ID H3A1N3_LATCH Unreviewed; 5051 AA.
AC H3A1N3;
DT 18-APR-2012, integrated into UniProtKB/TrEMBL.
DT 18-APR-2012, sequence version 1.
DT 27-MAR-2024, entry version 76.
DE RecName: Full=RCR-type E3 ubiquitin transferase {ECO:0000256|ARBA:ARBA00012249};
DE EC=2.3.2.33 {ECO:0000256|ARBA:ARBA00012249};
GN Name=MYCBP2 {ECO:0000313|Ensembl:ENSLACP00000003554.1};
OS Latimeria chalumnae (Coelacanth).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Coelacanthiformes; Coelacanthidae; Latimeria.
OX NCBI_TaxID=7897 {ECO:0000313|Ensembl:ENSLACP00000003554.1, ECO:0000313|Proteomes:UP000008672};
RN [1] {ECO:0000313|Proteomes:UP000008672}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Wild caught {ECO:0000313|Proteomes:UP000008672};
RA Di Palma F., Alfoldi J., Johnson J., Berlin A., Gnerre S., Jaffe D.,
RA MacCallum I., Young S., Walker B.J., Lander E., Lindblad-Toh K.;
RT "The draft genome of Latimeria chalumnae.";
RL Submitted (AUG-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSLACP00000003554.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=[E2 ubiquitin-conjugating enzyme]-S-ubiquitinyl-L-cysteine +
CC [acceptor protein]-L-threonine = [E2 ubiquitin-conjugating enzyme]-L-
CC cysteine + [acceptor protein]-3-O-ubiquitinyl-L-threonine.;
CC EC=2.3.2.33; Evidence={ECO:0000256|ARBA:ARBA00000333};
CC -!- PATHWAY: Protein modification; protein ubiquitination.
CC {ECO:0000256|ARBA:ARBA00004906}.
CC -!- SUBCELLULAR LOCATION: Cell projection, axon
CC {ECO:0000256|ARBA:ARBA00004489}.
CC -!- SIMILARITY: Belongs to the RING-Cys relay (RCR) family.
CC {ECO:0000256|ARBA:ARBA00005415}.
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DR EMBL; AFYH01032547; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01032548; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01032549; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01032550; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01032551; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01032552; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01032553; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01032554; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01032555; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01032556; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR STRING; 7897.ENSLACP00000003554; -.
DR Ensembl; ENSLACT00000003586.1; ENSLACP00000003554.1; ENSLACG00000003166.1.
DR eggNOG; KOG1428; Eukaryota.
DR GeneTree; ENSGT00940000155756; -.
DR HOGENOM; CLU_000063_0_0_1; -.
DR InParanoid; H3A1N3; -.
DR OMA; MAHPGCG; -.
DR TreeFam; TF313151; -.
DR UniPathway; UPA00143; -.
DR Proteomes; UP000008672; Unassembled WGS sequence.
DR Bgee; ENSLACG00000003166; Expressed in chordate pharynx and 6 other cell types or tissues.
DR GO; GO:0030424; C:axon; IEA:UniProtKB-SubCell.
DR GO; GO:0005737; C:cytoplasm; IEA:Ensembl.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0004842; F:ubiquitin-protein transferase activity; IEA:Ensembl.
DR GO; GO:0016198; P:axon choice point recognition; IEA:Ensembl.
DR GO; GO:0048677; P:axon extension involved in regeneration; IEA:Ensembl.
DR GO; GO:0048066; P:developmental pigmentation; IEA:Ensembl.
DR GO; GO:0021986; P:habenula development; IEA:Ensembl.
DR GO; GO:0016567; P:protein ubiquitination; IEA:UniProtKB-UniPathway.
DR GO; GO:0042068; P:regulation of pteridine metabolic process; IEA:Ensembl.
DR GO; GO:0031290; P:retinal ganglion cell axon guidance; IEA:Ensembl.
