ID H3A6P4_LATCH Unreviewed; 1192 AA.
AC H3A6P4;
DT 18-APR-2012, integrated into UniProtKB/TrEMBL.
DT 01-MAY-2013, sequence version 2.
DT 27-MAR-2024, entry version 75.
DE RecName: Full=Phospholipid-transporting ATPase {ECO:0000256|RuleBase:RU362033};
DE EC=7.6.2.1 {ECO:0000256|RuleBase:RU362033};
GN Name=LOC102350213 {ECO:0000313|Ensembl:ENSLACP00000005315.2};
OS Latimeria chalumnae (Coelacanth).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Coelacanthiformes; Coelacanthidae; Latimeria.
OX NCBI_TaxID=7897 {ECO:0000313|Ensembl:ENSLACP00000005315.2, ECO:0000313|Proteomes:UP000008672};
RN [1] {ECO:0000313|Proteomes:UP000008672}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Wild caught {ECO:0000313|Proteomes:UP000008672};
RA Di Palma F., Alfoldi J., Johnson J., Berlin A., Gnerre S., Jaffe D.,
RA MacCallum I., Young S., Walker B.J., Lander E., Lindblad-Toh K.;
RT "The draft genome of Latimeria chalumnae.";
RL Submitted (AUG-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSLACP00000005315.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + H2O + phospholipidSide 1 = ADP + phosphate +
CC phospholipidSide 2.; EC=7.6.2.1;
CC Evidence={ECO:0000256|ARBA:ARBA00034036,
CC ECO:0000256|RuleBase:RU362033};
CC -!- COFACTOR:
CC Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
CC Evidence={ECO:0000256|ARBA:ARBA00001946};
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141,
CC ECO:0000256|RuleBase:RU362033}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141, ECO:0000256|RuleBase:RU362033}.
CC -!- SIMILARITY: Belongs to the cation transport ATPase (P-type) (TC 3.A.3)
CC family. Type IV subfamily. {ECO:0000256|ARBA:ARBA00008109,
CC ECO:0000256|RuleBase:RU362033}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AFYH01178233; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01178234; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01178235; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01178236; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01178237; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01178238; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01178239; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01178240; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01178241; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01178242; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_014350658.1; XM_014495172.1.
DR RefSeq; XP_014350659.1; XM_014495173.1.
DR RefSeq; XP_014350660.1; XM_014495174.1.
DR RefSeq; XP_014350661.1; XM_014495175.1.
DR AlphaFoldDB; H3A6P4; -.
DR STRING; 7897.ENSLACP00000005315; -.
DR Ensembl; ENSLACT00000005362.2; ENSLACP00000005315.2; ENSLACG00000004724.2.
DR GeneID; 102350213; -.
DR KEGG; lcm:102350213; -.
DR eggNOG; KOG0206; Eukaryota.
DR GeneTree; ENSGT00940000161917; -.
DR HOGENOM; CLU_000846_3_2_1; -.
DR InParanoid; H3A6P4; -.
DR OMA; GFNTYYW; -.
DR OrthoDB; 275833at2759; -.
DR TreeFam; TF300654; -.
DR Proteomes; UP000008672; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR GO; GO:0140326; F:ATPase-coupled intramembrane lipid transporter activity; IEA:UniProtKB-EC.
DR GO; GO:0000287; F:magnesium ion binding; IEA:UniProtKB-UniRule.
DR GO; GO:0015914; P:phospholipid transport; IEA:InterPro.
DR CDD; cd02073; P-type_ATPase_APLT_Dnf-like; 1.
DR Gene3D; 3.40.1110.10; Calcium-transporting ATPase, cytoplasmic domain N; 1.
DR Gene3D; 2.70.150.10; Calcium-transporting ATPase, cytoplasmic transduction domain A; 1.
DR Gene3D; 3.40.50.1000; HAD superfamily/HAD-like; 1.
DR InterPro; IPR023299; ATPase_P-typ_cyto_dom_N.
DR InterPro; IPR018303; ATPase_P-typ_P_site.
DR InterPro; IPR023298; ATPase_P-typ_TM_dom_sf.
DR InterPro; IPR008250; ATPase_P-typ_transduc_dom_A_sf.
DR InterPro; IPR036412; HAD-like_sf.
DR InterPro; IPR023214; HAD_sf.
DR InterPro; IPR006539; P-type_ATPase_IV.
DR InterPro; IPR032631; P-type_ATPase_N.
DR InterPro; IPR001757; P_typ_ATPase.
DR InterPro; IPR032630; P_typ_ATPase_c.
DR InterPro; IPR044492; P_typ_ATPase_HD_dom.
DR NCBIfam; TIGR01652; ATPase-Plipid; 1.
DR NCBIfam; TIGR01494; ATPase_P-type; 2.
DR PANTHER; PTHR24092:SF52; PHOSPHOLIPID-TRANSPORTING ATPASE FETA; 1.
DR PANTHER; PTHR24092; PROBABLE PHOSPHOLIPID-TRANSPORTING ATPASE; 1.
