ID H3A5L7_LATCH Unreviewed; 654 AA.
AC H3A5L7;
DT 18-APR-2012, integrated into UniProtKB/TrEMBL.
DT 18-APR-2012, sequence version 1.
DT 24-JAN-2024, entry version 69.
DE SubName: Full=Solute carrier family 7 member 2 {ECO:0000313|Ensembl:ENSLACP00000004938.1};
GN Name=SLC7A2 {ECO:0000313|Ensembl:ENSLACP00000004938.1};
OS Latimeria chalumnae (Coelacanth).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Coelacanthiformes; Coelacanthidae; Latimeria.
OX NCBI_TaxID=7897 {ECO:0000313|Ensembl:ENSLACP00000004938.1, ECO:0000313|Proteomes:UP000008672};
RN [1] {ECO:0000313|Proteomes:UP000008672}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Wild caught {ECO:0000313|Proteomes:UP000008672};
RA Di Palma F., Alfoldi J., Johnson J., Berlin A., Gnerre S., Jaffe D.,
RA MacCallum I., Young S., Walker B.J., Lander E., Lindblad-Toh K.;
RT "The draft genome of Latimeria chalumnae.";
RL Submitted (AUG-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSLACP00000004938.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (JUL-2023) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=L-arginine(in) = L-arginine(out); Xref=Rhea:RHEA:32143,
CC ChEBI:CHEBI:32682; Evidence={ECO:0000256|ARBA:ARBA00034423};
CC -!- CATALYTIC ACTIVITY:
CC Reaction=L-lysine(in) = L-lysine(out); Xref=Rhea:RHEA:70935,
CC ChEBI:CHEBI:32551; Evidence={ECO:0000256|ARBA:ARBA00034422};
CC -!- CATALYTIC ACTIVITY:
CC Reaction=L-ornithine(in) = L-ornithine(out); Xref=Rhea:RHEA:71199,
CC ChEBI:CHEBI:46911; Evidence={ECO:0000256|ARBA:ARBA00034450};
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the amino acid-polyamine-organocation (APC)
CC superfamily. Cationic amino acid transporter (CAT) (TC 2.A.3.3) family.
CC {ECO:0000256|ARBA:ARBA00008572}.
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DR EMBL; AFYH01107679; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01107680; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01107681; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01107682; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_006000140.1; XM_006000078.2.
DR RefSeq; XP_006000141.1; XM_006000079.2.
DR RefSeq; XP_006000142.1; XM_006000080.2.
DR RefSeq; XP_006000143.1; XM_006000081.2.
DR Ensembl; ENSLACT00000004982.1; ENSLACP00000004938.1; ENSLACG00000004392.2.
DR Ensembl; ENSLACT00000026385.1; ENSLACP00000022888.1; ENSLACG00000004392.2.
DR GeneID; 102350006; -.
DR KEGG; lcm:102350006; -.
DR CTD; 6542; -.
DR GeneTree; ENSGT00940000160440; -.
DR HOGENOM; CLU_007946_15_7_1; -.
DR OrthoDB; 1421713at2759; -.
DR Proteomes; UP000008672; Unassembled WGS sequence.
DR Bgee; ENSLACG00000004392; Expressed in post-anal tail muscle and 6 other cell types or tissues.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0061459; F:L-arginine transmembrane transporter activity; IEA:UniProt.
DR Gene3D; 1.20.1740.10; Amino acid/polyamine transporter I; 2.
DR InterPro; IPR002293; AA/rel_permease1.
DR InterPro; IPR004755; Cat_AA_permease.
DR InterPro; IPR029485; CAT_C.
DR NCBIfam; TIGR00906; 2A0303; 1.
DR PANTHER; PTHR43243:SF35; CATIONIC AMINO ACID TRANSPORTER 2; 1.
DR PANTHER; PTHR43243; INNER MEMBRANE TRANSPORTER YGJI-RELATED; 1.
DR Pfam; PF13520; AA_permease_2; 1.
DR Pfam; PF13906; AA_permease_C; 1.
PE 3: Inferred from homology;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000008672};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 39..56
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 68..89
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 101..125
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 167..184
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 193..211
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 250..270
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 291..320
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 340..365
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 386..407
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 413..434
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 493..519
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 525..545
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 554..577
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 583..601
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 556..606
FT /note="Cationic amino acid transporter C-terminal"
FT /evidence="ECO:0000259|Pfam:PF13906"
FT REGION 610..654
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 622..654
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 654 AA; 70778 MW; 02A52BD24F3DB42F CRC64;
MLRCEAFLSF AQRLIRRKVV TLESLEDSKL CRCLSTIDLI ALGVGSTLGA GVYVLAGEVA
KADSGPSIVI SFLIAALASV MAGLCYAEFG ARVPKTGSAY LYSYVTVGEL WAFITGWNLI
LSYVIGTSSV ARAWSGTFDE LLGNRIGQFF STYCKMNSPG LAPYPDFFAV VLILILSGLL
SFGVKESAWV NKIFTAINVL VLMFVIITGF VKGDASNWKI KEEFLINVTA VMKNASSTEN
VTSSFGTGGF MPFGFTGTLA GAATCFYAFV GFDCIATTGE EVKNPQKAIP IGIVTSLLVC
FLAYFGVSAA LTLMMPYYLL DEKSPLPVAF EYVGWGPAKF VVAVGSLCAL STSLLGSLFP
LPRILFAMAR DGLLFKFLSH VSKRQAPVAA TLTAGVIAAV MAFLFDLKAL VDMMSIGTLL
AYSLVAACVL ILRYQPGSSY EKPKCSPEKT NLTKAESISE FNDLETNILK GEALSLQTIL
YPSMLPTEES STVVSVSVGC IAFLVCAVSV LLTYGGYAIL ALEAWSISLL AVFILVFATA
IVVIWRQPQS QEKVAFMVPC LPLLPVVSVF VNIYLMVQLS GETWIRFSIW MAVGFLIYFG
YGIRHSVEGQ CDEEEEEEDS NSSELEHKNS AVGEDDIIAS ENDRFIQDER TSEC
//