ID H3A4U8_LATCH Unreviewed; 2171 AA.
AC H3A4U8;
DT 18-APR-2012, integrated into UniProtKB/TrEMBL.
DT 18-APR-2012, sequence version 1.
DT 27-MAR-2024, entry version 70.
DE RecName: Full=FAT atypical cadherin 4 {ECO:0008006|Google:ProtNLM};
OS Latimeria chalumnae (Coelacanth).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Coelacanthiformes; Coelacanthidae; Latimeria.
OX NCBI_TaxID=7897 {ECO:0000313|Ensembl:ENSLACP00000004669.1, ECO:0000313|Proteomes:UP000008672};
RN [1] {ECO:0000313|Proteomes:UP000008672}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Wild caught {ECO:0000313|Proteomes:UP000008672};
RA Di Palma F., Alfoldi J., Johnson J., Berlin A., Gnerre S., Jaffe D.,
RA MacCallum I., Young S., Walker B.J., Lander E., Lindblad-Toh K.;
RT "The draft genome of Latimeria chalumnae.";
RL Submitted (AUG-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSLACP00000004669.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00076}.
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DR EMBL; AFYH01226351; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01226352; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01226353; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01226354; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01226355; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01226356; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01226357; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01226358; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01226359; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01226360; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR STRING; 7897.ENSLACP00000004669; -.
DR Ensembl; ENSLACT00000004708.1; ENSLACP00000004669.1; ENSLACG00000004156.1.
DR eggNOG; KOG1219; Eukaryota.
DR GeneTree; ENSGT00940000155719; -.
DR HOGENOM; CLU_000389_0_0_1; -.
DR InParanoid; H3A4U8; -.
DR OMA; SYANCIV; -.
DR TreeFam; TF316403; -.
DR Proteomes; UP000008672; Unassembled WGS sequence.
DR GO; GO:0005886; C:plasma membrane; IEA:InterPro.
DR GO; GO:0005509; F:calcium ion binding; IEA:UniProtKB-UniRule.
DR GO; GO:0007156; P:homophilic cell adhesion via plasma membrane adhesion molecules; IEA:InterPro.
DR CDD; cd11304; Cadherin_repeat; 15.
DR CDD; cd00054; EGF_CA; 3.
DR CDD; cd00110; LamG; 1.
DR Gene3D; 2.60.120.200; -; 1.
DR Gene3D; 2.60.40.60; Cadherins; 17.
DR Gene3D; 2.10.25.10; Laminin; 3.
DR InterPro; IPR002126; Cadherin-like_dom.
DR InterPro; IPR015919; Cadherin-like_sf.
DR InterPro; IPR020894; Cadherin_CS.
DR InterPro; IPR013320; ConA-like_dom_sf.
DR InterPro; IPR001881; EGF-like_Ca-bd_dom.
DR InterPro; IPR000742; EGF-like_dom.
DR InterPro; IPR000152; EGF-type_Asp/Asn_hydroxyl_site.
DR InterPro; IPR018097; EGF_Ca-bd_CS.
DR InterPro; IPR009030; Growth_fac_rcpt_cys_sf.
DR InterPro; IPR001791; Laminin_G.
DR PANTHER; PTHR24028; CADHERIN-87A; 1.
DR PANTHER; PTHR24028:SF310; STARRY NIGHT; 1.
DR Pfam; PF00028; Cadherin; 16.
DR Pfam; PF00008; EGF; 1.
DR Pfam; PF07645; EGF_CA; 1.
DR Pfam; PF00054; Laminin_G_1; 1.
DR PRINTS; PR00205; CADHERIN.
DR SMART; SM00112; CA; 17.
DR SMART; SM00181; EGF; 3.
DR SMART; SM00179; EGF_CA; 2.
DR SUPFAM; SSF49313; Cadherin-like; 17.
DR SUPFAM; SSF49899; Concanavalin A-like lectins/glucanases; 1.
DR SUPFAM; SSF57184; Growth factor receptor domain; 1.
DR PROSITE; PS00010; ASX_HYDROXYL; 2.
DR PROSITE; PS00232; CADHERIN_1; 6.
DR PROSITE; PS50268; CADHERIN_2; 17.
DR PROSITE; PS00022; EGF_1; 2.
DR PROSITE; PS01186; EGF_2; 3.
DR PROSITE; PS50026; EGF_3; 3.
DR PROSITE; PS01187; EGF_CA; 1.
DR PROSITE; PS50025; LAM_G_DOMAIN; 1.
PE 4: Predicted;
KW Calcium {ECO:0000256|ARBA:ARBA00022837, ECO:0000256|PROSITE-
KW ProRule:PRU00043};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157, ECO:0000256|PROSITE-
KW ProRule:PRU00076};
KW EGF-like domain {ECO:0000256|ARBA:ARBA00022536, ECO:0000256|PROSITE-
KW ProRule:PRU00076}; Membrane {ECO:0000256|ARBA:ARBA00022989};
KW Reference proteome {ECO:0000313|Proteomes:UP000008672};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989}.
