ID H3A6B9_LATCH Unreviewed; 479 AA.
AC H3A6B9;
DT 18-APR-2012, integrated into UniProtKB/TrEMBL.
DT 18-APR-2012, sequence version 1.
DT 27-MAR-2024, entry version 66.
DE RecName: Full=receptor protein serine/threonine kinase {ECO:0000256|ARBA:ARBA00012401};
DE EC=2.7.11.30 {ECO:0000256|ARBA:ARBA00012401};
GN Name=LOC102356523 {ECO:0000313|Ensembl:ENSLACP00000005190.1};
OS Latimeria chalumnae (Coelacanth).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Coelacanthiformes; Coelacanthidae; Latimeria.
OX NCBI_TaxID=7897 {ECO:0000313|Ensembl:ENSLACP00000005190.1, ECO:0000313|Proteomes:UP000008672};
RN [1] {ECO:0000313|Proteomes:UP000008672}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Wild caught {ECO:0000313|Proteomes:UP000008672};
RA Di Palma F., Alfoldi J., Johnson J., Berlin A., Gnerre S., Jaffe D.,
RA MacCallum I., Young S., Walker B.J., Lander E., Lindblad-Toh K.;
RT "The draft genome of Latimeria chalumnae.";
RL Submitted (AUG-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSLACP00000005190.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- COFACTOR:
CC Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
CC Evidence={ECO:0000256|ARBA:ARBA00001946};
CC -!- COFACTOR:
CC Name=Mn(2+); Xref=ChEBI:CHEBI:29035;
CC Evidence={ECO:0000256|ARBA:ARBA00001936};
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004479}; Single-
CC pass type I membrane protein {ECO:0000256|ARBA:ARBA00004479}.
CC -!- SIMILARITY: Belongs to the protein kinase superfamily. TKL Ser/Thr
CC protein kinase family. TGFB receptor subfamily.
CC {ECO:0000256|ARBA:ARBA00009605}.
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DR EMBL; AFYH01165938; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01165939; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01165940; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01165941; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01165942; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01165943; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01165944; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01165945; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01165946; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01165947; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; H3A6B9; -.
DR Ensembl; ENSLACT00000005236.1; ENSLACP00000005190.1; ENSLACG00000004610.1.
DR GeneTree; ENSGT00940000166078; -.
DR HOGENOM; CLU_000288_8_5_1; -.
DR Proteomes; UP000008672; Unassembled WGS sequence.
DR Bgee; ENSLACG00000004610; Expressed in post-anal tail muscle and 5 other cell types or tissues.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0004675; F:transmembrane receptor protein serine/threonine kinase activity; IEA:UniProtKB-EC.
DR CDD; cd14142; STKc_ACVR1_ALK1; 1.
DR Gene3D; 2.10.60.10; CD59; 1.
DR Gene3D; 1.10.510.10; Transferase(Phosphotransferase) domain 1; 1.
DR InterPro; IPR000472; Activin_recp.
DR InterPro; IPR003605; GS_dom.
DR InterPro; IPR011009; Kinase-like_dom_sf.
DR InterPro; IPR000719; Prot_kinase_dom.
DR InterPro; IPR017441; Protein_kinase_ATP_BS.
DR InterPro; IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
DR InterPro; IPR008271; Ser/Thr_kinase_AS.
DR InterPro; IPR045860; Snake_toxin-like_sf.
DR InterPro; IPR000333; TGFB_receptor.
DR PANTHER; PTHR23255:SF96; RECEPTOR PROTEIN SERINE_THREONINE KINASE; 1.
DR PANTHER; PTHR23255; TRANSFORMING GROWTH FACTOR-BETA RECEPTOR TYPE I AND II; 1.
DR Pfam; PF01064; Activin_recp; 1.
DR Pfam; PF07714; PK_Tyr_Ser-Thr; 1.
DR Pfam; PF08515; TGF_beta_GS; 1.
DR SMART; SM00467; GS; 1.
DR SMART; SM00220; S_TKc; 1.
DR SUPFAM; SSF56112; Protein kinase-like (PK-like); 1.
DR SUPFAM; SSF57302; Snake toxin-like; 1.
DR PROSITE; PS51256; GS; 1.
DR PROSITE; PS00107; PROTEIN_KINASE_ATP; 1.
DR PROSITE; PS50011; PROTEIN_KINASE_DOM; 1.
DR PROSITE; PS00108; PROTEIN_KINASE_ST; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|PROSITE-
KW ProRule:PRU10141};
KW Kinase {ECO:0000256|ARBA:ARBA00022527, ECO:0000256|RuleBase:RU000304};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|PROSITE-
KW ProRule:PRU10141}; Receptor {ECO:0000256|ARBA:ARBA00023170};
KW Reference proteome {ECO:0000313|Proteomes:UP000008672};
KW Serine/threonine-protein kinase {ECO:0000256|ARBA:ARBA00022527,
KW ECO:0000256|RuleBase:RU000304}; Signal {ECO:0000256|ARBA:ARBA00022729};
KW Transferase {ECO:0000256|ARBA:ARBA00022527, ECO:0000256|RuleBase:RU000304};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 91..116
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 148..177
FT /note="GS"
FT /evidence="ECO:0000259|PROSITE:PS51256"
FT DOMAIN 178..472
FT /note="Protein kinase"
FT /evidence="ECO:0000259|PROSITE:PS50011"
FT BINDING 205
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU10141"
SQ SEQUENCE 479 AA; 53774 MW; 2C096E7EC3B800FC CRC64;
QSQFECICEG SSCGQQKRCW GQQCFASVTL NEAAYVFQKG CLDVLEHGEM TCKTPPSRTQ
VVECCYGNLC NRNITVKPLS SQSCPSLKNN LFTMVLFVIS PVIVLIILSV AAVLICRKIH
QSRVQRLHAY DVEHGAVDGL IASNVGDSTL ADLLDHSCTS GSGSGLPFLV QRTVARQITL
LECVGKGRYG EVWRGQWQGE NVAVKIFSSR DEKSWFRETE IYNTVLLRHD NILGFIGSDM
TSRNSSTQLW LITHYHENGS LYDYLQHNTM DAGGCLNFAL SIASGLVHLH TEIFGTEGKP
AIAHRDLKSK NILVKKNSQC CIADLGLAVI HSQTNNQLDV GNNPKVGTKR YMAPEVLDES
IQIDCFDAYK RVDIWAFGLV LWEITRRTYS NGIVEEYKPP FYDMVPNDPS FEDMKKVVCI
EQQRPNIPNR WFSDPTLSTL AKLMKECWYQ NPSARLTALR IKKTLVKINN SLKKLKADC
//