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Database: UniProt
Entry: H3A1P5_LATCH
LinkDB: H3A1P5_LATCH
Original site: H3A1P5_LATCH 
ID   H3A1P5_LATCH            Unreviewed;      2725 AA.
AC   H3A1P5;
DT   18-APR-2012, integrated into UniProtKB/TrEMBL.
DT   18-APR-2012, sequence version 1.
DT   16-JAN-2019, entry version 43.
DE   SubName: Full=Inositol 1,4,5-trisphosphate receptor type 1 {ECO:0000313|Ensembl:ENSLACP00000003566};
GN   Name=ITPR1 {ECO:0000313|Ensembl:ENSLACP00000003566};
OS   Latimeria chalumnae (West Indian ocean coelacanth).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Coelacanthiformes; Coelacanthidae; Latimeria.
OX   NCBI_TaxID=7897 {ECO:0000313|Ensembl:ENSLACP00000003566, ECO:0000313|Proteomes:UP000008672};
RN   [1] {ECO:0000313|Ensembl:ENSLACP00000003566}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Wild caught {ECO:0000313|Ensembl:ENSLACP00000003566};
RX   PubMed=9215903;
RA   Zardoya R., Meyer A.;
RT   "The complete DNA sequence of the mitochondrial genome of a 'living
RT   fossil,' the coelacanth (Latimeria chalumnae).";
RL   Genetics 146:995-1010(1997).
RN   [2] {ECO:0000313|Ensembl:ENSLACP00000003566}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (FEB-2012) to UniProtKB.
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DR   EMBL; AFYH01205518; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AFYH01205519; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AFYH01205520; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AFYH01205521; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AFYH01205522; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AFYH01205523; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AFYH01205524; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AFYH01205525; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AFYH01205526; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AFYH01205527; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   STRING; 7897.ENSLACP00000003566; -.
DR   Ensembl; ENSLACT00000003598; ENSLACP00000003566; ENSLACG00000003176.
DR   eggNOG; KOG3533; Eukaryota.
DR   eggNOG; ENOG410XR97; LUCA.
DR   GeneTree; ENSGT00940000155071; -.
DR   InParanoid; H3A1P5; -.
DR   OMA; PRHAPYK; -.
DR   TreeFam; TF312815; -.
DR   Proteomes; UP000008672; Unassembled WGS sequence.
DR   GO; GO:0005783; C:endoplasmic reticulum; IEA:InterPro.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0070679; F:inositol 1,4,5 trisphosphate binding; IEA:InterPro.
DR   GO; GO:0005220; F:inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity; IEA:InterPro.
DR   InterPro; IPR016024; ARM-type_fold.
DR   InterPro; IPR014821; Ins145_P3_rcpt.
DR   InterPro; IPR000493; InsP3_rcpt.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR036300; MIR_dom_sf.
DR   InterPro; IPR016093; MIR_motif.
DR   InterPro; IPR013662; RIH_assoc-dom.
DR   InterPro; IPR000699; RIH_dom.
DR   InterPro; IPR015925; Ryanodine_recept-rel.
DR   InterPro; IPR035910; RyR/IP3R_RIH_dom_sf.
DR   PANTHER; PTHR13715; PTHR13715; 1.
DR   Pfam; PF08709; Ins145_P3_rec; 1.
DR   Pfam; PF00520; Ion_trans; 1.
DR   Pfam; PF02815; MIR; 1.
DR   Pfam; PF08454; RIH_assoc; 1.
DR   Pfam; PF01365; RYDR_ITPR; 2.
DR   PRINTS; PR00779; INSP3RECEPTR.
DR   SMART; SM00472; MIR; 4.
DR   SUPFAM; SSF100909; SSF100909; 2.
DR   SUPFAM; SSF48371; SSF48371; 1.
DR   SUPFAM; SSF82109; SSF82109; 2.
DR   PROSITE; PS50919; MIR; 5.
PE   4: Predicted;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000008672};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000008672};
KW   Repeat {ECO:0000256|SAAS:SAAS00903904};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   2249   2271       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   2283   2301       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   2329   2347       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   2367   2394       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   2415   2437       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   2546   2569       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN       58    112       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      119    169       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      177    233       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      240    319       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      325    381       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   COILED     1558   1578       {ECO:0000256|SAM:Coils}.
FT   COILED     2663   2704       {ECO:0000256|SAM:Coils}.
