ID H3A5Q8_LATCH Unreviewed; 857 AA.
AC H3A5Q8;
DT 18-APR-2012, integrated into UniProtKB/TrEMBL.
DT 18-APR-2012, sequence version 1.
DT 27-MAR-2024, entry version 72.
DE RecName: Full=G-protein coupled receptors family 3 profile domain-containing protein {ECO:0000259|PROSITE:PS50259};
GN Name=LOC102353341 {ECO:0000313|Ensembl:ENSLACP00000004979.1};
OS Latimeria chalumnae (Coelacanth).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Coelacanthiformes; Coelacanthidae; Latimeria.
OX NCBI_TaxID=7897 {ECO:0000313|Ensembl:ENSLACP00000004979.1, ECO:0000313|Proteomes:UP000008672};
RN [1] {ECO:0000313|Proteomes:UP000008672}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Wild caught {ECO:0000313|Proteomes:UP000008672};
RA Di Palma F., Alfoldi J., Johnson J., Berlin A., Gnerre S., Jaffe D.,
RA MacCallum I., Young S., Walker B.J., Lander E., Lindblad-Toh K.;
RT "The draft genome of Latimeria chalumnae.";
RL Submitted (AUG-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSLACP00000004979.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004651};
CC Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
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DR EMBL; AFYH01226607; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01226608; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01226609; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01226610; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; H3A5Q8; -.
DR Ensembl; ENSLACT00000005023.1; ENSLACP00000004979.1; ENSLACG00000004427.1.
DR eggNOG; KOG1056; Eukaryota.
DR GeneTree; ENSGT00950000182788; -.
DR HOGENOM; CLU_005389_5_1_1; -.
DR InParanoid; H3A5Q8; -.
DR OMA; KTHICIG; -.
DR TreeFam; TF331269; -.
DR Proteomes; UP000008672; Unassembled WGS sequence.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0004930; F:G protein-coupled receptor activity; IEA:UniProtKB-KW.
DR CDD; cd15283; 7tmC_V2R_pheromone; 1.
DR Gene3D; 3.40.50.2300; -; 2.
DR Gene3D; 2.10.50.30; GPCR, family 3, nine cysteines domain; 1.
DR InterPro; IPR001828; ANF_lig-bd_rcpt.
DR InterPro; IPR000337; GPCR_3.
DR InterPro; IPR011500; GPCR_3_9-Cys_dom.
DR InterPro; IPR038550; GPCR_3_9-Cys_sf.
DR InterPro; IPR017978; GPCR_3_C.
DR InterPro; IPR000068; GPCR_3_Ca_sens_rcpt-rel.
DR InterPro; IPR017979; GPCR_3_CS.
DR InterPro; IPR004073; GPCR_3_vmron_rcpt_2.
DR InterPro; IPR028082; Peripla_BP_I.
DR PANTHER; PTHR24061; CALCIUM-SENSING RECEPTOR-RELATED; 1.
DR PANTHER; PTHR24061:SF0; VOMERONASAL 2, RECEPTOR 23-RELATED; 1.
DR Pfam; PF00003; 7tm_3; 1.
DR Pfam; PF01094; ANF_receptor; 1.
DR Pfam; PF07562; NCD3G; 1.
DR PRINTS; PR00248; GPCRMGR.
DR PRINTS; PR01535; VOMERONASL2R.
DR SUPFAM; SSF53822; Periplasmic binding protein-like I; 1.
DR PROSITE; PS00981; G_PROTEIN_RECEP_F3_3; 1.
DR PROSITE; PS50259; G_PROTEIN_RECEP_F3_4; 1.
PE 4: Predicted;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW G-protein coupled receptor {ECO:0000256|ARBA:ARBA00023040};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Receptor {ECO:0000256|ARBA:ARBA00023170};
KW Reference proteome {ECO:0000313|Proteomes:UP000008672};
KW Signal {ECO:0000256|SAM:SignalP};
KW Transducer {ECO:0000256|ARBA:ARBA00023224};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..24
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 25..857
FT /note="G-protein coupled receptors family 3 profile domain-
FT containing protein"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5003579250"
FT TRANSMEM 592..614
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 626..647
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 659..682
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 703..721
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 747..770
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 782..802
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 814..837
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 588..844
FT /note="G-protein coupled receptors family 3 profile"
FT /evidence="ECO:0000259|PROSITE:PS50259"
SQ SEQUENCE 857 AA; 95366 MW; 926152BA200EB7D3 CRC64;
VQQTLASKMI SEMLLLLLLS ATVSENTQPG CNLQSLKPKG VAKHGDIIIG GIFPVKVMDF
VTENLFMEKP EPQSCKRFVL RAYRWLQTMI FAIEEINQNS KLLPNITLGY RIYDTCRQVS
QALEGTMWMI TGKEEPIPNY RCEPHSPLAA IIGEALSGIT MSVARLLGVY SYPQISYSST
VDLLSDKHQF PSFFRTIPSG ILQAHSLVRL LRHFGWTWVG IVAVDNDFGE LATQSLKQEL
DKTHICIGFS ETLPTIYSPE RIHLVAEVIK RSTVNSIVVI SSETYFFPLA KELTGQNVTG
RIWVATLDWS TSSSLFQHDQ VSLLTGTIGI ATHKSDIPGL KDFLLKNFWE EAFVCTWPRN
VTDQTTAVYD LGDAIKLCTG KEDVNKLNIS FFDVAESRIT YNVYNAVYAV AHALHDLRVC
KPGEGPFENG TCADIQYLEQ WQNVRFKNKL GEDIYFDAEG NAPALYDIIN WHLMPDGTLK
YLEVGRIDFS APPGEDFIIN SSALMWNGGQ TQVPRSVCSE SCPPGYRKAA RQGEPICCFD
CVFCSEGEIS SQTDSTDCLK CPNDHWSNSA RDKCIPKVIE FLSYKEPLGA TLASISSLSS
VIPVAILCTF IKYQDTPIVK ANNREVSYLL LLALVLCFLC SLVFVGYPMM ITCMLRQAAF
GIIFALCVSC VLAKTIMVVI AFNATKPNSN LQKWVGAKLP NSVVFICTML QVILCIAWLT
SSPPFPEENM KSQPGKIIIE CNEGSTVAFW CMLGYMGLLA IISFIVAFLA RNLPDSFNEA
KFITFSMLVF VSVWLAFIPA YLSTSGKYTV AVEIFAILAS SAGLLACIFF PKCYIILLRP
HMNTKGYLMG KGTFNNY
//