FT DOMAIN 1..81
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 82..188
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 189..292
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 293..393
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 394..498
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 499..602
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 603..703
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 712..808
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 809..912
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 912..1013
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 1014..1122
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 1131..1227
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 1228..1332
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 1333..1436
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 1437..1543
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 1544..1649
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 1656..1751
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 1940..1998
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 2000..2036
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 2038..2077
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 2078..2171
FT /note="Laminin G"
FT /evidence="ECO:0000259|PROSITE:PS50025"
FT DISULFID 1988..1997
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 2026..2035
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
SQ SEQUENCE 2171 AA; 238798 MW; 17069B98E27D959C CRC64;
VATTSPEQKD NQFTYSIVED DGDGIFALNP NNGEFTLTRS LDYESEQYYV LTVKATDKNG
HFSLARVYFN VLDMNDNPPV FFLEFYSIII KEDLPVGASI LTLNVTDADE GQNAALNVTI
ISGDFNQQFT IDGNGVLHLK RPVDREQQSI YHLIVQANDQ ALPEAVRLTS TAQVTINIAD
VNDNVPHFIL FPDTVFLPEN TDINTVVTVI QATDRDIGNN SVLEYSLEPR TGNMFTINAT
SGELHLTEEL DREHANSIYF QVIVTDKGMP PLSSITKMTI IVTDVNDNSP TFTTRVYNIT
VDENIPLGFD LLTVLATDPD ENMNGQVRYS ISYDKFLIDS VTGLISVVKN LDRERIPVHI
FEVVASDLGT SPRSGTATVK VVLRDINDFI PTFQPASVTV HLLENRSTLP QLLYQVTAHD
EDLGSNSQLI YAIDEGNEDG RFSLSFDGQL SVLQSLDREE TAEYRLFVTA ADSGIPALTG
IGTVIITVDD LNDNCPKFDK SFYSVTINED TPVGSTFIKM NASDPDEGVN GKIRYSIRNS
GFQFLIDPLT GEIITNAALD RESQDSFALT VLATDGNDIQ PLSSSVTVFV IVGDVNDEPP
QFLNDPYVAN IPMTVHSGSI VYAVTVQDAD SGINAELKFT LSGLDATKFT VDPCRGVIFA
AETMIGASDI TIAINVADQG VNPKMDSTTV TVRFQNSAEF PQTYVDIKSK IFPEDQPLGT
SIATVKAMTN RQGLQGPISY YLAAGNFGDS FQISQQTGEV IIKNPLDFET TNQYQLWVEA
RDSGSPPFSS YTKININISD VNDNFPVFDQ NIFRCEIYEN EPPGNVCSVS AMDMDSGLNR
ILQYSIIKGN VNNAFIINVD TAVIRTTQSL DRETLSLYTI IIEAKDKASV PKMSTATVLI
TVLDRNDNAP KFSQIFLAQV SENIPVGFKV IQITTIDKDS GANAVSTYSI ADQSGNLPFS
IDRHSGFLTV TKPLDREETE KYFIKVTAND SGWSVNTIVT IYITDVNDNG PQFLNSSYVL
TIPEQKEKNT FILQVSATDA DLGLNGQVIY YLKSPSDFFR VEATSGAVFT KQFIPFHFSD
MKAYSNIYNL IVVASDCSEK PIFSESKVTV TIVPKNNNPP QFLPFRPVMP IPMNIERGTK
LVQLKAVDND LYNNGIIEYL LTGGNSSSLF EIERDTGWIF INNYLSSSIN KLYTLVIAAK
DKGIPPLSKK TTISFLVTDE NQFAPRFSEL LVRFSVPEDL APGSFIGKVN AEDHDQGING
LVTYLITFGN SERDFAIDNT TGVITLVKNL DFEMQSLYML QICAKDKGWL SKSTSLNVTI
QVQDVNDNSP VFAVSEYFVS VPENSPTGIT VLELKATDAD SDLNTVINYV IVHGNKEMFA
MDQKTGVITT QDSFDFELQQ FYQITVKAFE AHNRNHYSLA KVSISISNVN EYYPRFTKTQ
FNFVVSEMAP IGTTIGRVLA TDYDLGSDGI VYYMLFGESK KKGFGINTIT GEMFISSNVK
KTNSENPIFL NVLAKNAGII HGFDIDYAVV NVSLVNVNDA PLFQSIIYQT CISEGLAVGS
LVTTVTAVDL DLVPEWSQFY YSLQNGNVNN SFSINPRTGG VFVSAPLDRE TLSLYNLTII
AVDGAPVPAT GSMQLEIVID DINDNSPILI TTEGHVMENQ PPGTFILTMN ATDSDLPSNK
GPFTYRLLGS NFTDSVILST DGILCTNTIL DREQDSDLYL PVLIIDAGAP PMSSTATVHI
AVLDQNDNPS QSKSIYIQVN YYGSYFPGGM IGCVKPEDPD ILDKFNCSIK SGNRNAFSIP
INTCDLIAAS QVGDVKFNLT VEGNDNVHDS VINSVYVSYR HFTNSTIDNS VVLYLSTPIF
KKFLADKYMK FIKTIDSLLI DTNLKTHVYG MMVWDNETLI FLSMKHSSGY YASSFTTVNF
FRVNKNVLES VSEVKIAAVT NDPCIDNSCH HGASCIKNSG ISPDIVVLES PSVIFVTHLP
FIPFTCSCPV GFTGPFCEVD INECYGSPCS NGGVCVNYAG GFFCSCRGGF SGPFCTSGVN
ECEKNLCQNG GTCENTYGDY HCICLHGYTG ITGRNCELSS LGFEELSYME FPPLDPRNNI
ISLEFATVKK NSLILYNYDN RKGVGGEFVA LEIIDGKLQF SYNLGNGIVR LTTEKKVADG
QFHTVQASRT G
//
