ID   H3A431_LATCH            Unreviewed;      1311 AA.
AC   H3A431;
DT   18-APR-2012, integrated into UniProtKB/TrEMBL.
DT   18-APR-2012, sequence version 1.
DT   27-MAR-2024, entry version 59.
DE   SubName: Full=Tetratricopeptide repeat domain 21B {ECO:0000313|Ensembl:ENSLACP00000004402.1};
GN   Name=TTC21B {ECO:0000313|Ensembl:ENSLACP00000004402.1};
OS   Latimeria chalumnae (Coelacanth).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Coelacanthiformes; Coelacanthidae; Latimeria.
OX   NCBI_TaxID=7897 {ECO:0000313|Ensembl:ENSLACP00000004402.1, ECO:0000313|Proteomes:UP000008672};
RN   [1] {ECO:0000313|Proteomes:UP000008672}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Wild caught {ECO:0000313|Proteomes:UP000008672};
RA   Di Palma F., Alfoldi J., Johnson J., Berlin A., Gnerre S., Jaffe D.,
RA   MacCallum I., Young S., Walker B.J., Lander E., Lindblad-Toh K.;
RT   "The draft genome of Latimeria chalumnae.";
RL   Submitted (AUG-2011) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSLACP00000004402.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (NOV-2023) to UniProtKB.
CC   -!- SIMILARITY: Belongs to the TTC21 family.
CC       {ECO:0000256|ARBA:ARBA00010935}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; AFYH01143168; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AFYH01143169; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AFYH01143170; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AFYH01143171; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AFYH01143172; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AFYH01143173; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AFYH01143174; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   STRING; 7897.ENSLACP00000004402; -.
DR   Ensembl; ENSLACT00000004440.1; ENSLACP00000004402.1; ENSLACG00000003915.1.
DR   eggNOG; ENOG502QQAB; Eukaryota.
DR   GeneTree; ENSGT00390000005979; -.
DR   HOGENOM; CLU_006149_0_0_1; -.
DR   InParanoid; H3A431; -.
DR   OMA; NATCVRA; -.
DR   TreeFam; TF314664; -.
DR   Proteomes; UP000008672; Unassembled WGS sequence.
DR   GO; GO:0007369; P:gastrulation; IEA:Ensembl.
DR   Gene3D; 1.25.40.10; Tetratricopeptide repeat domain; 5.
DR   InterPro; IPR011990; TPR-like_helical_dom_sf.
DR   InterPro; IPR019734; TPR_repeat.
DR   InterPro; IPR040364; TTC21A/TTC21B.
DR   PANTHER; PTHR14699; STI2 PROTEIN-RELATED; 1.
DR   PANTHER; PTHR14699:SF1; TETRATRICOPEPTIDE REPEAT PROTEIN 21B; 1.
DR   Pfam; PF13432; TPR_16; 1.
DR   Pfam; PF14559; TPR_19; 1.
DR   Pfam; PF13181; TPR_8; 2.
DR   SMART; SM00028; TPR; 15.
DR   SUPFAM; SSF48452; TPR-like; 6.
DR   PROSITE; PS50005; TPR; 3.
PE   3: Inferred from homology;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Reference proteome {ECO:0000313|Proteomes:UP000008672};
KW   Repeat {ECO:0000256|ARBA:ARBA00022737};
KW   TPR repeat {ECO:0000256|PROSITE-ProRule:PRU00339}.
FT   REPEAT          318..351
FT                   /note="TPR"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00339"
FT   REPEAT          784..817
FT                   /note="TPR"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00339"
FT   REPEAT          947..980
FT                   /note="TPR"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00339"
FT   COILED          212..239
FT                   /evidence="ECO:0000256|SAM:Coils"
SQ   SEQUENCE   1311 AA;  149648 MW;  B75D48DBD2804488 CRC64;
     QALISYYCQE RYFHHVQLAA NEGLKKYGND PVLIFFRAYG ILMEDQTQEA IRELEAIKDK
     REVSLCTLIA LIYAHKKSSN PDRDAVQELD AKLKEDRKSA GQKALYFAGL FLWHLGRHDK
     AREYIDRMMK VFNGAKEGWI LKGWIDLTCG REAYAKKSIK CFDEGMQDAK NIFAMMGRAS
     YFEMRQNYSG ALGTVNQVIV NFPGFLPAFI KKMKLQLALQ DWEQTIETAQ RLLEKDNHNF
     EALRMLALHH VCREGNLNEA ATKLGDLISA LDRCEPHNPE LFCKIALAFS RMCGRNQLIL
     KQTQALADRA FSMSSHDAQL ATELGYQVIL QGKTKEAVKW YKTAMTLDET SICALTGIIR
     CQLIEGQLED AEQQLEFLNE IQQSIGKSGE LSYLRAVLAV KRNRGQEEVI NLLNDAVDTH
     FSSLQGLPLG VQYFEKLNPD FLLEIIREYL IFYPTQPVAS SQPPCPLLKH CASVLETVAK
     TVPGLLEAVY LMAKVKYLAG DVDASQHSLQ HCLEQNPSYA DAHLLAAQVY LCQDNLKLCS
     QSLELCLSYN FEVREHPVYH LIKAQIQKKM GESQEAIKTL QMAMSLPGMR KVGSSTKSKG
     KKNGIALTDR VSIFLELADA HSINGEQHEA AKVMQDAINE FCGTPEELRV TIANADLALI
     QGDIELALSM LRNISPDQPY FVQAKEKMAD VYLYHRKDKK LYASCYRDLV EKHPGSHTYL
     LLGDAYMNIQ EPAEKSIVLC QESYKKNQKK VLMCEFMVKN MKHTKSFVTA INYYEAALKT
     GQQNFLRYDL AELLLKLKQY EKAEIVLQQA LDCEPANDLP ALMEDCRCQV LIAKIYSKME
     KMDEAILSLQ RAREVQARVL KRVQLEQPEA VPTQKQFAAE ICANIAKHST AQRDYEKAIK
     FYKEALVYCE TDNKVMLELA RLYLEQDDID ASQHQCALLL KIDQNNEAAT MMMADLLFRK
     QDYDQAVFHF QQLLERKPDN YATLSCLIDL LRRAGKLKEV PGFLDIAEKH SSRARLEPGF
     NYCKGLYLWY TGEPNDALRH FNKARKDSDW GQNAIYNMIE ICLNPDNDTV GGEVFENLDG
     DIGNSTEKQE SEQLAVRTAE KLLKELKPQT PQGHFQLRIL ENYCFMATKQ KANVERALTA
     FTEIATVEKD HIPALLGMAT AYMILKQTPK ARNQLKRIAK MNWNAIDAED FEKSWLLLAD
     IYIQSGKYDM AGELLKRCLR HNWSCCKAYE YMGYIMEKEQ AYKDAALNYE MAWNYGNQTN
     PTIGYKLAFN YLKAKRYVDA IDICHKVLGA HPDYPKMRKD ILDKARAALR S
//