SQ   SEQUENCE   2725 AA;  310764 MW;  BED3B034A164C3E8 CRC64;
     DCLFKLCPMN RYSAQKQFWK AAKPGANNTT DAVLLNKLHH AADLEKKQNE SENKKLLGTI
     IQYGNVIQLL HLKSNKYLTV NKRLPALLEK NAMRVTLDAA GNEGSWFYIQ PFYKLRSIGD
     SVVIGDKVVL NPVNAGQPLH ASSHQLVDNP GCNEVNSVNC NTSWKIVLFM KWSDNKEIIL
     KGGDVVRLFH AEQEKFLTCD EHRKKQYVFL RTTGRQSATS ATSSKALWEV EVVQHDPCRG
     GAGYWNSLFR FKHLATGHYL AAEVNPDYEE ECQDSRSSME SEQETSRARI RAVQEKMMYT
     LVSVPDGNDI SSIFELDPTT LRGGDSLVPR NSYVRLRHLC TNTWVHSTNI PIDKEEEKPV
     MLKIGTSPVK EDKEAFAIVP VSPAEVRDLD FANDASKVLA SIAGKLEKGT ITQNERRFVT
     KLLEDLVYFV ADVPNSGQDV LEVMVSKPNR ERQKLMREQN ILKQIFKLLQ APFTDCGDGP
     MLRLEELADQ RHAPFRHICR LCYRVLRHSQ QDYRKNQEYI AKQFGFMQKQ IGYDVLAEDT
     ITALLHNNRK LLEKHITGAE IDTFVSLVRK NREPRFLDYL SDLCVSMNKS IPVTQELICK
     AVLNPANADI LIETKLVLSR FEFEGMTVEE NTLETGEDEE EVWLFWKDVN KETRSKSVRE
     LAQDAKEGQK DDQDVLSYYR YQLNLFARMC LDRQYLAINE ISGQLDVDLI LRCMSDENLP
     FDLRASFCRL MLHMHVDRDP QEQVTPVKYA RLWSEIPSKI AIDDYDSNGT SKDEIKERFA
     QTMDFVEEYL RDVVCQRFPF SDKEKNKLTF EVVNLARNLI YFGFYSFSDL LRLTKILLAI
     LDCVHVTTIF PMTKLSKGED NKICNSDRSL LGSNVMKSIH GVGELMTQVV LRGGGFLPMT
     PLTPPDGTVV KQQSEPEKED ILVMDTKLKI IEILQFILNV RLDYRISCLL CIFKREFDES
     NTPSESSAGS NHLEGPSNVP GALDFEHIEE QAESIFGGSE ENTPLDLDDH GGRTFLRVLL
     HLTMHDYPPL VSGALHLLFR HFSQRQEVLQ AFKQVQLLVT SQDVENYKQI KQDLDQLRSI
     VEKSELWVYK GQGQDEANDA VDGATGESGH KKKGADSGSP GSDKSHKYES TSSYNYRVVK
     ELLTDLKYKS IQADNRKTKS KLQKENLFRN SIWGRNIVKI FMHSLQYEKT EDMRMQDIMK
     LAHEFLQNFC AGNPQNQALL HKHINLFLNP GILEAVTMQH IFMNNYQLCS EINERVVQHF
     VHCIETHGRN VQYIKFLQTI VKAEGKFIKK CQDMVMAELV NAGEDVLVFY NDRASFQTLV
     QMMRSERDRM DENSPLMYHI HLVELLAVCT EGKNVYTEIK CNSLLPLDDI VRVVTHEDCI
     PEVKIAYINF LNHCYVDTEV EMKEIYTSNH MWKLFENFLV DICRVCNNTS DRKHADTVLE
     KYVTETVMSI VTTFFSSPFS DQSTSLQTRQ PVFVQLLQGV FRVYHCNWLL PTQKASVESC
     IKVLSDVAKS RAIAIPVDLD SQVNNLFLKS HNIVQKTAMS WRLSARNAAR RDSVLAASRD
     YRNIIERLQD IVSSLEDRLR PLVQAELSVL VDVLHRPELL FPENTEARRK CESGGFICKL
     IKHTKQLLEE NEEKLCIKVL QTLREMMTKD RGYGEKLIAF DDELDIAELS QPPEKENPVE
     QELDQNLPQK QLEDQKRDKG EALRQLLVNR YYGNVRSGGR KESLTSFGNV PLSPGGANKP
     GAGGGGSGPG TLSRGEMSLA DVQCHLDKEG ASDLVIDLIM NATSDRVFHE SILLAIALLE
     GGNTTIQHSF YCRLTEDKKS EKFFKVFYDR MKVAQQEIKA TVTVNTSDLG NKKKDDDPLE
     RDVPVRRRAK ESTAQITEDA REQLLDASAA TRKAFNAFRR EADSEENFAS AEGTQPSGDK
     NKDDGEMSAV IAIMQPILRF LQLLCENHNR DLQNFLRCQN NKTNYNLVCE TLQFLDCICG
     STTGGLGLLG LYINEKNVAL INQTLESLTE YCQGPCHENQ NCIATHESNG IDIIIALILN
     DINPLGKKRM DLVLELKNNA SKLLLAIMES RHDSENAERI LYNMRPKELV EVIKKAYLQG
     EVEYEEGENG EDQSASPRNV GHNIYILAHQ ELWHSSDGLY LIFLGSKVTY KKGAQQAEYR
     TKYISQIKFI AFSLRFESVL FLSIANVCET PQGHNNFKIY RATTLSYSQF TQGNFNFANN
     SFSFQKQTNK QKNPTAKPVF YWCSRNMSFW SSISFNLAVL INLLVAFFYP FEGDRGGTLD
     PHLSWLLWLA ILISLAIVIA LPQPNGIRAL IASTILRLIF SVGLQPTLFL LGAFNVGNKI
     IFLMSFVGNR GTFTRGYKAT ILDVEFLYHL AYLLICAFGL FVHEFFYSLL LFDLVYREET
     LLNVIKSVTR NGRSIVLTAV LALILVYLFS IVGYLFFKDD FLLEVDLLDD ETLLANGVGE
     SIAQEFVPSD VCRLRNRENC SVLQPLEEKE PISEEETGKE HTCETLLMCI VTVLSHGLRS
     GGGVGDVLRK PSKEEPLFAA RVIYDLLFFF MVIIIVLNLI FGVIIDTFAD LRSEKQKKEE
     VLKTTCFICG LERDKFDNKT VTFEEHIKEE HNMWHYLCFI VLVKVKDSTE YTGPESYVAE
     MIKEHNLDWF PRMRAMSLVS SDSEGEQNEL RNLQEKLEST MKLVTNLSNQ LSELKEQMTE
     QRKQKQRIGL LGHPPHMNVN PQQPA
//
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