DR Pfam; PF13246; Cation_ATPase; 1.
DR Pfam; PF00702; Hydrolase; 1.
DR Pfam; PF16212; PhoLip_ATPase_C; 1.
DR Pfam; PF16209; PhoLip_ATPase_N; 1.
DR PRINTS; PR00119; CATATPASE.
DR SFLD; SFLDG00002; C1.7:_P-type_atpase_like; 1.
DR SFLD; SFLDF00027; p-type_atpase; 1.
DR SUPFAM; SSF81653; Calcium ATPase, transduction domain A; 1.
DR SUPFAM; SSF81665; Calcium ATPase, transmembrane domain M; 1.
DR SUPFAM; SSF56784; HAD-like; 1.
DR SUPFAM; SSF81660; Metal cation-transporting ATPase, ATP-binding domain N; 1.
DR PROSITE; PS00154; ATPASE_E1_E2; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|RuleBase:RU362033};
KW Magnesium {ECO:0000256|RuleBase:RU362033};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU362033};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741,
KW ECO:0000256|RuleBase:RU362033};
KW Reference proteome {ECO:0000313|Proteomes:UP000008672};
KW Translocase {ECO:0000256|ARBA:ARBA00022967, ECO:0000256|RuleBase:RU362033};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU362033};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|RuleBase:RU362033}.
FT TRANSMEM 80..98
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362033"
FT TRANSMEM 280..303
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362033"
FT TRANSMEM 323..349
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362033"
FT TRANSMEM 874..895
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362033"
FT TRANSMEM 907..927
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362033"
FT TRANSMEM 956..976
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362033"
FT TRANSMEM 996..1014
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362033"
FT TRANSMEM 1026..1049
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362033"
FT TRANSMEM 1069..1090
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362033"
FT DOMAIN 21..86
FT /note="P-type ATPase N-terminal"
FT /evidence="ECO:0000259|Pfam:PF16209"
FT DOMAIN 843..1097
FT /note="P-type ATPase C-terminal"
FT /evidence="ECO:0000259|Pfam:PF16212"
SQ SEQUENCE 1192 AA; 136383 MW; 47F8AEB4A68695BA CRC64;
MPLFGDCRKE RSEAETSRRL KANDREFNLS FEYATNAIKT SKYNLLTFLP LNLFEQFQRI
ANTYFLFLLI LQLIPEISSL SWFTTVVPLV LVLTVTAVKD GIDDLNRHKS DKQVNSRQVQ
VLIHGQLENK QWSDICVGDI IKLENNEFVT ADLLLLSSSE PYGLAYIETA ELDGETNLKV
RQALTLTGEM GNNIQKLYEF DGEVESEPPN NKLDKFTGTL VHKEQKYSLD NDKILLRGCT
LRNTDWCFGL VIFAGPDTKL MQNSGKTVFK RTSIDRLMNI LVLWIFGFLA FLCLVLAICN
GFWEHHKGYY FQVFLPWPES VSSATFSGFL TFWSYVIILN TLVPISLYVS VEIIRLGNSF
YIDWDRKMYY PKNNTPAEAR TTTLNEELGQ IKYIFSDKTG TLTQNIMTFN KCSINGKTYG
DVFNFAGQRI EITNQTEKVD FSYNQLADPK FVFYDHSLVE AVKLGDKSSH EFFRLLALCH
TVMSEEKQDG QLVYQAQSPD ENALVTAARN FGFVFHSRTP ESITVVEMGE TKIYELLAIL
DFNNFRKRMS VIVRSPENRL VLYCKGADTI IFQLLHQSCK QLMDNTTDHL DEFAGDGLRT
LVLAYKDLDK QYFEEWQSRY YEASTAMEER DEKLSELYEE IEKDMQLLGA TAIEDKLQDG
VPQTIEKLSN AGIKIWVLTG DKQETAINIG YSCNMLHDEM KEVFVIEGNT REEVQEELRN
ARAKMKPETL EEEKIIIRQP MKKTRLLPED TVTESYGIVI NGHSLAHALE EHLELELLRT
ACMCKSVICC RVTPLQKAQV VAVVKKYKKA VTLAIGDGAN DVSMIKEAHI GVGISGQEGM
QAVLSSDFSF AQFRYLQRLL LVHGRWSYIR MCKFLSYFFY KNFTFTLVHF WYAFFSGYSA
QTVYDEWFIT LYNLVYTSLP VLGMSLFEQD VDDRWSLEYP QLYEPGQQNL YFNKVAFMKC
VFHGIWSSLV LFFLPYGAIQ NLVRDDGKDV SDYQSFALVA QTCLLLVVSA EIGVDSTYWT
AVNQFFIWGS LAVYFTITFT MYSDGMYLIF TASFPFIGTA RNSLTQPSVW LSVFLTTILC
VLPVVAYRFF MVMLRPNFSD KLNYMISKSK KRPPPEQRRA RLRRVSSRRS SYAFSHQQGF
GALIMSGRNM RPRTAPAASS RVIDRSNTAA AAAGSSSRSA NATMRNVIVD GS
//