ID H3A6R2_LATCH Unreviewed; 574 AA.
AC H3A6R2;
DT 18-APR-2012, integrated into UniProtKB/TrEMBL.
DT 18-APR-2012, sequence version 1.
DT 27-MAR-2024, entry version 63.
DE RecName: Full=Geranylgeranyl transferase type-2 subunit alpha {ECO:0000256|ARBA:ARBA00014772, ECO:0000256|RuleBase:RU367120};
DE EC=2.5.1.60 {ECO:0000256|ARBA:ARBA00012656, ECO:0000256|RuleBase:RU367120};
DE AltName: Full=Geranylgeranyl transferase type II subunit alpha {ECO:0000256|RuleBase:RU367120};
GN Name=RABGGTA {ECO:0000313|Ensembl:ENSLACP00000005333.1};
OS Latimeria chalumnae (Coelacanth).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Coelacanthiformes; Coelacanthidae; Latimeria.
OX NCBI_TaxID=7897 {ECO:0000313|Ensembl:ENSLACP00000005333.1, ECO:0000313|Proteomes:UP000008672};
RN [1] {ECO:0000313|Proteomes:UP000008672}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Wild caught {ECO:0000313|Proteomes:UP000008672};
RA Di Palma F., Alfoldi J., Johnson J., Berlin A., Gnerre S., Jaffe D.,
RA MacCallum I., Young S., Walker B.J., Lander E., Lindblad-Toh K.;
RT "The draft genome of Latimeria chalumnae.";
RL Submitted (AUG-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSLACP00000005333.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- FUNCTION: Catalyzes the transfer of a geranyl-geranyl moiety from
CC geranyl-geranyl pyrophosphate to cysteines occuring in specific C-
CC terminal amino acid sequences. {ECO:0000256|RuleBase:RU367120}.
CC -!- FUNCTION: Catalyzes the transfer of a geranylgeranyl moiety from
CC geranylgeranyl diphosphate to both cysteines of Rab proteins with the
CC C-terminal sequence -XXCC, -XCXC and -CCXX, such as RAB1A, RAB3A, RAB5A
CC and RAB7A. {ECO:0000256|ARBA:ARBA00002902}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=geranylgeranyl diphosphate + L-cysteinyl-[protein] =
CC diphosphate + S-geranylgeranyl-L-cysteinyl-[protein];
CC Xref=Rhea:RHEA:21240, Rhea:RHEA-COMP:10131, Rhea:RHEA-COMP:11537,
CC ChEBI:CHEBI:29950, ChEBI:CHEBI:33019, ChEBI:CHEBI:57533,
CC ChEBI:CHEBI:86021; EC=2.5.1.60;
CC Evidence={ECO:0000256|ARBA:ARBA00001577,
CC ECO:0000256|RuleBase:RU367120};
CC -!- SIMILARITY: Belongs to the protein prenyltransferase subunit alpha
CC family. {ECO:0000256|ARBA:ARBA00006734, ECO:0000256|RuleBase:RU367120}.
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DR EMBL; AFYH01170731; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01170732; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01170733; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01170734; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01170735; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01170736; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01170737; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01170738; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01170739; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; H3A6R2; -.
DR STRING; 7897.ENSLACP00000005333; -.
DR Ensembl; ENSLACT00000005380.1; ENSLACP00000005333.1; ENSLACG00000004742.1.
DR eggNOG; KOG0529; Eukaryota.
DR GeneTree; ENSGT00550000075121; -.
DR HOGENOM; CLU_031996_3_2_1; -.
DR InParanoid; H3A6R2; -.
DR OMA; PKSYNAW; -.
DR TreeFam; TF315057; -.
DR Proteomes; UP000008672; Unassembled WGS sequence.
DR Bgee; ENSLACG00000004742; Expressed in muscle tissue and 3 other cell types or tissues.
DR GO; GO:0004663; F:Rab geranylgeranyltransferase activity; IEA:UniProtKB-UniRule.
DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR GO; GO:0097354; P:prenylation; IEA:UniProtKB-UniRule.
DR Gene3D; 1.25.40.120; Protein prenylyltransferase; 1.
DR Gene3D; 2.60.40.1130; Rab geranylgeranyltransferase alpha-subunit, insert domain; 1.
DR Gene3D; 3.80.10.10; Ribonuclease Inhibitor; 1.
DR InterPro; IPR032675; LRR_dom_sf.
DR InterPro; IPR002088; Prenyl_trans_a.
DR InterPro; IPR036254; RabGGT_asu_insert-dom_sf.
DR InterPro; IPR009087; RabGGT_asu_insert-domain.
DR PANTHER; PTHR11129:SF2; GERANYLGERANYL TRANSFERASE TYPE-2 SUBUNIT ALPHA; 1.
DR PANTHER; PTHR11129; PROTEIN FARNESYLTRANSFERASE ALPHA SUBUNIT/RAB GERANYLGERANYL TRANSFERASE ALPHA SUBUNIT; 1.
DR Pfam; PF01239; PPTA; 3.
DR Pfam; PF07711; RabGGT_insert; 1.
DR SUPFAM; SSF52058; L domain-like; 1.
DR SUPFAM; SSF48439; Protein prenylyltransferase; 1.
DR SUPFAM; SSF49594; Rab geranylgeranyltransferase alpha-subunit, insert domain; 1.
DR PROSITE; PS51147; PFTA; 3.
PE 3: Inferred from homology;
KW Leucine-rich repeat {ECO:0000256|ARBA:ARBA00022614};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Prenyltransferase {ECO:0000256|ARBA:ARBA00022602,
KW ECO:0000256|RuleBase:RU367120};
KW Reference proteome {ECO:0000313|Proteomes:UP000008672};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Transferase {ECO:0000256|RuleBase:RU367120}.
FT DOMAIN 247..349
FT /note="Rab geranylgeranyltransferase alpha subunit insert-
FT domain"
FT /evidence="ECO:0000259|Pfam:PF07711"
SQ SEQUENCE 574 AA; 66466 MW; 345C992F10680685 CRC64;
QHGRIKVKTT EEQQEVKRKE REKKLQLYLT CISTVFKKRQ NGELDQEMLE LTSQILGVNP
DVATLWNYRR EVFLELRKEN KNSPSGHPVI RGRFLQTVSS SIEFNPRTYS RFSQNRFQLH
KIGKPGAVTA LNYCAISLFA NFSFVTFFHC WDYRRFVVQR SAVLPVEELA YTNKLISTNF
SNYSSWHYRS KLLPLIHPDM ERKGRVTEDV LLKEYEMVQN AFFTDPNDQS AWFYYRWLLG
RAEQEESITC LYASWDMGQL VVGFSRPVNV LLESSELVLF VDGRPTPVKW QNPRKTQSYS
CVWVSVLRTV GLQSGAPIMT FFCVWGGGQY NKECILYPGR TETWCRDSAT DEQLFRCELS
VEKTTVLQSE LELCKQLQEI EPQNKWCILT IILLMRSLDP LAYEKETLLY FDTLKAADPM
RTAYFNDLRS KFIIENNILK MEYAEVRVID LSKKDLTSLC HLDQLLLVTH MNLSANQLKS
LPVSLSMMQC LEVLEVDDNE VASVEGLYNL PRLEEVSLRN NRILLLSICR PSDLCPLATC
PKLSILNLQG NPICDVIDVQ SELVLLLPNV EIIM
//
