCH Unreviewed; 117 AA.
AC H3A0Z3;
DT 18-APR-2012, integrated into UniProtKB/TrEMBL.
DT 18-APR-2012, sequence version 1.
DT 27-MAR-2024, entry version 45.
DE RecName: Full=Dynein light chain Tctex-type 3 {ECO:0000256|ARBA:ARBA00039901};
GN Name=DYNLT3 {ECO:0000313|Ensembl:ENSLACP00000003314.1};
OS Latimeria chalumnae (Coelacanth).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Coelacanthiformes; Coelacanthidae; Latimeria.
OX NCBI_TaxID=7897 {ECO:0000313|Ensembl:ENSLACP00000003314.1, ECO:0000313|Proteomes:UP000008672};
RN [1] {ECO:0000313|Proteomes:UP000008672}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Wild caught {ECO:0000313|Proteomes:UP000008672};
RA Di Palma F., Alfoldi J., Johnson J., Berlin A., Gnerre S., Jaffe D.,
RA MacCallum I., Young S., Walker B.J., Lander E., Lindblad-Toh K.;
RT "The draft genome of Latimeria chalumnae.";
RL Submitted (AUG-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSLACP00000003314.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- FUNCTION: Acts as one of several non-catalytic accessory components of
CC the cytoplasmic dynein 1 complex that are thought to be involved in
CC linking dynein to cargos and to adapter proteins that regulate dynein
CC function. Cytoplasmic dynein 1 acts as a motor for the intracellular
CC retrograde motility of vesicles and organelles along microtubules.
CC Probably binds BUB3 as part of transport cargo. Required for the
CC efficient progression through mitosis. {ECO:0000256|ARBA:ARBA00037393}.
CC -!- SUBCELLULAR LOCATION: Chromosome, centromere, kinetochore
CC {ECO:0000256|ARBA:ARBA00004629}. Cytoplasm, cytoskeleton
CC {ECO:0000256|ARBA:ARBA00004245}. Nucleus
CC {ECO:0000256|ARBA:ARBA00004123}.
CC -!- SIMILARITY: Belongs to the dynein light chain Tctex-type family.
CC {ECO:0000256|ARBA:ARBA00005361}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AFYH01102987; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01102988; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01102989; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; H3A0Z3; -.
DR STRING; 7897.ENSLACP00000003314; -.
DR Ensembl; ENSLACT00000003344.1; ENSLACP00000003314.1; ENSLACG00000002963.1.
DR eggNOG; KOG4081; Eukaryota.
DR GeneTree; ENSGT00940000155009; -.
DR InParanoid; H3A0Z3; -.
DR OMA; EEYHRPC; -.
DR TreeFam; TF313904; -.
DR Proteomes; UP000008672; Unassembled WGS sequence.
DR Bgee; ENSLACG00000002963; Expressed in muscle tissue and 6 other cell types or tissues.
DR GO; GO:0030286; C:dynein complex; IEA:UniProtKB-KW.
DR GO; GO:0000776; C:kinetochore; IEA:UniProtKB-KW.
DR GO; GO:0005874; C:microtubule; IEA:UniProtKB-KW.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0007049; P:cell cycle; IEA:UniProtKB-KW.
DR GO; GO:0051301; P:cell division; IEA:UniProtKB-KW.
DR CDD; cd21463; DLC-like_DYNLT3; 1.
DR Gene3D; 3.30.1140.40; Tctex-1; 1.
DR InterPro; IPR005334; Tctex-1-like.
DR InterPro; IPR038586; Tctex-1-like_sf.
DR PANTHER; PTHR21255:SF20; DYNEIN LIGHT CHAIN TCTEX-TYPE 3; 1.
DR PANTHER; PTHR21255; T-COMPLEX-ASSOCIATED-TESTIS-EXPRESSED 1/ DYNEIN LIGHT CHAIN; 1.
DR Pfam; PF03645; Tctex-1; 1.
PE 3: Inferred from homology;
KW Cell cycle {ECO:0000256|ARBA:ARBA00023306};
KW Cell division {ECO:0000256|ARBA:ARBA00022618};
KW Centromere {ECO:0000256|ARBA:ARBA00023328};
KW Chromosome {ECO:0000256|ARBA:ARBA00022454};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00023212};
KW Cytoskeleton {ECO:0000256|ARBA:ARBA00023212};
KW Dynein {ECO:0000256|ARBA:ARBA00023017};
KW Kinetochore {ECO:0000256|ARBA:ARBA00022838};
KW Microtubule {ECO:0000256|ARBA:ARBA00022701};
KW Mitosis {ECO:0000256|ARBA:ARBA00022776};
KW Motor protein {ECO:0000256|ARBA:ARBA00023175};
KW Nitration {ECO:0000256|ARBA:ARBA00023074};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000008672};
KW Transport {ECO:0000256|ARBA:ARBA00022448}.
SQ SEQUENCE 117 AA; 12990 MW; 0694D3B264AAA6E3 CRC64;
CEVRFAGFEL SFLFNAEEAS DMVKECIEGV IGRVDYNHNQ VNQWTAGIVE QSLTQLVKLG
KPLKYIVNCA VMQKSGAGLH TANSCFWDTT TDGSCTVRWE NRTMYCIVSV FAVAIAL
//