DR CDD; cd19799; Bbox2_MYCBP2; 1.
DR CDD; cd16463; RING-H2_PHR; 1.
DR Gene3D; 2.60.120.260; Galactose-binding domain-like; 1.
DR Gene3D; 2.60.40.10; Immunoglobulins; 1.
DR Gene3D; 2.60.120.820; PHR domain; 2.
DR Gene3D; 2.130.10.30; Regulator of chromosome condensation 1/beta-lactamase-inhibitor protein II; 2.
DR Gene3D; 3.30.40.10; Zinc/RING finger domain, C3HC4 (zinc finger); 1.
DR InterPro; IPR004939; APC_su10/DOC_dom.
DR InterPro; IPR017868; Filamin/ABP280_repeat-like.
DR InterPro; IPR008979; Galactose-bd-like_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR014756; Ig_E-set.
DR InterPro; IPR012983; PHR.
DR InterPro; IPR038648; PHR_sf.
DR InterPro; IPR009091; RCC1/BLIP-II.
DR InterPro; IPR000408; Reg_chr_condens.
DR InterPro; IPR001841; Znf_RING.
DR InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR PANTHER; PTHR45943; E3 UBIQUITIN-PROTEIN LIGASE MYCBP2; 1.
DR PANTHER; PTHR45943:SF1; E3 UBIQUITIN-PROTEIN LIGASE MYCBP2; 1.
DR Pfam; PF08005; PHR; 2.
DR Pfam; PF00415; RCC1; 1.
DR Pfam; PF13540; RCC1_2; 1.
DR PRINTS; PR00633; RCCNDNSATION.
DR SMART; SM01337; APC10; 1.
DR SMART; SM00184; RING; 1.
DR SUPFAM; SSF81296; E set domains; 1.
DR SUPFAM; SSF49785; Galactose-binding domain-like; 1.
DR SUPFAM; SSF50985; RCC1/BLIP-II; 1.
DR SUPFAM; SSF57850; RING/U-box; 1.
DR PROSITE; PS51284; DOC; 1.
DR PROSITE; PS50194; FILAMIN_REPEAT; 1.
DR PROSITE; PS00626; RCC1_2; 1.
DR PROSITE; PS50012; RCC1_3; 2.
DR PROSITE; PS50089; ZF_RING_2; 1.
PE 3: Inferred from homology;
KW Cell projection {ECO:0000256|ARBA:ARBA00023273};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Reference proteome {ECO:0000313|Proteomes:UP000008672};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Ubl conjugation pathway {ECO:0000256|ARBA:ARBA00022786};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW ProRule:PRU00175}.
FT REPEAT 831..886
FT /note="RCC1"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00235"
FT REPEAT 887..937
FT /note="RCC1"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00235"
FT REPEAT 2753..2846
FT /note="Filamin"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00087"
FT DOMAIN 4045..4223
FT /note="DOC"
