ID H3A317_LATCH Unreviewed; 1453 AA.
AC H3A317;
DT 18-APR-2012, integrated into UniProtKB/TrEMBL.
DT 18-APR-2012, sequence version 1.
DT 27-MAR-2024, entry version 59.
DE SubName: Full=Interphotoreceptor matrix proteoglycan 2 {ECO:0000313|Ensembl:ENSLACP00000004038.1};
GN Name=IMPG2 {ECO:0000313|Ensembl:ENSLACP00000004038.1};
OS Latimeria chalumnae (Coelacanth).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Coelacanthiformes; Coelacanthidae; Latimeria.
OX NCBI_TaxID=7897 {ECO:0000313|Ensembl:ENSLACP00000004038.1, ECO:0000313|Proteomes:UP000008672};
RN [1] {ECO:0000313|Proteomes:UP000008672}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Wild caught {ECO:0000313|Proteomes:UP000008672};
RA Di Palma F., Alfoldi J., Johnson J., Berlin A., Gnerre S., Jaffe D.,
RA MacCallum I., Young S., Walker B.J., Lander E., Lindblad-Toh K.;
RT "The draft genome of Latimeria chalumnae.";
RL Submitted (AUG-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSLACP00000004038.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Secreted, extracellular space, extracellular
CC matrix, interphotoreceptor matrix {ECO:0000256|ARBA:ARBA00004593}.
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DR EMBL; AFYH01067848; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01067849; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01067850; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01067851; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01067852; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01067853; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01067854; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR STRING; 7897.ENSLACP00000004038; -.
DR Ensembl; ENSLACT00000004074.1; ENSLACP00000004038.1; ENSLACG00000003595.1.
DR eggNOG; ENOG502QT6W; Eukaryota.
DR GeneTree; ENSGT00530000063503; -.
DR HOGENOM; CLU_005111_0_0_1; -.
DR InParanoid; H3A317; -.
DR OMA; ESSIWPW; -.
DR TreeFam; TF331340; -.
DR Proteomes; UP000008672; Unassembled WGS sequence.
DR GO; GO:0042995; C:cell projection; IEA:UniProtKB-KW.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-KW.
DR GO; GO:0033165; C:interphotoreceptor matrix; IEA:UniProtKB-SubCell.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0008201; F:heparin binding; IEA:UniProtKB-KW.
DR GO; GO:0007601; P:visual perception; IEA:InterPro.
DR Gene3D; 3.30.70.960; SEA domain; 1.
DR InterPro; IPR000742; EGF-like_dom.
DR InterPro; IPR039861; IMPG.
DR InterPro; IPR000082; SEA_dom.
DR InterPro; IPR036364; SEA_dom_sf.
DR PANTHER; PTHR12199; INTERPHOTORECEPTOR MATRIX PROTEOGLYCAN; 1.
DR PANTHER; PTHR12199:SF4; INTERPHOTORECEPTOR MATRIX PROTEOGLYCAN 2; 1.
DR Pfam; PF01390; SEA; 2.
DR SMART; SM00200; SEA; 2.
DR SUPFAM; SSF82671; SEA domain; 2.
DR PROSITE; PS01186; EGF_2; 1.
DR PROSITE; PS50024; SEA; 2.
PE 4: Predicted;
KW Cell projection {ECO:0000256|ARBA:ARBA00023273};
KW Extracellular matrix {ECO:0000256|ARBA:ARBA00022530};
KW Heparin-binding {ECO:0000256|ARBA:ARBA00022674};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000008672};
KW Secreted {ECO:0000256|ARBA:ARBA00022525};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..20
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 21..1453
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5003579183"
FT TRANSMEM 1316..1340
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 247..360
FT /note="SEA"
FT /evidence="ECO:0000259|PROSITE:PS50024"
FT DOMAIN 1113..1226
FT /note="SEA"
FT /evidence="ECO:0000259|PROSITE:PS50024"
FT REGION 26..50
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 541..580
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 938..962
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1453 AA; 162846 MW; 774CFC4E01BCC7C7 CRC64;
IFVFLWKICF LSLLFIFVNG NVQETRGKNE QPRTQPNSWT PAENPALPNR SNRTLSLRME
SRKRRSAFQR RKRAVLFPSG VRICPQEAIQ QAIADHLKYF KLRVCQEAVW EAFKIFWDRL
PEREEYHSWM KMCEEEISNV FDIGTNFSSS EEHLSLIQKV KQVTYSLEKI QTSCTVMWPT
RKCPHLTTPT AKRETTTLRD AATKVPPPQV VSIESKLGHD INQHEETENN ITNEIEQVLE
KPLKQATERV LEFSIQLPEE NYSEELADPT SMRYQELADM FITKVENVFE GLPGYKNVYV
NKFNLPRKSV EIHYAVSFDA SFGTKSNATL DFINLYSNKV DEDPYTEISE NPTVVYTLSD
FRDYITEALL KENLIGNTSL ALDPDSLQLI NAKTALYCIQ YIPSFFTPSV LFLDLLIYQG
SALKAERTPT TTSAPDINNI LPNNLAKGTY DIDSEQSNVI PPNDSWNDLG IPLITENEFS
VNSDITILES TLGPDISGWV STPPAFVDVP LFILLRHTLD PHYHLRLADS RDESEGFLFS
NELQSRPHTI TKPADSSTKR STVATADMDS GTSVVPGDNT KTMYTKTSEI TTVVPAEGIT
TTSMHDKAST ELSITHPIGN VNLTDVYTGS DIFYDEGSAS GFFHSGQGQE MDTWPWPTES
LEAVLYTLPD DWSEDNDPGV ITNEVISEEI LPDYIIDPPT TMDMTNNDVE VAYSEEVDLL
EPFVDKDNDV ISEATAEDAA IFWTQESLTV EMSAQTSESF EILDSTFNEL PTAMESIVHH
SASDIPVTET TTKFYSTDTP NVESPIKTQT ILETNEIEEL IKDLFTVEQP NIYSSIMEQT
TKGLSSMKEI STTEQPNITL LTNRHQVPEY AHTGLQDTTM QTTERTITES PIGQLFTGIS
TIYQETVDSS STDHLFIDET TASPMTVSLS STSQILTESF TEDQSAPSSP ATSSPITEST
AVVPKVPTRH QYTEGPTTAV QPTNEIFTTV HLINISRADA EDIIRQATTV TVANDVNVIY
PVNSLGSGVH SSESELGTVL PESETPSEEE VLSGITFVDH QDSLATNKHP MGSEKETAGS
HNREFATNIH LTDMASVAKP TSEGAKNSSL PARALVVFFS LRVTNMMFSE DLFNKSSPEY
KALEQRFLEL LVPYLQSNLT GFQNLEILNF RNGSIVVNSR MKFAKPVPRN VTNAVYIILE
DFCSTAYQTM NLAIDKYSLD VESGDQADPC KFQACNEFSQ CSVNRWSGEA ECICNPGYLS
VDGLPCQSTC DLQADFCQND GKCDIIAGQG AICRCRVGEN WWYRGEHCEE YVSEPLVVGI
AIASVAGFLL VASLVIFFLA RTLRDQYTKS DQEESIGHGD SLASVENAVK YNPMYESDTT
GCSHYYRRYP QLPSYSSTSA ETSTDFSSEE IRHIYEHSEL TKEEIQDRIR IIELYAKDRQ
FAEFVRQHQI KFM
//
