ID H3A2I4_LATCH Unreviewed; 959 AA.
AC H3A2I4;
DT 18-APR-2012, integrated into UniProtKB/TrEMBL.
DT 18-APR-2012, sequence version 1.
DT 27-MAR-2024, entry version 64.
DE SubName: Full=Bromodomain testis associated {ECO:0000313|Ensembl:ENSLACP00000003855.1};
GN Name=BRDT {ECO:0000313|Ensembl:ENSLACP00000003855.1};
OS Latimeria chalumnae (Coelacanth).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Coelacanthiformes; Coelacanthidae; Latimeria.
OX NCBI_TaxID=7897 {ECO:0000313|Ensembl:ENSLACP00000003855.1, ECO:0000313|Proteomes:UP000008672};
RN [1] {ECO:0000313|Proteomes:UP000008672}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Wild caught {ECO:0000313|Proteomes:UP000008672};
RA Di Palma F., Alfoldi J., Johnson J., Berlin A., Gnerre S., Jaffe D.,
RA MacCallum I., Young S., Walker B.J., Lander E., Lindblad-Toh K.;
RT "The draft genome of Latimeria chalumnae.";
RL Submitted (AUG-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSLACP00000003855.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR EMBL; AFYH01117512; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01117513; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01117514; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01117515; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01117516; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01117517; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01117518; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01117519; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01117520; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01117521; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; H3A2I4; -.
DR STRING; 7897.ENSLACP00000003855; -.
DR Ensembl; ENSLACT00000003890.1; ENSLACP00000003855.1; ENSLACG00000003432.1.
DR eggNOG; KOG1474; Eukaryota.
DR GeneTree; ENSGT00940000154549; -.
DR HOGENOM; CLU_001499_0_0_1; -.
DR InParanoid; H3A2I4; -.
DR OMA; PITYEMQ; -.
DR TreeFam; TF317345; -.
DR Proteomes; UP000008672; Unassembled WGS sequence.
DR Bgee; ENSLACG00000003432; Expressed in chordate pharynx and 2 other cell types or tissues.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0030154; P:cell differentiation; IEA:UniProtKB-KW.
DR GO; GO:0051321; P:meiotic cell cycle; IEA:UniProtKB-KW.
DR GO; GO:0007283; P:spermatogenesis; IEA:UniProtKB-KW.
DR CDD; cd05497; Bromo_Brdt_I_like; 1.
DR CDD; cd05498; Bromo_Brdt_II_like; 1.
DR Gene3D; 1.20.1270.220; -; 1.
DR Gene3D; 1.20.920.10; Bromodomain-like; 2.
DR InterPro; IPR031354; BRD4_CDT.
DR InterPro; IPR043508; Bromo_Brdt_I.
DR InterPro; IPR043509; Bromo_Brdt_II.
DR InterPro; IPR001487; Bromodomain.
DR InterPro; IPR036427; Bromodomain-like_sf.
DR InterPro; IPR018359; Bromodomain_CS.
DR InterPro; IPR027353; NET_dom.
DR InterPro; IPR038336; NET_sf.
DR PANTHER; PTHR22880:SF175; BROMODOMAIN TESTIS-SPECIFIC PROTEIN; 1.
DR PANTHER; PTHR22880; FALZ-RELATED BROMODOMAIN-CONTAINING PROTEINS; 1.
DR Pfam; PF17035; BET; 1.
DR Pfam; PF17105; BRD4_CDT; 1.
DR Pfam; PF00439; Bromodomain; 2.
DR PRINTS; PR00503; BROMODOMAIN.
DR SMART; SM00297; BROMO; 2.
DR SUPFAM; SSF47370; Bromodomain; 2.
DR PROSITE; PS00633; BROMODOMAIN_1; 2.
DR PROSITE; PS50014; BROMODOMAIN_2; 2.
DR PROSITE; PS51525; NET; 1.
PE 4: Predicted;
KW Bromodomain {ECO:0000256|ARBA:ARBA00023117, ECO:0000256|PROSITE-
KW ProRule:PRU00035}; Reference proteome {ECO:0000313|Proteomes:UP000008672};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT DOMAIN 45..117
FT /note="Bromo"
FT /evidence="ECO:0000259|PROSITE:PS50014"
FT DOMAIN 291..363
FT /note="Bromo"
FT /evidence="ECO:0000259|PROSITE:PS50014"
FT DOMAIN 508..590
FT /note="NET"
FT /evidence="ECO:0000259|PROSITE:PS51525"
FT REGION 1..23
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 206..270
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 396..428
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 443..520
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 582..688
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 772..792
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 868..940
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 214..233
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 238..263
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 396..414
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 468..483
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 486..502
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 503..520
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 594..614
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 643..670
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 671..685
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 868..909
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 920..939
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 959 AA; 108760 MW; B510A89F0A69893F CRC64;
MSGTKVPQQT TIVNPPPPEY LNSKKHGHLT NQLQYLQKVV MKALWRHNFA WPFQQPVDAR
SLNLPDYYVI IKNPMDLGTI KKRLEHNYYC KAMECIEDFN TMFTNCYVYN RPGDDIVLMA
QALEKLFLQK VAQMPQEEIE VSMIRDKRGG KAGIAIQFTK LKPPPLVSDP VIQQPVITVI
QTQTKVSQLP KTLTPLSSAQ LIPKVRKGVK RKADTTTPTT SVVTTSSESS PTPKELKPAK
IPSRRESGRP IKPPKKDLPD SQLQHQTGKK PKLSEQLKYC NCILKEMFAK KHAAYAWPFY
KPVDAEALGI HDYHDIIKHP MDLGTIKKKM DSREYKNAQE FAADIRLMFM NCYKYNPPDH
EVVAMARKLQ DVFEMRFARI PDELVESVPP FLPITGISKS SSSSESSSDD SSDSESSSEN
SEEERAQRLA RLQEQLRAVH EQLQALSQAP LSKPKKKKDK LKKKKEKCKR KDGGDEKKLL
CPQFSMKEEL NQQNQSKKIK QETPPECVSD EEINAKPMTY DEKRQLSLDI NKLPGDKLGR
VVNIIQSREL SLKDSSPDEI EIDFETLKPS TLRELEQYVK SCLKKKPKKT HAKKTTKCKE
DLHSEKKQEL EKRLQDVSGQ LNSGAKKNKS EKKIAAMEMG VPSRLSESSS SSSGSGSSSN
SSSSESSDSE SDMHIQFKKN KPLDSSSPKR YNLKLLRNLC YPHHFKICTQ LSACVASGSQ
QNAGLSCPCA CDHIRPPAVH FIEKELQDLQ GNNSFKQVSP YKRSLVTKSC GSEKDSSFST
HPAKSTDLQD GVSVTNSPVV QDIKIKNADS WASLGKMSTL TPPVIKSSSN SFKQFRKAAI
EKEEREKAFR AQELRKLQFD QAEKLPESVI QEKKREHDEG IVSEPVQKDQ EDLCRTQDEV
TREEKQEQEV QQPSLSSLDN DREVARKREQ ERRRREAMAG TIDMNLQSDI MATFEENLY
//