FT /evidence="ECO:0000259|PROSITE:PS51284"
FT DOMAIN 4810..4861
FT /note="RING-type"
FT /evidence="ECO:0000259|PROSITE:PS50089"
FT REGION 808..856
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2976..3002
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 3122..3165
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 3191..3252
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 3299..3318
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 3364..3389
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 3421..3462
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 3544..3569
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2988..3002
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 3129..3165
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 3196..3233
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 3428..3455
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 5051 AA; 555520 MW; 4C6D1E8BCF37D0A3 CRC64;
MGSGSGSGLG PGAQSDCRSR YQLLLSGKAL AERYRRIYTA AISDKDQGIQ QGRNKKILGK
KKLKRKQKSK SKVKARTKGD NLEGTFSVPD IKLHSNPSAF NVYCNVRQCV LEWQRKEASL
ALALKNSVLS GDSDSDEEEE SKELPVKLPK IVGIGLCGVF ELIKETRFSH PSLCHRSLQA
LLDMLQGQQP EGLQSEPTDV LESLFQLLLE TTIRSTGLND SMAQSLTALS CACLFSLVVA
WGDTGKTLQA ISAILTNNGS HACQTIQVPT ILNSLQRSVQ AVLVGKIQIQ DWFNNGIKKA
SLMHKWALKE VTVDEDEHCL LQSDGSFLYL LCRNGLYRVG SGYSGTVRGH VYSFTSNIRN
RKDKRSWLGF AKGFLLYREL VRIAGTFQAK FWSVDALDSL KSIITELTLC HQTEGQNILF
TDGEYINQIA ASKDDGFVVR IYATSTESVL QQELQLKLAR KCLHACGISL FDLEKDLHII
NSIASSFMGW LIELRTPGTG FDDDSAVLGA GREFALMKTA AGKIYYTGKY QSLGIKQGGP
AAGKWVELPI TKSPKIVQFS VGHDGSHALL VAEDGSVFFT GSSSKGEDGE STKSRRQAKP
YKPKKMIKME GKVALYTACN NGSSSVLTKD GELYMFGKDA IYCDSSNLVI ELKGHFVTQV
AMGKAHACVL TKNGEVWTFG VNNKGQCGRD TGSMNQGGKA PPKKKNSGTV SLRDIIYQLD
LDEKDEKAMM CPPGMHKWKL DQCMVCTACG DCTGYGPSCV SSGRPDRVPG GICGCGSGES
GCSVCGCCKA CARELDGQEA RQNLQCGPCP TRSQHRRASS VTSRRKEATN KQKTKFGGGG
DGSGERGEKD ASKTTTYPPG AVRFDCELRA VQVSCGFHHS VILMENGDVY TFGYGQHGQL
GHGDVNSRGA PTLVQGLPGP STQVTAGSNH TAVLLTDGQV STFGSFSKKK LKQNPSPTTT
SYLLKKKKKN QTDSAVKTPG PAVGLFVFLG GGPVTAVYPM PEKWEVQGVT LPSRSENKPH
VLPILDMPYW NAKPAPMPNI GAKYGRKATW IGASGDQTFL RIDEALINSH VLATSEIFAS
KQIIVCVYIN VSVREPSIHM IFDKSLHHHE GGPTNVHVLT HTKQPLRIFS NTENNNSAPK
