ID H3A6A2_LATCH Unreviewed; 370 AA.
AC H3A6A2;
DT 18-APR-2012, integrated into UniProtKB/TrEMBL.
DT 18-APR-2012, sequence version 1.
DT 27-MAR-2024, entry version 56.
DE SubName: Full=RNA terminal phosphate cyclase like 1 {ECO:0000313|Ensembl:ENSLACP00000005173.1};
GN Name=RCL1 {ECO:0000313|Ensembl:ENSLACP00000005173.1};
OS Latimeria chalumnae (Coelacanth).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Coelacanthiformes; Coelacanthidae; Latimeria.
OX NCBI_TaxID=7897 {ECO:0000313|Ensembl:ENSLACP00000005173.1, ECO:0000313|Proteomes:UP000008672};
RN [1] {ECO:0000313|Proteomes:UP000008672}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Wild caught {ECO:0000313|Proteomes:UP000008672};
RA Di Palma F., Alfoldi J., Johnson J., Berlin A., Gnerre S., Jaffe D.,
RA MacCallum I., Young S., Walker B.J., Lander E., Lindblad-Toh K.;
RT "The draft genome of Latimeria chalumnae.";
RL Submitted (AUG-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSLACP00000005173.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Nucleus, nucleolus
CC {ECO:0000256|ARBA:ARBA00004604}.
CC -!- SIMILARITY: Belongs to the RNA 3'-terminal cyclase family. Type 2
CC subfamily. {ECO:0000256|ARBA:ARBA00007089}.
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DR EMBL; AFYH01239769; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01239770; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01239771; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01239772; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01239773; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; H3A6A2; -.
DR STRING; 7897.ENSLACP00000005173; -.
DR Ensembl; ENSLACT00000005219.1; ENSLACP00000005173.1; ENSLACG00000004594.1.
DR eggNOG; KOG3980; Eukaryota.
DR GeneTree; ENSGT00530000063404; -.
DR InParanoid; H3A6A2; -.
DR OMA; YTDQNKG; -.
DR TreeFam; TF300831; -.
DR Proteomes; UP000008672; Unassembled WGS sequence.
DR Bgee; ENSLACG00000004594; Expressed in muscle tissue and 6 other cell types or tissues.
DR GO; GO:0005730; C:nucleolus; IEA:UniProtKB-SubCell.
DR GO; GO:0003824; F:catalytic activity; IEA:InterPro.
DR GO; GO:0042254; P:ribosome biogenesis; IEA:UniProtKB-KW.
DR GO; GO:0006396; P:RNA processing; IEA:InterPro.
DR CDD; cd00875; RNA_Cyclase_Class_I; 1.
DR Gene3D; 3.65.10.20; RNA 3'-terminal phosphate cyclase domain; 1.
DR Gene3D; 3.30.360.20; RNA 3'-terminal phosphate cyclase, insert domain; 1.
DR InterPro; IPR013791; RNA3'-term_phos_cycl_insert.
DR InterPro; IPR023797; RNA3'_phos_cyclase_dom.
DR InterPro; IPR037136; RNA3'_phos_cyclase_dom_sf.
DR InterPro; IPR000228; RNA3'_term_phos_cyc.
DR InterPro; IPR016443; RNA3'_term_phos_cyc_type_2.
DR InterPro; IPR020719; RNA3'_term_phos_cycl-like_CS.
DR InterPro; IPR013792; RNA3'P_cycl/enolpyr_Trfase_a/b.
DR InterPro; IPR036553; RPTC_insert.
DR NCBIfam; TIGR03400; 18S_RNA_Rcl1p; 1.
DR PANTHER; PTHR11096; RNA 3' TERMINAL PHOSPHATE CYCLASE; 1.
DR PANTHER; PTHR11096:SF1; RNA 3'-TERMINAL PHOSPHATE CYCLASE-LIKE PROTEIN; 1.
DR Pfam; PF01137; RTC; 1.
DR Pfam; PF05189; RTC_insert; 1.
DR PIRSF; PIRSF005378; RNA3'_term_phos_cycl_euk; 1.
DR SUPFAM; SSF55205; EPT/RTPC-like; 1.
DR PROSITE; PS01287; RTC; 1.
PE 3: Inferred from homology;
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000008672};
KW Ribosome biogenesis {ECO:0000256|ARBA:ARBA00022517}.
FT DOMAIN 14..334
FT /note="RNA 3'-terminal phosphate cyclase"
FT /evidence="ECO:0000259|Pfam:PF01137"
FT DOMAIN 187..291
FT /note="RNA 3'-terminal phosphate cyclase insert"
FT /evidence="ECO:0000259|Pfam:PF05189"
SQ SEQUENCE 370 AA; 40583 MW; 87CC74A24701DE68 CRC64;
LAEKKNMASS VLSYEGCNFF RQRVVLATLS GRPVKIRKIR AKDDNPGLRD FEASFIRLID
KITNGSRIEI NETGTTLYFQ PGLLHGKTVE HDCNPQRAIG YYLEGLLCLA PFMKHPLKAI
LRGVTNDQVD PSVDTLKATA IPLMKKFGID GGEFELKIVR RGMPPGGGGE VIFSCPVRRV
LKPVQLTDPG KIKRIRGVVY SVRVSPQIGN RIVESARAIL NKFIPDIYIY TDHMKGSNSG
KSPGFGISLV AETINGNFLS AELASNPQGQ GSPVLPEDLG KNCAKLLLEE VYRGGCVDSV
NQSLALLFMT LGQQDVSKIL LGPLSPYTYV QRKDLHSHFL TSLAIKVEAC LKVLLVHVIG
IVETLPSFLQ
//
