ID H3A199_LATCH Unreviewed; 743 AA.
AC H3A199;
DT 18-APR-2012, integrated into UniProtKB/TrEMBL.
DT 18-APR-2012, sequence version 1.
DT 27-MAR-2024, entry version 63.
DE RecName: Full=G-protein coupled receptors family 3 profile domain-containing protein {ECO:0000259|PROSITE:PS50259};
GN Name=LOC102353077 {ECO:0000313|Ensembl:ENSLACP00000003420.1};
OS Latimeria chalumnae (Coelacanth).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Coelacanthiformes; Coelacanthidae; Latimeria.
OX NCBI_TaxID=7897 {ECO:0000313|Ensembl:ENSLACP00000003420.1, ECO:0000313|Proteomes:UP000008672};
RN [1] {ECO:0000313|Proteomes:UP000008672}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Wild caught {ECO:0000313|Proteomes:UP000008672};
RA Di Palma F., Alfoldi J., Johnson J., Berlin A., Gnerre S., Jaffe D.,
RA MacCallum I., Young S., Walker B.J., Lander E., Lindblad-Toh K.;
RT "The draft genome of Latimeria chalumnae.";
RL Submitted (AUG-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSLACP00000003420.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004651};
CC Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
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DR EMBL; AFYH01226602; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01226603; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01226604; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01226605; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01226606; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; H3A199; -.
DR Ensembl; ENSLACT00000003450.1; ENSLACP00000003420.1; ENSLACG00000003050.1.
DR GeneTree; ENSGT00950000182788; -.
DR HOGENOM; CLU_005389_5_0_1; -.
DR Proteomes; UP000008672; Unassembled WGS sequence.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0004930; F:G protein-coupled receptor activity; IEA:UniProtKB-KW.
DR CDD; cd15283; 7tmC_V2R_pheromone; 1.
DR Gene3D; 3.40.50.2300; -; 2.
DR Gene3D; 2.10.50.30; GPCR, family 3, nine cysteines domain; 1.
DR InterPro; IPR001828; ANF_lig-bd_rcpt.
DR InterPro; IPR000337; GPCR_3.
DR InterPro; IPR011500; GPCR_3_9-Cys_dom.
DR InterPro; IPR038550; GPCR_3_9-Cys_sf.
DR InterPro; IPR017978; GPCR_3_C.
DR InterPro; IPR000068; GPCR_3_Ca_sens_rcpt-rel.
DR InterPro; IPR017979; GPCR_3_CS.
DR InterPro; IPR004073; GPCR_3_vmron_rcpt_2.
DR InterPro; IPR028082; Peripla_BP_I.
DR PANTHER; PTHR24061; CALCIUM-SENSING RECEPTOR-RELATED; 1.
DR PANTHER; PTHR24061:SF0; VOMERONASAL 2, RECEPTOR 23-RELATED; 1.
DR Pfam; PF00003; 7tm_3; 1.
DR Pfam; PF01094; ANF_receptor; 1.
DR Pfam; PF07562; NCD3G; 1.
DR PRINTS; PR00248; GPCRMGR.
DR PRINTS; PR01535; VOMERONASL2R.
DR SUPFAM; SSF53822; Periplasmic binding protein-like I; 1.
DR PROSITE; PS00981; G_PROTEIN_RECEP_F3_3; 1.
DR PROSITE; PS50259; G_PROTEIN_RECEP_F3_4; 1.
PE 4: Predicted;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW G-protein coupled receptor {ECO:0000256|ARBA:ARBA00023040};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Receptor {ECO:0000256|ARBA:ARBA00023170};
KW Reference proteome {ECO:0000313|Proteomes:UP000008672};
KW Transducer {ECO:0000256|ARBA:ARBA00023224};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 480..500
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 520..538
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 550..574
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 594..612
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 640..662
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 674..694
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 700..721
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 480..743
FT /note="G-protein coupled receptors family 3 profile"
FT /evidence="ECO:0000259|PROSITE:PS50259"
SQ SEQUENCE 743 AA; 83126 MW; 391D77B8E2DA6155 CRC64;
LITGKEEAVP NYRCSSSNPL AAIIGEASDK MTIAIATLLR VHNYPQISHA TTVDFLSDRQ
QFPSFFRTIP NGNYRSRSLV KLMQYFGWNW VGTVAEDNEI GELATQDLIQ ELDKTEICIG
FSETIPNVYS AIKIRHVVEV IRRSSVNAIV IISYELFIVP LIAEVTRQNI TGKVWVSTEA
WSTSASFYKG SQARTVTGTI GVAVHKGDIP GFKEFLLRLN PFTSQDNIYI KNFWEHMFGC
SWPNAETYQA IAASDMNEGI KFCTGSEKLN ELNVSFFDAS ESRITYNVYN GIYAIAHALH
DLYMCIPGEG PFENGTCANI HYFEPWQLLH YVKNVHFTNK LGEEIYFDGN GNPPPLYDII
NWHRVPDGNL KNVEVGRFNF SAPHGKDFII NNSALMWNGG NTQQIPHSIC SESCPPGYRK
AARRGQPICC FDCILCSEGE ITNQTDSIDC LKCPSDHWSS NGRDKCIPKT IEFLSYQEPL
GATLASVSIL FSLIPAAILC TFVKHRDTPI VKANNRELSY LLLLALMLCF LCSLIFIGQP
KISTCMLRQV AFGIIFALCV SCVLAKTIMV VIAFNATKPN SKLKKWVGPK LPNAVVFVCT
VIQVIICIAW LSSSPPFPEQ NMRSQIQKII IECNDGSTTA FWLVLGYMGI LAIVCFIVAF
LARNLPDSFN EAKFITFSML VFVTVWLSFI PAYLSTKGKY MVAVEIFAIL ASSTGLMACI
FSPKCYIIIL RPERNTREYL MGK
//