TRTPPHTHTQ CIYIALIGTE AAGLTVACSV ERRDLSARNL KIKQTKLKIL GAPAVAATKR
PGIPFGAHSH PKMRLNSSPG TSSDEKALAL VDFSFSKDPV FDVLWRFMSD TREFWCYNSV
VADARLPSVS DMQTRCSILS PELALPIGPK AFTTRSHGAL HVLACIHILS SCSFSNRWWF
SRPALSPPEH VARTMASGYA VLGLFRSHGG GWGYSAHSVE AIRFCADTDI LLGGLGLFGG
RGEYTAKIKL FELGPDGGDH ETDGDLLAET DVLAYDCAAR EKYAMMFDEP VILQSGWWYV
AWARVSGPSS DCGSHGQASI TTDDGVIFQF KSSKKSNNGT DVNAGQIPQL LYRLPSSDGN
GSKGKQQTSE PVHILKKSFA RTVSVECFES LLSILHWSWT TLVLGVEELR GLKGYQYIAT
LLDLERLKFV GTCCLRLLRV YTCEIYPISE YYMFSMCTTG HAHVFYNRNA LPVKEVSTVL
IYLCELVVPL NFFCAIAICF LINLRFTSVA TKAVVEETSK LAECIGKTRS LLKGVDHCMV
KLDNDPQGYH SQPLALLEAV LQECHNTFTA CFHSFYPTPA LQWACLCDLL NCLDQTSSSR
LLAAVMSALC HTSVKLTSIL PIAYDGEVLL RTLAKQASTE NDSALAHRFP LLVAQMEKLS
QKKENEENLT GITSFREVLE KMLVIVVLPV RKSLRQEMEL FSPHLVSNTC GLLASIVCEL
TVLALGSEKY RKLLLTPSLH KSSPNRFTKT SQGRSWNTGN GSPDAICFMV DKPGVVVVGF
CVYGGGGIHE YELEVLVDDS ENTGDSSHSH RWTTLELVKG TYSTDDSSSD MAEIRLDKAV
PLKENVKYAV RLRNYGSRTA NGDGGMTTVQ CPDGVTFTFS TCSLSSNGTN QTRGQIPQIL
YYRFVCFCGV KQADINLNRR KNYSFVLHVL HKRIIQYPSC VHNIDIETER QRDLKYSIVF
FAIMTCNFFF WFCRSEYDGD LQSQLLSKAN EEDKNCSRAL SVVGAVARAA KDLLHRAVAV
DASLASLLKY SDRQTDRSNL TLDVGLAQLP PSRVKRGNTS ESFLSSCIIM SSVLGFPSRR
GVDLNLGVVC ICISLCLFKN KTKQKKKTTA TFIICYTTVI EKKPTQVEIA DDIPELLSSS
SLFSMLLPLI LAYIGPVAAT IPKAAVEVFG LVQQLLPAVA ALNQKYAPPA FNPNQSTDSA
TGNMPEQGLS ACTTSNHYAV VESDHPYKPA SVAQYKVSFP ECVRWMTIEF DPQCGTGQPE
DVLRLLIPSR AFQNSGFASK QTAVPDSLNS WIELKKFSCS SGWPTTVLVL PGKVHSFYKL
TQNKTCTMQL CFDVLGADNL PHKESIPTPT PEQNKEAEPK MRVYSVAKIF KMSQSWRHSP
FFFSGNEALF SLETASDYVK DEKACFFGFK CIAVGYEFSP GTDEFFSGII QLEKELAYLG
SVCAAALMKK DLALPIGSEL EEDLEILEES ALQVCKAHSG ILGKGLVLSH SPTILEALEG
NLPIHIHTNE HSFLEDFIAC VPGSSGGRLA RWLQPDSYAD PQKTSLLLNK DDIRCSWPVT
ITVLTKDQYG DVVHVPNMKV EVKAIPVSQK KTSVQQENIK KLQRIPGSPA IASSSSDLTF
GGLPSPKLEA SYEPVIVKEA RYIAVTMMKA YENYSFEELR FASPTPKRPS ENMLIRANND
GSYSANWTPG AVGLYTVHVT IDGIEIDAGL EVEVKDPPKG MIPPGTQLVK PKVEPQPSKV
RVFVAKDSAG LRIRSHPSLQ SEQIGIVKVN GTITFIDEIH NDDGVWLRLN DETVKKYVPN
MNGYTEAWCL SFNQHLGKSL LVPVDNREKK MYRKSATSLL RGQKNPPTAS PPSLPGEKSP
LSRPPPPPIF LFYRANTIGS RSSDSSSKPF LNPGLRWMLE DIECNIQNKS SKRQAPFVFG
QPLSFQPPQP QLLTKPCYFV STVHIGANFC IHWWVLVLGG GAARLRSLQE FFFGINMVNA
PPRSRAESPA PGSRSSSPKQ KALPGGKSSP SSVSSPRSLS PHDKSLPQKV VQENLHSEVV
EVCTSSTLKA NGSESIEENG DVKHAEDNSS KVHFSIGKAP SKEEQDTRAS PKVSRKSTTR
HVRPKKAVEP AKQAMSPSVA ECARAVFAAF LWHEGIVHDA MACSSFLKFN PELSKEHAPI
RSNLTSQQSA DEKETKLKNR HSLEISSALN MFNISPHGPD ISKMGSINKN KVLSMLKEPP
LHEKCEDAKA ESTSDDAPGP HQTTSKSKSP LPLTLQHLVA FWEDISLATI KAATQNMIFP
SPGSSAVLKK KENEKDNRRY KKEKKKKDKS EVRPREMAQL AMGGPEKDTI CELCGESHPY
PVTYHMRQAH PGCGRYAGGQ GYNSIGHFCG GWAGNCGDGG IGGSTWYLVC DRCREKYLRE
KQAAAREKSV RQRRQEKKKR GEPLNPRGKK NIDLWLRNEK YSAWIEKSST SLINDVSSPV
ALLKLDFTDT SLYRDPTKVD VGFVAEIILH EMKHKGKGSE ANNTKMSGEI SSKICTCAQS
GVSRSNSAAE PSILCYHPPK PFLSQLPSLR EGISEDLPAK MTCLYLQTLA RYCINNCSLG
NTIEESSSSV EARWGGGGGI SGVITKTLFN NFSVSGSIPL LKRKKEENNH PTYQLLQMHA
PMSLRSLKHS ALPARVKAVP RRRVNSGDAE ILICYSDNSA RQLTKDLIAS EIMSLAEVGS
SLLRHPSPEL SRLISAHSSL CKGERNFQWP VLAFVIQHHD LEGLEVAMKH ALRKSACRVF
AMEAFNWLLC SVIQTTSLHD ILWHFVASLT PSPVSQPLGG GEKDTRVCEH PLSDIVIAGE
AAHPLPHTFH HLLQTISDLM MSLPGGSALQ QMALRCWSLK FKQSDHQFLH QSNVFHHINN
ILSKSDDGDS EESFNISVQS GYEAMNQIQP SKCSRPNNEL CMVTCLKDLT AIVDIKTSSR
PAMIGSLTDG STETFWESGD EDKNKTKSIT VSCVKGINAH YISVHVDNSR DLGNKVTSMA
FLTGKTVEEL CRIKQMDLDS RHIGWVTCEV PGGESHVIKI ELKGPENTLR VRQVKVLGWK
DGESIKIAGQ IAASVAQQKN CEAETLRVFR LITSQVFGKL MSNGLPIHAL LLIDNAGAHP
GPESLKAADR SIRAPSDADL KEHMVGIIFS RSKLTNLQKQ VCTHIVQAIR MEATRVREEW
EHAISSKENA NSQPSDEDAS SDAYCFELLS MVLALSGSNV GRQYLAQQLT LLQDLFSLLH
TASPRVQRQV TSLLRRVLPE VTPACLASII GVKALPPADI SDIIHSTEKG DWNKLGILDM
LLGCIAKALT VQLKAKGTTI TGTAGTAAEG GSSNVMNGYV LKNKNKKKLY GLVVLCLVSS
SLSNSSQILV SFPLNDSSGS LPPFLLSFLP PPPPNSYIRR GENHWWMKGS TPTQIAEIII
KLVKDMGAGH LSEAWSRVTK NAIAETIIAL TKMEEEHRSP VRCIATTRLW LALASLCVLD
QDHVDRLSSG RWMVLMCIPN PMCDNHDDGE TAAIILCNVC GNLCTDCDRF LHLHRRTRTH
QRQVFKEEEE AIKVDLHEGC GRTKLFWLMA LADSKTMKAM VEFRENTGKP TSSSNEACRF
CGSRSGTELS AVGSVCSDPD CQEYAKAACS KTHPCGHICG GVKNEEQCLP CLHGCDKSTS
SLKQDADDMC MICFTEALSA APAVQLDCSH VFHLQCCRRV LENRWIGPRI TFGFLACPIC
KNTVNHPRLK DLLDPIRQLY EDVRKKALMR LEYEGLHKSV RFYNDPAGFA MNRYAYYVCY
KCKKKYINRL NTKLGKHFHI RELYCRDCKD PCTASATQMC PKHGTDFLEY KCRYCCSVAV
FFCFGTTHFC NACHDDFQRI TSIPKEELPR CPAGPRGKQV EGTECPLHVV HPPTGEEFAL
GCGVCRNAHT F
//
